2/1562 1020E324 Candidate's Seat

First M.B.B.S. (New Course) Examination

Anatomy
Paper-
Date 19-10-2020, Monday} Max.Marks 100
[Time: 3 Hours

instructions (1) Answer to the point.

(2) Figure io the right indicates marks.
(3) Draw diagrams wherever necessary.
4) Write legibly.
(5) Use separate answer books for each section

Section-1
Q-1 Write the folowing Structured Long Question (Any 1 out of 2) 1x10=10

1. Describe root value, course, branches, applied anatomy and muscles supplied by UI nar
Nerve in hand. (1+2+2+3+2)
2. Describe Type, ligaments, relations, mus cles responsible for the movement and applied
añatomy of Shoulder joint. (1+2+2+2+3)

0-2a) Write the following Case based scenario/Applied Short notes. (Any 2 out of 3) 2x6=12

A 53-year-old man presented with the foliowing: sagging down of the left side of his face; left
inferior eyelid everted, widened left palpebral fissure, difficulty in chewing and dribling of
saliva. (1+3+2)
What will be your provisional diagnosis?
, What are the anatomical reasons for the presenting features?
What other symptoms/signs will you look for/ elicitin this patient?
2. Applied anatomy of spinal cord
3 A medical student was observing some coolies on the street. One of them was trying to stand in
front of wall and rest a little. As the man was pushing his upper limbs on the wall, the medical
student noticed that there "Winging of scapula" on the right side. (1+3+2)
What is winging ofscapula?
Which nerve is affected in this condition? Write its anatomical basis.
List out reasons for injury to the nerve
Q-2 (b Write Short Notes (Any 3 out of 4) 3x6-18

Classification of joint with exampies aial aundicuul tRul, veLtebe

Histoiogy of Hyaline Cartilage
Histology of Cerebelium
Development of Tongue
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 1020E324 2

Q-3 Answer only in 2-3 sentences (Any 5 out of 6)

Sn2=10
What is End artery? Give
examples
Write derivatives of Second Branchial arch.
Which are the types of Neuroglia?
Define Prime movers with one exanple.
Wnat is Stratified Squamous epithelium? Which are the sites where it is present?
What is portal triad?

Section-2
Q-4 Write foilowing Structured Long Question (Any 1out of 2) 1x10-10
1 Describe Origin, insertion, supply, actions and
nerve
applied ana tomy of Extra ocular
muscles. (2+2+2+2+2)
Classify Dural venous sinuses. Describe Relations, communication and applied anatomy of
cavernous sinus.(2+2+3+3)
Q-5 (a) Write Short Notes (Any 2 out of 3) 2x6-12
Brachial Artery
Boundaries and content of Middle Ear
3. Pierygopalatine Ganglion

Q-5 () Write Short Notes (Any 3 out of 4)

3x6-18
1 Corpus Callosumn
2 Circle of Willis
Transverse section of Midbrain at the level of Superior colliculus
Third Ventricle
-5 Answer oniy in 2-3 sentences (Any 5 out of 6) 5x2-10
vWhat is CarpalTunnel syndrome?
V Name the muscles of mastication and its nerve supply.
Which is the safety muscle of larynx? Why?
What is Rotator cuff syndrome?
Explain "Black eye" in case of accident.
(5.Define Neurobiotaxis with example
2/1562 1020E325 Candidate's Seat N
First M.B.B.S. (New Course) Examination
Anatomy

Date 20-10-2020, Tuesday]

Paper-
Max. Marks 100
[Time 3 Hours

Instructions : (1) Answer to the point.

(2) Figure to the right indicates marks.
(3) Draw diagrams wherever necessary.
(4) Write legibly.
(S) Use separate answer books for each section.

Section-1
Q-1 Write the following Structured Long Question (Any 1 out of 2) 1x10-10

1. Describe type, relations, ligaments, muscles res ponsible for the movement and applied
anatomy of the Hip joint. (1+2+2+2+3)
Describe origin,insertion-nervesupnly actions and applied anatomy of Hamstring
Muscles. (2+2+2+2+2)
Q-21a) Write the following Case based scenario/Applied Short notes. (Any 2 out of 3) 2x6=12

1. A 30 year- old man complained of pain around the umbilicus for two days. Then his pain is
shifted to the right iliac fossa and became severe.(1+3+2)
What is your suspicion about the condition?
.How is the position of the organ related to pain? Write its anatomical basis.
CWhat is relationship of McBurney's point to the condition?

2. A 25 year old man came to the clinic with complaints of numbness over the right first
interdigital cleft for about 2 months. He also had difficulty in walking and had dragged his right
foot; he felt his right foot was drooping down and because of this he was tripping whenever he
tried to walk fast. On examination, there was no swelling, no edema or discoloration. the
second time the man came in, the physician noticed a few pressure marks and the man said he
had just removed his shoes. (1+3+2)
a. What is the most probable cause for the numbness and difficulty in walking?
b. When the man said he was dragging his foot, what condition would
you have expected?
What is the confirmation? Write its anatomical bases in detail.
How would you rule out anterior compartment syndrome or any other?
3. Describe Clinical correlation of Pleura.
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 1020E325-2
Q-2 (b) Write Short Notes (Any 3 out of 4) 3x6=18

Karyotyping
2. Histology of Stomach

Fertilization
Development of Interatrial Septum

3 Answer only in 2-3 sentences (Any 5 out of 6) 5x2=10

What is genetic Counselling?
2Write histological features of pancreas.
Which are the derivatives of Neural crest?
4/Write embryological basis of fallot's tetralogy.
Which are the remnants of Notochord?
6,What is Red pulp and White pulp of Spleen?

Section-2
Q-4 Write the following Structured Long Question (Any 1 out of 2) 1x10-10

1. Describe gross anatomy (relations, interior, blood supply, nerve supply) and applied
anatomy of Anal canal. (2+242+2+2)
Pescribe various sites of Portocaval anastomosis and its associated clinical conditions.
(5+5)
Q-5 la} Write Short Notes (Any 2 out of 3) 2x6-12
Coeliac trunk
t2Rectus sheath
Femoral artery
Q-5 (b) Write Short Notes (Any 3 out of 4) 3x6=18

Broncho pulmonany segments

2Left coronary artey
Respiratory movements
4. Azygos vein

Q-6Answer only in 2-3 sentences (Any 5 out of 6) 5x2=10

Enumerate the tributaries of Coronary sin

Define Plural effusion. Which is the preferred site for the plural tapping?
Enumerate the contents of spermatic cord.
Give anatomical basis of spread of carcinoma of prostate to vertebral column.
What is hybrid muscle? Give two examples
6. Which are the abductors and medi al rotator of the thigh? Write their Nerve supply
2/1562 1020E326 Candidatc's Seat
First M.B.B.S. (New Course) Examination
Physiology
Paper-I
Date 21-10-2020, Wednesdayl Max. Marks 100
Time 3 Hours
Instructions : (1) Answer to the point.
(2) Figure to the right indicates marks.
(3) Draw diagrams wherever necessary.
(4) Write legibly.
(5) Use separate answer books for each section.

SECTION-
Q.1. Write the following Structured Long Question (any 1 out of 2) 1x10-10 marks
1. Define Cardiac cycle. Enumerate phases of Cardiac Cycle and Describe Ventricular
events in detail. How is Ejection Fraction calculated?
2. Define Blood Pressure and Enumerate the factors affecting Blood Pressure. Describe
Baro-receptor Reflex in detail.

Q.2.(A) Write the following case-based scenario/ Applied short Notes (any 2 out of 3)
2x6-12 marks

A patient with long-standing pulmonary tuberculosis (TB) has a Residual volume of

500ml, Total Lung Capacity of 3200ml, and Peak Expiratory Flow Rate of2001/min:
Which type of lung disease is the patient suffering from? (2marks)
Define Timed Vital Capacity. (2marks)
Write the significance of Timed Vital Capacity in the díagnosis of Lung disease
(2marks)
2 38 year old female suffered from malignancy of stomach and as a part of treatment,
her stomach was removed. On examination, signs and symptoms of sub-acute combined
degeneration of spinal cord were seen. Here blood report showed RBC:
3million/cu.mm., Hb: 9gm/dL, MCV: 130um, MCHC: 36%. On giving vitamin B12, the
patient has shown improvement.
Laldentfy the clinical condition in the given scenario. (2marks)
bExplain it's physiological basis. (2marks)
Describe it's characteristic features. (2marks)
3. Describe the waves of a Normal Electrocardiogram mentioning the cause, duration and
voltage of each.
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 1020E326-2
Q.2.(B) Write Short Notes (any 3 out of
4) 3x6-18 marks
1.Describe Apoptosis with it's
significance.
Differentiate between Active and Passive Transport processes.
Enumerate various T-cells and write functions of each.
Enumerate functions of Plasma Proteins.
Q.3. Answer in only 2-3 sentences (any 5 out of 6)
5x2-10 marks
Define Cardiac output.
2Write Normal A:G ratio.
3 Write function of Endoplasmic Reticulum.
4. What is Direct
Cross-matching of blood?
SWrite the cause of 1" and 2d Heart sounds
What is Sinus Arrhythmia?

SECTION-
Q.4. Write the following Structured long Question (any 1 out of 2) 1x10-10 marks
1. Define Lung Surfactant. Describe it's action. Write a note on Respiratory distress
syndrome.
2 Enumerate the various Respiratory Centers. Describe Neural Control of Respiration.
What is Apneustic Breathing?
Q.5. (A) Write short notes (any 2 out of 3)
2x6=12 marks
1. Describe Heat gain and Heat loss mechanisms in our body.
Write any six changes in body occurring during exercise.
What is Homeostasis? Give 2 examples.
Q.5. (B) Write short notes (any 3 out of 4)
3x6-18 marks
Enumerate functions of kidney.
Describe the factors affecting GFR.
3. Describe the components of Normal
Cystometrogram.
4 Enumerate and describe the professional qualities and roles of a physician.
Q.6. Answer only in 2-3 sentences (any 5 out of 6) 5x2-10 marks
1Explain "splay" in renal absorption curve of glucose.
2. What is a diuretic? Give one example.
3What is "mountain sickness"?
What is "dysbarism'"?
What is AlveolarVentilation?
Write the value of normal body temperature.
2/1562 1020E327 Candidate's Seat N
First M.B. B.S. (New Course) Examination
Physiology
Paper-I
Date : 22-10-2020, Thursday| (Max. Marks 100

Time: 3 Hours
Instructions : (1) Answer to the point.
(2) Figure to the right indicates marks.
(3) Draw diagrams wherever necessary.
(4) Write legibly.
(5) Use separate answer books for each section.

SECTION-
out of 2) 1x10-10 marks
Q1. Write the following Structured Long Question (any 1

Define and Classify Synapse. Describe properties of Synapse.

2. Define Sleep and write the stages of sleep. Differentiate between REM and NREM sleep.
Q.2.(A) Write the following case-based scenario/ Applied short Notes (any 2 out of 3)

2x612 marks

with complaints of muscle weakness and fatigue with

1A 60 year old patient presents
work which rest. He has
improves on complaint of drooping of eyelids, double vision and
there is
difficulty in swallowing. When doctor injects anti-cholinesterase drug,
improvement in patient's muscle weakness.
aIdentify the clinical condition in the given scenario. (2marks) M
(2marks) R Ao
Write the cause of this clinical condition.

Explain the physiological basis of treatment of this clinical condition? (2marks)

intolerance to heat,
36year old female presents with complaints ofswelling neck,
in
A excessive sweating, weight loss and nervousness. On examination doctor finds enlarged
neck gland and protrusion of eyeballs.

aIdentify the probable clinical condition in given scenario.(2marks)

What is the cause of enlargement of neck gland in this clinical
condition?(2marks) 6oita
What is the cause of protrusion of eyeballs in this clinical condition? (2marks
3. Describe any three functions and any three dysfunctions of Basal Ganglia.

Q.2. (B) Write Short Notes (any 3 out of 4) 3x6-18 marks

1. Contraceptives.
1Spermatogenesis. P.TO
3. Mechanism of HCl secretion in stomach.
 1020E327-2
Functions of Saliva.
5x2-10 marks
Q.3. Answer in only 2-3 sentences (any 5 out of 6)

Aypothalamus acts as a thermodetector and thermostat. Explain.

2What is Deglutition Apnoea?
3Define upper motor neuron and lower motor neuron.
What is the role of fetal t st in sex differentiation?
S. Give the use of "Morning after" pill.
6Kastric mucosal surface is protected from damage by gastric acid. Explain.
SECTION-
Q.4. Write the following Structured long Question (any 1 out of 2) 1x10=10 marks

of Diabetes Mellitus.
1Define Diabetes mellitus? Describe the causes, signs and symptoms
Enumerate complications of Diabetes Mellitus.
2. Differentiate between Gigantism and Acromegaly.
Q.5. (A) Write short notes (any 2 out of 3) 2x6-12 marks

1/Define and explain Sarcomere.

Describe the sequence of events in Excitation-contraction coupling
3. Define and differentiate between Neuron and Neuroglia.
Q.5.(8) Write short notes (any 3 out of 4) 3x6=18 marks

Errors of Refraction.

Functions of Middle Ear.

Types of Colour Blindness.
Fight or Flight reaction
Q.6. Answer only in 2-3 sentences (any 5 out of 6) 5x2=10 marks

Name the various types of Taste sensations. S3,BU)

What is Olfactory fatigue? A
What is Aldosterone escape?
nia. Explain.
4Hypofunction of Para-thyroid gland causes Hypocalo
5/Which nerve fibers carry Pain sensation?C,E
Para-sympathetic nervous system is anabolic. Explain.
2/1562
1020E328 Candidate's Seat No
First M.B.B.S. (New Course) Examination
Bio-Chemistry
Date 23-10-2020, Fridayl Paper-
Max. Marks 100
ITime 3 Hours

Instructions : (1) Answer to the point.

(2) Figure to the right indicates marks.
3) Draw diagrams wherever necessary.
(4) Write legibly.
(5) Use separate answer books for each section.

SECTION-I
Q.1 WRITE THE FOLLOWING STRUCTURED LONG QUESTION: (Any 0l out of02) Ix10 =10
A.Give the structural characteristics of Heme. Name any four proteins or enzymes that have Heme as
prosthetic group. Describe catabolism of heme. What is the fate of catabolic end product of Heme &
how is it affected in obstructi ve jaundice?
(1+2+3+4)
W h a t is glycogen? Where is it present in body? Write its role in maintaining glucose homeostasis in
body. Name the key enzymes of its metabolism & explain their regulation by various mechanisms.
(1+1+2+6)
Q.2 A.WRITE THE FOLLOWING CASE BASED SCENARIO JAPPLIED SHORT NOTES:
(Any 02 out of 03) 2x6 12
a)Read the following case history & answer the questions.
A 20 year old boy developed fever with rigors & chills. The family physician suspected malaria and
he was given tablet Primaquin. After two days fever subsided but his condition deteriorated. He had
fatigue, dizziness, breathlessness, headache & paraesthesia. His urine colour was reddish black. On
examination: Pallor present, icterus present, mild splenomegaly present. Laboratory findings were:
Hemoglobin = 8 gm/di,
Serum Bilirubin = 6.2 mg/dl, Direct Bilirubin =0.2 mg/dl, Indirect Bilirubin = 6.0 mg/dl,

RBC GPD enzyme= 0.3u/g of Hb (Reference range-4.6 to 13.5 wg of Hb).

Patient was admitted and treated as per standard protocol.On his discharge doctor gave him a list of
drugs which he should avoid in future.
GPD enzyme is an enzyme of which pathway? Give the reaction catalyzed by it.
What is the importance of enzyme GsPD in RBCs?
Explain the cause of development of acute hemolytic crisis in this case.
V. What is glutathione and what is its role in body?
Give two other reactions or pathways where NADPH is required (other than reduction of
glutathione).
Will Bilirubin be present in urine of the patient? Justify
b) Write a short note on Thalassemia, its types, molecular defects, clinical presentation & laboratory
diagnosis.
fWritea short note on laboratory assessment of Glomerular Filuration Rate. C Uy

0.2B WRITE SHORT NOTES: (Any 03 out of 04) 3x6 18

Substrates for gluconeogenesis & how they enter gluconeogenetic pathway.
bYDescribe the components of Electron Transport Chain (ETC) using a diagram. illustrate the sites of
action of various uncouplers & inhibitors of ETC.
c)Write basic forms of patterns of communication in Doctor-Patient relationship.
Role of cytokines in immunology
 1020E328-2
Q,3ANSWER IN 2-3 SENTENCES ONLY: (Give biochemical justification) (Any 05 out of 06) 5 x2 = 10
a Although no ATPs are generated in Rapoport Leubering cycle, it is beneficial for RBCs.
by t is advisable to test an elder person's serum cholinesterase level before giving general
anaesthesia to the patient.
Hematin is used in treatment ofAcute Intermittent Porphyria.
d)Oral administration of glucose along with sodium is helpful in preventing loss of sodium ions in diarrhea
fluid
e) A wide variety of Immunoglobulins can be synthesized in response to an antigen even though there are
limited number of genes for immunoglobulin molecules.
fFlipped pattern of Serum LDH is seen in Myocardial Infarction.

SECTION-II

Q4WRITE THE FOLLOWING STRUCTURED LONG QUESTION: (Any 0I out of 02) 1x 10= 10
A h a t are different types of enzyme inhibitors? Write their mechanism of action and effect on enzyme
kinetics. Name any four drugs which are enzyme inhibitors and give their mechanism of action. (2+6+2)
B. What are lipoproteins? Give their types & composition. Discuss the metabolism of HDL & LDL
highlighting roles of various enzymes & receptors. Explain their reciprocal role in
TAT
atherosclerosis.(1+3+4+2)

95A WRITE SHORT NOTES: (Any 02 out of 03) 2x6-12

Role of kidney in maintaining Acid Base balance
Role of Renin-Angiotension system in Water& Electrolyte Balance
Tumour markers & their significance Ce

Q.5 B WRITE SHORT NOTES: (Any 03 out of 04) 3 x 6 188

Ketoacidosis
bCompare & Contrast -Radioimmunoassay& Enzyme Linked Immunosorbent Assay
Prostaglandins
d Describe the mechanism of activation of Proto-oncogenes to oncogenes.

Q.6 ANSWER IN 2-3 SENTENCES ONLY: (Give biochemical justification) (Any 05 out of 06)
5x2 10
Cytochrome P450 plays central role in detoxification.
a

Role of Carnitine in oxidation of Fatty acid.

Anion gap is helpful to diagnose type of metabolic acidosis.
dDonan membrane equilibrium maintains electrolyte balance.
e)Lecithin is a lipotropic factor.
Hemoglobin acts as a buffer.
 1020E329 Candidate's Seat Nc
2/1562
Examination
First M.B.B.S. (New Course)
Bio-Chemistry
Paper-II
(Max. Marks 1000
Date 24-10-2020, Saturday|
Time: 3 Hours

Instructions (1) Answer to the point.

(2) Figure to the right indicates marks.
(3) Draw diagrams wherever necessary.
(4) Write legibly.
(5) Use separate answer books for each section.

SECTION-I
i WRITE THE FOLLOWING STRUCTURED LONG QUESTION: (Any 01 out of02) 1x10 =10

Describe the process of Eukaryotic Transcription and how it differs from prokaryotic Transcription.
Name various types of RNAs and type of RNA polymerase required for each. Describe post
transcriptional modifications of primary transcript to form different types of RNAs. (5+1+4=10)
B. What are the com1mon causes of DNA damage? Describe various types of DNA Repair mechanisms.
Write briefly about disorders or malignancies associated with defective DNA repair mechanisms.
(2+5+3-10)
Q.2 AWRITE THE FOLLOWING CASE BASED SCENARIO IAPPLIED SHORT NOTES:
(Any 02 out of 03) 2x6 12
a) Read the following case history & ans wer the questions:
A 3 year old fair boy was brought to the hospital with complaints of delayed developmental mile stones,
mental retardation, seizures & eczema. His skin, eyes & hair were light colored. Blood phenyalanine
level was 30 mg/dl (normal 1-2 mg/dl). Guthrie bacterial inhibition assay showed bacterial growth in.
presence of child's blood & Ferric Chloride test of urine showed blue green color.

What is probable diagnosis and possible cause of this disorder?

What is cause of fair skin and light color hair & eyes?
Name the biologically important substances formed from tyrosine.
Why Tyrosine becomes an essential amino acid in such cases?
What is the cause of mousy odour in this patient?
What special dietary advice should be given for such patients?

h a t is Gout? Describe biochemical defects underlying a case of Gout and its primary and secondary
causes.

c)Briefly describe the principle and technique of Gene therapy, its success so far and future prospects.

QBWRITE SHORI NOTES: (Any 03 out of 04) 3 x 6 18

W h a t is Recombinant DNA technology? Name the various enzymes used in this techniques & their uses.
bFree radicals generation in body & their beneficial action in body.
Describe effect of insulin on various metabolic pathways of carbohydrates, proteins & lipids metabolism
Write salient features of genetic code. Explain why majority of mutations have no phenotypic effect.

. 3 ANSWER IN 2-3 SENTENCES ONLY: (Any 05 out of 06) 5x2 10

aReplication is semiconservative.
bRole of p53 Tumor suppressor gene in apoptosis.
) Role of miRNA & Si RNA in regulation of gene expression
dTelomerase inhibitors are used as anticancer drugs.
Antibiotic Tetracycline has an effect on bacterial translation but not on human cells.
Drowing chiidren and pregnant females have positive Nitrogen balance.

P.T.O.
 1020E329-2

SECTION-II

Q4WRITE THE FOLLOWING STRUCTURED LONG QUESTION: (Any 01 out of 02) ix 10- 10
, AWhat is Transdeamination and how ammonia is transported without increasing its level in blood?
Explain the pathway of its final detoxification in liver. (5+5-10)
B. Name the Vitamins which have a role in
hematopoisis. Give their structural characteristics, biochemical
roles, important dietary sources, deficiency features & their clinical
significance. (2+8-10)

A WRITE SHORT NOTES: (Any 02 out of03) 2 x6=12

Define Basal Metabolic Rote & explain the factors affecting it
b) Discuss Iron homeostasis and biochemical basis of hemosiderosis.
Chronic complications of Diabetes Mellitus and Biochemical basis of their development. (Polyol
Pathway & Glycation of proteins)

B WRITE SHORT NOTES ON: (Any 03 out of 04) 3x6 18

Pathways & mechanism of action of hormones acting through second messenger.
Various transport proteins present in plasma, molecules they transport & their clinical significance.
Neurotransmitters synthesized from amino acid
d) One Carbon group generation and utilization

ANSWER IN 2-3 SENTENCEs ONLY: (Any 05 out of 06) 5 x2 10

pefective folding of protein can lead to disease state even if primary structure is normal.
Patient of Chronic Kidney Disease develops Osteodystrophy.
Explain why proteins have no electrophoretic mobility at their Isoelectric pH
Differentiate between Carbamoyl phosphate synthetase -I & Carbamoyl phosphate synthaetase-ll
e) Vitamin K injection is given to new born baby.
ALn containing enzymes & its role.
ADr,CA
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