The clinical
neuropsychiatry
of stroke
Cognitive, behavioral, and
emotional disorders following
vascular brain injury
ROBERT G. ROBINSON
CAMBRIDGE
UNIVERSITY PRESSand he smoked cigarettes continual throughout the interview. His
eg was constantly bouncing and he had a naticeabe tremor of hs
"ght hand. Te patent stated that he fet exttemely depressed ard
\was fing hopeless about the future He sated that he morted to
Feturnto work and felt he was a faite becauee he ws unable odo
50. He had ost interest in al of his rewus aces and id not go
‘tof the house. Hs son ha jst bought anew car and wanted
{ake the patient fora ride out the patient refused to leave hs home:
He eft home onl to see his doctors,
‘On cognitive examination thepatent was not onented tothe year
nor ded he know the date of the month or the place were the
interview was being conducted. The patient's real as intact. and
he wasableto serial subtract 7sbeginaingurth 10D ut was unaDle
to wnte a sentence and was unabe ta draw the intersecting penta
‘9015 onthe minv-mental state examination
The pavent was startedon amtrptyine and his dose wasinceased
to 75mg daly Exact 2 weeks after reaching dose of 100%m9
arntnptyin, the patents depression remitted. He ro longer had
feelings of amet, depression, thoughts of death, felings of hope
lesness,o sleep disturbance. The patent, however. compatned of
Sedation and marked constipation. He was sated to 759 noe
‘niptyine and was abet torte tis medicaton
The pant ws not seen aftr that fr 18 months. When seen
‘298i he reported that he had been dong wel during the ner
aithovgh he continued tobe unable to walk. The patient fr the fist
time, ale to take care of many of his complex daly acts,
Such as setinghs father's estate, and manag hs finer vest
iments, He stated that he had no slep or appetite disturbance snd
‘had gained appronmatey 10lb (25k) during the past yes The
patent then stated that he woulalketotaper af his 75mg nosh.
line wich was scheduled to occur over 3 -month petiog
Three months later the patient etvened and stated thot when his
rnortnpyine dose got to 25mg he began to experience increasing
anvety, tabi, deoesson, seep difcuty low energy, end fet
that he was urable to cope withthe daly stresses, HS dose wos
increased back to 751mg and within 3 weeks he reported tht he
‘mood was stable, that he was sleeping wel and hs eopeite Wes
‘geod, Three months ater, ater the patient's daughter hed mares
he eported that he planned to get an electri wheeicharso tat he
‘ould get around mare easly Heated that he hed had no peviodsof