Forskolin

Cat#: orb545962 (CoA)

Forskolin
CAS 66575-29-9
orb545962
7 α -Acetoxy-8,13-epoxy-1 α,6 α,9 α -trihydroxylabd-14-en-11-one
Lot # MC5340

Physical Properties: White powder; MP = 229-232°C

MW=410.5 C22H34O7
Analysis: ≥99% (HPLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (10 mg/ml); or ethanol (4 mg/ml). Note, DMSO is the solvent of
choice in experimental protocols for adenylate cyclase activation. Do not use ethanol which inhibits forskolin-
stimulated adenylate cyclase.

Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 4 months.
Pharmacology: Extremely useful activator of adenylate cyclase (EC50=2- 1,2. A hypotensive,
vasodilatory and positive inotropic agent3. Induces stem cell neuronal differentiation4. Cell permeable and
active in vivo.

References:

1. PA Insel and RS Ostrom Cell Mol. Neurobiol. 2003 23:305

2. A Laurenza et al. Trends Pharmacol. Sci. 1989 10:442
3. NJ De Souza Med. Res. Rev. 1983 3:201
4. SS Kim et al. Neuroreport 2005 16:1357

Not for human therapeutic use or for medicinal purposes. For research applications only.