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'gut microbiota kidney transplant' OR (('gut'/exp OR gut) AND ('microbiota'/exp OR

microbiota) AND ('kidney'/exp OR kidney) AND ('transplant'/exp OR transplant))

RECORD 1
TITLE
Gut microbiota dysbiosis is a novel risk factor for urinary tract
infections in kidney transplant recipients
AUTHOR NAMES
Lee J.R.; Magruder M.; Sholi A.N.; Edusei E.Y.; Zhang L.T.; Albakry S.Y.; Lubetzky
M.L.; Dadhania D.; Taur Y.; Ling L.; Burnham P.; De Vlaminck I.; Pamer E.;
Suthanthiran M.
AUTHOR ADDRESSES
(Lee J.R.; Magruder M.; Sholi A.N.; Edusei E.Y.; Zhang L.T.; Albakry S.Y.; Lubetzky
M.L.; Dadhania D.; Suthanthiran M.) Weill Cornell Medicine, New York, NY, United
States.
(Taur Y.; Ling L.; Pamer E.) Memorial Sloan Kettering Cancer Center, New York, NY,
United States.
(Burnham P.; De Vlaminck I.) Cornell University, Ithaca, NY, United States.
CORRESPONDENCE ADDRESS
J.R. Lee, Weill Cornell Medicine, New York, NY, United States.
FULL RECORD ENTRY DATE
2020-12-29
SOURCE
Journal of the American Society of Nephrology (2018) 29 (79-80). Date of Publication:
2018
SOURCE TITLE
Journal of the American Society of Nephrology
PUBLICATION YEAR
2018
VOLUME
29
FIRST PAGE
79
LAST PAGE
80
DATE OF PUBLICATION
2018
PUBLICATION TYPE

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 Conference Abstract
CONFERENCE NAME
Kidney Week 2018
CONFERENCE LOCATION
United States, San Diego, CA
CONFERENCE DATE
2018-10-23 to 2018-10-28
ISSN
1533-3450
BOOK PUBLISHER
American Society of Nephrology
ABSTRACT
Background: The gut is the presumed source of urinary tract infection (UTI) but direct
evidence for this supposition is lacking. Methods: We recruited 169 kidney transplant
recipients for serial collection of fecal specimens and profiled 516 fecal specimens using
16S rRNA gene deep sequencing of the V4-V5 hypervariable region. Among the cohort,
36 subjects developed Escherichia bacteriuria within the first 6 months of
transplantation (Escherichia Group) and 133 subjects did not (No Escherichia Group);
36 subjects developed Enterococcus bacteriuria (Enterococcus Group) and 133
subjects did not (No Enterococcus Group). Results: The relative gut abundance of
Escherichia was significantly higher in the fecal specimens in the Escherichia Group
than in those in the No Escherichia Group (P<0.001, Wilcoxon rank sum test) (Fig 1A)
and the relative gut abundance of Enterococcus was significantly higher in the fecal
specimens in the Enterococcus Group than in those in the No Enterococcus Group
(P<0.001) (Fig 1B). Using a Cox Regression with gut abundance as a time-dependent
covariate, a relative gut abundance of 1‰ Escherichia was a risk factor for future
development of Escherichia bacteriuria (HR= 3.2, P<0.001), and a relative gut
abundance of 1‰ Enterococcus was a risk factor for future development of
Enterococcus bacteriuria (HR = 2.6, P= 0.006). Strain analysis of the Escherichia coli in
paired urine-fecal specimens using shotgun metagenomic sequencing revealed that the
E. coli strain in the urine specimens was most similar to the E. coli strain in the fecal
specimens from the same subject, supporting the gut as the source of the urine strain
(Fig 1C). Conclusions: Our findings support the hypothesis that gut microbial
composition is a contributor to UTI in kidney transplant recipients. Modulating the gut
microbiota may be a novel and effective strategy for preventing this frequent
complication.
EMTREE DRUG INDEX TERMS
endogenous compound; RNA 16S
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
intestine flora; kidney graft; risk factor; urinary tract infection

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EMTREE MEDICAL INDEX TERMS
adult; bacteriuria; cohort analysis; complication; conference abstract; controlled
study; Escherichia coli; feces; female; high throughput sequencing; human; human
tissue; human versus nonhuman data; major clinical study; male; metagenomics;
nonhuman; prevention; rank sum test; surgery
LANGUAGE OF ARTICLE
English
LANGUAGE OF SUMMARY
English
PUI
L633737744
EMBASE LINK
https://www.embase.com/search/results?subaction=viewrecord&id=L633737744&from=
export
COPYRIGHT
Copyright 2020 Elsevier B.V., All rights reserved.

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