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5

Relative Incidence of
Adverse Effects of
Newer
Antidepressants7,9,30
Weight Weight Sexual
Drug Sedation Activation GI Upset
Gain Loss Dysfunction
Brexanolone ++++ + + +
++ ++
Bupropion + ++++ ++ +++
Citalopram + + + + ++++ ++++
Desvenlafaxine ++ +++ + + ++++ ++++
Duloxetine +++ +++ ++++
++
Escitalopram ++ ++ ++++
++++ ++++ ++++
Esketamine + +++ +
+
Fluoxetine ++++ ++++ ++++
Fluvoxamine ++ ++ ++++
++ ++++
Levomilnacipran + +++ +++ ++
++ ++
Mirtazapine +++ + +
Nefazodone ++ + + + ++ +
Paroxetine ++ ++ + + ++++ ++++
Sertraline + +++ + + ++++ ++++
Venlafaxine ++ +++ + + ++++ ++++
Vilazodone + + + + ++++ ++
Vortioxetine + + + + ++++ +
+, minimal; ++, low;
+++, moderate; +++
+, high; GI,
gastrointestinal.

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