MD 406, 2022

 1- Suppurative inflammation
i. Localized
ii. Diffused
2- Nonsuppurative inflammation
i. Catarrhal inflammation
ii. Membranous inflammation
iii. Fibrinous inflammation
iv. Serous inflammation
v. Sero-fibrinous inflammation

MD 406, 2022
 1- Suppurative inflammation
(Septic, Purulent, Pyogenic
inflammation):
◦ Pus formation
◦ Caused by pyogenic
organisms:
Staphylococcus aureus
Streptococci
Pneumococci
Gonococci
Meningococci

MD 406, 2022
 Pyogenic organisms TOXINS

Attract leukocytes Tissue necrosis

Pus cells

The liquefied material mixed with pus cells

and fluid exudate form the pus.
 SUPPURATIVE
INFLAMMATION

Localized: Diffused:
e.g. Abscess, boil e.g. Cellulitis
(furuncle), carbuncle

Staphylococcus Streptococcus
aureus Hemolyticus
Coagulase Streptokinase (fibrinolysin)
Hyaluronidase (spreading
factor)
 Abscess = cavity containing pus,
showing 3 zones:

◦ Central zone of necrosis

◦ Mid zone of pus
◦ Peripheral zone (pyogenic membrane) of
inflammation showing neutrophils, pus cells,
macrophages and fibrin.

MD 406, 2022
Localized Suppurative Inflammation
Abscess commonly occurs in the
subcutaneous tissue, but may occur in any
organ as lung, brain.

 Boil (furuncle) is a small abscess related to

hair follicles or sebaceous glands
 Carbuncle = multiple
communicating deep
subcutaneous
abscesses, opening
onto surface by
multiple sinuses.

 Sites of carbuncle
include back of neck,
scalp,more common
in diabetics.

MD 406, 2022
 Fistula is a tract communicating the abscess
cavity & a hollow organ or between two hollow
organs e.g. ano-rectal fistula complicating a
preanal abscess.

MD 406, 2022
 1- Catarrhal inflammation: thick exudate of
mucus and white blood cells caused by the
swelling of the mucous membranes usually
associated with common cold

MD 406, 2022
 2- Serous inflammation: outpouring of watery,
low protein exudate/ Burns.

 3-Fibrinous inflammation: rich in fibrinogen/

pericarditis

MD 406, 2022
 4- Sero-fibrinous inflammation:
Excess fluid exudate rich in fibrinogen

◦ Inflammation in serous sacs (pleura,

pericardium, and peritoneum)

◦ Serous membrane is thick opaque & grayish

(fibrin deposition)
◦ Serous sac contains excess fluid (wet type)

MD 406, 2022
 5- Membranous inflammation:
◦ Yellowish gray
Pseudomembrane
◦ Composed of necrotic
patches and excessive fibrin
due to severe inflammation
of the mucus membranes

◦ Caused by bacteria producing

exotoxins as diphtheria and
bacillary dysentery

MD 406, 2022
 Fate of acute inflammation
Resolution Regression/Repair

Acute Chronic
Injury Inflammation Inflammation

Progression
Septicaemia
and spread

MD 406, 2022