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Food Molecules that may a role in Cancer 

Inhibition
Quercetin
IP-6 Molecule
Fisetin
Sulforaphane
Omega-7
Allicin
Vitamin D3
Epigallocatechin gallate (EGCG)
Resveratrol
Data Website https://www.worldofmolecules.com/foods/#:~:text=There%20are%204%20(four)
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%20omnivorous%20animals%20that%20can%20consume%20both%20plant%20and%20animal
%20products.

Quercetin Molecule
Quercetin is a flavonoid and, to be more specific, a flavonol.
Chemical structure -- molecular mass 302.236 g/mol -- molecular formula C15H10O7

It is the aglycone form of a number of other flavonoid glycosides, such as rutin and
quercitrin, found in citrus fruit & onions. Quercetin forms the glycosides quercitrin and
rutin together with rhamnose and rutinose, respectively.
Medicinal properties
Quercetin is found to be the most active of the flavonoids in studies and many medicinal
plants owe much of their activity to their high quercetin content. Quercetin has
demonstrated significant anti-inflammatory activity because of direct inhibition of
several initial processes of inflammation. For example, it inhibits both the manufacture
and release of histamine and other allergic/inflammatory mediators. In addition, it exerts
potent antioxidant activity and vitamin C-sparing action. Quercetin also shows anti-
tumour properties. A study in the British Journal of Cancer showed that, when treated
with a combination of quercetin and ultrasound at 20 kHz for 1 minute duration, skin
and prostate cancers show a 90% mortality within 48 hours with no visible mortality of
normal cells.[2] Note that ultrasound also promotes topical absorption by up to 1,000
times making the use of topical quercetin and ultrasound wands an interesting
proposition.
Recent studies have supported that quercetin can help men with chronic prostatitis, and
both men and women with interstitial cystitis, possibly because of its action as a mast
cell inhibitor.
Quercetin may have positive effects in combating or helping to prevent cancer,
prostatitis, heart disease, cataracts, allergies/inflammations, and respiratory diseases
such as bronchitis and asthma. It also has antidepressant properties.
What Foods are rich in Quercetin?
Foods rich in quercetin include capers (1800mg/kg)_ref-3-[4], lovage (1700mg/kg),
apples (440mg/kg), tea (Camellia sinensis), onions (higher concentrations of quercetin
occur in the outermost rings[5]), red grapes, citrus fruits, broccoli and other leafy green
vegetables, cherries, and a number of berries including raspberry, bog whortleberry (158
mg/kg, fresh weight), lingonberry (cultivated 74mg/kg, wild 146 mg/kg), cranberry
(cultivated 83 mg/kg, wild 121 mg/kg), chokeberry (89 mg/kg), sweet rowan (85 mg/kg),
rowanberry (63 mg/kg), sea buckthorn berry (62 mg/kg), crowberry (cultivated 53mg/kg,
wild 56 mg/kg),[6] and the fruit of the prickly pear cactus. A recent study found that
organically grown tomatoes had 79% more quercetin than "conventionally grown". A
study by the University of Queensland, Australia, has also indicated the presence of
quercetin in varieties of honey, including honey derived from eucalyptus and tea tree
flowers.
Dru/g interactions
Quercetin is contraindicated with antibiotics; it may interact with fluoroquinolones (a
type of medicinal antibiotic), as quercetin competitively binds to bacterial DNA gyrase.
Whether this inhibits or enhances the effect of fluoroquinolones is not entirely clear.
Quercetin is also a potent inhibitor of CYP3A4, an enzyme that breaks down most drugs
in the body.[11] As such, quercetin would be expected to increase serum levels, and
therefore effects, of drugs metabolized by this enzyme.
Cancer
Quercetin, a natural existing polyphenol compound, has shown anticancer capacity for
liver, breast, nasopharyngeal and prostate carcinoma but has not been clinically
approved yet. Quercetin induces apoptosis and inhibits migration. We are the first to
show that quercetin displays potent inhibition on bladder cancer cells via activation of
AMPK pathway. see: Quercetin induces bladder cancer cells apoptosis by activation of
AMPK signaling pathway
The research team concluded that "in order to have a maximum anticancer effect,
green tea or green tea extract should be used together with quercetin."  See: Quercetin
boosts green tea antioxidant capacity two to fourfold to fight cancer development
A study suggests that quercetin could inhibit cell proliferation and colony formation of
human bladder cancer cells by inducing DNA damage and that quercetin may be an
effective chemopreventive and chemotherapeutic agent for papillary urothelial bladder
cancer after transurethral resection. see: Chemotherapeutic potential of quercetin on
human bladder cancer cells.
"... Apart from antioxidant activity, Qu also exerts a direct, pro-apoptotic effect in tumor
cells, and can indeed block the growth of several human cancer cell lines at different
phases of the cell cycle. Both these effects have been documented in a wide variety of
cellular models as well as in animal models..."  see: Quercetin and Cancer
Chemoprevention

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