2nd Bucharest Polymer Conference

Bucharest, ROMANIA - June 10-12, 2020

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Name: Tudorașcu
Surname: Andreea

Affiliation:Advanced Polymer Materials Group

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 2nd Bucharest Polymer Conference
Bucharest, ROMANIA - June 10-12, 2020

POLYMER PARTICLES WITH APPLICATIONS IN THE

ADMINISTRATION OF ACTIVE SUBSTANCES

Andreea Tudorașcu1, Adi Ghebaur1, Horia Iovu 1

Advanced Polymer Materials Group,Univeristy Politehnica of Bucharest 1-7 Gheorghe
Polizu street, 011061, Bucharest, Romania
andreea.tudorascu27@gmail.com

Introduction
Chitosan is a natural, biocompatible, biodegradable, nontoxic and easily available polymer that can be
used to prepare nanoparticles. Chitosan nanoparticles can be widely used in pharmaceutical industries as
an antimicrobial agent or as drug delivery vehicle [1]. In medicine, chitosan is useful in bandages to
reduce bleeding and as an antibacterial agent can also be used to help deliver drugs through the skin. It is
also used in the development of chitosan drug control releasing systems including chitosan sponges,
chitosan film, chitosan beads, chitosan microbeads (microspheres) and chitosan nanoparticles [2].
The purpose of this study is to promote the development of a hybrid drug control release system.
Experimental methods
Chitosan nanoparticles were prepared by ionic gelation method, chitosan polysaccharide is dissolved in
aqueous acidic solution to obtain the cation of chitosan. Then the sodium tripolyphosphate solution is
added drop by drop in the solution of chitosan. Due to the complexation between opposing charges
(positive/negative), chitosan undergoes ionic gelation and precipitates to form spherical nanoparticles.
The nanoparticles were characterized by UV-Vis spectroscopy, FTIR (Fourier transform infrared
spectroscopy), DLS (Dynamic Light Scattering), X-ray photoelectron spectroscopy (XPS).
Results and Discussion
Results revealed that the size of the prepared alginate and chitosan nanoparticles varied. Furthermore,
increasing either sodium tripolyphosphate or chitosan concentration increased the size of their
nanoparticles [3].
Conclusion
Chitosan nanoparticles were successfully prepared by ionic gelation method.
ACKNOWLEDGMENT
The authors acknowledges Executive Agency for Higher Education and Research Funding (UEFISCDI)
and National Research Council  (CNCS) for the financial support through the PN III research project
‘Smart materials for medical applications-INTELMAT’  no. 39PCCDI/2018. The DLS analyses on
(Malvern Zetasizer Nano ZS90) were possible due to European Regional Development Fund through
Competitiveness Operational Program 2014-2020, Priority axis 1, Project No. P_36_611, MySMIS code
107066, Innovative Technologies for Materials Quality Assurance in Health, Energy and Environmental -
Center for Innovative Manufacturing Solutions of Smart Biomaterials and Biomedical Surfaces –
INOVABIOMED.
References
[1] Megha Agarwal, Mukesh Kumar Agarwal, Nalini Shrivastav , Sarika Pandey, Ritu Das, Priyanka
Gaur,Preparation of Chitosan Nanoparticles and their In-vitro Characterization, 22 Feb 2018,
[2] Arezou Ghadi, MSc,1 Soleiman Mahjoub, PhD,2,3 Fatemeh Tabandeh, PhD,4 and Farid Talebnia,
Synthesis and optimization of chitosan nanoparticles: Potential applications in nanomedicine and
biomedical engineering,156-161 February 2014
[3] Morteza Hasanzadeh Kafshgari; Mohammad Khorram; Mohsen Mansouri; Abdolreza Samimi;
Shahriar Osfouri, Preparation of alginate and chitosan nanoparticles using a new reverse micellar system,
99–107, 2012.