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• These infective agents can spread from a source of infection (e.g. patients,
sick animals) to a person through various routes of transmission .
(DH, 2022)
Chain of Infection
• Human reservoirs
• Many common infectious diseases have human reservoirs.
• e.g. measles and many respiratory pathogens.
• Animal reservoirs
• The term zoonosis refers to an infectious disease that is transmissible from vertebrate animals to humans.
• e.g. plague (rodents), rabies (dogs)
• ?? Ebola, SARS are thought to have emerged from animal hosts, but not yet been identified.
• Environmental reservoirs
• Soil, and water in the environment are also reservoirs for some infectious agents.
• e.g. Outbreaks of Legionnaires disease are often traced to water supplies in cooling towers
(CDC, 2012)
Chain of Infection
• 3. Portal of Exit
• Portal of exit is the path by which a pathogen leaves its host. The portal of exit
usually corresponds to the site where the pathogen is localized. For example,
influenza viruses exit the respiratory tract.
(CDC, 2012)
Chain of Infection
• 4. Modes of transmission
• An infectious agent may be transmitted from its natural reservoir to a
susceptible host in different ways. (CDC, 2012)
• Contact transmission
• Droplet transmission
• Airborne transmission
• Blood / Body Fluid transmission
• Food borne / fecal oral transmission
• Vector borne transmission (DH, 2022)
Contact transmission
• Through direct body contact with the infected
person
• e.g. Lifting client or assisting in taking bath
(DH, 2022)
Droplet transmission
• Refers to spray with relatively large, short-range aerosols produced by
sneezing, coughing, or even talking.
• Direct spray can travel over a few feet, before the droplets fall to the ground.
(CDC, 2012)
• e.g. Influenza, SARS
(CDC, 2012)
Blood / Body Fluid transmission
• Through injury by
contaminated needles, sharps
(DH, 2022)
Vector-borne transmission
• Vectors such as mosquitoes, and
ticks may carry an infectious agent
• (e.g. Dengue fever, malaria, zika,)
• Use the same portal to enter a new host that they used to exit the source
host. For example, influenza virus exits the respiratory tract of the source
host and enters the respiratory tract of the new host.
• Specific immunity refers to protective antibodies that are directed against a specific agent.
• Such antibodies may develop:
• 1. In response to infection or vaccine,
• 2. By transplacental transfer from mother to fetus;
• 3. By injectionof antibodies.
• Nonspecific factors that defend against infection include the skin, mucous membranes,
gastric acidity, cilia in the respiratory tract and the cough reflex.
• Factors that may increase susceptibility to infection by disrupting host defenses include
malnutrition, and disease or therapy that impairs the nonspecific immune response.
(CDC, 2012)
Why are residential care homes for the elderly more
vulnerable to outbreaks of communicable diseases?
• 1. Collective living places where communicable diseases can easily spread through
close person-to-person contact, leads to cross-infection.
• 2. The frailty of the residents also aids the spread by showing less obvious
symptoms. This makes the infection more difficult to detect resulting in potential
delay of treatment and risk of transmission within residential care home.
Building up immunity
Healthy lifestyle
Vaccination
(DH, 2022)
When to perform hand hygiene?
For staff, “5 moments for hand hygiene”
• Before touching a resident;
• Before a clean or aseptic procedure;
• After blood, body fluid, secretion, excreta, wound or
mucous membrane exposure risk, e.g. after
changing diaper;
• After touching a resident;
• After touching contaminated items or resident
surrounding environment.
(DH, 2022)
When to perform hand hygiene?
For residents, “5 moments for hand hygiene”
• Before handling or eating food /
medications;
• After using the toilet;
• After coughing or sneezing;
• After touching public installations or
equipment, such as escalator handrails,
elevator control panels or door knobs
• Before and after touching eyes, nose and
mouth (not recommend to touch eyes, nose
indeed). (DH, 2022)
1.2 Use of Personal Protective Equipment (PPE)
• To minimise the risk of infection or
further transmission.
(DH, 2022)
1.3 Environmental cleaning and disinfection
• 1 : 99 diluted household bleach: Clean and disinfect frequently touched surfaces,
furniture, rehabilitation aids, floor, toilets and bathrooms regularly.
• 1 : 4 diluted household bleach: For spillage of blood. leave for 10 minutes and then
rinse with water and keep dry.
*(For 1:99, 1:49 and 1:4, mixing 1 part of household bleach containing 5.25% sodium
hypochlorite with 99, 49 & 4 parts of water respectively)
**Care should be taken to avoid its use on metal surfaces since sodium hypochlorite is
corrosive to metal. Use 70% alcohol to disinfect metal surfaces. (DH, 2022)
1.3 Environmental cleaning and disinfection
• Always keep the windows open for good indoor ventilation.
• Keep appropriate distance between beds or groups of beds (not less than
1 metre as far as possible or with partitioned barrier between beds) to
reduce the chance of transmission of infective agents by droplets.
(DH, 2022)
1.4 Proper handling of used or soiled linen
• Infective agents can be transmitted through contact with linen.
Therefore, all linen should be washed thoroughly after use.
(DH, 2022)
1.5 Proper clinical waste disposal
(Lab practice)
• Separate clinical waste from domestic waste.
• Clinical waste includes used needles and gauze with.
• Pack and label clinical waste properly in colour-coded bags
with biohazard signs.
• Red bag: clinical waste
• Yellow bag: human and animals tissues or organs
• Black bag: domestic waste
• Wear gloves before handling clinical waste and wash hands
thoroughly afterwards.
• Store clinical waste securely before collected by licensed
clinical waste collector.
• Keep a record of the clinical waste consigned.
(DH, 2022)
1.5 Proper clinical waste disposal
(Lab practice)
(DH, 2022)
1.6 Proper handling of sharps (Lab practice)
• Do not recap used needles.
• Syringes and sharps must be disposed of in a
puncture-proof and spill-proof container labelled
‘Biohazard’ on the outside, generally named “Sharp
box”
• A sharp box should not be overloaded and should be
disposed of properly when it is 70% to 80% full.
• Seal the sharp box and dispose in a Red bag by using
‘swan-neck’ sealing method with a warning sign
reading ‘Biohazard’ or ‘Beware of Sharps’ to alert
others during disposal.
(DH, 2022)
2. Transmission-based precautions
• In addition to standard precautions, additional precautions should be
adopted when dealing with diseases with different modes of
transmission.
• 2.1 Contact precautions
• 2.2 Droplet precautions
• 2.3 Airborne precautions
(DH, 2022)
2.1 Contact precautions
• Perform hand hygiene properly.
• Use of PPE depends on the nature of contact.
• Clean and disinfect used items.
• Increase the frequency of environmental
cleaning and disinfect all frequently touched
surfaces.
• Do not share towels and other personal items.
• Centre for Health Protection. (2022). Residential Care Home for the Elderly. Department of
Health, The Government of the Hong Kong Special Administrative Region.
https://www.chp.gov.hk/en/features/21702.html