Innovation in Aging, 2022, Vol. 6, No.
S1
included in each group. No differences present in 30-days all-
cause readmission(RR=1.04, CI95% =0.92–1.17, p=0.49),
mortality(RR=0.63, CI95%=0.30–1.29, p=0.28), ICU
admission(RR=1.01, CI95%=0.89–1.15, p=0.79), gastro-
intestinal bleeding(RR=1.09, CI95%  =  0.85–1.40, p=0.51),
and intracranial hemorrhage(RR=0.69, CI95%=0.26–1.83,
p=0.62) between groups.  Conclusion: LDA didn’t improve
the evaluated outcomes in older persons 30 days after admis-
sion. A plausible explanation is that COVID-19’s thrombo-
genic mechanism is likely atypical.
COMORBIDITIES ASSOCIATED WITH RISK OF
MYOCARDITIS IN HOSPITALIZED COVID-19 OLDER
ADULTS
Andrew Crawford,1 Andres Redondo,2 Ali Vaeli Zadeh,3
Alan Wong,1 Ricardo Criado Carrero,4
Alexander  Fleischhacker,4 Elias Collado,3 and
Joshua Larned5, 1. Holy Cross Health-University of Miami,
Fort Lauderdale, Florida, United States, 2. University of
Miami, Fort Lauderdale, Florida, United States, 3. Holy
Cross Health-Jim Moran Cardiovascular Research Institute,
Fort Lauderdale, Florida, United States, 4. University of
Miami/Holy Cross Hospital, Fort Lauderdale, Florida,
United States, 5. Holy Cross Health- University of Miami,
Miami, Florida, United States
Background: Older adults are afflicted more severely by
COVID-19. SARS-CoV-2 can be complicated by myocarditis
(MC), and the incidence of MC has been shown to correlate
linearly with severity. However, data on comorbidities asso-
ciated with MC in this population is scarce. Methods: Data
were obtained from the PearlDiver database (PearlDiver
Technologies, Fort Wayne, IN). The study used ICD codes
to include patients hospitalized with a primary diagnosis
of COVID-19, aged 65–75, and Elixhauser Comorbidity
index(ECI)>4. Within this cohort, we identified patients diag-
nosed with MC 60 days after admission and compared their
baseline comorbidities upon admission to those without MC.
Pearson’s chi-squared test was used to compare groups. The
strength of association was reported by Risk Ratios (RR).
A p-value < 0.05 was deemed significant. Results: 412,582
patients admitted with COVID-19 as the primary diagnosis
were identified. 0.12% of this cohort developed MC over
the following 60 days. The MC group was more likely to be
male(57%, p=0.0001), with similar mean age(70.4, p=0.86)
and mean ECI(9.4, p=0.07) to the no-MC group. Patients
who developed MC have significantly higher rates of prior
heart failure(RR= 1.30, CI95%=1.07–1.57, p=0.008). There
was no difference between groups in terms of history of
arrhythmias(p=0.36), cerebrovascular disease(p=0.09),
chronic kidney disease(p=0.13), CAD(P=0.19),
diabetes(p=0.48), ischemic heart disease(p=0.06), tobacco
use(p=0.39), alcohol use(p=0.17), HIV(p=0.79), and severe
liver disease(p=0.14). Conclusion: A history of heart failure
increased the likelihood of developing MC in older adults.
ASSOCIATION BETWEEN STATE AND TRAIT
ANXIETY AND CARDIOVASCULAR DISEASE
Ruifeng Cui,1 Montgomery Owsiany,2 and Alaa Shalaby3,
1. VA Pittsburgh Healthcare System, Morgantown, West
Virginia, United States, 2. West Virginia University,
851
Morgantown, West Virginia, United States, 3. VA Pittsburgh
Healthcare System, Pittsburgh, Pennsylvania, United States
Cardiovascular disease (CVD) consistently ranks among
the top ten leading causes of death, with prevalence rates
being the highest among middle aged and older adults.
Research has found that CVD has a negative bidirectional
association with anxiety. However, the literature is limited
regarding what specific aspects of anxiety, i.e., state and/
or trait, are associated with CVD. The present study inves-
tigated the association between state and trait anxiety and
CVD in a national sample of 640 middle aged and older
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adults. Participants (M age = 56.2, SD = 11.8) were from the
Midlife in the United States (MIDUS) Biomarker sub-project.
State anxiety was assessed with the Mood and Anxiety
Symptom Questionnaire-anxiety subscale and trait anxiety
was assessed with the Spielberger Trait Anxiety Inventory. In
a binary logistic regression model including both state and
trait anxiety, only trait anxiety significantly predicted pres-
ence of CVD (p  =  .05). In particular, trait anxiety was sig-
nificantly associated with circulatory disease (p = .05), heart
murmurs (p = .03), and blood clots (p = .03). Among middle-
aged and older adults, trait anxiety is associated with having
several different CVDs. These findings support assessing and
addressing trait anxiety among middle aged and older adults
with CVD.
AGE DIFFERENCES IN DEPRESSION AND ANXIETY
LEVELS OF OPEN HEART SURGERY PATIENTS
Crim Sabuncu, and  Amy Ai, Florida State University,
Tallahassee, Florida, United States
Age, as well as gender, are key demographic measures in
cardiac patients. Further, depression and anxiety have been
long established to be comorbidities of heart disease (HD).
In this prospective study, to examine the impact of age and
gender in preoperative depression and postoperative anx-
iety symptoms of HD patients receiving open heart surgery
(OHS), we collected two waves of survey data along with
medical indices from patients at a top-10 heart center in the
USA (n = 481, mean age = 62.18 ± 12.04, female 42%). The
collected survey data included socio-demographic informa-
tion (age, gender, race), religious affiliation and other reli-
gious factors, general health and health behaviors, medical
comorbidities, cardiovascular health indices, dispositional
optimism, hope, social support, depression symptoms, and
anxiety symptoms. Statistical analysis was carried out using
hierarchical linear regression analyses. Findings support
that higher age correlates with increased levels of cardiac
symptoms. Further, younger age was associated with higher
levels of postoperative depression, while older age was as-
sociated with higher levels of postoperative anxiety. Higher
levels of dispositional optimism were consistently associ-
ated with lower levels of both postoperative depression and
postoperative anxiety regardless of age. Female gender had
an impact on depression scores but not on anxiety scores.
Findings suggest that medical practitioners might benefit
from being more attentive to non-medical conditions such
as mood states, dispositional optimism, and general positive
expectations about the future in post-OHS life. The findings
also suggest that there might be age and gender differences
in expected postoperative psychosocial symptomology for
OHS patients.