Restoring homeostasis by movement:

- Exercise and manipulation can normalize connective tissue homeostasis following

injury.
o Tensile force will increase aggregation of collagen resulting in thicker and
denser tissue, thus improve tissues stiffness and strength
o Compression has opposite effect, resulting in thinner and mechanically low-
quality tissue (tendons heat compression)
- Ultrastructure of tissue depend on type of technique
o Continuous stretching will result in structurally longer tissue even in presence
of scare contraction

Connective tissue matrix:

- Movement encourages normal turnover of collagen+ alignment along lines of stress
a tissue with better tensile properties
- Movement improves balance of GAG+ water content within tissue helps maintain
inter-fibril distance and lubrication
o Reduced potential abnormal cross-link formation and adhesion
- In avascular structures: movement provide a pumping function increasing flow of
synovial fluid increased metabolic need of tissue during inflammation repair.
- Even if needs increase, can in synthesize more collagen?

Joints:
- Movement produce pressure fluctuation within joints
o Important for formation and removal of synovial fluid
o Movement encourages smearing of synovial fluid onto articular surface
- Synovial fluid:
o Important nutrition for chondrocytes as articular cartilage has no direct blood
supply
o Stress from movements stimulate metabolic activity of chondrocytes->
proteoglycan and collagen synthesis
 Viability and repair of articular cartilage depend on these processes