CHEMIST

SYNTHESIS
RY OF
ASPRINE
CHEMISTRTY INVESTIGATORY
PROJECT
YEAR 2021-2022

BY
KAYTHANAA.P
ACKNOWLEDGEMENT
We gratefully acknowledge the blessings and heart
pledged support bestowed upon us by everyone for
the successful completion of this project.
First of all, we would like to thank the supreme power,
the Almighty God for helping us to successfully
complete this project.
We are extremely thankful to our Chemistry
teachers Mrs. Fausiya Rafeeque, Mrs. Asha
Susan , for their valuable guidance that has helped us
patch this project and make it a success. Their
suggestions and instructions have served as a major
contributor towards the completion of this project.
We wish to thank our parents as well for their
undivided support throughout this journey of
exploring such a wonderful topic.
This project would not have come so far without
the support from the people we have mentioned
before.
We are indebted to you all
 CERTIFICATE

This is to certify that the work entered in this

investigatory project is the bonafied work of
Miss KAYTHANAA.P
S.NO TOPIC
1 Introduction
2 Aim
3 Procedure
4 Reaction
5 Results
6 Uses
7 Harmful effects
 A
(
f
i
u
In 1897, scientists at the Bayer company began p
studying acetylsalicylic acid as a less-irritating
replacement medication for common salicylate
medicines. By 1899, Bayer had named it A
"Aspirin" and sold it around the world.Aspirin d
decomposes rapidly in solutions of ammonium u
acetate or the acetates, carbonates, citrates, or a
hydroxides of the alkali metals. It is stable in dry i
air, but gradually hydrolyses in contact with e
moisture to acetic and salicylic acids. In solution A
 d

● Abdominal or stomach
pain, cramping, or burning.
● bloody or cloudy urine
● change in consciousness
● chest pain or discomfort
● constipation
● dark urine
● decreased frequency or
amount of urine
● diarrhea
● difficult breathing
● fainting
● fast breathing
● feeling that something
terrible will happen
3)Take the acyl chloride
solution formed and add it to
salicylic acid followed by
sodium hydroxide in china
dish.
4) After this heat the china
dish placed over tripod stand
on a Bunsen burner .
5) Stir the solution being
heated with a glass rod till
crystals of aspirin do not
start forming or appearing.
6) When aspirin crystals
start appearing in china dish
dehydrate them to a great
extent through heating.
7) After getting a crystals in
china dish scratch them using
spatula on a paper and dry
them thoroughly.
8) Then you are ready with
aspirin crystals.
SAMPL Weight of crystals formed after
drying: 0.450 g
E
⮚ Aspirin inhibits the synthesis of
chemical known as prostaglandins
which simulate inflammation in the
tissue and cause pain.

⮚ These drugs are effective in

relieving skeletal pain such as that due
to arthritis.

⮚ These drugs are also use to reduce

fever (antipyretic).

⮚ These drugs are also used for

preventing platelet coagulation
because of its anti-blood clotting
action.
CHEMICAL ▪ CH3COOH + HCl
REACTIONS (conc.)  CH3COCl + H2O
INVOLVED

RESULTS
ASPRIN CRSYTALS
FORMED
 To Synthesize Asprin
AIM (2Acetoxybenzoicacid) from Salicyliic
Acid

APPARATUS Bunsen Burner, Tripod

REQUIRED Stand ,China Dish ,Glass rod ,
Spatula

CHEMICALS Saclicylic Acid, Acetic Acid

REQUIRED (Pure), Sodium
Hydroxide,Conc.Hydrochloric
Acid

PROCEDUR 1.Add conc. Hydrochloric

E acid to a small amount of
pure
acetic acid which on
reaction gives Acetyl
chloride.

2.Then weigh about 2g of

salicylic acid and pour it in
a china dish.