JMJ Marist Brothers

Notre Dame of Marbel University

Alunan Avenue, City of Koronadal
College of Arts and Sciences
NURSING DEPARTMENT
1st Semester School Year 2022 – 2023
NCM 106: NURSING PHARMACOLOGY
(TOPIC 3)
LECTURE GUIDE: CHEMOTHERAPEUTIC AGENTS
TOPIC CONTENT
A. Nucleus
B. Cell Membrane
1. The Cell
C. Mitochondria
D. Lysosomes
A. Therapeutic Action
B. Anti-infective Activity
2. Anti-Infective Agents C. Human Immune Response
D. Resistance/Acquiring Resistance
E. Purpose
A. Aminoglycosides
B. Carbapenems
C. Cephalosporins
D. Fluoroquinolones
E. Penicillins
F. Sulfonamides
3. Antibiotics G. Tetracyclines
(Note: Please give H. Antimycobacterials
importance to this) (ATTENTION: Your TB DOTS drugs are given IMPORTANCE here)
I. Other Antibiotics
 Ketolides
 Lincosamides
 Lipoglycopeptides
 Macrolides
 Manobactam
A. Azole Antifungal
B. Echinocandin Antifungal
4. Anti-fungal Agents
C. Other Antifungal
D. Topical Antifungal
A. Malaria/ Malarial Drugs
(ATTENTION: drug TOPIC are given IMPORTANCE)
5. Anti-protozoal drugs
B. Other protozoal Infections
C. Other protozoal Agents
A. Helminthic Infections
6. Anti-Helmentic drugs B. Intestine-Invading worm infections
C. Tissue invading worm infections
A. Agents for influenza A and Respiratory Virus
7. Anti-Viral agents B. Agents for Herpes and Cytomegalovirus
C. Agents for HIV and AIDS
A. Alkylating Agents
B. Antimetabolites
8. Anti-Neoplastic C. Antineoplastic Antibiotics
Agents D. Mitotic Inhibitors
E. Hormones and Hormone Modulators
F. Cancer Cell Specific Agents

I don’t own the copyrights of the sources, Credits are given to the rightful owner. (Mr. Welmer bebing,RN)
Transcribed by: MLBalinas (1st SY: 2022-2023) Page 1
 JMJ Marist Brothers
Notre Dame of Marbel University
Alunan Avenue, City of Koronadal
College of Arts and Sciences
NURSING DEPARTMENT
1st Semester School Year 2022 – 2023

TUBERCOLOSIS DRUGS
DETAILS
(1st Line)
R RIFAMPICIN
I ISONIAZID
P PYRAZINAMIDE
E ETHAMBUTOL
Description:
 Discovered in 1943 as an aminoglycoside antibiotic
 It was the first antibiotic discovered that was effective
against TB.
 is derived from the actinobacterium Streptomyces griseus.
It inhibits protein synthesis and causes the death of
microbial cells. It is a useful broad-spectrum antibiotic.
 is added to first line regimens because patients that have
previously been treated for TB are more likely to have
developed some drug resistance.
 This drug can only be given by injection.
Side Effects & Adverse effects:
 loss of hearing (which can become permanent if Tx levels
are continued, the risk of hearing loss is higher in pt. with
kidney damage)
 Worsen kidney damage (generally reversible if Tx is
stopped)
 Dizziness and unusual drowsiness, sense of balance
 Headache, Vertigo
 Impaired coordination
S STREPTOMYCIN  Rashes
 Fevers
 Yeast infection
 Oral thrush (slightly raised, creamy white, sore patches in
mouth or tongue
 Persistent diarrhea (even after stopping the medication)
 Easy bleeding or bruised
 Unusual tiredness, muscle weakness, body aches
 Numbness or tingling of skin
 Nephrotoxicity and Ototoxicity
Contraindication/Cautions:
 Decreased kidney functions in older adults
 Pregnancy (Babies will have problems in hearing or
balance)
Nursing Implementation:
 Culture and Sensitivity report, Renal function test, Liver
Function test, monitor magnesium level
 Give deep IM
 Ensure adequate hydration of patient when under Tx of this
medications (before and after)
 Monitor for paralysis and muscle weakness

I don’t own the copyrights of the sources, Credits are given to the rightful owner. (Mr. Welmer bebing,RN)
Transcribed by: MLBalinas (1st SY: 2022-2023) Page 2