@ StemCyte CORD BLOOD BANKING ISAONCE - IN - A - LIFETIME OPPORTUNITY CHOOSE QUALITY, CHOOSE STEMCYTE ! INDIA’S ONLY HYBRID CORD BLOOD BANK !Gee AS fee Ae oePROMISING FUTURE ! Because of the boundless love we feel for our kids, it’s only natural we want to do everything in our power to see them grow up healthy. Cord blood stem cells have the extraordinary potential to save lives and safeguard the health of your child. Your little step will soon make your world more beautiful and happier. As expecting parents, you must be busy preparing for your little bundle, ensuring that you give your baby nothing but the best. Health is wealth and you now hold the key to providing a safeguard of good health for your baby by preserving the newborn stem cells at thetime of birth. Stem cell collection and preservationis as easy as flipping the pages of abook. ‘As you learn more about the importance of stem cells and their preservation through this journey, we hope that you make a responsible choice today and secure your child and family’s health for a better tomorrow !WHAT IS UMBILICAL CORD BLOOD (UCB) ? @ Once regarded as biological waste, it has become an accepted source of hemato- poietic stem cells. These cells can be used to replenish a patient's immune system by providing stem cells for transplantation. It is used to treat 80+ diseases. @ The umbilical cord develops during the 5"-7" week of pregnancy. Oxygen and food material in the mother's blood diffuse across the placenta into the embryo's blood and then carried along the umbilical cord to the embryo. Placenta Nutrients and Oxygen to baby Arteries Vein Waste and Carbon Dioxide from baby PAGE | 2UMBILICAL CORD BLOOD : A LIFELINE Saving Cells, Saving Lives ... PAGE | 3WHAT ARE STEM CELLS ? What makes newborn stem cells so powerful? It just so happens that these stem cells are the youngest and the most powerful of all stem cells. Not only do these cells have the ability to change into many different types of cells within the body, but they also have the potential to repair and regenerate the cells by stimulating the potential and regenerative mechanisms. NERVE CELL CARDIAC CELL BLOOD CELL LIVER CELL WBE muscwe ceu Stem cells are special human cells that are able to develop into many different coll types. Stem cells provide new cells for the body as it grows, and replace specialized cells that are damaged or lost. They have two unique properties that enable them to do this : @ They can divide over and over again to produce new cells. As they divide, they can differentiate into the other types of cells that make up the body. PAGE | 4WHY CORD BLOOD STEM CELLS ? SOURCES OF STEM CELLS Bo els Peripheral " Blood oul Tissue Cord Blood Minimum Graft Easier to find Non-invasive —_ Easy to collect & v/sHost Diseases HLAMatched procedure can be preserved (GvHD) Unit for many years PAGE | 5WHY CORD BLOOD BANKING ? India has the largest number of children with thalassemia major in the world, about I to 1.5 lakh, and about 10,000-15,000 children having thalassemia major are born every year. After the USA and China, India ranks 3“ highestin reported cases of Blood Cancer. There are nearly 25,000 children diagnosed with cancer in india every year and around 9000 of these have leukemia, CORD BLOOD BANKING IS ONCE IN A LIFETIME OPPORTUNITY AND CAN BE USED 10 TREAT 80+ LIFE THREATENING DISEASE INCLUDING THALASSEMIA, LEUKEMIA, LYMPHOMA AND MANY MORE... TREATMENT AVAILABLE FOR SPECTRUM OF DISEASES BLOOD CANCER & BLOOD RELATED DISORDERS ‘Acute Biphenotypic Leukemia Acute Lymphoblastic Leukemia (Alt) Acute Myolofibrosis ‘Acute Myelogenous Leukemia (AML) ‘Acute Undifferentiated Leukemia Se Ge oe Agnogenic Myeloid Metaplasia Aplastic Anemia Beta Thalassemia Major Chronic lymphocytic Loukernia (Ct) Chronic Myelogenous Leukemia (CML) Chronic Myelomonocytic Leukernia (CMML) Congenital Dyserythropoictic Anemia Congenital Thrombocytopenia eee eee Se eee eeerrerrer cee Diamone-Blackfan Anemia Essential Thrombocythemi Fanconi Anemia lanzmann Thrombasthenia Hodgkin's lymphoma Juvenile Chronic Myelogenous Leukemia (JCML) Juvenile Myelomonocytic Leukernia (uMML) Medulloblastoma Neuroblastoma Non-Hodgkin's Lymphoma (Burkitt's ymphoma) Paroxysmal Nocturnal Hemoglobinuria (PNH) Plasma Cell Lukemia Polyeythemia Vera Pure Red Cell Aplasia Refractory Anemia PAGE | 6see eeoe TREATMENT AVAILABLE FOR SPECTRUM OF DISEASES Refractory Anemia with Excess Blasts Refractory Anemia with Excess Blasts in Transformation Retinoblastoma Shwachman-Diamond Syndrome Sideroblastic Anemia Sickle Cell Disease Waldenstrom's Macroglobulinemia METABOLIC DISORDERS oe Cee e were er rere se ‘Adrenoloukodystrophy (ALD) Hunter Syndrome (MPS) Hurler Syndrome (MPS-IH) Krabbe Disease Lesch-Nyhan Syndrome Maroteaux-Lamy Syndrome (MPS-V)) Motachromatic Loukodystrophy Morquio Syndrome (MPS-IV) Mucolipidosis i (-cellDisease) Niomann-Pick Disease Osteopotrosis Pelizaous-Merzbacher Disease sandhoft| Sanfilippo Syndrome (MPS-Il) Scheie Syndrome (MPS-Is) sly Syndrome (MPS-Vi) Wolman Disease IMMUNE DISORDERS Ataxia-Telangiectasia Bare Lymphocyte Syndrome Cartilage-Hair Hypoplasia Chediak-Higashi syndrome Chronic Granulomatous Disease (c6D) Common Variable immunodeficiency DiGeorge Syndrome Erythropoietic Porphyria Hemophagecytic Lymphohisti Hermansky-Pudlak Syndrome Kostmann syndrome Leukocyte Adhesion Deficiency tymphoproliferative Disorders X-linked Muitiple Myeloma Myelokathexis Neutrophil Actin Deficieney omen Syndrome Pearson's Syndrome Reticular Dysgenesis SCID which is X-linked SCID with absence of T.8 Cells SCID with absence of T Cells, Normal B Cells SCID with Adenosine Deaminase Deficiency systemic Mastocytosis Wiskott-Aldrich syndrome ee Geese 6 eee errr eee Geers PAGE | 7FUTURE POSSIBILITIES Aging Froity ‘Nopecia Areata ‘zhoimerscisoase “Amyotrophic Lateral Sclerosis (AS) ‘nuts ‘rancho Pulmonary Dysplasia (2PD) Cartilage injury Cerebral Palsy Critical Limb Ischemia (cu) Crohn's Disease Diabetes, Type | (this is Auto-Inmune) Diabetes Type Ezzema (Atopic Dermatitis) Encephalopathy pidermolyss Bullosa ye Diseases Clobal Developmental Delay Hearing Loss (acquired sensorineural) HI Intraventricular Hemorrhage Liver Cirrhosis Liver Failure lupus Lysosomal storage Diseases ‘Osteoarthritis osteochondral Lesion Parkinson's disease Peripheral Arterial Disease (PAD) Premature Ovarian Failure Rheumatoid Arthritis, ‘Severe Combined Immunodeficioncy Spinal Cord injury Stroke ‘Surgery for Congenital Heart Detects ‘systomie Sclerosis Tay-Sachs Disease Troumatic Brain Injury STEMCYTE SPONSORED CLINICAL TRIALS @ Rutcers stemeyte partners with Professor Wise Young at Rutgers University in researching spinal Cord injury (SC). Hualien TZU Chi Hospital on his studios on chronic Stroke in Taiwan, Dy tisk an ‘allen Taw Chi Hospital DUKE UNIVERSITY MEDIAL CENTER, Stemcyte partners with Families who banked with Dr. John Lin, professor of StemCyte have participated in Nourosurgery and Cerebral Palsy and Autism clinical Superintendent of trials headed by Dr. Kurtzberg of Duke University Medical Cent : PAGE | 8ADVANCED COLLECTION KIT BOX The collection kit matters when choosing a cord blood bank. The kit contains everything your medical providers need in order to collect the cord blood. It then also must be able to keep those stem cells safe and healthy until they can be processed at a laboratory. stemCyte has taken steps to make sure our kit excels at every step of the process. OF a a ®) A 9 yx! Es eperond 5B Q os * bs : Nae) Stemcyte’s advanced collection kit box is FDA approved and ensures sterile, safe and smooth collection and transportation of UCB units. ° UN Ce TTS) PAGE | 9CORD BLOOD COLLECTION, PROCESSING & PRESERVATION Shipments Monitored & Tracked Down Round The Clock Highly Tensile coos st Saatase ef f @i Transportation of UcBCollection kit ” ToStemcyte a Laboratory Sen. en Unit Reaches ToLaboratory Within Stipulated Time Line ! shockproof ucB Collection Kit Box /} s “ead none Collection By a a Collection of Trained cstn Professional men Sterile Technique PAGE | 10CORD BLOOD COLLECTION, PROCESSING & PRESERVATION -{ Testing &Processing }--->--., = = ° Transferred Into Freezing Bag TNC Count, (D34+ Count, Plasma Depletion Coll Viability Technology = : & More Ensuring upto 99.96% od : Cell Recovery ; * \ Placed In ‘, Canister Preserved In Liquid Nitrogen Tank (-)196°c Controlled Rate Freezing PAGE | 11ABOUT STEMCYTE ! StemCyte is a global cord blood bank and pioneers in regenerative therapeutics that operates internationally in USA, Taiwan and India. StemCyte has built one of the largest inventories of private and public cord blood units in the world which gives extended support to patients and physicians when cord blood transplants are needed. StemCyte India is the only hybrid cord blood bank in the country which is actively involved in both private and public cord blood banking. It is strategically located in Apollo Hospital campus, Ahmedabad, Gujarat. It's association with Apollo Hospitals and Cadila Pharmaceuticals; India’s leading healthcare services providers offers a distinct advantage to our clientele. StemCyte’s global presence makes it a trusted name worldwide ! 9 aar0 nou Me 9 9 2000 TAMAR Strategic demographic locations to cater vast ethnic group worldwide ! PAGE | 12HOW STEMCYTE MAKES A DIFFERENCE Transplant Experience Global Presence 2200+ CBUs released usa (1997) in 350+ Transplant Centres Taiwan (2000) including 47 CBUs in India India (2010) Highest Accreditations Hybrid Model Private + Public rae Banking FDA,FOCA, NABI, ISO- 9001, (CBA Member Bost Quali Qualky) PD Technology Highest TNe Count Upto 99.96% Highest co34+ Count coll Recovery Highost Preserved Volume PAGE | 13HOW DOES HYBRID BANK WORKS ? PUBLIC BANK PRIVATE BANK Anywhere in India = eeheye B= Anywhere in India Anyone {CSS Family StemCyte Client-No _« a Others - Yes RETRIEVAL COST Free Allogeneic ={§ SST autologous / Allogeneic CRITERIAS FOR A CORD BLOOD UNIT TO BE BANKED IN PUBLIC BANK Total Nucleated Cell Count 2900 Millions Viable CD34 Count 21.25 Millions Total Viability 285% Absolute Cord Blood Volume 260ml Microbial Screen Negative for aerobes, anaerobes, fungus PAGE | 14STEMCYTE : INDIA’S ONLY & LARGEST HYBRID CORD BLOOD BANK M Viability Assurance Ifcell viability of stored cord blood unitis unsuitable for transplant, one unit free of cost ormonetary assurance for the purchase of cord blood unit. @ Additional Unit As per the dosage criteria requirement of transplant physician, one unit free of cost. M Replacement Unit If HLA does not match with stored cord blood unit, one unit free of cost. WY Life Saver Guarantee Ifcord blood unit fails to engraft; one unit free of cost ormonetary assurance for the purchase of cord blood unit. © Unsuitability Because Of Genetic Disorder If a patient is unable to use stored cord blood unit due to unsuitability because of genetic disorder, one unit free of cost. © Disaster Relief Program One unit free of costin case of natural calamities. PAGE | 15PLASMA DEPLETION (PD) TECHNOLOGY. PD Technology is superior method for cord blood processing and it is StemCyte’s Proprietary technique. Whole Cord Blood Collected Volume Varies from Patient to Patient Processing luted Gryo Protectant Added Orc) 99.96% eta UCB Distribution Cell Distribution Distinct Advantages with PD Technology PAGE | 16STEMCYTE ACCREDITATIONS stemCyte India has been approved and trusted by the world’s leading accrediting bodies consistently ! een eee od Sree ose Laboratories eal Organization for Beitre sn y aa Accredited © eo PCy Fe a peered Cea peers Penang Cer or) peony eres Een rl perenne ere penne From 2016 onwards, StemCyte is the only Hybrid Cord Blood Bank in India with FACT Accreditation ! PAGE | 17DOCTOR'S SPEAK I prefer to register with Stomoyte, the second time because of Higher call count Partnership with Apollo. = Recommended by follow medical astociates fromuSA. Al their transplant record is credible ‘and a deciding factor to choose Stemcyte. Dr. Ramya Pochotti (pote Hospital Myderabad) * feo! privileged to be associated with such a good company li smeyte and | would like to be ‘ssociated for along term and definitely from my side more patients will bo recommended for your company as all my patient escalate good feedback about stemeyte,” Dr. Vijaya Manohar (Apalio rode, Bangaior) " stemcyte India is a Cord Blood Banking facility Which Ihave used for my Pationts and lam very Satisfied with it's Quality and Services. Lam especially pleased about their options of Private & Public cord blood prosorvation.” Wishing all the best for the future. Dr. Harsh Desai Groring Hosp Anmecebad) “Lam writing this letter to thank Stemcyte India Team {or all support that starts from making @ good quality cord blood unit avail ble, various tests performed ‘on the cord blood before the preservation, as well as, at the time of transplant. must say that lam particularly eatisfied with the TNC and Viability of ‘CU that Ihave received. Your involvement in the entire process of transplant and support during this tenure should: $0 be mentioned here,” Dr. Sameer Melinkeri (Boenanath Mangeshkar Hospital and Research Contr Puno) PAGE | 18CUSTOMERS SPEAK “weny. many thankeforyourtstond | ‘efficient service. Not only did you provide | ‘me with allthe information Irequired but | youhave sent yourteamand responded — | 1 1 1 extremely quickly” + | 1 | “stemeyte:Acompany with best | ! Nenaseeontine | | 1 I Thank you stemcyte | 1 | 1 ! opti ceabad | “rank youstemoytofortheexcolint | presentation and genuine information | provided tohelpustaketheright decision” 1 1 1 1 4 pocccooo “They have the best processing technique. They follow all standard properly. A roliable and quality Stem Cell Bank” | a 1 | | \ “Very good services, quite I | protestnatanatenaypeone® | | 1 | | ! I ! sonra tcone t 4 forthe services and help in making our experiance memorable. We feel emotionally ‘connected with and would strongly recommend all couple to experiance ‘ond personalized services" 1 ! "We porsonally thank the entireteam of stemcyte | 1 ! 1 ronda (on) et rae. cuorat | | PAGE | 19SUCCESS STORIES Fightor Adit, who Defeated Thalassemia with the Help of Stemcyte Stem Coll Banking. ABoon to Baby Boy: Nevelash ‘Autologous Transplant from Malaysia pat Name: Nova Nome: atoy Disease : edecolisytemewn tit Disease = seoto(cetintne tin) Doctor or tvethins) Doctor: or. sernekrtzberg Hospital : Apt osptal Channa Hospital : vk vei Sh Torrente De Tang tering {chang Gung Chiron Howl HeGRY oscar» est: wing verrneathyrermatse Successful Treatment of Thalassemia by Cord Blood Transplant Name Nite Disease ‘Thalassemia Major Ageofthe Transplant : 2% Years Doctor +: Dr.Uday Deotro Hospital Sterling Hospital, Ahmedabad Transplant Date: 19.05.2012 Health status ¢ Transfusion free leading a very healthy lite MIRACLES HAPPEN ONLY AT STEMCYTE ! PAGE | 20Mission Statement StemCyte is dedicated to helping the world’s physicians save more lives by providing high quality, safe and effective stem cell transplantation and therapy to all patients in need. Fen ral LE Ceme eO eStemCyte 'A.GLOBAL REGENERATIVE THERAPEUTICS COMPANY Co Cae Ci Pree seks tey Teeter) CSE EPL EEt) Rescneere yr Lideloto) info@stemeyteindia.com erent RS es Ra