Professional Documents
Culture Documents
Situation:
Jenny, a 34-year-old pregnant client who is 35 weeks pregnant, visited the RHU of Brgy. Maliwanag. During the assessment, it was found out that she has persistent,
dull low backache, persistent uterine contractions, low abdominal cramping, and cervical dilatation of 2 cm. The physician has concluded that she is experiencing
premature labor.
DRUG STUDY
NAME OF DRUG MECHANISM OF ACTION CONTRAINDICATIONS SIDE ADVERSE NURSING RESPONSIBILITIES
EFFECTS EFFECTS
GENERIC NAME Inhibits the synthesis of Acetaminophen is Breathing Hives NURSING ASSESSMENT:
prostaglandins in the central contraindicated in: problems Assess for an allergy to
nervous system and Difficulty breathing acetaminophen.
Acetaminophen (IV) peripherally blocks pain Patients with known Nausea
impulse generation; produces hypersensitivity to Swelling in the
Assess the patient for pain by
antipyresis from inhibition of Acetaminophen or to any of Vomiting face, lips, tongue,
asking the patient to rate on a
BRAND NAME hypothalamic heat-regulating the excipients in the or throat
scale of 1-10, and describe pain
center; binds to opiate intravenous formulation Constipation
characteristic, duration, and
receptors in the CNS, causing Skin redness
frequency.
Ofirmev inhibition of ascending pain Patients with renal or Agitation
pathways, altering the hepatic impairment Rash that spreads
If given as an antipyretic, assess
perception of and response to Itching and causes
pain; causes cough Elderly, pregnant or blistering and temperature.
CLASSIFICATION
suppression by direct central breastfeeding patients Headache peeling
action in the medulla;
produces generalized CNS Children under age 2 Insomnia Chest pain Assess for pregnancy or lactation.
Analgesics
depression. Acetaminophen is a category B
Upper stomach risk meaning the risk of fetal
INDICATION A: Acetaminophen has 88% pain harm is possible but unlikely.
oral bioavailability and DRUG INTERACTIONS: Administration is safe under the
Acetaminophen is one of the
reaches its highest plasma Activated charcoal and Loss of appetite prescription and supervision of a
most commonly used drugs
concentration 90 minutes cholestyramine decrease the healthcare provider.
among pregnant women, and it
after ingestion. absorption of Dark urine
is usually the first-choice
acetaminophen.
analgesic and antipyretic. For Assess for acetaminophen
D: Acetaminophen appears to Clay-colored stools
the reason that the intensity of toxicity: nausea, vomiting,
be widely distributed Barbiturates,
pain experienced by women abdominal pain, elevated bilirubin
throughout most body tissues carbamazepine, isoniazid, Jaundice
during labor has been shown to and liver enzymes.
except in fat. rifampin, and more can
influence labor progress, fetal
increase the risk of
well-being, and maternal
M: Acetaminophen is mainly hepatotoxicity.
psychology. Intravenous NURSING INTERVENTION:
metabolized in the liver by
acetaminophen is an effective Routinely monitor the
first-order kinetics and its Hormonal contraceptives
non-opioid pain reliever that has effectiveness of acetaminophen by
metabolism of comprised of 3 can decrease the
no significant maternal or fetal assessing pain levels and fever
pathways: conjugation with effectiveness of
side effects. reduction.
glucuronide, conjugation with acetaminophen.
DOSAGE & FREQUENCY
sulfate, and oxidation through
Dosage for Adult and pediatric: IV acetaminophen should be
the cytochrome P450 enzyme Oral anticoagulants may
pathway, mainly CYP2E1, to have an increased infused over 15 minutes.
● 500mg/50mL
produce a reactive metabolite anticoagulant effect.
● 1000mg/100mL (N-acetyl-p-benzoquinone For patients who are at risk for
imine or NAPQI). hepatotoxicity or renal toxicity,
the nurse should closely monitor
FOR PAIN AND FEVER: E: Acetaminophen FOOD INTERACTIONS: AST and ALT levels and BUN and
metabolites are mainly Alcohol may increase risk creatinine.
Adult dosage excreted in the urine. Less of hepatotoxicity.
than 5% is excreted in the Acetaminophen can cause
● Weighing less than 50kg:
urine as free (unconjugated) hematologic reactions. The nurse
12.5 mg/kg IV every 4 should monitor for anemia and
acetaminophen and at least
hours or 15 mg/kg IV decreased red and white blood
90% of the administered dose
every 6 hours; not to is excreted within 24 hours. counts.
exceed 750 mg/dose or
3.75 g/day The antidote for acetaminophen
overdose is N-acetylcysteine given
● Weighing over 50 kg: 650
either orally or IV.
mg IV every 4 hours or
1000 mg IV every 6 PATIENT TEACHING:
hours; not to exceed 4 Instruct patients to never take
g/day more than 4,000 mg of
acetaminophen per 24 hours. This
● Infuse IV over at least 15
includes all forms of
minutes
acetaminophen and
acetaminophen-containing
products.
Pediatric dosage
Group 1
Esquibal, Shanthal
Estac, Cyra
Escosio, Irish
Espiritu, Sheena
Estigoy, Mary Ruth
Estrada, Princess Joy
Fabia, Ginia
Ferrer, Hannah Grace