Name : SANYAM JAIN

Class : XII-C
Roll No: 29
 ACKNOWLEDGEMENT
 
The success and the final outcome of this project required a lot
of guidance and assistance from many people and we extremely
fortunate to have got this all along the completion of our
assignment work. Whatever we have done is only due to such
guidance and assistance and we would not forget to thank
them. I respect and thank Mrs. Mamta Rampal for giving us an
opportunity to do this project and providing us all the support
and guidance which made us complete the project on time. We
are extremely grateful to her for providing such nice support
and guidance. This project could not be completed without the
effort and cooperation from our group members. Last but not
least we would like to express our gratitude to our friends who
help us a lot in finalizing this project.
 CERTIFICATE
This is hereby to certify that, the original and genuine
investigation work has been carried out to investigate
about the subject matter and the related data collection
and investigation has been completed sincerely and
satisfactorily by Tushar Gupta of CLASS XII C, LOVELY
PUBLIC SENIOR SECONDORY SCHOOL,
PRIYADARSHINI VIHAR regarding his project titled
“SYNTHESIS OF ASPIRINE”.

Teacher’s Signature
 CONTENTS

S.NO TOPIC

1. Introduction

2. Aim

3. Procedure

4. Reactions

5. Result

6. Uses

7. Harmful effects
 Introduction
Aspirin (Acetylsalicylic acid) was first synthesized in 1893 by
Felix Hofmann. This compound had the medicinal properties of
salicylic acid (an extract of willow bark), without the unpleasant
taste or the high degree of irritation of the mucous membranes
lining the mouth, gullet and stomach.

Aspirin is used extensively as a pain killer (analgesic) and as a

fever-reducing drug (antipyretic). When ingested, acetylsalicylic
acid remains intact in the acidic stomach, but in the basic
medium of the upper intestinal tract, it hydrolyzes forming the
salicylate and acetate ions.

This project is concerned with aspirin, its synthesis and its uses
and harmful and adverse effects. The project presents a simple
way to synthesize aspirin in lab and brings out its uses in today’s
era as medicine and drugs.
AIM: To synthesize aspirin (2-Acetoxybenzoicacid) from
Salicylic acid.

APPARATUS REQUIRED: Bunsen burner, tripod stand, china

dish, glass rod, spatula.

CHEMICALS REQUIRED: Salicylic acid, Acetic acid (pure),

Sodium hydroxide, conc.
Hydrochloric acid

PROCEDURE:

1) Add conc. Hydrochloric acid to a small amount of pure

acetic acid which on reaction gives Acetyl chloride.

2) Then weigh about 2g of salicylic acid and pour it in a china

dish.

3) Take the acyl chloride solution formed and add it to

salicylic acid followed by sodium hydroxide in china dish.
 4) After this heat the china dish placed over tripod stand on
a Bunsen burner .

5) Stir the solution being heated with a glass rod till crystals
of aspirin do not start forming or appearing.

6) When aspirin crystals start appearing in china dish

dehydrate them to a great extent through heating.

7) After getting a crystals in china dish scratch them using

spatula on a paper and dry them thoroughly.

8) Then you are ready with aspirin crystals.

CHEMICAL REACTIONS INVOLVED :

▪ CH3COOH + HCl (conc.) -----🡪 CH3COCl + H2O

▪
RESULT : Aspirin crystals were formed.
SAMPLE:

Weight of crystals formed after drying: 0.450 g

USES OF ASPIRIN

⮚ Aspirin inhibits the synthesis of chemical known as prostaglandins

which simulate inflammation in the tissue and cause pain.

⮚ These drugs are effective in relieving skeletal pain such as that due
to arthritis.

⮚ These drugs are also use to reduce fever (antipyretic).

⮚ These drugs are also used for preventing platelet coagulation

because of its anti-blood clotting action.
 ⮚ Aspirin finds use in prevention of heart attacks.

HARMFUL EFFECTS

● Abdominal or stomach pain, cramping, or burning.

● bloody or cloudy urine
● change in consciousness
● chest pain or discomfort
● constipation
● dark urine
● decreased frequency or amount of urine
● diarrhea
● difficult breathing
● fainting
● fast breathing
● feeling that something terrible will happen
● fever
● general tiredness and weakness