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  • Proceeding Book PB Diinduksi Vaksin

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    Dini Daniaty
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    1) A 77-year-old woman experienced an outbreak of blisters on her hands, feet, and armpits about two weeks after receiving the second dose of the COVID-19 vaccine. She also had painful swelling on her lower legs. 2) Medical examination found blisters, sores, and redness in several areas of her body along with a fever and fast heartbeat. Tests showed signs of inflammation. 3) The COVID-19 vaccine likely caused an immune response that disrupted the basement membrane beneath the skin and revealed antigens, triggering the production of autoantibodies and a relapse of the woman's pre-existing bullous pemphigoid condition. It is important to identify precipitating factors

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    1) A 77-year-old woman experienced an outbreak of blisters on her hands, feet, and armpits about two weeks after receiving the second dose of the COVID-19 vaccine. She also had painful swelling on her lower legs. 2) Medical examination found blisters, sores, and redness in several areas of her body along with a fever and fast heartbeat. Tests showed signs of inflammation. 3) The COVID-19 vaccine likely caused an immune response that disrupted the basement membrane beneath the skin and revealed antigens, triggering the production of autoantibodies and a relapse of the woman's pre-existing bullous pemphigoid condition. It is important to identify precipitating factors

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    4 views1 page

    Proceeding Book PB Diinduksi Vaksin

    Uploaded by

    Dini Daniaty
    1) A 77-year-old woman experienced an outbreak of blisters on her hands, feet, and armpits about two weeks after receiving the second dose of the COVID-19 vaccine. She also had painful swelling on her lower legs. 2) Medical examination found blisters, sores, and redness in several areas of her body along with a fever and fast heartbeat. Tests showed signs of inflammation. 3) The COVID-19 vaccine likely caused an immune response that disrupted the basement membrane beneath the skin and revealed antigens, triggering the production of autoantibodies and a relapse of the woman's pre-existing bullous pemphigoid condition. It is important to identify precipitating factors

    Copyright:

    © All Rights Reserved
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    of 1

    BULLOUS PEMPHIGOID SUSPECTED INDUCED BY COVID-19

    VACCINE AND CYSTITIS IN A GERIATRIC PATIENT


    Dini Daniaty1*, Karin Rachmani2, Shannaz Nadia Yusharyahya3, Lili Legiawati4, Rinadewi
    Astriningrum5
    1-5
    Departemen Dermatologi dan Venereologi Fakultas Kedokteran Universitas Indonesia -
    Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo, Jakarta, Indonesia
    *081358111121, dr.dini.daniaty1987@gmail.com

    Abstract

    Introduction: bullous pemphigoid (PB) is an autoimmune disease that induce subepidermal bullae
    and very common among the elderly. Various precipitating factors such as infection and vaccination
    play a role in causing or exacerbating PB. The Covid-19 vaccination can produce a variety of
    cutaneous adverse effects including PB. The purpose of this paper is to describe cases of PB relapse
    following Covid-19 vaccination. Case: a 77-year-old obese woman complained of blisters on the
    palms of her hands, feet, and armpits that started as itchy red areas and were getting worse 2 weeks
    following the second dose of Covid-19 vaccination. She also suffered of painful erythematous oedema
    on both lower legs. Fever and tachycardia were presented. Erythematous plaques, tense bullae,
    erosions, and excoriations were found in the armpits, palms and feet, abdomen, arms, and thighs.
    There were no Nikolsky or Asboe-Hansen signs discovered. Erythematous, widespread, warm plaques
    were detected on both lower limbs. ALT-70 score of 4, Naranjo score of 4, leucocytosis, high CRP,
    and procalcitonin were found. Discussion: vaccination-induced inflammation can cause basement
    membrane disruption and reveal hidden antigens, causing autoantibodies to form. Molecular mimicry
    initiates PB in bacterial infections. The existence of immunosenescence in the geriatric population can
    diminish immune system performance when combined with infectious diseases, resulting in antigens
    that can cross-react and activate inflammatory pathways. Conclusion: it is critical to identify and
    prevent various precipitating factors to raise patient’s and doctor’s awareness in the case of a future
    recurrence of PB.

    Keywords: bullous pemphigoid, geriatric, Covid-19 vaccination

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