You are on page 1of 8

doi:10.1111/iej.

12225

Randomized control trial comparing calcium


hydroxide and mineral trioxide aggregate for
partial pulpotomies in cariously exposed pulps of
permanent molars

P. Chailertvanitkul1, J. Paphangkorakit1, N. Sooksantisakoonchai1, N. Pumas1,


W. Pairojamornyoot1, N. Leela-apiradee1 & P. V. Abbott2
1
Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand; and 2School of Dentistry, The University of Western
Australia, Nedlands, WA, Australia

Abstract after 24 h, 3 months, 6 months, 1 year and 2 years.


Mean survival times and incidence of extraction were
Chailertvanitkul P, Paphangkorakit J, Sooksanti-
calculated using exact binomial confidence intervals.
sakoonchai N, Pumas N, Pairojamornyoot W, Leela-
Results The median survival time for both ProRoot
apiradee N, Abbott PV. Randomized control trial
MTA and Dycal groups was 24 months. Three teeth
comparing calcium hydroxide and mineral trioxide aggregate
had unfavourable outcomes with the incidence rate of
for partial pulpotomies in cariously exposed pulps of permanent
0.20/100 tooth-months with ProRoot MTA (95% CI:
molars. International Endodontic Journal, 47, 835–842, 2014.
0.02–0.71) and 0.11/100 tooth-months with Dycal
Aim To compare the treatment outcomes when (95% CI: 0.001–0.60). The incidence of unfavourable
calcium hydroxide and mineral trioxide aggregate are outcomes was 0.05/100 (95% CI: 0.001–0.30) and
used for partial pulpotomy in cariously exposed young 2.38/100 (95% CI: 0.29–8.34) tooth-months in teeth
permanent molars in a randomized control trial. with small (<5 mm2) and large (>5 mm2) pulp
Methodology Eighty-four teeth in 80 volunteers exposure areas, respectively.
(aged 7–10 years) with reversible pulpitis and carious Conclusions Partial pulpotomy in teeth of young
pulp exposures were randomly divided into two groups. patients with reversible pulpitis, either using ProRoot
Exposed pulps were severed using high-speed round MTA or Dycal, resulted in favourable treatment out-
burs until fresh pulp was seen. Cavities were irrigated comes for up to 2 years. The incidence of unfavour-
with 2.5% sodium hypochlorite, and the pulp exposures able outcomes tended to be higher in teeth with pulp
were photographed and measured. Dycal or ProRoot exposure areas larger than 5 mm2.
MTA was placed on the pulp. Vitremer was placed over
Keywords: calcium hydroxide, mineral trioxide
the material until the remaining cavity was 2 mm deep;
aggregate, pulp exposure, pulpotomy.
amalgam was then placed. Teeth were evaluated for
clinical symptoms and radiographic periapical changes Received 29 January 2013; accepted 30 November 2013

pulp tissue. This treatment preserves pulp function,


Introduction
thus allowing continued root development (Webber
Partial pulpotomy is generally regarded as the 1984). Cvek (1978) reported that 96% of teeth healed
treatment of choice for immature teeth with exposed after being treated with partial pulpotomies associated
with complicated crown fractures. This technique
consists of the surgical amputation of 2–3 mm of
inflamed coronal pulp tissue. The wound surface is
Correspondence: Paul V. Abbott, School of Dentistry, The
treated with a capping agent to promote healing and
University of Western Australia, Nedlands, WA 6009, Aus-
tralia (Tel.: +61 8 9346 7636; Fax: +61 8 9346 7666; maintain viability of the remaining pulp tissue. It has
e-mail: paul.v.abbott@uwa.edu.au). been suggested that partial pulpotomy, compared

© 2013 International Endodontic Journal. Published by John Wiley & Sons Ltd International Endodontic Journal, 47, 835–842, 2014 835
Calcium hydroxide versus MTA for pulpotomies Chailertvanitkul et al.

with cervical pulpotomy, has many advantages frequent presence of an odontoblastic layer were
including preservation of the cell-rich coronal pulp evident when human teeth were capped with MTA
tissue, a necessary element for better healing (Fong & compared with calcium hydroxide. After 6 months,
Davis 2002), and the physiologic apposition of 0.43-mm-thick dentine bridges were evident when
dentine in the coronal area. In contrast, cervical MTA was placed compared with 0.15 mm with no
pulpotomy removes all the coronal pulp tissue, leav- odontoblastic layer when calcium hydroxide was used.
ing the crown without the possibility of physiologic Several studies have reported that mineral trioxide
apposition of dentine, thereby increasing the risk of aggregate (MTA) has good physical characteristics
cervical fracture (Camp et al. 2002, Pitt Ford & (Torabinejad et al. 1995a,b) and is biocompatible
Shabahang 2002). (Kettering & Torabinejad 1995). It provides a good
Whilst high rates of pulp survival have been seal, has excellent marginal adaptation and maintains
reported for partial pulpotomies in traumatized teeth, a high pH for a long period of time (Torabinejad et al.
the outcomes of treatment of cariously exposed pulps 1995a,b). In addition, an in vitro study (Moghad-
with partial pulpotomy in permanent teeth have not dame-Jafari et al. 2005) has shown that MTA did not
been extensively reported. In a systematic review, Ag- induce apoptosis of pulp cells but instead induced pro-
uilar & Linsuwanont (2011) found only six articles liferation of these cells. These authors stated that their
that met their inclusion criteria, and they all had low findings suggested a potential mechanism to explain
average scores for quality of methodology. The studies the regenerative effect seen in the pulp when MTA is
included in their review were reported in the litera- used for direct pulp capping. Barrieshi-Nusair & Qude-
ture from 1989 to 2007, with half being published in imat (2006) clinically and radiographically evaluated
the 1990s. Only 199 teeth were included in these the outcome of using grey-MTA for partial pulpoto-
studies, and the follow-up period ranged from mies in young permanent teeth in which pulps were
6 months to 3 years. The only materials reported in exposed by caries. They concluded that grey-MTA
this review for use as the capping agent were calcium was a suitable material for partial pulpotomy in cari-
hydroxide and mineral trioxide aggregate (MTA). Suc- ously exposed young permanent first molars.
cess rates at 6–12 months ranged from 100% with The aim of this in vivo study was to clinically and
calcium hydroxide (Baratieri et al. 1989) to 82.1% radiographically compare the outcome of partial
with MTA (Barrieshi-Nusair & Qudeimat 2006). Suc- pulpotomies in cariously exposed pulps of young per-
cess rates after more than 3 years were reported to be manent molars using mineral trioxide aggregate and
from 98.8% (Mej are & Cvek 1993) to 100% (Mass & calcium hydroxide in a randomized controlled trial.
Zilberman 1993), both with calcium hydroxide. The
outcomes with MTA were only reported up to 1–
Materials and methods
2 years with success in 95.2% (Barrieshi-Nusair &
Qudeimat 2006) and 96% (Qudeimat et al. 2007). The research protocol was reviewed and approved by
For many decades, calcium hydroxide has been the the Ethics Committee of the Khon Kaen University in
material of choice amongst the various pulp-capping Thailand. Informed consent was obtained from the
materials that are available. Clinical studies have parents of all volunteers before the initiation of
reported a high rate of favourable outcomes of partial clinical procedures. Figure 1 shows the CONSORT
pulpotomies carried out with calcium hydroxide in flowchart summarizing the design of the study.
cariously exposed young permanent molars (Baratieri Eighty-four teeth in 80 volunteers having one or two
et al. 1989, Mass & Zilberman 1993, Mej are & Cvek first permanent molars with deep occlusal carious
1993, Nosrat & Nosrat 1998). Despite the wide use of lesions that resulted in cariously exposed pulps were
calcium hydroxide, many studies have shown that it included in this study. The ages of the volunteers ran-
has physical limitations such as nonadherence to den- ged from 7 to 10 years, and none of the participants
tine, dissolution in tissue fluids and degradation upon had any medical problems to contraindicate or alter
tooth flexure (Cox & Suzuki 1994, Silva et al. 2006). the treatment procedures. The patients were offered
Cox et al. (1996) demonstrated that the hard tissue root canal treatment or extraction if any adverse
bridge that formed under calcium hydroxide had symptoms of irreversible pulpitis, apical periodontitis
many imperfections and tunnel defects that may per- or infection occurred at any time during the study.
mit bacterial penetration. Aeinehchi et al. (2002) On examination, all teeth had Black’s classification
reported that a thicker dentinal bridge and the more class I cavities that could be restored with amalgam.

836 International Endodontic Journal, 47, 835–842, 2014 © 2013 International Endodontic Journal. Published by John Wiley & Sons Ltd
Chailertvanitkul et al. Calcium hydroxide versus MTA for pulpotomies

Enrolment Assessed for eligibility (n = *)

Excluded (n = **)
♦ Not meeting inclusion criteria (n = **)
♦ Declined to participate (n = **)
♦ Other reasons (n = **)

Randomized (n = 80)

Allocation
Dycal group MTA group
Allocated to intervention (n = 40 patients) Allocated to intervention (n = 40 patients)
♦ Received allocated intervention (n = 40 teeth) ♦ Received allocated intervention (n = 44 teeth)
♦ Did not receive allocated intervention (n = 0) ♦ Did not receive allocated intervention (n = 0)

Follow -Up
Lost to follow-up (give reasons) (n = 4) Lost to follow-up (give reasons) (n = 2)
REASON: Did not attend follow-up appointment REASON: Did not attend follow-up appointment

Discontinued intervention (give reasons) (n = 0) Discontinued intervention (give reasons) (n = 0)

Analysis
Analysed (n = 35 teeth) Analysed (n = 41 teeth)
♦ Excluded from analysis (give reasons) (n = 0) ♦ Excluded from analysis (give reasons) (n = 0)
NOTE: 1 tooth extracted before 24 month review NOTE: 1 tooth extracted before 12 month review

* Note: Volunteer children were screened for possible inclusion unl a total of 80 parcipants were
found. The total number of children screened was not recorded.

** Note: All possible teeth that might have met the inclusion criteria were treated – but some did
not have pulp exposures and therefore they were excluded. Some teeth required root canal
treatment (for varying reasons) and were therefore excluded. The numbers of teeth excluded in
these ways were not included but the children’s teeth were treated appropriately.

Figure 1 CONSORT flow chart outlining the study design.

The teeth had no previous operative procedures, no


history of spontaneous pain, and they responded nor-
mally to an electric pulp tester (Analytic Technology
Corp, Redmond, WA, USA). The teeth demonstrated
no mobility or swelling, and no tenderness to percus-
sion or palpation. Radiographs showed normal
appearance of the periradicular tissues. In all cases,
the diagnosis was reversible pulpitis with normal
periradicular tissues.
To control the angulations of the radiographs
taken, a jig for each participant was made using an
impression material (Fig. 2). This jig was attached to
a Rinn XCP film holder (Rinn Corporation, Elgin, IL,
USA.) and used for radiographs taken at every Figure 2 A jig was constructed for each tooth using impres-
follow-up appointment (Figs 3 and 4). Following sion material attached to a Rinn XCP film holder to ensure
administration of mepivacaine hydrochloride 3% that reproducible angles were used for each follow-up radio-
without vasoconstrictor (Septodontâ, Saint-Maur- graph.
des-Fosses, France), the tooth was isolated with rub-
ber dam. A cavity was prepared using a fissure bur in excavators were used to excavate all of the carious
a high-speed handpiece with water coolant. A large dentine. Exposed pulp tissue was removed using a
round bur in a low-speed handpiece and spoon sterile round bur with a high-speed handpiece under

© 2013 International Endodontic Journal. Published by John Wiley & Sons Ltd International Endodontic Journal, 47, 835–842, 2014 837
Calcium hydroxide versus MTA for pulpotomies Chailertvanitkul et al.

exposed pulp and cavity were photographed with a


Sirocam camera (Sirona Dental Systems GmbH, Bens-
heim, Germany). A sterile ball bearing with known
diameter was placed in the cavity to enable the area
of the pulp exposure to be calculated later (Fig. 5).
Once the pulp exposure was confirmed, each tooth
was randomly allocated to a pulp-capping material
using pre-prepared envelopes so that 40 volunteers
(44 teeth) received MTA (ProRootâ; Dentsply Tulsa
Dental, Tulsa, OK, USA) and the other 40 volunteers
(40 teeth) received calcium hydroxide (Dycalâ; L.D.
Caulk, Milford, DE, USA). Each participant chose one
of the sealed envelopes to allocate the material to be
used.
Figure 3 The jig attached to the XCP film holder was used The ProRoot MTA and Dycal were freshly mixed
for radiographs taken at each follow-up. according to manufacturer’s directions immediately
prior to use. The material was gently placed against
(a) the fresh pulp wound with a plastic instrument, and
the excess material was scraped off. Light-cured
Vitremer (3M ESPE, St. Paul, MN, USA) was placed to
cover the capping material with a thickness of 2–
3 mm, and the remaining cavity was restored with
amalgam. All procedures (including screening,
diagnosis and treatment) were carried out by two
clinicians (WP and NL). Immediate postoperative
periapical radiographs were taken to serve as compar-
isons for further postoperative evaluations.
Twenty-four hours after treatment, each tooth was
reviewed for any clinical symptoms and the amalgam
restorations were polished. The teeth were then
(b)
reviewed radiographically and clinically after 3-, 6-,

Figure 4 Radiographs of a representative case in the study.


(a) Preoperative radiograph of tooth 36; (b) follow-up
radiograph of tooth 36 after 24 months.

water coolant to a depth of 2–3 mm. The pulp wound


was gently flushed, and bleeding was controlled using Figure 5 The exposed pulp cavity was photographed using a
a cotton pellet saturated with 2.5% sodium Sirocam camera by placing a sterile ball bearing with known
hypochlorite solution applied for 1–2 min. The diameter as the reference.

838 International Endodontic Journal, 47, 835–842, 2014 © 2013 International Endodontic Journal. Published by John Wiley & Sons Ltd
Chailertvanitkul et al. Calcium hydroxide versus MTA for pulpotomies

12- and 24-month intervals. All recall examinations the findings at each recall appointment for each
were performed by another investigator (PC) who was material grouped according to the areas of the pulp
blinded with respect to the type of capping material exposures. Two teeth from the ProRoot MTA group
used. All periapical radiographs were examined by a and one tooth from the Dycal group were extracted
further investigator (JP) who was also blinded regard- due to unfavourable treatment outcomes. The inci-
ing the capping materials used. The treatment out- dence rate of unfavourable outcomes was 0.20/100
come was considered as unfavourable if one or more tooth-months (95% CI: 0.02–0.71) in the ProRoot
of the following were present: pain, swelling, sinus MTA group and 0.11/100 tooth-months (95% CI:
tract, tenderness to percussion, evidence of periradicu- 0.001–0.60) when Dycal was used.
lar or furcation pathosis, root resorption or a lack of When the sizes of the pulp exposures were grouped
continuation of root development in immature teeth. into small (<5 mm2) and large (>5 mm2) areas, the
Median survival time and the incidence of tooth incidence rates of unfavourable outcomes were 0.05/
extraction per 100 tooth-months with 95% exact 100 (95% CI: 0.001–0.30) and 2.38/100 (95% CI:
binomial confidence interval (CI) were calculated. Par- 0.29–8.34) tooth-months for ProRoot MTA and
ticipants who dropped out during the follow-up period Dycal, respectively (Table 2).
were treated as censored data (i.e. they were used in Six participants (four from the Dycal group; two
the survival analysis up to the time they left the from the ProRoot MTA group) were removed from
study) as it could not be assured that those teeth the study – five because they did not attend the 12-
would be present after the 2-year follow-up time. month review appointments and one who did not
attend the 24-month appointment. One tooth from
the ProRoot MTA group had been extracted by the
Results
time of the 12-month recall appointment, and one
The median survival time for both ProRoot MTA and tooth from the Dycal group had been extracted by the
Dycal groups was 24 months, and these were not time of the 24-month appointment. The volunteers
statistically significantly different. Table 1 summarizes and their parents chose to extract these teeth rather
Table 1 Area of pulp exposure and outcome of partial pulpotomy treatment over the 24-month follow-up period. Numbers
indicate the number of teeth with a favourable outcome at each review for each material and area of exposure

Capping Review at Review at Review at Review at


material used 3 months 6 months 12 months 24 months

Area of pulp exposure (mm2) Dycal MTA Dycal MTA Dycal MTA Dycal MTA Dycal MTA

0.01–1.0 23 23 23 23 23 23 21 22a 21 22
1.01–2.0 5 11 5 11 5 11 5 10a 5 10
2.01–3.0 4 2 4 2 4 2 4 2 4 2
3.01–4.0 2 2 2 2 2 2 2 2 2 2
4.01–5.0 4 4 4 4 4 4 3a 4 3 4
5.01–6.0
6.01–7.0
7.01–8.0 1 1 1 1 1
a
8.01–9.0 1 1 1 1
b b
9.01–10.0 1 1 1 1 1 1 1
Totals 40 44 40 44 40 44 37 41 35 41
a
Indicates participants who had withdrawn from the study and did not attend any further review appointments.
b
Indicates a tooth had been extracted prior to the review appointment.

Table 2 Median survival time and incidence rate (tooth extraction rate)/100 tooth-month

Number Time at risk/ Median survival Incidence rate/100


Variables of teeth tooth-months time (month) tooth-month (95% CI)

Dycal 40 924 24 0.11 (0.001–0.60)


MTA 44 1020 24 0.20 (0.02–0.71)
Exposure area <5 mm2 80 1860 24 0.05 (0.001–0.30)
Exposure area >5 mm2 4 84 24 2.38 (0.29–8.34)

© 2013 International Endodontic Journal. Published by John Wiley & Sons Ltd International Endodontic Journal, 47, 835–842, 2014 839
Calcium hydroxide versus MTA for pulpotomies Chailertvanitkul et al.

than having root canal treatment because of the costs for all patients. The teeth were restored immediately
and the time constraints. after the pulp treatment with a definitive restoration,
which may have played an important role in the suc-
cess rate obtained, since it is well documented that
Discussion
preventing bacterial ingress is a determinant factor
Root canal treatment in first permanent molars in for the success of pulp treatment (Cox et al. 1987).
young children can present difficulties and is affected Barthel et al. (2000) reported that the success rate of
by the child’s ability to cooperate with, and tolerate, pulp capping of carious exposures in permanent teeth
a long treatment time. Moreover, if the tooth is only was significantly affected by placing a definitive resto-
partially erupted and/or if the root is not fully formed, ration within the first 2 days after the pulp exposure.
then the treatment can be even more difficult. Instead In the study by Bjørndal et al. (2010), the teeth were
of performing endodontic treatment at a very early not definitively restored until 1 month after the pulp
age, partial pulpotomy might be the treatment of treatment had been carried out. In addition, rubber
choice for many teeth. The teeth in this study were dam was not placed until after the pulps had been
immature at the time of treatment and maintaining exposed. Both of these factors may have contributed
the pulp in the radicular portion allowed further root to the poor treatment outcomes reported in that
development. study. In addition, the patients’ ages may have played
Trope et al. (2002a,b) suggested that partial pulpoto- a role as older pulps are more fibrous, less cellular
my with a calcium hydroxide dressing and a good coro- and may have less blood supply (Massler 1972). The
nal restoration was a preferable procedure over direct studies by Barthel et al. (2000) and Bjørndal et al.
pulp capping for the inflamed pulp. Barthel et al. (2010) both involved adult patients with the former
(2000) in a retrospective study found that the success having a small number of patients aged 10–20 years,
rate of capping cariously exposed pulps in permanent but none <10 years old, whereas in the current study
teeth after 5 and 10 years was only 37% and 13%, all patients were aged 7–10 years. Undergraduate
respectively, in patients across a broad range of ages dental students performed the procedures in the Bar-
(10–70 years old). Bjørndal et al. (2010) also reported thel et al. (2000) study, and this may have been
low success rates for both direct pulp capping (31.8%) another factor affecting the outcome.
and partial pulpotomy (34.5%) when treating cariously Matsuo et al. (1996) suggested observing the
exposed pulps in adult teeth with no statistical degree of pulp bleeding rather than relying on preop-
difference between the two groups. On the other hand, erative clinical signs and symptoms. Profuse bleeding
a higher success rate (91.4–93.5%) was obtained by that is difficult to stop indicates severe pulp inflamma-
partial pulpotomy when performed on cariously tion. A study by Hafez et al. (2002) showed that
exposed pulps of permanent teeth in patients aged 6– sodium hypochlorite is an effective haemostatic agent
15 years (Mej are & Cvek 1993). A systematic review in direct pulp capping. It is not toxic to pulp tissue
by Aguilar & Linsuwanont (2011) has shown that par- and does not interfere with pulp healing. Therefore,
tial pulpotomy and full pulpotomy in permanent teeth in this study, the pulp wound was rinsed and
with cariously exposed pulp had a high success rate haemorrhage was controlled with a cotton pellet
over 3 years or more. Complete pulpotomy was not saturated with 2.5% sodium hypochlorite applied for
chosen in this study because it may destroy cell-rich 1–2 min.
coronal pulp tissue, will arrest dentine formation at the Dycal was selected instead of a Ca(OH)2 paste
cervical area and can result in calcification of the root because Ca(OH)2 with its very high pH creates super-
canals (Fong & Davis 2002). Furthermore, a 10-year ficial obliteration zones and coagulation necrosis
radiographic review of pulps after partial pulpotomy in where reparative dentine ultimately begins to form in
young permanent molars by Mass & Zilberman (2011) the deeper zones. Dycal, with its lower pH, may avoid
supported the clinical impression that partial major tissue damage and stimulate reparative dentine
pulpotomy is warranted in well-chosen cases. more directly (Stanley 1989). The mechanism of
When encountering a cariously exposed pulp, it is action of calcium hydroxide is similar and comparable
difficult to assess the condition of the pulp, which with MTA. Holland et al. (1999) theorized that the
plays a critical role in the outcome of the pulp ther- tricalcium oxide in MTA reacts with tissue fluids to
apy. In this study, strict criteria were followed to form calcium hydroxide, which can result in hard
select cases and strict aseptic techniques were used tissue formation similar to that of calcium hydroxide.

840 International Endodontic Journal, 47, 835–842, 2014 © 2013 International Endodontic Journal. Published by John Wiley & Sons Ltd
Chailertvanitkul et al. Calcium hydroxide versus MTA for pulpotomies

Fernandes et al. (2008) analysed the immunohisto- survival analysis with Cox’s proportional hazards
chemical expression of fibronectin and collagen in regression model. However, the incidence rates of
human dental pulps that had been submitted to direct unfavourable outcomes were very low in the pres-
pulp capping with calcium hydroxide or a single-bond ent study, which would affect the validity of such
adhesive system. The results demonstrated that adhe- analysis. Hence, descriptive statistics (median sur-
sive systems in direct contact with healthy pulps will vival time and the incidence rate) were used
not lead to expression of proteins that are believed to instead. It was found that partial pulpotomy with
be essential for pulp repair. In contrast, calcium either ProRoot MTA or Dycal was highly successful
hydroxide showed good biocompatibility properties for treating cariously exposed molars in young
with the pulp tissue, inducing the expression of patients.
reparative molecules. They therefore suggested that
calcium hydroxide still remains the material of choice
Conclusions
for the treatment of clinically normal pulps that have
been accidently exposed. Within the limited 2-year follow-up period of the pres-
The length of time necessary for adequate ent study, it can be concluded that:
postoperative follow-up remains unclear although it is 1. The partial pulpotomy procedure with a strict
recommended that such teeth should be followed for aseptic technique resulted in favourable treatment
longer time periods to evaluate the success rate on a outcomes for teeth with reversible pulpitis due to
long-term basis. Many calcium hydroxide studies caries in the vast majority of young patients.
showed that failures occur soon after treatment. Ma- 2. There was no different in the success rate of the
tsuo et al. (1996) reported the success rate after direct partial pulpotomy using ProRoot MTA and Dycal.
pulp capping of cariously exposed pulps was similar 3. Although there were limited numbers of cases
between groups, which had 3 months and 18 months with large pulp exposure areas (>5 mm2), there
follow-up periods (ranging from 80–83.3%). They was a tendency towards less favourable outcomes
suggested that 3 months was adequate for a tentative in these teeth.
assessment of the outcome of the treatment. In this
study, the follow-up time period was 2 years, and one
References
might expect that if failure was anticipated to happen
then it would have occurred within these 2 years. Aeinehchi M, Eslami B, Ghanbartha M, Saffar AS (2002)
The time taken for apexogenesis after pulpotomy Mineral trioxide aggregate (MTA) and calcium hydroxide
ranges from 1 to 2 years, depending upon the extent of as pulp-capping agents in human teeth: a preliminary
root development at the time of injury and treatment. report. International Endodontic Journal 36, 225–31.
Aguilar P, Linsuwanont P (2011) Vital pulp therapy in vital
In this study, the patients were recalled at 24 h,
permanent teeth with cariously exposed pulp: a systematic
3 months, 6 months, 1 year and 2 years after the
review. Journal of Endodontics 37, 581–7.
treatment. An absence of clinical symptoms does not Baratieri LN, Montiero S Jr, Caldeira de Andrada MA (1989)
necessary reflect the true state of the pulp and therefore Pulp curettage: surgical technique. Quintessence Interna-
when evaluating pulpotomies, clinical signs such as tional 20, 285–93.
swelling or sinus tract formation and radiographic Barrieshi-Nusair KM, Qudeimat MA (2006) A prospective
signs of pulp and periradicular pathologic changes are clinical study of mineral trioxide aggregate for partial
the major means of indicating the state of the pulp. pulpotomy in cariously exposed permanent teeth. Journal
In this study, three teeth were extracted even of Endodontics 32, 731–5.
though the research protocol was to perform pulpec- Barthel CR, Rosenkranz B, Leuenberg A, Roulet JF (2000)
tomy if the partial pulpotomy had an unfavourable Pulp capping of carious exposures: treatment outcome
after 5 and 10 years: a retrospective study. Journal of
outcome. The parents of the patients decided to have
Endodontics 26, 525–8.
the teeth extracted rather than contacting the
Bjørndal L, Reit C, Bruun G et al. (2010) Treatment of deep
researchers because extraction is included in the free caries lesions in adults: randomized clinical trials compar-
government healthcare system. They preferred not to ing stepwise vs. direct complete excavation, and direct
spend time and money having further treatment at pulp capping vs. partial pulpotomy. European journal of
the dental hospital. Oral Sciences 118, 290–7.
The most appropriate multivariable statistical Camp JH, Barrett EJ, Pulver F (2002) Pediatric endodontics:
analysis for this time-censored data would be endodontic treatment for the primary and young

© 2013 International Endodontic Journal. Published by John Wiley & Sons Ltd International Endodontic Journal, 47, 835–842, 2014 841
Calcium hydroxide versus MTA for pulpotomies Chailertvanitkul et al.

permanent dentition. In: Cohen S, Burns RC, eds. Path- Matsuo T, Nakanishi T, Shimizu H, Ebisu S (1996) A clinical
ways of the Pulp, 8th edn. St Louis, MO: Mosby, pp. 823– study of direct pulp capping applied to carious-exposed
33. pulps. Journal of Endodontics 22, 551–6.
Cox CF, Suzuki S (1994) Re-evaluating pulp protection: cal- Mej are I, Cvek M (1993) Partial pulpotomy in young perma-
cium hydroxide liners vs. cohesive hybridization. Journal of nent teeth with deep carious lesions. Endodontics & Dental
the American Dental Association 125, 823–31. Traumatology 9, 238–42.
Cox CF, Keall CL, Keall HJ, Ostro E, Bergenholtz G (1987) Moghaddame-Jafari S, Mantellini MG, Botero TM, McDonald
Biocompatibility of surface-sealed dental materials against NJ, Nor JE (2005) Effect of ProRoot MTA on pulp cell
exposed pulps. Journal of Prosthetic Dentistry 57, 1–8. apoptosis and proliferation in vitro. Journal of Endodontics
Cox CF, Subay RK, Ostro E, Suzuki S, Suzuki SH (1996) 31, 387–91.
Tunnel defects in dentin bridge: their formation following Nosrat IV, Nosrat CA (1998) Reparative hard tissue forma-
direct pulp capping. Operative Dentistry 21, 4–11. tion following calcium hydroxide application after partial
Cvek M (1978) A clinical report on partial pulpotomy and cap- pulpotomy in cariously exposed pulps of permanent teeth.
ping with calcium hydroxide in permanent incisors and International Endodontic Journal 31, 221–6.
complicated crown fracture. Journal of Endodontics 4, 232–7. Pitt Ford TR, Shabahang S (2002) Management of incom-
Fernandes AM, Silva GB, Lopes N Jr, Napimoga MH, Benatti pletely formed roots. In: Walton RE, Torabinejad M, eds.
BB, Alves JB (2008) Direct capping of human pulps with a Principles and Practice of Endodontics, 3rd edn. Philadelphia,
dentin bonding system and calcium hydroxide: an immu- USA: WB Saunders, pp. 388–404.
nohistochemical analysis. Oral Surgery Oral Medicine Oral Qudeimat MA, Barrieschi-Nusair KN, Owais AI (2007) Cal-
Pathology Oral Radiology & Endodontics 105, 385–90. cium hydroxide v mineral trioxide aggregates for partial
Fong CD, Davis MJ (2002) Partial pulpotomy for immature pulpotomy of permanent molars with deep caries. European
permanent teeth, its present and future. Pediatric Dentistry Archives of Paediatric Dentistry 8, 99–104.
24, 29–32. Silva GAB, Lanza LD, Lopes-Junior N, Moreira A, Alves JB
Hafez AA, Cox CF, Tarim B, Otsuki M, Akimoto N (2002) (2006) Direct pulp capping with dentin bonding system in
An in vivo evaluation of hemorrhage control using sodium human teeth: a clinical and histological; evaluation. Opera-
hypochlorite and direct capping with a one- or two-com- tive Dentistry 31, 297–308.
ponent adhesive system in exposed nonhuman primate Stanley HR (1989) Pulp capping: conserving the dental pulp
pulps. Quintessence International 33, 261–72. - Can it be done? Is it worth it? Oral Surgery Oral Medicine
Holland R, deSouza V, Nery MJ, Otoboni Filho JA, Bernabe Oral Pathology 68, 628–39.
PFE, Dezan E Jr (1999) Reaction of root connective tissue Torabinejad M, Hong CU, Pitt Ford TR (1995a) Physical
to implanted dentin tubes filled with mineral trioxide properties of a new root end filling material. Journal of End-
aggregate or calcium hydroxide. Journal of Endodontics 25, odontics 21, 349–54.
161–6. Torabinejad M, Wilder Smith P, Pitt Ford TR (1995b) Com-
Kettering JD, Torabinejad M (1995) Investigation of mutage- parison investigation of marginal adaptation of mineral
nicity of mineral trioxide aggregate and other commonly trioxide aggregate and other commonly used root end fill-
used root-end filling materials. Journal of Endodontics 21, ing materials. Journal of Endodontics 21, 295–9.
537–9. Trope M, Chivian N, Sigurdsson A, Vann FV Jr (2002a)
Mass E, Zilberman U (1993) Clinical and radiographic evalu- Traumatic injuries. In: Cohen S, Burns RC, eds. Pathways
ation of partial pulpotomy in carious exposure of perma- of the Pulp, 8th edn. St. Louis, MO: Mosby, pp. 603–49.
nent molars. Pediatric Dentistry 15, 257–9. Trope M, McDougal R, Levin L, May KN, Swift EJ (2002b)
Mass E, Zilberman U (2011) Long-term radiologic pulp eval- Capping the inflamed pulp under different clinical condi-
uation after partial pulpotomy in young permanent tions. Journal of Esthetics and Restorative Dentistry 14,
molars. Quintessence International 42, 547–54. 249–57.
Massler M (1972) Therapy conductive to healing of the Webber RT (1984) Apexogenesis versus apexification. Dental
human pulp. Oral Surgery 34, 122–30. Clinics of North America 28, 669–97.

842 International Endodontic Journal, 47, 835–842, 2014 © 2013 International Endodontic Journal. Published by John Wiley & Sons Ltd

You might also like