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HEMATOLOGY REPORT
HbA1C (Glycosylated Haemoglobin)
GLYCOSYLATED HEMOGLOBIN (HbA1c) 6.0
ESTIMATED AVERAGE GLUCOSE 125.5
Interpretation:
Interpretation For HbA1c% As per American Diabetes Association (ADA)
Note:
1. Since HbA1c reflects long term fluctuations in the blood glucose concentration, a diabetic patient who is recently under good control may still have a high concentration of HbA1c.
Converse is true for a diabetic previously under good control but now poorly controlled. 2. Target goals of < 7.0 % may be beneficial in patients with short duration of diabetes, long life
expectancy and no significant cardiovascular disease. In patients with significant complications of diabetes, limited life expectancy or extensive co-morbid conditions, targeting a goal of
< 7.0 % may not be appropriate.
Comments :
HbA1c provides an index of average blood glucose levels over the past 8 - 12 weeks and is a much better indicator of long term glycemic control as compared to blood and urinary
glucose determinations ADA criteria for correlation between HbA1c & Mean plasma
glucose levels.
HbA1c(%) Mean Plasma Glucose (mg/dL) HbA1c(%) Mean Plasma Glucose (mg/dL)
6 126 12 298
8 183 14 355
10 240 16 413
BIOCHEMISTRY REPORT
Glucose Fasting (BSF)
GLUCOSE FASTING 82 mg/dL 70 - 100
Method : Hexokinase
Interpretation:
Normal: 70-99
Impaired Tolerance: 100-125
Diabetes mellitus: >= 126
(on more than one occassion) (American diabetes association guidelines 2018)
BIOCHEMISTRY REPORT
Lipid Profile
TOTAL CHOLESTEROL 221 mg/dL Desirable : <200
Method : Enzymatic - Cholesterol Oxidase Borderline : 200-239
High : >240
TRIGLYCERIDES 119 mg/dL Normal : <150
Method : Colorimetric - Lip/Glycerol Kinase Borderline : 150-199
High : 200-499
Very high : >500
HDL CHOLESTEROL 45 mg/dL >50
Method : Accelerator Selective Detergent
NON HDL CHOLESTEROL 176 mg/dL <130
Method : Calculated
LDL CHOLESTEROL 152.2 mg/dL Optimal <100
Method : Calculated Near optimal/above optimal
100-129 Borderline high
130-159
High 160-189
Very high >190
V.L.D.L CHOLESTEROL 23.8 mg/dL < 30
Method : Calculated
CHOL/HDL Ratio 4.91 - 3.5 - 5.0
Method : Calculated
HDL/ LDL RATIO 0.3 - Desirable : 0.5 - 3.0
Method : Calculated
Borderline : 3.1 - 6.0
Interpretation:
Lipid level assessments must be made following 9 to 12 hours of fasting, otherwise assay results might lead to erroneous interpretation. NCEP recommends of 3 different samples to be drawn at intervals of 1 week
for harmonizing biological variables that might be encountered in single assays.
NATIONAL LIPID ASSOCIATION TOTAL CHOLESTEROL TRIGLYCERIDE in LDL CHOLESTEROL in NON HDL CHOLESTEROL
RECOMMENDATIONS (NLA-2014) in mg/dL mg/dL mg/dL in mg/dL
BIOCHEMISTRY REPORT
Creatinine
CREATININE 0.8 mg/dL 0.57 - 1.11
Method : Photometric
Interpretation:
Creatinine estimation is done to assess kidney function. It is not dependent on dietary factors. Normal values are obtained in kidney diseases,
except in advanced renal failure and therefore its estimation is more valuable if coupled with clearance.
BIOCHEMISTRY REPORT
FT4 (Free Thyroxine 4)
T4, Free 0.733 ng/dL 0.93 - 1.7
Method : ECLIA
Interpretation:
Note:
Thyroid Peroxidase antibodies may be detected in individuals without clinically significant thyroid disease. They do not define the patient’s
thyroid functional status. Anti TPO is technically superior and a more specific method for measuring thyroid antibodies. It is especially useful in
patients presenting with subclinical hypothyroidism where TSH is elevated but free T4 levels are normal.
Clinical Use
ꞏ Confirm presence of Autoimmune thyroid disease
Increased Levels
ꞏ Hashimoto thyroiditis
ꞏ Graves disease
ꞏ Postpartum thyroiditis
ꞏ Primary hypothyroidism due to Hashimoto thyroiditis
BIOCHEMISTRY REPORT
SGPT / ALT
SGPT/ALT 20.6 U/L 0 to 55
Method : IFCC without P5P
Interpretation:
Serum ALT is used for differential diagnosis of diseases of hepatobiliary system and pancreas. Increased in alcohalic hepatitis, cirrhosis,
hepatocellular carcinoma, chronic hepatitis. Decreased in genito-urinary tract infection, malignancy, pyridoxal phosphate deficiency states
(malnutrition, pregnancy, alcoholic liver disease).
BIOCHEMISTRY REPORT
Vitamin D 25 Hydroxy
Vitamin D 25 - Hydroxy 19.4 ng/mL Deficiency : <30 ng/mL
Method : ECLIA
Interpretation:
25-Hydroxy vitamin D represents the main body reservoir and transport form. Mild to moderate deficiency is associated with Osteoporosis /
Secondary Hyperparathyroidism while severe deficiency causes Rickets in children and Osteomalacia in adults. Prevalence of Vitamin D deficiency
is approximately >50% specially in the elderly. This assay is useful for diagnosis of vitamin D deficiency and Hypervitaminosis D. It is also used
for differential diagnosis of causes of Rickets & Osteomalacia and for monitoring Vitamin D replacement therapy.
BIOCHEMISTRY REPORT
Prolactin (PRL)
Prolactin 18.4 ng/mL Men 4.04 - 15.2
Method : ECLIA
Women(Not-pregnant)4.79 -
23.3
Interpretation:
Note:
1. Since prolactin is secreted in a pulsatile manner and is also influenced by a variety of physiologic stimuli, it is recommended to test 3 specimens
at 20-30 minute intervals after pooling.
2. Major circulating form of Prolactin is a nonglycosylated monomer, but several forms of Prolactin linked with immunoglobulin occur which can
give falsely high Prolactin results.
3. Macroprolactin assay is recommended if prolactin levels are elevated, but signs and symptoms of hyperprolactinemia are absent or pituitary
imaging studies are normal
Clinical Use
ꞏ Diagnosis & management of pituitary adenomas
ꞏ Differential diagnosis of male & female hypogonadism
Increased Levels
ꞏ Physiologic: Sleep, stress, postprandially, pain, coitus
ꞏ Systemic disorders: Chest wall or thoracic spinal cord lesions, Primary / Secondary hypothyroidism, Adrenal insufficiency, Chronic renal failure,
Cirrhosis
ꞏ Medications:
Psychiatric medications like Phenothiazine, Haloperidol, Risperidone, Domperidone, Fluoexetine, Amitriptylene, MAO inhibitors etc.,
Antihypertensives: Alphamethyldopa, Reserpine, Verapamil
Opiates: Heroin, Methadone, Morphine, Apomorphine
Cimetidine / Ranitidine
ꞏ Prolactin secreting pituitary tumors: Prolactinoma, Acromegaly
ꞏ Miscellaneous: Epileptic seizures, Ectopic secretion of prolactin by non-pituitary tumors, pressure / transaction of pituitary stalk,
macroprolactinemia
ꞏ Idiopathic
Decreased levels
ꞏ Pituitary deficiency: Pituitary necrosis / infarction
ꞏ Bromocriptine administration
ꞏ Pseudohypoparathyroidism
BIOCHEMISTRY REPORT
TSH 3rd Generation
THYROID STIMULATING HORMONE (TSH) 55.3 mIU/L 0.27 - 4.20
Method : ECLIA
Interpretation:
TSH levels are subject to circadian variation, reaching peak levels between 2 - 4.a.m. and at a minimum between 6-10 pm . The variation is of the
order of 50% . hence time of the day has influence on the measured serum TSH concentrations.
Primary malfunction of the thyroid gland may result in excessive (hyper) or below normal (hypo) release of T3 or T4. In addition as TSH directly
affects thyroid function, malfunction of the pituitary or the hypo - thalamus influences the thyroid gland activity. Disease in any portion of the
thyroid-pitutary-hypothala- mus system may influence the levels of T3 and T4 in the blood. In primary hypothyroidism, TSH levels are
significantly elevated, while in secondary and tertiary hypothyroidism, TSH levels may be low. In addition, in the Euthyroid Sick Syndrome,
multiple alterations in serum thyroid function test findings have been recognized in patients with a wide variety of non-thyroidal illnesses (NTI)
without evidence of preexisting thyroid or hypothalami c-pitutary diseases.
Thyroid Binding Globulin (TBG) concentrations remain relatively constant in healthy individuals. However, pregnancy, excess estrogen, androgen,
antibiotics, steroids and glucocorticoids are known to alter TBG levels and may cause false thyroid values for Total T3 and T4 tests.
HbA1c(IFCC)=42.0mmol/mol HbA1c(NGSP)=6.0%
eAG(ADA)=125.1mg/dl eAG(ADA)=6.9mmol/l
0.03
0.025
0.02
ABS
0.015
0.01
HbA1c
0.005
0
0 20 40 60 80
Time(S)
Diagnosis: