E. facalis MSSA MRSA Strep sp.

Enteric gram neg Pseudomonas Abdom Oral Atypicals

UTI, skin, (aerobic gram – anaerobes (B Anaerobes (legionella,
endocarditis bacilli) fragilis, (peptostrepto) chalmydia,
peptostrep, mycoplasma)
clostridium,
fusobact)
PCN ++ +/- - ++ - - ++ +/- -
Ampicillin/amoxicillin ++ +/- - + + - + +/- -
BL-ase inhibitors + + - + + - + + -
(Unasyn/Augmentin)
Nafcillin/oxacillin - ++ - + - - - - -
Anti-PsA (pip/tazo, + + - + some ++ + + -
ticar/clav)
Meropenem/doripenem - + + -
Meropenem/vaborbactam +/- + - + + + + + -
Imipenem + + - + + + + + -
Ertapenem - + - + + - + + -
Aztreonam - - - - Some but not + - - -
many (-)
1st gen (cefazolin) - ++ - + - - +/- - -
nd
2 gen (cefuroxime) - + - + - - +/- - -
2nd gen (cefotetan/ - + - + - - + + -
cefoxitin)
3rd gen (ceftriaxone) +/- + - + - - + +/- -
3rd gen (ceftazidime) - - - + some + +/- - -
Ceftazidime/avibactam - - - + + + +/- - -
Ceftolozane/tazobactam - - - + + + +/- - -
th
4 gen (cefepime) - + - + + + +/- - -
5th gen (ceftaroline) - - + + + - - +/- - -
MRSA coverage
Ciprofloxacin - - - +/- + + - - +
Levofloxacin + + - + + + +/- - +
Moxifloxacin + + - + + - + +/- +
Azithromycin - +/- - +/- - - +/- - +
Aminoglycosides +/- +/- - +/- enterobacterales + - - -
 Bactrim - + + +/- +/- - - - legionella
Clindamycin - + +/- + - - ++ + +/-
Metronidazole - - - - - - + ++ -
Doxycycline +/- + + + Non- - - - ++
enterobacterales
Linezolid + + + + - - - - -
Daptomycin + + + + - - - - -
Vancomycin + + + + - - - - -
Fosfomycin +/- +/- +/- - enterobacterales - - - -

Blue: gram + cocci

Enterobacterales (gram – bacilli)

- Citrobacter
- E coli
- Klebsiella
- Morganella
- Proteus
- Salmonella
- Serratia
- Shigella

Non-enterobacterales

- Pertussis
- H flu
- Legionella
- Morexella

Common UTI bugs: Proteus, e coli, klebsiella, enterococcus, staph

Common pneumonia bugs: H flu, strep pneumo, legionella, morexella, staph, chlamydia, mycoplasma (HAP/VAP: pseudomonas, klebsiella, enterobacter,
acinetobacter, e coli)

Intra-abdominal: Cover gram negatives (e coli, klebsiella, pseudomonas but not all the time) and anaerobes (more for abscess) --> bacteroides fragilis and strep
spp
SSTI: Stap aureus, strep spp, pseudomonas