Spleen transplantation

Spleen transplantation is the transfer of spleen or its fragments

Spleen transplantation
from one individual to another. It is under research for induction of
immunological tolerance for other transplanted organs. Success has ICD- 41.94 (http://icd9cm.chrisen
been achieved in rodent models. Recently, evidence has been 9-CM dres.com/index.php?srchtyp
obtained for a tolerogenic effect of a spleen transplant in miniature e=procs&srchtext=41.94&Su
swine. Also, the spleen harbors primitive hematopoietic progenitor bmit=Search&action=searc
cells. Spleen transplantation has been performed on humans with h)
mixed results.[1][2]

Contents
Autotransplantation
See also
References

Autotransplantation
Splenic tissue can be deliberately autotransplanted after splenectomy, as some tissue will still be viable, to
attempt to preserve some splenic function (with the goal of preventing OPSI). Usually this involves leaving
parts of splenic parenchyma in pouches of omentum. This is not without risk or complication. This was
performed after splenosis was understood; splenosis is the spontaneous reimplantation of splenic tissue
elsewhere in the body (usually the abdomen) after it has broken off from the spleen due to trauma or
surgery.[3]

According to a 2020 review of 18 experimental studies, the transplanted spleen appears functional, with
95% of re-implanted tissue undergoing regeneration (by scintigraphy) and 90% of patients having a
normalized blood film (suggesting functional blood filtration). All studies also report restoration of antibody
levels. There is insufficient evidence to draw conclusions about OPSI rates. Of patients, 3.7% suffer from
complications.[3]

See also
Accessory spleen – Small nodule found apart from the main body of the spleen
Polysplenia – Developmental failure in spleen formation
Splenectomy – Surgical removal of the spleen

References
1. Wu; et al. (January 2011). "Graft-versus-host disease after intestinal and multivisceral
transplantation". Transplantation. 91 (2): 219–224. doi:10.1097/tp.0b013e3181ff86ec (https://
doi.org/10.1097%2Ftp.0b013e3181ff86ec). PMID 21076376 (https://pubmed.ncbi.nlm.nih.go
v/21076376).
 2. Deierhoi; et al. (April 1986). "Lethal graft-versus-host disease in a recipient of a pancreas-
spleen transplant". Transplantation. 41 (4): 544–546. doi:10.1097/00007890-198604000-
00028 (https://doi.org/10.1097%2F00007890-198604000-00028). PMID 3515658 (https://pu
bmed.ncbi.nlm.nih.gov/3515658).
3. Surendran, A; Smith, M; Houli, N; Usatoff, V; Spelman, D; Choi, J (April 2020). "Splenic
autotransplantation: a systematic review". ANZ Journal of Surgery. 90 (4): 460–466.
doi:10.1111/ans.15383 (https://doi.org/10.1111%2Fans.15383). PMID 31576640 (https://pub
med.ncbi.nlm.nih.gov/31576640).

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