Automatic high speed machines to

dose pharmaceutical powders and

liquids into vials, bottles and caps.

We are part of
Tecnotrend, part of Comas Group, is a leading company in designing and manufacturing automatic
filling machines to dose pharmaceutical powder and liquids into vials or special containers.

In 1993, Tecnotrend patented a system to develop unique

machines in the world, able to dose pharmaceutical powders, by
keeping the product in A class, i.e. MicroPura system.

In 1999 a new motion system was patented to improve bottles

transfer and perform several operations while still achieving high
production speeds. Thanks to this high technical knowledge and a
wide range of dosing systems, Tecnotrend is able to design and
manufacture “tailor-made” machines. For many years Tecnotrend
made a wide part of its company turnover by supplying dosing and
capping and sealing machines to big Italian and European
machines constructors for pharma: these machines were integrated
in their lines.
Many special requests that involve a long project phase are often
disregarded by the major pharma manufacturers who prefer to
focus on standard production, so these specific projects are taken
in charge by Tecnotrend who is devoted to a professional research
and constant attention to innovation.
Thanks to this “niche” job, Tecnotrend is also able to develop
customized machines for R&D having specific configurations, in
strict compliance with GMP and FDA.
 
Research and Innovation have always been our asset.

COMPANY PROFILE
 PRODUCTS TO HANDLE SUGGESTED DOSING SYSTEM TECNOTREND MACHINES SERIES

Levels to take a
medicine

1° Products for external use: For powders: Vacuum / pressure dosing system For powders:
powders or liquids to be applied on skin. with dosing disk. FM series
For liquids: peristaltic pumps, syringes, piston For liquids:
pump fillers FL series
2° Edible products: For powders: For powders: 
dry or liquid syrups, vitamins, nutraceutical -For dry syrups: Vacuum / pressure dosing For dry syrups: FM series
products (e.g. caps filled with powder for system with dosing disk For caps: FX series
 
extemporaneous use) -For caps for extemporaneous use: dosing For liquids:
  needles with powder compression FL series
For liquids:
-peristaltic pumps, syringes, piston pump fillers

3° Inhalation and ophthalmic products:   For powders: For powders: 

-sprays for breathing problems (asthma) -Vacuum / pressure dosing system without FY series, FX series
-Nasal sprays dosing disk or
-Eye drops dosing needles system with powder compression For liquids:
For liquids: FL series
-peristaltic pumps, syringes, Magnetic inductive
flowmeter dosators and Mass flowmeters

4° Products for intramuscular use For powders: For powders: 

  -Vacuum / pressure dosing system with or FY series , FV series
-Antibiotics without dosing disk   
-Vaccines For liquids: For liquids:
- injectable medicines -peristaltic pumps, syringes, Magnetic inductive FL series
  flowmeter dosators and Mass flowmeters

5° Products to be injected into veins. For powders: For powders: 

  -Vacuum / pressure dosing system without FY series
Penicilline, cephalosporins, and anti-cancer dosing disk   
drugs etc. For liquids: For liquids:
-peristaltic pumps, syringes, Magnetic inductive FL series
flowmeters dosators and Mass flowmeters

STERILITY LEVELS based on medicine intake

OUR POWDER DOSING SYSTEMS

MACRO-
 FM: vacuum/pressure system with disk => For
powders with low granulometry (from μ5 to μ200)

DOSING  FG: gravity system with high granulometry (more than

μ200).

MICRO-  FX: powder compression with dosing needles

DOSING

MICRO-  FV: vacuum/pressure system with disk

DOSING
 FY: vacuum/pressure system without disk
FM SERIES: VACUUM/ PRESSURE DOSING SYSTEM WITH
DOSING DISK
The VACUUM/PRESSURE dosing system is a VOLUMETRIC system,
based on the principle that a certain quantity of HOMOGENEOUS
product corresponds to a precise VOLUME. The product is not
transferred directly from the first container (powder tank) to the final
one (bottle) but in a first phase it is placed in an INTERMEDIATE
CONTAINER (the dosator).
 MORE ABOUT FM SERIES
The powder dosing unit in these machines consists
of:
• an upper tank (pos. 1) with a capacity of 50 liters
• a lower working hopper (pos. 2) in which mixers are
placed to avoid powder agglomerates
• one or more rotating discs (pos. 6) containing the
dosing chambers in which the pistons are located
(pos. 7)
• a series of funnels (between the disk and the
bottles)
Operation:
• The DISK is placed in rotation,
• Thanks to the rotation, each dosing chamber inside the disk
passes under the powder working hopper.
• The air is sucked (VACUUM) through the piston so as to put the
dosing chamber in depression and the powder is filled into the
chamber.
• During the rotation of the disc, from the powder loading position to
the powder ejecting position, the powder is retained with
continuous suction (VACUUM).
• Once the powder ejecting position has been reached, after a
rotation of 180°, the dosing chamber is placed vertically on the
bottle that in the meantime has been positioned under the funnel.
• The depression is interrupted, indeed a slight pressure is created
by blowing air (PRESSURE) through the piston, and the powder is
so ejected into the funnels then into the bottle
Advantages of our vacuum/pressure system
• with the same filling quantity we achieve higher speeds and at
the same speed we can do bigger dosages.
• there are fewer places where the dust can collect.
• there is no powder spillage within machine area thanks to a
tighter connection between the dosing elements and the bottles.
• adjustments are made by acting on time, pressure, and this
improves filling accuracy.
• the “fume extraction” is made by means of an external suction
group, which is removable, washable and sterilizable.
 FG SERIES: gravity dosing system
The gravity system is used when the
granules have a granulometry of more
than 200 µ and therefore the
vacuum/pressure system is not
appropriate.

It is based on the assumption that the

powder to dose is so smooth that its
weight makes the granules fall down.

The dosing unit in these machines consists of:

• Powder tank: above the dosing cylinder

• Dosing cylinder: it is filled with the granules up to the
edge, then the granules are levelled using a scraping
device without breaking them.
• Valve: below each dosing cylinder
• Funnels / Conveyors: they are located between the
cylinder and the bottle to fill.
After the scraping the valve underneath opens and the
powder falls first in the funnels then into the bottles.
FX SERIES: powder
compression with dosing needles
MORE ABOUT FX SERIES
Operation

 The piston of the powder compression system is

movable.
 The piston goes down compressing the powder
inside the needle on the tank bottom so to create a
compact powder tablet.
 The piston rises slightly.
 The needle is able to hold the powder while moving
towards the container to dose.
 The powder ejection is mechanical, due to the
piston movement, and the ejection is made after
the needle has been introduced into the final
container (vial, bottle or cap).

The dosing unit in these machines consists of : Advantages of our system

• Unlike the vacuum pressure systems, the sealing
• a feeding group, that conveys the powder to a free sector placed
and scraping elements of the dosing disk are not
inside a tank.
present, therefore the main cause of heat and
•a powder tank: the tank is kept at a constant level, either by its own
movement or by a scraping element, with continuous or intermittent
particle generation as well as the dispersion of
motion. powder are eliminated by using a mechanical
•Dosing needles: one sector of the tank is uncovered, and in this ejection.
part the DOSING elements, needle-shaped, plunge into. • Absence of the connection of compressed air and
As for the rotating disk, inside these needles there is a piston, vacuum circuits to the moving dosators.
whose position is adjustable in order to change the dosing
conditions.
FV SERIES: vacuum/ pressure
dosing system with dosing disk

MORE ABOUT FV SERIES:
The powder dosing unit in these machines consists
of:
• an upper tank (pos. 1) with a capacity of 50 liters
• a lower working hopper (pos. 2) in which mixers are
placed to avoid powder agglomerates
• one or more rotating discs (pos. 6) containing the
dosing chambers in which the pistons are located (pos.
7)
Operation:
• The DISK is placed in rotation,
• Each dosing chamber inside the disk passes under the powder
working hopper.
• The air is sucked (VACUUM) through the piston so as to put
the dosing chamber in depression and the powder is filled into
the chamber.
• During the rotation of the disc, from the powder loading
position to the powder ejecting position, the powder is retained
with continuous suction (VACUUM).
• Once the powder ejecting position has been reached, after a
rotation of 180°, the dosing chamber is placed vertically on the
vial that in the meantime has been positioned under the disk.
• The depression is interrupted, indeed a slight pressure is
created by blowing air (PRESSURE) through the piston, and the
powder is so ejected into the vial.
Advantages of our vacuum/pressure system
• with the same filling quantity we achieve higher speeds and at
the same speed we can do bigger dosages.
• there are fewer places where the dust can collect.
• there is no powder spillage within machine area thanks to a
tighter connection between the dosing elements and the
bottles.
• adjustments are made by acting on time, pressure, and this
improves filling accuracy.
• the “fume extraction” is made by means of an external
suction group, which is removable, washable and sterilizable.
 i l i ty
st er
…in

FY SERIES: vacuum/pressure system without dosing disk

MORE ABOUT FY SERIES
The dosing unit consists of:
• vacuum pressure pistons and dosing
needles
• Powder main tank
• powder working tank with constant level
No holding and scraping elements are
present
There are no moving parts inside the
needles.
Operation
 The dosing needle moves vertically down to the
powder working tank
 The needle enters the powder with a slight suction
 The suction in this case (unlike the system with disk),
serves to let the air out and not to take the powder.
 There is nothing that passes over the vials to dose,
just the needles, since the tank is placed under the
vials path.
 The powder is then ejected with a minimal air jet into
the vial.
Advantages
 Combining the advantages of the needle movement with those
of vacuum/pressure, a dosing system with innovative features is
obtained, in which there is almost no particles generation.
 With the needle system you need very little vacuum / suction for
the formation of the powder slug and very little compressed air to
eject it.
 Less powder dispersion and greater precision.
 CG SERIES: capping machines
Advantages:
• High production capacity with a minimum footprint
• Customized capping system based on cap features
All our dosing machines can be
equipped with single or multiple
capping stations to handle any kinds
of caps: flip-off caps, screw caps,
ROPP, child –proof, dosing glasses,
spray pump, droppers and so on.
The capping area can be separated
from the dosing area by
polycarbonate panels.
The caps feeders can be set either
inside or outside the machine hood.
Each cap feeding vibrator can be
connected to an automatic cap
feeding system.
 CG SERIES: blade sealing
machine
Sealing machine with fixed blade
system, where the bottle rotates on
itself and moves forward following a
motion in the shape of a semicircle.

The bottle is kept under pressure

from above and below by two
plates: here the sealing of the alu-
cap takes place around the bottle
neck.

Production speed: up to 30.000

bottles / hour.

Advantages:
• Latest state-of-the-art technology for vial sealing after filling with injectable drugs
• Ranked Class B of sterility due to least particle generation
• Longer blade to carry out a “high cosmetic” sealing level
 FL SERIES: liquid filling machines from 100 to 500 pcs/min.
The liquid dosing systems based on the physical liquid characteristics, production speed and quantity to fill, are:
1. Peristaltic pumps
2. Syringes
3. Mass flowmeter dosators
4. Magnetic inductive flowmeter dosators
Note: each machine can therefore be equipped with one of the aforementioned dosing systems depending on the technical
specifications
MORE ABOUT FL SERIES

Advantages:

We make use of bottles movements that gather bottles in groups, then we fill the them simultaneously,
even up to 16 bottles at a time, while at machine infeed and outfeed the bottles are transported in
continuous motion.

With this combination of intermittent and continuous motion we can maintain high speeds while
carrying out high dosages as well as many operations on the bottles.
OPTIONS

All our machines can be equipped with:

• Automatic feeding systems for bottles and caps

• 100% IPC control weight system
• Nitrogen flow before, during and after filling
• Camera control systems
• Vertical Laminar flow
• Opened or Closed RABS
• CIP/SIP
• VIABLE and NO-VIABLE particles monitoring
• Compliance to 21 CFR part 11 (upon request)
• Remote Assistance
• Compliance 4.0 Industry
 High dosage accuracy, least product spillage,
minimum residual product in machine powder
hopper;

Least particle generation within machine

working area;

High speed even by big dosages and big

bottles dimensions;

High flexibility;

Minimum footprint layout;

STRENGTH POINTS
 MANY THANKS FOR
YOUR KIND ATTENTION !