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Coombs test

1- Direct Coombs test is used to detect antibodies on RBCs.

Direct Coombs test is positive in autoimmune hemolytic anemia, transfusion reactions, and some drug-
induced hemolytic anemia.

2- Indirect Coombs test is used to detect antibodies in the sera.

Indirect Coombs test is routinely used in compatibility testing before transfusion.

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