Empower FR2 Release Notes

R E L E A S E N O T E S
Waters Empower 3 Feature

Release 2
Waters® Empower® 3 Feature Release 2 (FR2) software is a major new release which includes many new
features and enhancements. It also corrects various software defects.
These release notes contain the following important information that explains the system and software
requirements, and the use of Empower 3 FR2 software.
Unless superseded, all previous release notes and product support information apply to this software
release.
Table of Contents
Table of Contents ....................................................................................................................... 1
GxP compliance requirements .................................................................................................... 3
System and software requirements ............................................................................................ 3
Before you install Empower 3 FR 2 software .............................................................................. 3
New features in this release ....................................................................................................... 4
Empower software options .......................................................................................................... 8
Issues fixed in this release ......................................................................................................... 8
Issues fixed in Empower 3 FR2: ................................................................................................... 8
Issues fixed in Method Validation: ............................................................................................... 12
Issues fixed in Empower Toolkit .................................................................................................. 14
Known software issues in this release ...................................................................................... 15
Known issues in data analysis and processing ............................................................................... 15
Known issues in system configuration and project management...................................................... 18
Known issues for installation, upgrade, administration, and instrument control software .................... 19
Known issues in reporting .......................................................................................................... 21
Known issues in Empower software application components: .......................................................... 22
Known issues in Method Validation Manager ................................................................................. 23
Known issues in the Empower toolkit ........................................................................................... 27
Known issues in the Empower Online Information System .............................................................. 27

Waters and Empower are registered trademarks
and “THE SCIENCE OF WHAT’S POSSIBLE.” is a trademark of Waters Corporation.
All other trademarks are the sole property of their respective owners.
Copyright  2013 Waters Corporation
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Program files modified in this release ...................................................................................... 28
Test configurations ................................................................................................................... 38
Windows database server........................................................................................................... 38
Solaris database server.............................................................................................................. 39
RedHat Linux database server .................................................................................................... 39
RedHat Linux RAC database server .............................................................................................. 40
Citrix® server (XenApp™ Server 6.5 Enterprise): .......................................................................... 41
Citrix® server (XenApp™ Server 6.0 Enterprise): .......................................................................... 41
Citrix® server (Presentation Server v4.5): .................................................................................... 42
Client: ..................................................................................................................................... 42
Standalone/Personal Workstation:............................................................................................... 44
LAC/E32 module: ....................................................................................................................... 44
VMware vCenter server .............................................................................................................. 46
SQL 2008 server ....................................................................................................................... 46
VM Storage Unit ........................................................................................................................ 46
VM Backup Storage Unit............................................................................................................. 46
VMware ESXi v4.1 servers .......................................................................................................... 46
Empower 3 Database server virtual machine ................................................................................ 46
Citrix Server – XenApp 6 virtual machine ..................................................................................... 47
Empower 3 File Server virtual machine ........................................................................................ 47
Empower 3 Clients virtual machine .............................................................................................. 47
VMware vSphere v5.0 servers .................................................................................................. 48
VM Storage Unit ........................................................................................................................ 48
VM Backup Storage Unit............................................................................................................. 48
VMware vCenter server and SQL 2008 server ............................................................................... 48
VMware vCenter Server 5.0 ...................................................................................................... 49
SQL 2008 Server....................................................................................................................... 49
VMware vCenter Server (v5.1 environment only) ..................................................................... 50
VMware vCenter Server 5.1 ............................................................................................................ 50
VMware vSphere Update Manager 5.1 ............................................................................................... 50
SQL 2008 Server....................................................................................................................... 51
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GxP compliance requirements
When you install Empower software for the first time, or when you uninstall it, you must qualify the
software so that it meets GxP compliance requirements.
Recommendation: Whenever you install or uninstall software in a GxP environment, follow your
organization’s management-approved, standard operating procedures for changing software.
System and software requirements

Empower 3 FR2 software supports Windows® 7 Professional, Enterprise, and Windows Server 2008 R2,
with Service Pack 1. Specifically, it supports these platforms and operating systems:
Platform Operating systems
Windows 7 Professional or Enterprise with Service Pack 1, 64-

Personal workstation
bit
• Windows 7 Professional or Enterprise with Service Pack 1, 64-

Client or LAC/E32
™ module bit, or
• Windows XP Professional with Service Pack 3, 32-bit
• Windows Server 2008 R2, Enterprise edition with Service

Pack 1, 64-bit (Oracle RDBMS 11.2.0.2.0 with Patchset 15)
• Windows Server 2008 R2, Standard edition with Service Pack
Database server 1, 64-bit (Oracle RDBMS 11.2.0.2.0 with Patchset 15)
• Oracle Solaris 10 (8/11), patched to 9/11 (Oracle RDBMS
11.2.0.2.3)
• Red Hat Enterprise Linux 6.2 (Oracle RDBMS 11.2.0.3.6)
• Oracle Enterprise Edition for Windows, 64-bit, version

11.2.0.2, Patch Set 11
RAC server
• Oracle Enterprise Edition for Solaris and Red Hat, version
11.2.0.3.6
Citrix® Server XenApp 6.0, 6.5 • Windows 2008 R2, Enterprise, 64-bit (Citrix XenApp 6.0/6.5)
Citrix Server XenApp 5.0 • Windows 2003 R2, SP2 Enterprise, 32-bit (Citrix XenApp 5.0)
Data Guard server Windows 2008 R2, Enterprise, 64-bit
Before you install Empower 3 FR 2 software

Back up all Empower projects, library information, and databases before installing this software.
See: The Empower 3 Installation, Configuration, and Upgrade Guide for complete installation instructions.
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New features in this release
The following table lists many of the new features and enhancements in this release.
Feature Description
User Interface • Empower 3 is refreshed with new icons, graphics, and backgrounds with this
Changes release.
• A new Pro Interface is a streamlined version of the classic 6-button interface,
containing three choices: Configure system, Run Samples, and Browse
Projects. The classic Pro Interface is still available as a global user preference
in system polices.
• The Quickstart interface is refreshed.
• The Browse Project Window is reformatted to allow better visibility of project
names.
New technology • Support for Red Hat Enterprise Linux 6.2.

updates
• VMWARE vSphere v5.0 and 5.1
• Windows Server 2008 R2 Standard
• Citrix XenApp Server 6.5
Empower Provides key chromatography performance dashboards to help maximize your

Analytics laboratory resources.
You can use these five, built-in Empower laboratory dashboards to quickly and
accurately determine how laboratory resources are used:
• System Summary
• System Usage
• Project Usage
• User Analysis (optional)
• Methods Analysis
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Feature Description
Processing and • A new Mass Analysis window is now available in Review for analyzing MS,
viewing mass PDA, and UV data in a single view.
spectrometry
data • A new mass calculator enables you to determine the average and
monoisotopic mass from the empirical formula.
• Label peaks based on their Base Peak Intensity m/z.
• Overlay MS and UV Chromatogram channels without needing to first process
the data.
• Improved processed channel descriptions for MS data, which now contain the
channel description (example ES+ or ES-), Cone Voltage, Mass Range, CODA
parameters, and 3D blank subtract settings.
• Automatically remove noise in MS data using CODA (COmponent Detection
Algorithm) for centroid data only. You can view continuum data as centroid
data.
• Automatically subtract a user-selected region in the 3D mass channel to
improve signal-to-noise as part of batch processing.
Method Validation Many new features and enhancements in Method Validation, including those that
Manager provide these capabilities:
enhancements • Work with Validation projects in QuickStart.
and updates
• Include grouped peaks (both timed and named) in all validation tests.
• Include unnamed Impurity in the processing parameters and acceptance
criteria for all tests.
• Specify channel and matrix for acceptance criteria.
• In a Validation Protocol Method, specify how to conduct averaging when
performing multiple injections and multiple preparations.
• A new field, Pass Validation Test, indicates whether the validation results for a
particular test passed or failed.
• Ability to assess linearity with additional fit types.
• Additional options for calculating results in Stability, Specificity, and Filter
Validation tests.
New impurity ICH Impurity processing is now included. The LC processing method includes a
processing new Impurity tab that you can use to specify impurity processing parameters to
identify, group, and fault Impurity peaks. Impurity processing includes a new
type of group peak, Impurity Group, used to calculate Total Impurities and other
user-defined impurity summaries.
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Feature Description
Toolkit updates • Two New Viewers are now available: Audit Trail and Message Center.
• Improved ELN integration using the Sample Set Method Template Defined
User Prompt fields such as vial position and custom fields.
• New toolkit enhancements for mobile applications include new functions you
can use to do these tasks:
• View instrument status
• Sign off results
• Access signed-off PDF reports
• Set a user’s password when creating a new user
• Grant read-only access to Global System Polices
• Grant access to set the group administrator
• Show plots for MS and PDA channels
LDAP • Support for non-Active Directory LDAP servers.

enhancements
• Option to turn on or turn off the use of SSL with LDAP.
• With appropriate privileges, you can modify system policies and local login
accounts in LDAP mode, without having to change the authentication mode
back to local. Also, you can create a local login account while in LDAP mode.
Review • Using the new Result Audit Viewer available in Review, you can view all the
enhancements audit trail information for your results in one place.
• Modify and delete integration events on a chromatogram.
• Redo integration events (enhances the existing Undo integration events
capability).
• View the Purity field in the system.
Run Samples • With the appropriate privileges, you or another user can resume a sample set
that another user paused.
• Start a run from Monitor by clicking Start, without having to first click Stop.
• In the event of a user-specified abort, a new check box can prevent the
shutdown method from running.
• Queued Sample Sets are available after an instrument failure.
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Feature Description
LC Processing • Name unnamed peaks using the peak’s RRT (relative retention time), not RT.
enhancements
• Define components based on RRT, relative to the main component’s retention
time, specified in the RT Reference field on the Component tab of the
processing method.
• Process data using another processing method without having to re-integrate
peaks.
• Combine two separate data channels (for example, UV and fluorescence
channels) into a single processed result, using the new “switch to” operator in
the method set derived channels.
System suitability • Specify System Suitability parameters in the New Processing Method wizard.
enhancements
• Specify relative acceptance criteria using formulas, in addition to specifying
absolute criteria.
Project window • Save customized views in a single project window using “Save Preferences” or
enhancements selected project window views using “Save Preferences in all project
windows”.
• Navigate between a series of “View As” conditions in the project window using
new “View As Next” and “View As Previous” buttons.
• Save an instrument method in a method set all in one step, using the new
menu item “Save With Method Set”.
Show Me In QuickStart, the “Show Me” interactive Help is a guided work flow wizard that
Interactive Help assists users with performing common tasks, such as collecting, processing, and
reporting data, as well as exporting and emailing results. This feature has been
updated and re-introduced for this release.
Configuration • View long project names in project selection lists, such as the Parent Project
Manager list and Browse Project list.
enhancements
• View the status of users in groups, view active users only, and view user’s full
name and status.
• When you clone project hierarchies, Configuration Manager now allocates the
cloned sub-projects the same amount of tablespace as that allocated for the
original sub-projects.
• Create an empty library in Configuration Manager, and then add libraries to it.
Report Publisher • Suppress mismatched data messages from appearing on reports (based on
user privileges).
• Use expanded filtering capability to view the level of sign off in the Sign Off
dialog box.
• New reporting features and report groups that support enhancements to Mass
Analysis and Method Validation Manager.
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Feature Description
Agilent GC • View the syringe size used for a complete injected sample set in the Sample
Instrument Set report.
Control
• COM ports on the PC or LAC/E32 module can now control the Agilent 6890 GC.
• The Agilent 7693A autosampler is now supported on the Agilent 6890 GC as a
basic GC injector. See also PCS 45618.
Empower software options

The following software options have been discontinued:
• Web server
• Pattern Matching
• Data converter options, including Waters Data Converter, AccessChrom, ChemStation, and
MassLynx Data Converter. As a result, the Import MassLynx Data and Waters Data Converter
selections have been removed from Empower 3 menus. These options have been replaced by the
Waters Data Converter 2 (WDC 2) software.
• In addition, the GPC, GPCV, and GPCVLS options have been replaced by the GPC/SEC option.
Tip: This change does not alter any GPC, GPCV, or GPCVLS functionality. These options continue
to be enabled on a per-project basis within the project properties.
• AutoArchive for Empower Workgroup and Empower Enterprise.
Important: AutoArchive is available for Empower Personal.
Issues fixed in this release

The following table contains a list of the software problems fixed in Empower 3 Feature Release 2. The
PCS (Product Change System) numbers identify software issues that Waters personnel monitor within a
system change request tracking tool.
Issues fixed in Empower 3 FR2:
PCS Number Description
30857, 37258, The processing method includes a new field where you can specify the Retention
43904, 37349, Time Reference for unknown peaks. Unknown peaks are then named based on
39756 the Relative Retention Time value calculated using the Reference peak.
48870 A screen unlocking error was corrected.
48629 The Empower 3 application would exit unexpectedly when attempting to run a
sample set that contained a percent sign (%) in the name.
44188 A derived channel created by extracting a chromatogram from 3D data

appeared to have a Data Start value shifted by one data point.
47794 An Empower 2 method named with more than one accented character could not
be opened in Empower 3.
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45577 A new audit trail entry records the event "Connected to existing system”.
45498 The Review application exited unexpectedly when clearing overlaid

chromatograms.
48796 An application locking error was corrected.
47846 In the Japanese release of Empower 3, the QuickStart application would

generate an MFC error when double-clicking to open a method set that
contained a processing method.
47150 The size limit for the recover.log file was increased to 10 Mb.
48492 When a node’s property access is set to Owner, Group, and World, and specific
groups were selected, accessing the Node Properties dialog box generated an
Oracle Error ORA-00001. This no longer occurs.
47619 The Waters DHCP Server service was broadcasting across all network ports on
the LAC/E module, which newer network switches could classify as illegal
broadcast activity.
46088 The DHCP Configuration no longer sets a secondary IP address of 64.1.1.1 for
the Instrument Network.
48799, 42378 After processing a sample set in the Review window, and saving the results, the
Processed By field now displays the user type.
44578 In the Message Center, sorting on the Time column of the Acquisition tab (or
other tabs) caused the view to display all entries in that tab.
This problem no longer occurs.
42917 When restoring a project, if the project directory contained a 0 byte data file, it
failed to update to the next version.
47495, 48822 When importing an AIA file into Empower, x-axis data in seconds was incorrectly
displayed as minutes.
49038 Privilege issue when an administrator-level account was associated with other
user types.
48860 The 2790 format plate type was the default plate type used for the ACQUITY
SM-FTN.
The ANSI-48Vial2mL plate is now the default plate type for the ACQUITY SM-
FTN.
47486 A global count of login failures from all Empower applications now serves as the
basis for user authentication.
49430 It is no longer possible to print a result report without saving a modified report
method.
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50017, 47936 Under some circumstances, modifying Report Publisher default groups would
permanently alter the list of groups available to the report editor.
50010 The PDA Reference display plot (in Review) displayed a jagged pattern due to an
XML reading error.
45274 The Message Center no longer displays details in the Email tab when incorrect
credentials are used.
47964 The limit for the number of projects in the tree view has been increased from
10000 to 65000.
47638 Following an application timeout, unlocking the 6-button Empower window

required that you authenticate twice. Now, you need only authenticate once to
unlock all application windows.
41501 GC syringe size is now an available field in the Report Publisher application.
44289 PC COM ports now support control of the Agilent 6890.
45618 Empower control of the Agilent 6890 GC now supports the 7693A autosampler.
The following requirements must be met in order to support the 7693
autosampler on a 6890 GC:
• Updated 6890 firmware. The 6890A and 6890 “Plus” require firmware revision
A.03.08. The 6890N requires firmware version N.06.07
• An updated autosampler controller kit (G4526A) for the 6890 GC. The
G4526A 6890 Upgrade Kit is available in three versions:
– Opt 001 is for a 6890A (inlet cover and G4517A External ALS controller
box)
– Opt 002 is for a 6890 plus (inlet cover and G4516A Internal ALS controller
board)
– Opt 003 is for a 6890N (inlet cover only)
• The updated 6890A and 6890 Plus are compatible only with the 7693 ALS.
Once updated, the 6890 GC will no longer be compatible with the 7683.
Restriction: You cannot use the 7683 and 7693 autosamplers on the same
6890 GC.
Requirement: The 6890 GC must have either one or two 7683 injectors with
a G2613A or G2913A controller and no firmware update, or one or two 7693
injectors with a G4526A controller and updated GC firmware.
Important: While the 7693 injector is capable of making 6 different "steps"
when setting an injection volume (for example, using a 10 uL syringe allows
the injector to inject 0.2, 1.0, 2.0, 3.0, 4,0, or 5.0 microliters), the 6890 GC
does not have the capability to access step number 6. When used with a
6890 GC, the 7693 injector functions as a "5 step" injector.
43281 You can now modify system policies when LDAP mode is enabled without having
to change the authentication mode back to local.
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44625 You can now create a local login account while in LDAP mode.
45746 You can now enable the use of LDAP authentication without using SSL.
50504 When running in LDAP mode, choosing a Toolkit application from the Project
window menu sometimes produced a login failure.
This behavior is corrected in Empower 3 FR2.
50515,50516 In the Empower 3 System Administrator's Guide, the process to recover the
database was updated to correct errors.
40895 The processing server would exit unexpectedly if results were processed in a
project that contained GPC distribution custom fields with inter-sample labels.
38980 The columns in an exported file from a GPC distribution report are now aligned.
49298 In the Empower SystemsQT for Software IQ, the Pass/Fail reviewer and
approver text is no longer shown when performing an electronic sign off.
47376 Printing an instrument method or post run report no longer causes information
to overlap in the footer.
47008 In the channel description field of 2D channels table, the 3D channel polarities
have been added after the extracted channel name.
44100, 44313 You can now perform cross-channel quantitation using the component set in the
Curve Reference column in the Processing Method Component table.
41556 The Method Set Editor now provides expanded smoothing level choices for MS
processing methods and MS derived channels. In addition, COmponent
Detection Algorithm (CODA) analysis is available.
You apply the CODA algorithm in the processing method to reduce noise in MS
data. Data processed using this algorithm results in a new 3D channel that can
reveal peaks previously hidden by noise.
40908, 45573 You can now perform batch processing using MS data (all types) with real time
3D baseline automatic subtraction.
42038 Online Help for Empower Database properties was corrected to distinguish
between the tablespace management capabilities built into Empower 3 Personal
and those available for Empower 3 Workgroup and Enterprise, which use Oracle
Enterprise Manager to manage tablespace.
47815 For non-FAT projects, the "Modify Report Scaling Only" privilege was not applied
when opening the Properties dialog box for a plot. This privilege is now applied.
47846 In the QuickStart Interface, clicking away from the Method Set editor could
cause the application to exit unexpectedly.
48851 There is no longer a difference between the scan number observed in Review
compared to the scan number observed in Reporting, when an MS offset is used
in the processing method.
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48969 Under certain circumstances, it was possible to delete a locked custom field.
49995,50238, In response to USP 35 chapter <621>, Chromatography, effective 01 December

50386 2012, as well as changes to chapter 2.2.46, Chromatographic Separation
Techniques, of EP 7.06, the signal-to-noise calculation was modified:
• USP s/n is still calculated as H/h, but the determination of H and h has
been changed to be the same as it is for the EP and JP s/n calculations.
The default width of the region used to calculate h (the Half Height
Multiplier) remains 5.
• EP s/n continues to be calculated as H/h, but the default width of the
region used to calculate h (the Half Height Multiplier) is now 5 instead of
20.
48889 The initial project quota for a cloned subproject is now the same as the project
quota of the source subproject.
Issues fixed in Method Validation:
Issues fixed in Method Validation
39018, 42271, In the Specificity test, you can now specify the Significance and Assessed Field
40505, 40470, in the Component Type table in the Processing Parameters.
42272
39883 You can now specify the channel used for the linearity test.
41430 The "Stability by Time" test no longer displays a red X when a channel name did
not exist.
41192 You can now calculate a Slope Ratio against a different component. In the
Linearity Comparison test, in addition to 2 channels, you can specify 2
component type names (Component Type 1 and Component Type 2), one for
each curve (these component types can be either the same type or different
types).
40772, 41834, You can now use real (numeric) fields from all peak types as the Assessed Field
42272, 47020, in all validation tests except Linearity, Linearity Comparison, and LDL/LQL
47575, 47980, Determination (including Accuracy). These fields are available as long as the
50245 option controlling them is enabled in the project. The options that control peak
fields include System Suitability, PDA, MS, CE/CIA, GPC, GPCV, LS, and
Dissolution.
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42191, 45864, Level values that start with numbers are now sorted separately as number
45885 values and placed in the list before level values that do not start with numbers.
If multiple level values start with the same number, they are sorted first as
numbers and then sorted using the text after the number.
Example: The levels 80%, 100% and 120%, that were listed as 100%, 120%,
and 80% when ordered as strings, are now listed as 80%, 100%, and 120%
when ordered as numbers.
41003 You can now set the the Relative Assessed Field % threshold based on the new
impurity processing values.
42069 Filter Validation, Specificity and Stability results can be held to an acceptance
criterion of total number of impurity peaks set to zero, indicating that no
impurity peaks are observed.
41002 You can now sum all degradation products in Filter Validation, Specificity, and
Stability testing using the new Impurity Processing feature in the processing
method.
39548 You can now assess the matrix effects on the recovery of impurities and drug
44659 substances from the drug product matrix on the analytical performance and
45079 characteristics of a method.
42818,45081 When performing a Robustness test, you can now select one-factor-at-a-time
instead or a multi-factor Design of Experiment.
46855, 44479 You can now configure an Intermediate Precision/Repeatability test based on
Japanese Ministry of Health, Welfare and Labour (MHWL) guidance.
40943 Group peaks are no longer excluded from MVM processing.
42717 The results calculated from a Robustness test now include the theoretical range
for each numerical factor where the p-value will pass.
42887 In MVM, you can now control how multiple injections and multiple preparations
are averaged.
39096 Each result that does not meet its MVM acceptance criteria is now shown as
faulted.
41984, 42756 In the Overall Study Status field within Validation Manager, the status of Study
Complete is now shown as either “Study Complete – All Tests Pass Acceptance
Criteria” or “Study Complete with exceptions”.
40494 You can now print Method Validation results directly to SDMS after the results
are signed off.
42065,42067 You can now set acceptance criteria based on various Component Type and
Level options for the Relative Peak limits.
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42066 When validating an impurity method, the RRF calculated in a Linearity test can
now be calculated relative to the main component.
41076 For stability and filter validation, all peaks types have been added to the
Relative Peak table.
41258,41852, For Stability and Filter Validation tests, the % change, relative % area and
45078 relative % recovery are calculated.
40917 You can now calculate the stability Reference Ratio = Assessed Field / Reference
Assessed Field.
42453 For the Intermediate Precision test, Empower calculates the Pooled SD and
Pooled %RSD values. These values are listed in the ANOVA tables in the Error
(or Intra) row as the SD and %RSD values (respectively).
42913 Specificity Testing can now calculate results when peaks are missing.
40561, 40615, Additional fit types are now available for assessing linearity.
40983
Issues fixed in Empower Toolkit
Issues fixed in Empower Toolkit
41315 When using the InstConfig operator in the Empower Toolkit Instrument object, a
connection to the instrument is no longer required.
42152 When using the Empower Result viewer to search enumerated custom fields, the
operator mtkEQ or mtkNEQ returned incorrect results.
This has been corrected.
49106 You can use a new Toolkit function, Instrument::System Information, to return
a list of systems associated with a specified Empower node.
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Known software issues in this release
The following tables describe known software issues and workarounds for Empower 3 Feature Release 2.
The PCS (Product Change System) numbers identify software issues that Waters personnel monitor within
a system change request tracking tool.
• Data analysis and processing
• System configuration and project management
• Installation, administration, and instrument control software
• Reporting
• Empower software application components
• Method Validation Manager
• Empower Toolkit
• Empower Online Information System
Known issues in data analysis and processing
Known issues in data analysis and processing:
51446 When you view a method set that contains more than one channel using the
same processing method, then proceed to the processing method view, and
then proceed to Browse Project, QuickStart may exit unexpectedly.
Workaround: Do not save the processing method from the method view.
Instead, click Browse Project, and then click Yes when prompted to save the
method. If you are not saving the method, proceed to the method set view, and
then return to the processing method view before selecting Browse Project.
51268 Extracting a mass spec spectrum, when on a PDA channel, extracts a spectrum
at that time for each of the 3D MS channels in the order that the channels
appear in the 3D channel table.
The software then selects the first 3D MS channel in the 3D channel table as the
selected channel.
If you want to extract a chromatogram from a different 3D MS channel, you
must select it first.
51287 In rare cases, when performing CODA, 3D blank subtract and baseline correction
on 3D MS continuum data, small artifacts in displaying the spectra can occur.
The effect is exacerbated with the spectra used for 3D blank subtract or baseline
correction are of high intensity, which is not representative of noise in the
spectrum. Use CODA, 3D blank subtract and baseline correction on centroid
data only. Continuum data can be viewed as centroid data when needed.
47206 When stacking a multi-channel 2D chromatogram that contains fractions, and

those fractions are wide such that they cover the entire chromatogram, when
you click an area to zoom that is inside a fraction, zooming does not work.
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49551 The Component Editor may allow you to save changes to a processing method
when errors exist in the Component table.
Because Empower software imposes stricter cross-channel referencing rules,
during processing, existing processing methods may have invalid cross-channel
references, resulting in a Q74 processing code.
In order for Empower to detect errors in the Component table, while editing the
method, you must access the Component table at least once, before saving the
processing method. Doing so enables Empower software to verify the
component information.
49835 When performing background processing and printing from an Empower client,
do not use a printer queue that displays a dialog box to enter a file name. When
running in the background as a local system, the dialog box is not available to
the desktop.
Important: Do not perform this workaround while you are acquiring data from
the client computer. Also, this workaround prevents you from accessing the
acquisition system remotely.
Workaround: Stop WatersService and set it to "manual".
49985 A derived channel created from two other 2D channels may produce different
integration results than expected based on the integration of each of the other
channels.
Tip: Combining 2D channels works best if both channels have the same data
rate. If the combined channels do not have the same data rates, peak
integration will change. When this happens, a P23 processing code is added to
the Result Code field.
50639 When processing a sample set that includes several diagnostic channels, and
then reviewing the data in the Review window, the results reflect only the data
from the detector channels, not the diagnostic channels.
When processing data that includes diagnostic channels, you must use the table
in the method set to specify the additional channels you want to process, along
with a processing method.
If you use only a processing method, or use a processing method that you
saved in a method set, without specifying the channels to process in the table,
Empower software does not process the diagnostic channels.
(716003923), Rev. D
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50903 When you identify a component in the 3D Component table whose parameters
fall outside of the criteria for a peak, the Components table and Mass Analysis
spectra are blank.
An empty mass spectrum also occurs if you do not override the channel for the
component. For example, when there is no MS data at the retention time of the
peak or when you manually extract spectra when there is no MS data at the
extraction time.
An empty PDA spectrum also occurs when the main result is not a PDA result or
when you manually extract spectra when there is no PDA data at the extraction
time.
Background: During quantitation or calibration, the spectra and Base Mass
from the MS 3D channel that has the highest intensity mass spectrum is
overridden with the component's MS 3D channel's spectra and Base Mass. If the
component's MS 3D channel is not found, a P40 processing code: "Problem
setting the Base Mass and spectra for this peak. Cannot find the 3D MS channel
specified by the user" is added to the peak. The peak’s Base Mass, scan
number, and spectra are cleared.
If the component's MS 3D channel is found, and an apex spectrum cannot be
extracted, a P48 processing code: "Problem using the 3D MS channel specified
by the user to set the Base Mass and spectra for this peak" is added to the
peak. The peak’s Base Mass, scan number, and spectra are cleared. "
51000 In the Processing Method Wizard, when you click “yes” to include the channel in
the Components table, and continue on to name peaks using their RRT value, on
the page with Name and Retention time, the peak name may exceed the 30-
character limit, preventing you from proceeding to the next Wizard page.
Rationale: The software does not truncate the auto-generated name, as that
name may not be meaningful to you or other users.
Solution: You can modify the auto-generated name to one that is meaningful to
you, and that is within the 30-character limit.
51150 In the Processing Method editor, the 3D Channel table presentation is

inconsistent because it sizes to fit the data in the table.
If you did not enterany components in the Component table on Components tab,
the 3D Channel table showed only column headers. The column headers size
only to their content, while the rest of the table is empty. If the table contains
components, then it displays a row for each component.
51259 When % Adjusted Area, % w/w, or % Area against the Main Component is used
in a custom field that is the impurity response, the impurity response value is0
until the custom field is calculated.
51387 An MS/PDA injection cannot be deleted after background processing with the
Enable 3D MS check box selected.
Workaround: Close the Processing Monitor window, and then wait 5 to 10
minutes before deleting the injection.
(716003923), Rev. D
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51399 Processing data using either CODA or MS 3D Subtract creates a temporary

channel. The channel ID for the temporary channel is referenced in the result
and in the audit trail for the result. However, the temporary channel is not
viewable.
Known issues in system configuration and project management
Known issues in system configuration and project management:
48526 In a client/server or RAC environment, when starting a project back-up from a

client computer, if the listener on the server disconnects or is shut down, the
project backup is unable to continue because it cannot access the database to
complete the process. In some cases an error message appears, indicating that
that the export process failed, and in some cases, Configuration Manager may
exit unexpectedly.
49904 When planning to upgrade a large number of projects, review the system
resources on the server to ensure that you do not use up disk space for either
the archive log area or the Oracle data files. Also, ensure that you do not use up
the 9 index and the 9 User tablespace files, each of which is a maximum of
20GB.
Large numbers of projects can take time to upgrade, but you can minimize this
by monitoring resources on the server. Waters also recommends that you
archive older projects, prior to upgrading active projects.
50068 When creating a standard project, and copying view filters, methods,
preferences, and custom fields from an MVM project into the newly created
standard project, a “copy from project” error occurs.
Rule: Anytime you create a new project from another project, you must set the
tablespace quota large enough to accommodate the methods, custom fields, and
other such items.
Recommendation: Set the size of the new project quota to at least 140MB.
50897 Status of LDAP testing with SSL and non-SSL configurations.

The following LDAP configurations have been tested:
• Windows Active directory – non-SSL
• Windows Active Directory – SSL
• Non-Windows Active Directory – non SSL
Non-Windows Active Directory with SSL has not been tested.
50987 The Audit Trail message for the Toolkit error code 468 is incorrect.
Incorrect message: “The user “User A” is logged on from 1 location”.
Correct message: “The user “User A” is logged on from more than one
location.”
(716003923), Rev. D
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Known issues in system configuration and project management:
51126 The Empower SQT project may not generate results in an OQ project, and may
produce error messages from Configuration Manager.
Rationale: In a client/server environment, this situation can occur when two
operations access the same database object at the same time, which generates
an Oracle deadlock. For example, running an SQT while another user is running
a process that accesses the same object in the same project.
Recommendation: If the SQT does not produce results, verify that no other
user is accessing the Empower project and repeat the SQT.
51422 The Empower project window may lock when copying certain sample sets from
one project into another project.
Rationale: This can occur when using Red Hat Enterprise Linux as the Empower
database server, and when multiple channels refer to the same vial.
Workaround: Close the Project window and then open it again. Attempt to
copy the sample sets again.
Known issues for installation, upgrade, administration, and instrument

control software
Known issues for installation, upgrade, administration, and instrument control software:
48913 Installing an Empower 3 FR2 client on the Windows XP operating system (SP3),
using a Lenovo M57 computer can cause the PC to freeze.
To prevent this problem, before you install Empower 3 FR2 on a Lenovo M57
computer, turn off the Windows firewall, and remove the antivirus software from
the computer. Then, install the Empower 3 FR2 client software on the computer.
48917 During a project restoration, when the system prompts you to update the
project to the next point release, if you click multiple times in the dialog box,
the dialog box may display a “not responding” status, and a message indicating
that MFC is not responding.
Workaround: Wait for the dialog box to respond and for the Finish button to
become active.
49459 When using traditional packed GC columns with the Purged Packet inlet, use
column dimensions of zero (0) and place the GC into Pressure Control mode. In
the instrument method, specify either the Constant Pressure or Ramped
Pressure technique.
50122 The Waters Deployment Manager does not install the Instrument Control
Software for Waters 2420 and Waters 2465 on the server.
Workaround: Install the ICS for the Waters 2420 and Waters 2465 using the
installer included with the ICS, not the Waters Deployment Manager.
(716003923), Rev. D
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50519 When attempting to start the “Enterprise Manager Web Console” from the
Empower Start menu, nothing appears. The Console is unable to access Oracle
Enterprise Manager (OEM).
This problem occurs as a result of the security fix, KB2661254 that Microsoft
released to fix security holes in smaller certificates.
To resolve the OEM issue, Waters recommends that you disable this security fix
for the entire system. Both solutions disable mandatory 1024 (minimum)
certificates. This solution was suggested by both Microsoft and Oracle.
50625 The first attempt to run an ICS driver push installation on Windows XP starts,
and then exits without logging any error messages and without successfully
completing the installation. This situation also occurs when push installing ICS
drivers on Citrix server PS 4.5.
Solution: After the first attempt to push install ICS drivers on Windows XP or a
Citrix server PS 4.5, reboot the system, and then rerun the ICS push
installation. The installation finishes successfully.
50705 To ensure that you can verify files successfully, after removing the software,
you must reboot the computer before you uninstall the Agilent ICF Support
software.
After you reboot the computer, do these tasks:
1. From the Start menu, click All Programs > Empower > Remove Waters
Instrument Component Software.
2. Click Remove.
3. Select the product you want to remove, and then click Next.
4. Follow the prompts to remove the ICS (instrument component software)
from your system.
Result: The registry and new CRC checksums are updated for the
Empower installation. No Oracle or system files are affected.
Rule: Removing Waters support for the Agilent ICF does not remove the
Agilent ICF itself. You can remove Agilent ICF from the Windows Control
Panel using the Add/Remove Programs utility on Windows XP or the
Programs and Features on Windows 7.
50777 When upgrading to Empower 3 FR2 from base Empower 3 or Empower 3 SR1,
the first time you log onto Empower, an Oracle error, “904:
“OQMVMCOMM”:invalid identifier” may appear in the Message Center.
The error message appears only the first time a user logs onto Empower. After
the Empower database completes the update to database version 7.20, the
error no longer appears.
(716003923), Rev. D
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51102 During an upgrade of the Empower software, the body of the Upgrade Status
dialog box can appear blank, with the title showing, “Database Upgrade (Not
Responding)”. This can happen if you pause the pointer over or click on the
“progress” dialog box. The upgrade is still progressing, but the dialog box stops
showing this progress.
Workaround: To view the current status of the upgrade, use a text editor to
open the log file located in Empower\Script\updatadatabase.log. This log file
shows the status of the upgrade at the time that you open the file. Close and
then reopen the log file to see an updated status.
51265 When archiving an audit trail to text, only the first 1000 items in the audit trail
are placed in the file. When restoring the binary archive to offline, it contains
the full number of lines.
Workaround: To archive all system audit trail entries to text, set the Max Rows
value to a number that is greater than the number of rows in the table. Click
Update. Archive to Text should now generate a file with all the entries.
Known issues in reporting
Known issues in reporting:
47206 When stacking a multi-2D channel chromatogram that contains fractions, and
those fractions are wide such that they cover the entire chromatogram, when
you click an area to zoom and that area is inside a fraction, zooming does not
work.
51097 If you acquired data from a W3100 instrument using an Empower software
version prior to Empower 3, you cannot report the Comprehensive Status. This
message appears: 'Comprehensive Status report group contains information
that doesn't match the data being reported'.
51125 The MS 3D Channel Component table is not shown in the default Processing
Method report.
The "MS 3D Channel Name (Description)" field is included in the Component
table and is the same as that displayed in the MS 3D Channel Component table.
51221 When previewing data in a report, tables may overlay the chromatogram.
Rationale: When placing report groups next to each other horizontally across
the report method page, if at least one of these groups generates a data
mismatch error, the error can affect the placement of other report groups beside
it. This sometimes causes report groups to overlap in the Preview window and in
printouts.
Workaround: You can avoid this problem by modifying the report method, and
repositioning the report groups such that they are not placed side-by-side on
the page.
(716003923), Rev. D
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Known issues in reporting:
51315 In the Korean and Chinese versions of Empower software, the Analytics Viewer
legend font size is too big to fit within the legend box.
51391 In the Review window, the field “MS Match Score” is a field that is always blank.
You can view the MS Match Score on two tabs:
• In the Results windows, accessed from the Review window, in the MS
Library Match tab
• On the Library Match tab in the Spectrum Review window
51447 When reporting the MS Combined spectrum Triple Plot, no legend is displayed
on the report.
Known issues in Empower software application components:
Known issues in Empower application components:
51467 In the ConnectionsAQT English protocol folder on the media is empty.

Workaround: The Chinese, Japanese, and Korean protocol folders contain the
missing protocol file in all languages.
51446 When you view a method set that contains more than one channel using the
same processing method, then proceed to the processing method view, and
finally proceed to Browse Project, QuickStart may exit unexpectedly.
Workaround: Do not save the processing method from the method view.
Instead, click Browse Project, and then click Yes when prompted to save the
method. If you are not saving the method, proceed to the method set view, and
then return to the processing method view before selecting Browse Project.
51392 In the Japanese version of Empower, in the Group column in the Result Audit
Viewer, the following items appear in English:
ProcMethLC,
SampleSetMethodDB
InstMethDB
MethSet
51062 For localized systems, the Analytics Viewer “Start Date” and “End Date” controls
show the text "Select a date" in English when the control does not contain a
value.
50864 Save preferences in the Compare windows does not work.
50208, 50209 You cannot log onto a new session using Open Access or QuickStart if your Pro
interface login is locked out.
(716003923), Rev. D
Page 22 of 51
Known issues in Empower application components:
49314 For optimum performance, use Empower Enterprise software over a Wide Area
Network (WAN) with a latency of 200 milliseconds or less.
Known issues in Method Validation Manager
Known issues in Method Validation Manager:
51462 During Specificity testing, the main component is incorrectly faulted for Relative
Resolution and Absolute Value of Relative Resolution in the Relative Peaks Table
because the values are blank.
51530 When there is an invalid reference in relative criteria, a value of "-50,000" is

displayed instead of a blank value without an error message.
Workaround: In the table properties in Preview/Publisher, select Report Values
with Formulas to assist in troubleshooting relative criteria assessments.
50975 In Method Validation Manager reporting, both the LDL and LQL validation fields
appear erroneously as being available for plotting on a trend plot.
50905 When restoring MVM projects from versions of Empower prior to Empower 3 FR2
that contain Validation Studies, the study status field shown in the Project
application may not show the actual study status while the validation study is
open in the Validation Manager, until you save the study. In some cases,
creating new validation results may be required to update the field.
50805, 50995 When a Validation Study shows a new study status, such as "Study Complete -
No Criteria", that study status does not appear in Preview/Publisher window
when using a report method or report group created prior to Empower 3 FR2 (or
when selecting "Use a Report Method that was generated to be appropriate for
the selected data").
In such cases, you can add the Study Status field to the report using Report
Publisher.
50984 Some faults only appear in the Relative Peak table and do not appear in the
data and summary tables. Refer to the Validation Result table for these types of
faults.
51013 With the addition of the new Study Status Field, the first time you open
previously-processed studies, a “Save Results” window appears because MVM is
updating this field.
Click OK. The results are not altered, reprocessed, or changed. Only the Study
Status Field is updated. You can view data as usual in both Validation Review
and Preview.
51152 Pass/Fail criteria for the new % Change fields for Stability and Filter Validation
are assessed as-is, without determining the absolute value of the % Change.
Set criteria using the ABS formula as needed.
(716003923), Rev. D
Page 23 of 51
51232, 51320 If you chose to report Relative Acceptance Criteria in a separate table in MVM
Reports, the table does not distinguish between the Criteria table for criteria
defined in Per Component Type and in Per Component Type Per Level fields.
51236 In some cases, Relative Criteria information may appear in both the Peak table
and in the Validation Result table.
51237 When using Relative Criteria, the "Fault on Target" selection is available but not
applied when selected.
51241 Unlike entries in the Processing method, it is possible to overwrite the Lower
and Upper Limits calculated from the % Range value without clearing the entry
in the % Range column in the Processing and Acceptance Criteria tab in the
Validation Test Parameter Window. It is recommended that the review of the
test configuration include an assessment of the Lower and Upper Limits in
addition to the % Range value.
51276 Because the Grubbs Test fields are commonly blank during a typical outlier test
workflow (either the Cochran test passed or did not have a specification), blank
Grubbs Test fields will not cause a data fault.
51278 When performing the Linearity Comparison test, the referenced Linearity Test
results must be results from the Linearity of the Method processing. Otherwise
the message, “Validation Result incomplete” appears after Validation Processing.
51292 Summary-type functions are not supported in Relative Criteria for LDL/LQL
Determination Tests unless the method of determination is Signal-to-Noise
because of the type of data that is generated using the other methods of
determination.
51294 Relative Criteria for the Peak or Result fields is not supported in the LDL/LQL
Determination Tests unless the method of determination is Signal-to-Noise
because of the type of data that is generated using the other methods of
determination.
51337 When a formula in a Relative Criteria data field (not a Result field) has a
summary function inside of a summary function, the criteria formula calculator
does not generate a value.
(716003923), Rev. D
Page 24 of 51
51346 In the Parameters dialog box of any validation test, on the Processing and
Acceptance Criteria tab, you can initially specify a fixed number of component
types and a fixed number of acceptance criteria in the table.
You can create additional rows when you want to specify more component types
or acceptance criteria. Here are some techniques for creating more rows:
• If you want to create a row when there is already a partial row visible at the
bottom of the table, click in any field in the partial row. A scroll bar should
appear next to the table, indicating that a row has been added to the table.
• If you want to create a row when there is no partial row at the bottom of the
table, click a non-enumerated field in the last row, and then press the down
arrow key. A scroll bar should appear next to the table, indicating that a row
has been added to the table.
Exception: For some validation tests, the table may only contain enumerated
fields. It may not be possible to add a row to such a table.
51349 If you attempt to change the test name of a legacy validation test in Validation
Manager, all further interactions with the user interface will display an error
message. When this happens, close, and then reopen, Validation Manager.
51352, 51367 In Report Publisher, the Stability Table Properties dialog box has a Results tab.
If you click Help, the message, “Help Error ‘Cannot find the requested help
topic’” appears.
Many of the validation test specific report groups do not have context-sensitive
Help.
Alternative: From the Help menu, click Empower Help topics, which opens the
Empower Online Information System. On the Search tab, search for the
information that you need.
51353 Reports for validation results that report the Criteria table produce a message
stating, “Criteria Table – table contains no data” under these conditions:
• No criteria were set for the validation test
• Only absolute or range type acceptance criteria were specified
If the validation test contains any relative acceptance criteria, then the message
does not appear.
51357 In the Acceptance Criteria tables for any validation test, you can enter any
number of relative acceptance criteria with the same field type, field name, and
component type.
If you attempt to mix an absolute or range type acceptance criterion with
relative acceptance criteria, and all of the criteria have the same field type, field
name, and component type, the message “You cannot have two rows with the
same component type, field type, and component name in the Acceptance
Criteria tables” appears.
The message should read: “You cannot have an absolute acceptance criteria row
with the same component type, field type, and component name as another row
in the Acceptance Criteria table”.
(716003923), Rev. D
Page 25 of 51
51373 In Chinese versions of the Empower Report Publisher, the

LegacyFilterOverlayComponent report group, found under Method Validation
Groups > Filter Validation Groups > Filter Validation Plots, is missing.
In Chinese versions of the Empower Report Publisher, in the Manage Defaults
dialog box (under Edit > Manage Defaults), the following default methods are
missing in the list of default methods (in the Load Default Method section on the
Default Methods tab).
• Default Val Legacy Stability
• Default Val Legacy Specificity
• Default Val Legacy Filter Validation
51374 In Japanese versions of the Empower Report Publisher, the Legacy Specificity
Chromatograms report group, found under Method Validation Groups >
Validation Chromatograms, is missing.
In Japanese versions of the Empower Report Publisher, in the Manage Defaults
• Default Val Legacy Filter Validation
51375 In Korean versions of the Empower Report Publisher, the translated version of
the Legacy Specificity Chrom Data report group, found under Method Validation
Groups > Validation Test Data Tables, is missing. The English version is
available.
In Korean versions of the Empower Report Publisher, in the Manage Defaults
• Default Legacy Filter Validation
51420 When entering formulas as part of relative acceptance criteria, some error
messages that appear may be unclear in the context of Method Validation
because these messages were inherited from the custom field formula
calculator.
51421 When you review LDL/LQL determination test results in Validation Review,
options to show relative acceptance criteria information in the table are
unavailable.
Tip: You can report the criteria information using Report Publisher.
(716003923), Rev. D
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Known issues in the Empower toolkit
Known issues in the Empower toolkit:
49102 Toolkit cannot access the message center password.
51363 Authentication failures through the Empower Toolkit are not associated with a
user account. Login attempts are kept locally, which is appropriate for a single
user but if a second user attempts to log in before the first user either fails the
maximum attempt or successfully logs on, the second user’s login attempts are
attributed to the first user.
Known issues in the Empower Online Information System
Known issues in the Empower Online Information System:
49459 Online Help explains the use of GC Column Dimensions for Packed Columns in
an Empower GC instrument method.
Agilent recommends using no column dimension values for packed columns and
only using Constant Pressure or Ramped Pressure for flow control with packed
columns. This information has been added to the Column tab topic for the 6890
GC.
Recommendation: When using traditional packed GC columns with the Purged
Packed inlet on a GC, use column dimensions of zero (0) in order to place the
GC into Pressure Control mode. In the instrument method, specify either the
Constant Pressure or Ramped Pressure technique.
51060 In Empower Analytics, you can schedule scans using the Windows Task
Scheduler, specifying the program name AnalyticsSetup.exe located in the
Empower/Bin directory. Start only one job at a time, per database.
Many online resources contain information on the Windows Task Scheduler.
This information is not in the Empower online Help.
51386 When creating relative criteria for the left and right side of a formula, the screen
name is called "New Custom Field Wizard - Formula Entry." If you request Help
(F1 or the Help button), the Help content incorrectly uses the name “Custom
Field Wizard”.
(716003923), Rev. D
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Program files modified in this release
The following program files in the Empower\Bin directory were modified for Empower 3 Feature Release 2:
File name Description
AutoArchive.exe The AutoArchive application.
Cmgr.exe The Configuration Manager application.
Empower.exe The main Empower application.
InstrumentServer.exe The Instrument Service application.
Mil0.dll Contains base objects which implement database connection,

security, user and user type objects, etc.
Mil1.dll Contains base objects which implement higher level objects

such as methods, results, etc.
Mil2.dll Contains base objects which implement higher level objects

including data processing, integration, calibration, etc.
Mil3.dll Contains objects which implement higher level objects such as

reporting groups and display graphics.
MilTK.dll Contains basic Toolkit objects.
OQ.exe The Operations Qualification application.
ProcSrvr.exe The Processing Server application.
Quickset.exe The Run Samples application.
QuickStart.exe The QuickStart application.
Report Publisher.exe The Report Publisher application.
Review.exe The Review application.
WatersService.exe The Waters Service
VerifyOpt.exe The Verify Options application.
AnalyticsObjects.dll Contains objects for the Empower Analytics application
AnalyticsSetup.exe Analytics Setup application
Waters.Empower.AnalyticsViewer. Waters Empower Analytics Viewer application

exe
ShowMeHelpSynchronizer.dll Contains objects for the Empower Show Me Help
English Language Directory (Empower\Bin\en)
(716003923), Rev. D
Page 28 of 51
AutoArchiveRes.exe Resources for Auto Archive (English)
CmgrRes.dll Resources for Configuration Manager (English)
CompareRes.dll Resources for Compare (English)
DconvertRes.dll Resources for Dconvert (English)
EmpowerRes.dll Resources for the Empower application (English)
ImmdsrvRes.dll Resources for Immd server (English)
ImpexpRes.dll Resources for Import export application (English)
InEditorRes.dll Resources for Instrument Editor application (English)
InstrumentServerRes.dll Resources for Instrument Server application (English)
MantuneRes.dll Resources for Manual Tune application (English)
Mil0Res.dll Resources for Mil0 (English)
MilresRes.dll General resources (English)
MilTkRes.dll Toolkit resources (English)
msdiagRes.dll Resources for the msDialog (English)
mseditorRes.dll Resources for the MS Editor application (English)
MsgCenterRes.dll Resources for the Message Center application (English)
MtkCtrlRes.dll Resources for the Toolkit Control (English)
Open Access Res.dll Resources for the Open Access application (English)
optintRes.dll Resources for the OptInt application (English)
OqRes.dll Qualification resources (English)
PdacalibRes.dll Resources for the PDA calibration application (English)
pdadiagRes.dll General resources (English)
pmeditorRes.dll Toolkit resources (English)
ProcMonRes.dll Resources for the Processing Monitor application (English)
ProcSrvRes.dll Resources for the Processing Server application (English)
ProjectRes.dll Project resources (English)
(716003923), Rev. D
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QuicksetRes.dll Quickset resources (English)
QuickStartRes.dll QuickStart resources (English)
Report PublisherRes.dll Resources for the Report Publisher application (English)
restoreDBRes.dll General resources (English)
ReviewRes.dll Resources for the Review application (English)
RPTViewerRes.dll Resources for the Report Viewer application (English)
SetArchDatabaseRes.dll Resources for the Set Archive Database application (English)
SetEmailDatabaseRes.dll Resources for the Set Email Database application (English)
SSEditorRes.dll Resources for the Sample Set Editor application (English)
SysmonRes.dll System Monitor resources (English)
update2487Res.dll General resources (English)
ValidationManagerRes.dll Validation Manager resources (English)
ValidationReviewRes.dll Validation Review resources (English)
VerifyOptRes.dll Verify Opt resources (English)
WatersEmailServiceRes.dll Waters Email Service resources (English)
Japanese Language Directory (Empower\Bin\ja)
AutoArchiveRes.exe Resources for Auto Archive (Japanese)
CmgrRes.dll Resources for Configuration Manager (Japanese)
CompareRes.dll Resources for Compare (Japanese)
DconvertRes.dll Resources for Dconvert (Japanese)
EmpowerRes.dll Resources for the Empower application (Japanese)
ImmdsrvRes.dll Resources for Immd server (Japanese)
ImpExpRes.dll Resources for Import export application (Japanese)
InEditorRes.dll Resources for Instrument Editor application (Japanese)
InstrumentServerRes.dll Resources for Instrument Server application (Japanese)
ManTuneRes.dll Resources for Manual Tune application (Japanese)
(716003923), Rev. D
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Mil0Res.dll Resources for Mil0 (Japanese)
MilresRes.dll General resources (Japanese)
MilTkRes.dll Toolkit resources (Japanese)
msdiagRes.dll Resources for the msDialog (Japanese)
msEditorRes.dll Resources for the MS Editor application (Japanese)
MsgCenterRes.dll Resources for the Message Center application (Japanese)
MtkCtrlRes.dll Resources for the Toolkit Control (Japanese)
Open Access Res.dll Resources for the Open Access application (Japanese)
optintRes.dll Resources for the OptInt application (Japanese)
OqRes.dll Qualification resources (Japanese)
PdacalibRes.dll Resources for the PDA calibration application (Japanese)
pdadiagRes.dll General resources (Japanese)
pmeditorRes.dll Toolkit resources (Japanese)
ProcMonRes.dll Resources for the Processing Monitor application (Japanese)
ProcSrvRes.dll Resources for the Processing Server application (Japanese)
ProjectRes.dll Project resources (Japanese)
QuicksetRes.dll Quickset resources (Japanese)
QuickStartRes.dll QuickStart resources (Japanese)
Report PublisherRes.dll Resources for the Report Publisher application (Japanese)
restoreDBRes.dll General resources (Japanese)
ReviewRes.dll Resources for the Review application (Japanese)
RPTViewerRes.dll Resources for the Report Viewer application (Japanese)
SetArchDatabaseRes.dll Resources for the Set Archive Database application (Japanese)
SetEmailDatabaseRes.dll Resources for the Set Email Database application (Japanese)
SSEditorRes.dll Resources for the Sample Set Editor application (Japanese)
SysmonRes.dll System Monitor resources (Japanese)
(716003923), Rev. D
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update2487Res.dll General resources (Japanese)
ValidationManagerRes.dll Validation Manager resources (Japanese)
ValidationReviewRes.dll Validation Review resources (Japanese)
VerifyOptRes.dll Verify Opt resources (Japanese)
WatersEmailServiceRes.dll Waters Email Service resources (Japanese)
Waters.Empower.AnalyticsViewer. Waters Analytics Viewer resources (Japanese)

resources.dll
Korean Language Directory (Empower\Bin\ko)
AutoArchiveRes.exe Resources for Auto Archive (Korean)
CmgrRes.dll Resources for Configuration Manager (Korean)
CompareRes.dll Resources for Compare (Korean)
DconvertRes.dll Resources for Dconvert (Korean)
EmpowerRes.dll Resources for the Empower application (Korean)
ImmdsrvRes.dll Resources for Immd server (Korean)
ImpExpRes.dll Resources for Import export application (Korean)
InEditorRes.dll Resources for Instrument Editor application (Korean)
InstrumentServerRes.dll Resources for Instrument Server application (Korean)
ManTuneRes.dll Resources for Manual Tune application (Korean)
Mil0Res.dll Resources for Mil0 (Korean)
MilresRes.dll General resources (Korean)
MilTkRes.dll Toolkit resources (Korean)
msdiagRes.dll Resources for the msDialog (Korean)
msEditorRes.dll Resources for the MS Editor application (Korean)
MsgCenterRes.dll Resources for the Message Center application (Korean)
MtkCtrlRes.dll Resources for the Toolkit Control (Korean)
Open Access Res.dll Resources for the Open Access application (Korean)
optintRes.dll Resources for the OptInt application (Korean)
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OqRes.dll Qualification resources (Korean)
PdacalibRes.dll Resources for the PDA calibration application (Korean)
pdadiagRes.dll General resources (Korean)
pmeditorRes.dll Toolkit resources (Korean)
ProcMonRes.dll Resources for the Processing Monitor application (Korean)
ProcSrvRes.dll Resources for the Processing Server application (Korean)
ProjectRes.dll Project resources (Korean)
QuicksetRes.dll Quickset resources (Korean)
QuickStartRes.dll QuickStart resources (Korean)
Report PublisherRes.dll Resources for the Report Publisher application (Korean)
restoreDBRes.dll General resources (Korean)
ReviewRes.dll Resources for the Review application (Korean)
RPTViewerRes.dll Resources for the Report Viewer application (Korean)
SetArchDatabaseRes.dll Resources for the Set Archive Database application (Korean)
SetEmailDatabaseRes.dll Resources for the Set Email Database application (Korean)
SSEditorRes.dll Resources for the Sample Set Editor application (Korean)
SysmonRes.dll System Monitor resources (Korean)
update2487Res.dll General resources (Korean)
ValidationManagerRes.dll Validation Manager resources (Korean)
ValidationReviewRes.dll Validation Review resources (Korean)
VerifyOptRes.dll Verify Opt resources (Korean)
WatersEmailServiceRes.dll Waters Email Service resources (Korean)
Waters.Empower.AnalyticsViewer. Waters Analytics Viewer resources (Korean)

resources.dll
Chinese Language Directory (Empower\Bin\zh-CHS)
AutoArchiveRes.exe Resources for Auto Archive (Chinese)
CmgrRes.dll Resources for Configuration Manager (Chinese)
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CompareRes.dll Resources for Compare (Chinese)
DconvertRes.dll Resources for Dconvert (Chinese)
EmpowerRes.dll Resources for the Empower application (Chinese)
ImmdsrvRes.dll Resources for Immd server (Chinese)
ImpExpRes.dll Resources for Import export application (Chinese)
InEditorRes.dll Resources for Instrument Editor application (Chinese)
InstrumentServerRes.dll Resources for Instrument Server application (Chinese)
ManTuneRes.dll Resources for Manual Tune application (Chinese)
Mil0Res.dll Resources for Mil0 (Chinese)
MilresRes.dll General resources (Chinese)
MilTkRes.dll Toolkit resources (Chinese)
msdiagRes.dll Resources for the msDialog (Chinese)
mseditorRes.dll Resources for the MS Editor application (Chinese)
MsgCenterRes.dll Resources for the Message Center application (Chinese)
MtkCtrlRes.dll Resources for the Toolkit Control (Chinese)
Open Access Res.dll Resources for the Open Access application (Chinese)
optintRes.dll Resources for the OptInt application (Chinese)
OqRes.dll Qualification resources (Chinese)
PdacalibRes.dll Resources for the PDA calibration application (Chinese)
pdadiagRes.dll General resources (Chinese)
pmeditorRes.dll Toolkit resources (Chinese)
ProcMonRes.dll Resources for the Processing Monitor application (Chinese)
ProcSrvRes.dll Resources for the Processing Server application (Chinese)
ProjectRes.dll Project resources (Chinese)
QuicksetRes.dll Quickset resources (Chinese)
QuickStartRes.dll QuickStart resources (Chinese)
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Report PublisherRes.dll Resources for the Report Publisher application (Chinese)
restoreDBRes.dll General resources (Chinese)
ReviewRes.dll Resources for the Review application (Chinese)
RPTViewerRes.dll Resources for the Report Viewer application (Chinese)
SetArchDatabaseRes.dll Resources for the Set Archive Database application (Chinese)
SetEmailDatabaseRes.dll Resources for the Set Email Database application (Chinese)
SSEditorRes.dll Resources for the Sample Set Editor application (Chinese)
SysmonRes.dll System Monitor resources (Chinese)
update2487Res.dll General resources (Chinese)
ValidationManagerRes.dll Validation Manager resources (Chinese)
ValidationReviewRes.dll Validation Review resources (Chinese)
VerifyOptRes.dll Verify Opt resources (Chinese)
WatersEmailServiceRes.dll Waters Email Service resources (Chinese)
Waters.Empower.AnalyticsViewer. Waters Analytics Viewer resources (Chinese)

resources.dll
The following Waters files in the Empower\Bin\ directory were rebuilt for this release. These files were not
modified.
Rebuilt file name Description
andims.dll Contains ANDI mass spectrometry library objects.
CmgrLib.dll Contains the Configuration Manager library.
Compare.exe The Compare application.
dconvert.exe The application that restores pre-Millennium 3.0 data.
EthernetIeee.dll Contains all the control objects necessary to connect and use
the National Instruments Ethernet to IEEE converter box.
ImmdSrvr.exe Contains immediate background processing reporting and

exporting support.
impexp.dll The Import/Export Library
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InEditor.exe The Instrument Editor application.
Interop.OPTINTLib.dll C Sharp support library
IPalisade.dll Contains the Palisade mass spectrometry library.
ManTune.exe The Manual Tune application.
MillServices.dll Contains definitions for the Millennium user interface.
milp.dll Contains base objects which implement higher level objects

including data processing, integration, calibration, etc.
Milres.dll Common resources.
msdiag.exe The TMD Diagnostics application.
mseditor.exe The Method Set Editor application.
msgcenter.exe The Message Center application.
MtkCtrl.dll Contains Toolkit control objects.
netcdf.dll Contains low level processor format objects.
Open Access.exe The Open Access application.
OptInt.dll Contains licensing and option objects.
Pdacalib.exe The PDA Calibration application.
Pdadiag.exe The PDA Diagnostic application.
pmeditor.exe The Processing Method Editor application.
procmon.exe The Processing Monitor application.
project.exe The Project application.
restoredb.exe The Restore Database application.
RptViewer.exe The Report Viewer application.
setarchdatabase.exe The Set AutoArchive database application.
SetEmailDatabase.exe The Set E-Mail database application.
Sseditor.exe The Sample Set Editor application.
StoreSrv.dll Contains Storage Server classes.
StoreSrv.exe The Storage Server application.
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StoreSrvProxy.dll Contains Storage Server proxy stubs.
SysMon.exe The System Monitor application.
Update2487.exe Firmware updates for the 2487 Detector.
ValidationManager.exe The Validation Manager application.
ValidationReview.exe The Validation Review application.
WatersEmailService.exe The Waters E-mail service.
Waters.Licensing.Wizard.exe The Waters Licensing Wizard application.
Waters.UI.WatStyle.dll The Waters Licensing UI style objects.
Waters.UI.WatTreeView.dll The Waters Licensing UI tree view objects.
Waters.UI.WatValidator.dll The Waters Licensing UI validation objects.
The following support files in the Empower\Bin directory were rebuilt for this release. These files were not
modified
InstrumentServerps.dll Instrument Server proxy stub library
memlib32.dll Library support dll.
pallib32.dll Library support dll.
pbmlib32.dll Library support dll.
pltlib32.dll Library support dll.
reflib32.dll Library support dll.
ulblib32.dll Library support dll.
UpdateDBUtils.dll Support library
wlylib32.dll The Wiley library support dll.
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Test configurations
Empower 3 Feature Release 2 software was tested on the following system configurations.
Windows database server

Operating system and service pack: Windows Server 2008 R2 SP1 64-bit, Enterprise Edition,IE9
Windows Hotfixes:
KB981391, KB981392, KB977236, KB981111, KB977238, KB982861, KB977239, KB2592687,

KB2786081, KB2786400, KB976902, KB982018
Operating system and service pack: Windows Server 2008 R2 Standard SP1 (English), 64-bit, IE9
Windows Hotfixes:

KB2621440, KB2631813

KB2709981
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Solaris database server
Operating system and patch set: Sun® Solaris 10™ Database server with Patchset 10
Packages:
SUNWarc Lint Libraries (usr)
SUNWbtool CCS tools bundled with SunOS
SUNWcsl Core Solaris, (Shared Libs)
SUNWhea SunOS Header Files
SUNWi15cs X11 ISO8859-15 Codeset Support
SUNWi1cs X11 ISO8859-1 Codeset Support
SUNWi1of ISO-8859-1 (Latin-1) Optional Fonts
SUNWlibC Sun Workshop Compilers Bundled libC
SUNWlibm Math & Microtasking Library Headers & Lint Files (Usr)
SUNWlibms Math & Microtasking Libraries (Usr)
SUNWsprot Solaris Bundled tools
SUNWtoo Programming Tools
SUNWxwfnt X Window System platform required fontsHotfixes:
Patches: 20753-06: SunOS 5.10: Microtasking libraries (libmtsk) patch, 139574-03: SunOS 5.10
141414-02 141444-09
RedHat Linux database server

Operating system: Red Hat Linux Server release 6.2
Packages:
binutils-2.20.51.0.2-5.28.el6.x86_64
compat-libstdc++-33-3.2.3-69.el6.x86_64
elfutils-libelf-0.152-1.el6.x86_64
elfutils-libelf-devel-0.152-1.el6.x86_64
gcc-4.4.6-3.el6.x86_64
gcc-c++-4.4.6-3.el6.x86_64
glibc-2.12-1.47.el6.x86_64
glibc-2.12-1.47.el6.i686
glibc-common-2.12-1.47.el6.x86_64
glibc-devel-2.12-1.47.el6.x86_64
glibc-headers-2.12-1.47.el6.x86_64
libaio-0.3.107-10.el6.x86_64
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libaio-devel-0.3.105-2.x86_64
libgcc-4.4.6-3.el6.x86_64
libgcc-4.4.6-3.el6.i686
libstdc++-4.4.6-3.el6.x86_64
libstdc++-devel-4.4.6-3.el6.x86_64
make-3.81-19.el6.x86_64
RedHat Linux RAC database server

Operating system: Red Hat Linux Server release 6.2
Packages:
binutils-2.20.51.0.2-5.28.el6.x86_64
compat-libstdc++-33-3.2.3-69.el6.x86_64
elfutils-libelf-0.152-1.el6.x86_64
elfutils-libelf-devel-0.152-1.el6.x86_64
gcc-4.4.6-3.el6.x86_64
gcc-c++-4.4.6-3.el6.x86_64
glibc-2.12-1.47.el6.x86_64
glibc-2.12-1.47.el6.i686
glibc-common-2.12-1.47.el6.x86_64
glibc-devel-2.12-1.47.el6.x86_64
glibc-headers-2.12-1.47.el6.x86_64
libaio-0.3.107-10.el6.x86_64
libaio-devel-0.3.105-2.x86_64
libgcc-4.4.6-3.el6.x86_64
libgcc-4.4.6-3.el6.i686
libstdc++-4.4.6-3.el6.x86_64
libstdc++-devel-4.4.6-3.el6.x86_64
make-3.81-19.el6.x86_64
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Citrix® server (XenApp™ Server 6.5 Enterprise):
Operating system and service pack: Windows Server 2008 R2 SP1 64-bit, Enterprise Edition
Citrix Latest Hotfix: XA650W2K8R2X64025
Windows hotfixes:

KB2547666, KB2552343, KB2560656, KB2563227, KB2564958, KB2567680, KB2570947 KB2574819,
KB2706045, KB2709162, KB2709630, KB2709715, KB2709981, KB2712808, , KB2718704, KB2719857,
KB890830, KB890830, KB890830, KB971468, KB972270, KB974431, KB974571, KB975467
KB975560, KB976264, KB976422, KB976662, KB976932, KB977074, KB977236, KB977238, KB977239,
KB978542 , KB978637, KB978886, KB979099, KB979309, KB979482, KB979538, KB979559, KB979683,
KB978601, KB981390, KB982214
Citrix® server (XenApp™ Server 6.0 Enterprise):

Operating system and service pack: Windows Server 2008 R2 SP1 64-bit, Enterprise Edition
Citrix Latest Hotfix: XA600W2K8R2X64R02
Windows hotfixes:

KB2658846, KB2659262, KB2660075, KB2661254, KB2667402, KB2676562, KB2685811 KB2685939,
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KB977238, KB977239, KB981111, KB981390, KB981391 , KB982018, KB982671, KB2506212,
KB2741355, KB2761217, KB2786081, KB981392
Citrix® server (Presentation Server v4.5):

Operating system and service pack: Windows Server 2003 R2 SP2, 32-bit, Enterprise Edition
Citrix Hotfix: PSE450W2K3R07
Windows hotfixes:

KB2476687, KB2478960, KB2478971, KB2479628, KB2482017-IE7, KB2483185, KB2485376, KB24856,
KB2535512, KB2536276-v2, KB2539631, KB2544521-IE7, KB2544893-v2, KB2562937, KB2564958,
KB2572073, KB2586448-IE7, KB2592799, KB2641690-v2, KB914961, KB921503, KB923561, KB924667-
v2, KB925398_WMP64, KB925398_WMP64, KB925902, KB926122, KB927891, KB929123, KB930178,
KB935840, KB936021, KB936357, KB936782, KB938127-IE7, KB938464, KB939653-IE7, KB941202,
KB941568, KB941569, KB94164, KB942615-IE7, KB942763, KB943055, KB943460, KB943485,
KB948233v2, KB948496, KB948646, KB949226, KB949777, KB950230, KB950762, KB950974,
KB952954, KB953298, KB953298, KB954155, KB954211, KB954550-v5, KB954550-v5, KB954600,
KB956844, KB957097, KB958215-IE7, KB958469, KB958481, KB958483, KB958484, KB958644,
KB958687, KB958869, KB959426, KB960225, KB960714-IE7, KB960803, KB960859, KB961118,
KB961371, KB961371-v2, KB9613, KB961501, KB963707, KB967715, KB967723, KB968389, KB968537,
KB968816, KB969059, KB969897-IE7, KB969898, KB969947, KB970238, KB970430, KB970653-v3,
KB971029, KB971032, KB971468, KB971557, KB971633, KB971657, KB971737, KB971961, KB972260
IE7, KB972270, KB973346, KB973354, KB973507, KB973540, KB973687, KB973815, KB973825,
KB975558_WM8, KB975558_WM8, KB975560, KB975562, KB975713, KB976098-v2, KB976576,
KB976769v2, KB977354v2, KB977816, KB977914, KB978037, KB978207-IE7, KB978251, KB978262,
KB979683, KB979687, KB979907, KB979907, KB979909, KB980182-IE7, KB980195, KB980218,
KB951698, KB980232, KB980436, KB981322, KB981349, KB981793, KB982132, KB982214, KB982381-
IE7, MMC30CoreNLSDownlevelMapping, Q954430, Q973688R2-In-bandR2-New-files
SP1WIXpsEPSCXpsEPSC
Client:
Operating system and service pack: Windows 7 Enterprise Service Pack 1, 64 bit, IE9
Windows Hotfixes:
KB983590 KB982799 KB982670 KB982665 KB982664 KB982526 KB982519 KB982214 KB982132

KB982110 KB982018 KB981852 KB981793 KB981332 KB981078 KB980846 KB980436
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KB2779562 KB2779030 KB2770660 KB2763523 KB2762895 KB2761465 KB2761451
KB2739159 KB2737019 KB2736233 KB2735855 KB2732500 KB2732487 KB2732059
KB2718704 KB2712808 KB2709981 KB2709630 KB2705219 KB2699779 KB2698365
KB2676562 KB2667402 KB2661254 KB2660649 KB2660075 KB2659262 KB2658846
KB2647753 KB2645640 KB2644615 KB2641690 KB2640148 KB2639417 KB2633952
KB2616676 KB2607576 KB2604121 KB2604115 KB2603229 KB2600217 KB2592687
KB2570947 KB2570791 KB2567680 KB2567053 KB2564958 KB2563894 KB2563227
KB2541014 KB2539636 KB2539635 KB2536276 KB2536276 KB2536275 KB2534366
KB2518870 KB2518869 KB2515325 KB2511455 KB2511250 KB2510531 KB2509553
KB2491683 KB2488113 KB2487426 KB2485376 KB2484033 KB2482017 KB2479943
KB2447568 KB2446710 KB2446708 KB2443685 KB2442962 KB2425227 KB2423089
KB2378111 KB2347290 KB2345886 KB2305420 KB2296011 KB2286198 KB2284742
Operating system and service pack: Windows7 Professional SP1, 64 bit, IE9
Windows Hotfixes:
KB971033 KB2305420, KB2393802, KB2425227, KB2479943, KB2484033, KB2488113, KB2491683,

KB2813347, KB2817183, KB958488, KB976902, KB976932, KB982018
Operating system and service pack: Windows XP Professional Service Pack 3
Windows Hotfixes:
KB909520 ie7 ie8, KB2183461-IE7, KB2510531-IE8, KB2598845-IE8, KB2618444-IE8, KB2744842-IE8,

KB2797052-IE7, KB2797052-IE8, KB2809289-IE7, KB2809289-IE8, KB2817183-IE8, KB923689,
KB938127-IE7, KB941569, KB942615-IE7, KB944533-IE7, KB969897-IE7, KB982381-IE8 Q282784
Wdf01009, KB2564958, KB971513, KB888111WXPSP2, KB936929, KB2079403, KB2115168, KB2160329,
KB2535512, KB2536276-v2, KB2544893-v2, KB2566454, KB2570947, KB2584146, KB2585542,
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KB2646524, KB2653956, KB2655992, KB2659262, KB2661254-v2, KB2661637, KB2676562, KB2686509,
KB2691442, KB2698365, KB2705219-v2, KB2712808, KB2719985, KB2723135-v2, KB2727528,
KB2736233, KB2749655, KB2753842-v2, KB2757638, KB2758857, KB2770660, KB2778344, KB2779562,
KB923561, KB938464-v2, KB946648, KB950760, KB950762, KB950974, KB951066, KB951376-v2,
KB951748, KB951978, KB952004, KB952287, KB952954, KB954459, KB954550-v5, KB954600,
KB982018
Standalone/Personal Workstation:
Operating system and service pack: Windows 7 Professional SP1, 64 Bit, IE9
Windows Hotfixes:

KB982018
LAC/E32 module:
Operating system and service pack: : Windows XP Professional Service Pack 3
Windows Hotfixes:
ie7 ie8, KB2510531-IE8, KB2544521-IE7, KB2647516-IE7, KB2797052-IE7, KB2797052-IE8, KB2809289-

IE7, KB2809289-IE8, KB941569 Q282784 Wdf01009, KB2564958 MSCompPackV1 Wudf01000,
KB2506212, KB2507618, KB2507938, KB2508429, KB2509553, KB2510581, KB2535512, KB2536276-v2,
KB2544893-v2, KB2566454, KB2570222, KB2570947, KB2584146, KB2585542, KB2592799, KB2598479,
KB2641690, KB2646524, KB2653956, KB2655992, KB2659262, KB2660465, KB2661254-v2, KB2661637,
KB2676562, KB2686509, KB2691442, KB2698365, KB2705219-v2, KB2712808, KB2719985, KB2723135-
v2, KB2727528, KB2736233, KB2749655, KB2753842-v2, KB2757638, KB2758857, KB2770660,
KB950762, KB950974, KB951376-v2, KB951978, KB952004, KB952287, KB952954, KB953155,
KB954459, KB954550-v5, KB956572, KB956744, KB956802, KB956844, KB958644, KB959426,
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KB981997, KB982132, KB982665
Operating system and service pack: Windows 7 Professional SP1, 64 bit
Windows Hotfixes:

KB890830, KB971033 KB972270 KB97443 KB974571, KB975467, KB975496, KB975560,
KB982665, KB982670, KB982799
Empower 3 support on VMware® vSphere

Unless noted below, there is no deviation in supported operating systems when Empower 3 is installed in a
virtualized environment. Therefore, the following platforms and operating systems are supported by
Empower 3 for native and virtual installations.
• Empower database server - Windows Server 2008 R2 Enterprise, 64-bit
• Empower File server - Windows Server 2008 R2 Enterprise, 64-bit
• Empower Clients - Windows 7 Professional or Enterprise, 64-bit; Windows XP Professional SP3, 32-
bit
• Citrix® server (includes the Citrix server, license server, farm controller, and webserver) -
Windows
• Server 2008 R2 Enterprise, 64-bit, XenApp™ Server 6.0 with client online plug-in version 12
Exception: Acquisition Clients and/or LAC/E32 are not supported for use in a virtual environment.
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VMware vCenter server
Windows Server 2008 Enterprise R2, 64-bit with hotfixes: KB890830, KB2467659 KB2419640,
KB2385678, KB2442962 KB2305420, KB2423089, KB2296199, KB2436673, KB2416400, KB2443685,
KB2360131, KB2387149, KB2416471 KB979687 KB2160841 KB981957 KB982132 KB2158563 KB979688
KB1262765 KB2416472KB2207566 KB979538 KB2347290 KB982664 KB981550 KB2272691 KB983590
KB2160329 KB2032276KB2079403 KB2183461 KB978886 KB981852 KB982526 KB982671 KB982110
KB980846 KB2286198 KB979099 KB982799
VMware vCenter server v4.1
VMware Update Manager v4.1
SQL 2008 server

Windows Server 2008 Enterprise R2, 64-bit with hotfixes: KB2423089, KB2436673, KB890830,
KB979482, KB981332, KB971961, KB973917,KB978601, KB980248
Microsoft SQL Server 2008
VM Storage Unit
27 x 600GB fiber SCSI (fSCSI) drives in a single disk group
VM Backup Storage Unit

14 x 1.0TB fiber ATA (fATA) drives in a single disk group
VMware ESXi v4.1 servers

The following virtual machines were configured for use across the VMware ESXi servers
Empower 3 Database server virtual machine

Windows Server 2008 Enterprise R2, 64-bit with hotfixes: KB2160841, KB2416472,
KB2347290,KB2345886, KB2296011, KB2272691, KB9811111, KB981392, KB977238, KB982132,
KB982110, KB981957, KB979688, KB979687 KB979538, KB2416471, KB2398632, KB2387149,
KB981332, KB980408, KB980232, KB980218,KB980195, KB979916, KB979482 KB979309, KB979099,
KB2160329, KB2079403, KB2032276, KB982632, KB982381, KB981793, KB981332
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Citrix Server – XenApp 6 virtual machine
KB976662, KB976422, KB976264, KB975560, KB975467, KB974571, KB974431, KB972270, KB971468
Empower 3 File Server virtual machine

KB975467, KB974571, KB974431, KB972270, KB971468
Empower 3 Clients virtual machine

Windows 7 Professional, 64-bit with hotfixes: KB2473228, KB2160841, KB976902,
KG2454826,KB2419640, KB9835590, KB982799, KB982665, KB982214, KB982132, KB982110,
KB979687, KB979538, KB979482, KB979099K, B978886, KB978637, KB978542, KB977074, KB976662,
KB978601, KB979309,
Windows XP 32-bit with hotfixes: KB909520, Q282784, KB971513, KB898461, KB2079403,

KB2115168, KB2121546, KB2141007, KB2158563, KB2229593 KB2259922, KB2279986, KB2286198,
KB2419632, KB2423089, KB2436673, KB2440591, KB2443105, KB2443685, KB2467659, KB915800-v4,
KB923561, KB946648, KB950760, KB950762, KB950974, KB951376-v2, KB951748, KB951978,
KB952004, KB952287, KB952954, KB954459, KB954550-v5, KB955759, KB956572, KB956744,
KB975025 KB975467, KB975560, KB975562, KB975713, KB977816 , KB977914, KB978037, KB978338,
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Windows 7 Enterprise 64-bit with hotfixes: KB971033, KB2032276, KB2079403, KB2207566,
KB982799, KB983590
VMware vSphere v5.0 servers

VM Storage Unit
24 x 600GB iSCSI drives in a single disk group
VM Backup Storage Unit

24 x 600GB iSCSI drives in a single disk group
VMware vCenter server and SQL 2008 server

Windows 2008 Ent R2 SP1 x64 with the following hotfixes:
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VMware vCenter Server 5.0
SQL 2008 Server
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VMware vCenter Server (v5.1 environment only)
VMware vCenter Server 5.1
VMware vSphere Update Manager 5.1
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SQL 2008 Server
Windows 2012 Standard x64 with the following hotfixes:
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Empower FR2 Release Notes

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Empower FR2 Release Notes

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R E L E A S E N O T E S

Waters Empower 3 Feature

GxP compliance requirements .................................................................................................... 3

System and software requirements ............................................................................................ 3

Before you install Empower 3 FR 2 software .............................................................................. 3

New features in this release ....................................................................................................... 4

Empower software options .......................................................................................................... 8

Issues fixed in this release ......................................................................................................... 8

Issues fixed in Empower 3 FR2: ................................................................................................... 8

Issues fixed in Method Validation: ............................................................................................... 12

Issues fixed in Empower Toolkit .................................................................................................. 14

Known software issues in this release ...................................................................................... 15

Known issues in data analysis and processing ............................................................................... 15

Known issues in system configuration and project management...................................................... 18

Known issues in reporting .......................................................................................................... 21

Known issues in Empower software application components: .......................................................... 22

Known issues in Method Validation Manager ................................................................................. 23

Known issues in the Empower toolkit ........................................................................................... 27

Known issues in the Empower Online Information System .............................................................. 27

Test configurations ................................................................................................................... 38

Windows database server........................................................................................................... 38

Solaris database server.............................................................................................................. 39

RedHat Linux database server .................................................................................................... 39

RedHat Linux RAC database server .............................................................................................. 40

Citrix® server (XenApp™ Server 6.5 Enterprise): .......................................................................... 41

Citrix® server (XenApp™ Server 6.0 Enterprise): .......................................................................... 41

Citrix® server (Presentation Server v4.5): .................................................................................... 42

LAC/E32 module: ....................................................................................................................... 44

VMware vCenter server .............................................................................................................. 46

SQL 2008 server ....................................................................................................................... 46

VM Storage Unit ........................................................................................................................ 46

VM Backup Storage Unit............................................................................................................. 46

VMware ESXi v4.1 servers .......................................................................................................... 46

Empower 3 Database server virtual machine ................................................................................ 46

Citrix Server – XenApp 6 virtual machine ..................................................................................... 47

Empower 3 File Server virtual machine ........................................................................................ 47

Empower 3 Clients virtual machine .............................................................................................. 47

VMware vSphere v5.0 servers .................................................................................................. 48

VM Storage Unit ........................................................................................................................ 48

VM Backup Storage Unit............................................................................................................. 48

VMware vCenter server and SQL 2008 server ............................................................................... 48

VMware vCenter Server 5.0 ...................................................................................................... 49

SQL 2008 Server....................................................................................................................... 49

VMware vCenter Server (v5.1 environment only) ..................................................................... 50

VMware vCenter Server 5.1 ............................................................................................................ 50

VMware vSphere Update Manager 5.1 ............................................................................................... 50

SQL 2008 Server....................................................................................................................... 51

System and software requirements

Platform Operating systems

Windows 7 Professional or Enterprise with Service Pack 1, 64-

• Windows 7 Professional or Enterprise with Service Pack 1, 64-

• Windows Server 2008 R2, Enterprise edition with Service

• Oracle Enterprise Edition for Windows, 64-bit, version

Data Guard server Windows 2008 R2, Enterprise, 64-bit

Before you install Empower 3 FR 2 software

New technology • Support for Red Hat Enterprise Linux 6.2.

Empower Provides key chromatography performance dashboards to help maximize your

LDAP • Support for non-Active Directory LDAP servers.

Empower software options

• AutoArchive for Empower Workgroup and Empower Enterprise.

Important: AutoArchive is available for Empower Personal.

Issues fixed in this release

Issues fixed in Empower 3 FR2:

PCS Number Description