DISEASE EVOLUTION TABLE (DET)

HEALTH Status of Regulation / Deregulation DISEASE

Humoral Phases Matrix Phas es Cellu lar Phases

Organ System/Tissue Excretion Phase Inflammation Phase Deposition Phase Impregnation Phase Degeneration Phase Dedifferentiation Phase
1. EPIDERMAL
Increased sweating, Cerumen, Sebum, Dermatitis, Impetigo, Abscess, Hyperkeratosis, Seborrhoic eczema, Atopic eczema, Urticaria, Warts, Psoriasis, Decubitus ulceration, Squamous cell carcinoma,
Smegma Furuncle, Otitis externa Naevus, Skin tags (soft warts) Fissura ani, Acne rosacea, Hirsutism Radiation injury, Pemphigus vulgaris Basal cell carcinoma, Melanoma

2. ORODERMAL
Hypersalivation, Hyperlacrimation Otitis media, Pharyngitis, Stomatitis,
Gingivitis, Apthous ulceration, Glossitis,
Rhinitis (acute), Sinusitis (acute),
Laryngitis, Dental abscess
ECTODERMAL
Nasal polyp, Eustachian tube catarrh Atopic rhinitis, Hay fever, Otosclerosis, Deafness (transmission), Leucoplakia (orodermal),
(serous otitis media), Dental granuloma Sinusitis (chronic), Rhinitis (iatrogenic), Ozaena, Atrophic rhinitis, Dental caries, Cancer of the tongue, Laryngeal cancer,
Anosmia, Menière’s syndrome, Parodontosis Nasopharyngeal cancer, Tracheal cancer
Hypoacusis

3. NEURODERMAL Increased secretion of neurotransmitters Neuralgia, Neuritis, Polyneuritis, Neuroma, Amyloid deposition, Epilepsy (petit mal), Paresis, Tics, Parkinson disease, Epilepsy (grand mal), Glioma, Meningioma, Astrocytoma
PNS and CNS Meningitis, Encephalitis, Heavy metal deposition Neuritis (toxic), Attention-deficit/ Alzheimer’s disease, Multiple sclerosis,
Trigeminal neuralgia (acute) hyperactivity syndrome (ADHS), Guillain- Amyotrophic lateral sclerosis,
Barré syndrome, Poliomyelitis (acute), Peripheral neural atrophy,
Trigeminal neuralgia (chronic) Diabetic neuropathy, Neurofibromatosis

4. EYE
Conjunctivitis (acute) Pterygium, Mouches volantes (floaters), Uveitis, Allergic conjunctivitis, Glaucoma, Cataract, Hemianopsia, Retinal cancer, Retinoblastoma
Iris spots (initial) Iris spots (chronic), Iritis, Astigmatism, Macular degeneration, Paralytic mydriasis
Myopia, Presbyopia, Keratoconus,
Pannus, Arch (senile)

5. SYMPATHICODERMAL Increased adrenalin and Flushes, Hypervagotony, Ganglion neuroma Dysautonomia (including orthostatic Addison’s disease, Reflex sympathetic Pheochromocytoma, Neuroblastoma
noradrenaline secretion Hypersympathicotonus hypotension) dystrophy (RSD) or Sudeck’s syndrome,
Horner’s syndrome

1. Respiratory Sputum Bronchitis (acute), Tracheitis Nasal polyp Bronchitis (asthmatic), COPD (chronic obstructive pulmonary Tracheal cancer, Bronchial cancer
Chronic tracheitis (viral), Cystic fibrosis disease), Atrophy of bronchial mucosa
6. MUCODERMAL

2. Digestive Increased digestive juices Esophagitis (acute), Gastritis (acute), Gastric polyps, Intestinal polyps, Gastric ulcer, Duodenal ulcer, Crohn´s disease, Colitis ulcerosa, Barret’s esophagus, Esophageal cancer,
Gastroenteritis (acute), Colitis Obstipation, Melanosis of the colon Gluten enteropathy (mild), Atrophy of the small intestinal villi, Gastric cancer, Duodenal cancer,
Leaky gut syndrome, Dysbiosis Gluten enteropathy (severe) Rectal cancer
ENDODERMAL

3. Urogenital Increased mucous production Bartholinitis, Cystitis, Urethritis, Bladder polyps, Uterine polyps Interstitial cystitis Atrophy of the urogenital mucosa Bladder cancer, Cervical carcinoma
Infections of the urogenital mucosa

1. Exocrine Lactorrhea Mastitis Mammary cysts, Breast calcifications Mammary fibroadenoma, Breast atrophy, Gynecomastia Mammary carcinoma
REG UL ATION/ COMPE NSATION DIVISION
Sexual Fibrocystic mastopathy
7. ORGANODERMAL

2. Exocrine Increased bile salt secretion,
Digestive Increased gastric acid secretion
3. Respiratory
4. Endocrine
Increased thyroid hormones, Parathyroid
hormones, Thymic hormones, Insulin, Gluca-
gon, Enteric hormones, Cortico-suprarenal
hormones, Adenohypophyseal hormones
Pancreatitis, Sialitis
Acute pulmonary abscess, Pneumonia
Thyroiditis , e.g. de Quervain’s thyroiditis
Cholelithiasis, Steatosis hepatica, Pancreatic Chronic hepatitis, Chronic pancreatitis, Hepatic cirrhosis, Liver cancer, Pancreatic cancer
calcifications, Pancreatic cysts, Liver cysts, Viral pancreatitis (e.g. mumps), Hepatic iatrogenic disease
Wilson’s disease, Salivary gland calcifications Alcoholic hepatitis, Cystic fibrosis
Bronchiectasis, Pneumoconiosis Bronchial asthma, Cystic fibrosis Emphysema, Chronic pulmonary abscess, Pulmonary cancer
Interstitial fibrosis of the lung,
Fungal balls
Thyroid cysts, Adrenal cysts, Adrenal ade- Grave’s disease, Hashimoto’s disease (2nd stage), Thyroid cancer, Parathyroid cancer,
noma, Hypophyseal adenoma, Thymoma, Hashimoto’s disease (1st stage), Riedel’s thyroiditis, Parathyroid atrophy Adrenal cancer, Carcinoid syndrome
Insulinoma, Parathyroid gland adenoma, Puerpural thyroiditis, Cushing’s syndrome,
Thyroid goiter, Adrenal adenomas Precocious puberty, Adrenal exhaustion

8. CONNECT. TISSUE Increased secretion of metalloproteinases, Abscess, Reactive inflammatory response Lipoma, Storage of toxins in the matrix, Mixed connective tissue disease (MCTD), Scleroderma, Carbohydrate deficient Sarcoma
Increase in glycoprotein formation of the matrix, Tendinitis Amyloidosis, Mucopolysaccharidosis, Marfan’s syndrome, glycoprotein syndrome, Peyronie’s disease,
Periarthritis humeroscapularis calcinosa Ehlers-Danlos syndrome, Sphingolipidosis Progeria, Dupuytren’s contracture

9. OSTEODERMAL
Osteomyelitis, Chondroitis Osteophyte formation, Bone cysts Osteomalacia, Early osteoporosis Osteoporosis, Paget’s disease Osteosarcoma

1. Blood Leukocytosis neutrophila, Thrombocytosis, Polycytemia (reactive), Eosinophilia, Leukopenia, Anemia Aplastic anemia, Thrombocytopenia Leukemia
Anemia related to acute infection Hypercoagulation (including anemia of chronic disorders), (including idiopathic thrombocyopaenic
MESENCHYMAL
10. HEMODERMAL

Hypercoagulation purpura), Pancytopenia, Vaquez’s disease

2. Heart Increased cardiac output, Tachycardia Myocarditis, Extrasystoles, Left ventricular hypertrophy, Angina pectoris, Atrial enlargement, Myocardial infarct, Ventricular arrhytmia, Sarcoma
Acute rheumatic fever Coronary atheroma Arrhytmia cordis, Rheumatic fever affecting Stenosis and insufficiency of the cardiac
the heart, Prolapse of the mitral valve valves
(Barlow’s syndrome), Cardiomyopathy
3. Vascular Increased production of Phlebitis, Arteritis, Venous stasis, Arterial plaques (atheroma), Vasculitis, Arteriosclerosis, Varicose veins, Peripheral vascular disease, Aneurysm, Angiosarcoma
endothelial mediators Endothelial inflammation Hemorrhoids Panarteritis nodosa, Angioma, Varicocele Arteritis obliterans

11. LYMPHODERMAL Increased lymph production Tonsillitis, Adenitis, Adenoiditis, Lymph edema, Lymph adenopathy, Indurated edema, Lymphatic tuberculosis, Elephantiasis Lymphoma (Hodgkin’s, Non Hodgkin’s),
Lymphangitis Tonsillar hypertrophy, Venerial lymphogranuloma, Lymphosarcoma
Adenoid hypertrophy Cat scratch disease
MESODERMAL

12. CAVODERMAL Increased synovial liquid, Arthritis, Polyarthritis, Synovitis, Hydrops (articular), Gouty tophi, Chronic arthritis, Reiter’s syndrome, Arthrosis, Ankylosing spondylitis Sarcoma, Chondrosarcoma
Cerebrospinal fluid Acute rheumatic disease Hemarthrosis Hydrocephaly, Spinal disc herniation

13. NEPHRODERMAL Frequent urination Nephritis, Glomerulonephritis, Pyelitis Nephrolithiasis, Renal cysts, Renal sand, Pre-clinical nephrosis, Nephrotic syndrome, Nephrosis, Chronic glomerulonephritis, Hypernephroma, Wilms’ tumor
Orthostatic albuminuria, Hematuria Chronic hematuria, Tuberculosis of the urogenital tract
Goodpasture’s syndrome,
Auto-immune glomerulonephritis

14. SERODERMAL Increased production of serous fluid Pleuritis, Peritonitis, Pericarditis Pleural effusion Chronic exsudative pleuritis and Pleural, pericardial and peritoneal Mesothelioma,
serositis, Ascites, Chronic pericarditis tuberculosis, Pleural adhesions Primary peritoneal carcinoma,
Primary pleural cancer

M Increased seminal fluid Prostatitis, Epididymitis, Orchitis Spermatocoele, Early benign prostatic Benign prostatic hyperplasia (BPH), Sterility Prostate cancer, Testicular cancer,
hyperplasia (BPH) Oligo asthenospermia Seminoma, Teratoma
15. GERMINODERMAL

F Heavy menstruation Ovaritis, Adnexitis, Metritis, Dysmenorrhea Ovarian cysts, Uterine polyps, Chronic adnexitis, Amenorrhea Infertility, Ovarian atrophy Ovarial cancer, Ovarial teratoma
Uterine fibroids

16. MUSCULODERMAL Myalgia Myositis Myogelosis, Myositis ossificans Muscular asthenia, Muscular atrophy, Muscular dystrophy Myosarcoma
Mitochondrial myopathy,
Autoimmune dermatomyositis
46486/1208/Ach

© IAH 2011
Self regulation. Self-healing effects. Favourable Prognosis. Compensation. Tendency to aggravation. Doubtful Prognosis.
Disease Evolution Table (DET) – Manual
Brief guide on how to use the DET
1. Introduction
The Disease Evolution Table (DET) is a 2-dimensional graphic
representation of the progression or regression of illnesses
in 6 successive phases in response to how the body’s defen-
se system reacts to the presence of homotoxins (exogenous
and/or endogenous).
On the horizontal axis are the phases of diseases in order of
severity. The horizontal axis also represents how the body
deals with the homotoxins present. On the vertical axis are
the different tissues/organs according to their embryological
origin.
Theoretically, each presenting clinical condition or disease
state can be classified within this 6-phase DET.
In consulting the DET, it is important to remember that
the body will activate its natural defense mechanisms at
3 major pathophysiological levels or phases (humoral, ma-
trix, or cellular) in an attempt to inactivate or detoxify and
eliminate the homotoxins at each level. Each of these major
pathophysiological phases is further subdivided into 2 other
phases. If not successful at the first stage, the body will at-
tempt again in the next phase. The illnesses will become
more serious and the attempts to treat them will become
increasingly difficult as the phases progress toward the last
phases on the right of the table.
The DET is a very useful conceptual and practical means for
clinically evaluating and following the natural tendency or
evolution of the biological disease processes in the patient.
To be able to classify the current status or stage of a patient
in such a table, and to be able to follow the patient’s clinical
history, it is necessary to become familiar with the interpre-
tation of each axis in the DET. Depending on the patient’s
location on the DET, specific antihomotoxic therapeutic stra-
tegies will need to be enacted to induce positive curative
changes.
Therefore, not only does the table indicate the stage and
severity of pathological processes, it also becomes the basis
for determining or planning what therapeutic approach is
best needed to accomplish an improvement of the patient’s
health status.
2. The differentiation of tissues and phases
of disease
2.1 The embryonic differentiation of tissues
(vertical axis)
Tissues are classified vertically according to their development
from the 3 embryonic layers. They are classified according to
the development stages of the embryo into four poles.
2.2 The 6 phases of the table
(horizontal axis)
The horizontal axis of the DET shows 6 successive phases in
which diseases may occur. Patients do not have to pass all
the phases one by one to reach a phase at the right side of
the table. The history of the patient may show zigzag pat-
terns, or some phases may be skipped and will not even oc-
cur in the history.
In fact, the 6 successive phases refer to the characteristics of
the relationship between the organism and the presence of
homotoxins. Initially, we see how the body reacts to intoxi-
cation. Further on, we see what the intoxication does to the
body.
2.2.1 The humoral phases
The humoral phases on the DET group the excretion phases
and inflammation phases, both related by their “humoral”
characteristics. Both phases are characterized by the final
excretion of homotoxins, via direct excretion pathways or a
complex process of inflammation.
Excretion phases
The excretion phase covers all the hypersecretions (endocri-
ne) and hyperexcretions of the body in different organs and
tissues. Because those secretions and excretions are increa-
sed compared with the normal standards in the population,
they may be seen as a first stage of disease. Of course, the
presence of homotoxins is a dormant danger and elimination
and detoxification is needed. However, in normal conditions,
detoxifying organs and excretion systems will eliminate them
without any significant clinical signs and symptoms manife-
sting because this is merely an amplification of a physiologi-
cal process.
In this case, although there is a certain level of intoxication,
by the normal way of living, the body almost passively deals
with it without really causing any clinical manifestations ty­
pical of defensive reactions. Thus, the elimination of toxins
occurs as a normal increased excretion process and the pati-
ent has no other clinical complaints.
Inflammation phases
Once homotoxins manage to reach extracellular and/or in-
tracellular levels, the body will begin some form of a local
defense reaction to counter the “intoxication” status. The
appearance of this local “inflammatory” reaction is the rea-
son why the patient is considered to be in an “inflammation
phase.” Thus, all acute inflammations are classified within
this phase.
This first inflammatory reaction should be seen as a welco-
med natural and physiological attempt of the organism to
try to do away with the toxins. Furthermore, the activation
of phagocytes and phagocytosis should be seen as the first
reactive step of detoxification.
All of the classic characteristics of inflammation might be
present: swelling, redness, pain, temperature increase, and
loss of function in the affected tissue.
Acute inflammation should be seen as a “cleaning” pro-
cess of the matrix. The cell is not involved yet, although the
inflammatory processes can passively damage the cell (eg,
when free radicals are released by “frustrated or overzea-
lous” neutrophils). This inflammation is hallmarked by nor-
mal angiogenesis and mostly complete tissue restitution.
2.2.2 The matrix phases
The matrix phases group both the deposition and impregna-
tion phases because the extracellular matrix (ECM) is central
in both.
Deposition phases
This phase is an expression of the body’s incapacity to elimi-
nate (excrete) homotoxins and in which predominate storage
of toxins within the ECM causes regulation disorders. It is
reached when the body has to temporarily store (deposit)
toxins. This may occur for 2 reasons:
• the inflammatory process (previous phase) was not ade-
quately activated or was blocked or suppressed (eg, by
anti-inflammatory drugs)
• the excretion mechanisms are hypofunctional or the to-
xic load is excessive.
Therefore, if inflammation pathways are blocked or the
amount of homotoxins gets out of hand, the organism will
choose a process of (temporary) storage or deposition of the
homotoxins.
Clinically, this phase is a relatively silent process with very few
clinical signs and symptoms; however, it is a quite dangerous
process. It is only a question of time before the homotoxins
will impregnate into the cell or interfere with and have many
effects on normal cellular functions from outside the cell.
Impregnation phases
Once the homotoxins begin to “impregnate” in the ECM
or within the cells, inducing intracellular effects, diseases of
the impregnation phases appear. Homotoxins practically be-
come part of the structural components of the connective
tissue and the matrix. Some toxins (eg, viruses) may also
directly penetrate cells within the connective tissues and/or
cells of the parenchyma. Toxins that reach this stage will be-
gin to induce functional changes in both the matrix and in
cells, such as blocking enzymes or metabolic pathways and
compromising the mitochondrial respiratory chain. We see
less efficient functioning of the cell, and the reactions of the
organism towards the homotoxins are often not purposeful;
a minimal load of specific homotoxins produces an overre-
action of the organism’s defense mechanisms (eg, asthma,
hay fever, migraine, or gastric ulcer). Histologically, some
changes in structural components begin to become evident.
Clinically, signs and symptoms that are indicative of cellular
damage will appear.
A number of diseases classified in this phase will manifest as
low grade chronic inflammation with episodes of acute ex-
acerbation, such as asthma or inflammatory bowel disease.
Impregnation phases can be reached in a very short time,
depending on the characteristics of the homotoxins. Most
viruses will try to get into a host cell and proliferate rapidly;
although the organism will try to develop a specific defense
(immunoglobulins) and eliminate the infected cells (T-cell ac-
tivity and NK cell–induced elimination), the immediate situ-
ation is an impregnation phase because of the intracellular
presence of the homotoxins (viruses).
Sometimes, afterward, even if tissues are fully restored and
the lost cells are replaced, the viral condition remains in an
impregnation phase while the virus is present if the virus is
incorporated into the genetic material of the cell host. In
postviral syndromes, this situation might last for a long time,
even years.
2.2.3 The cellular phases
In the cellular phases, the cell itself is involved and the di-
seases occurring are purely cell-related. The cellular phases
group both the degeneration phases and the dedifferentia-
tion phases. These phases are hallmarked by chronic inflam-
mation, tissue scarring as well as abnormal angiogenesis,
which is seen in degenerative diseases such as osteoarthritis
as well as in cancerous processes.
Degeneration phases
The natural defense system is no longer able to eliminate or
excrete toxins from the cells and/or the matrix, or the homo-
toxins imbedded in there cause disruption in the cell-to-cell
communication as well as the matrix-to-cell communication. separating line between the phases in which simple excretion
Intracellular structures, including genetic components, cel- of toxins is still possible and tissue restoration is achieved and
lular membranes, and groups and systems of cells, become the impregnation phase, in which simple excretion is no lon-
increasingly and seriously damaged. Predominately cellular ger achievable, at least spontaneously, and the healing and
damage occurs in this phase. The progressive intoxication compensation is hallmarked by destruction of tissues (fibrosis
causes complete functional loss of the affected cells until or metastatic cancer growth)
they die. In the long-term, we see tissue loss and a limited
function of the whole affected tissue. By definition, degene- To the left of the RCD, the tendency of the organism is to
ration phases accommodate chronic degenerative diseases, regain homeostasis. Deregulations are the target of correc-
most of them irreversible. tions, and intoxications are purposefully drained and deto-
xified if possible. To the right of the RCD, the organism will
Dedifferentiation phases change its strategy and choose compensating measures to
keep functioning for as long as possible. Because regulation
The dedifferentiation phases accommodate all diseases in capacities are more or less lost, the organism seeks compen-
which abnormal cell proliferation (tissue growth) is the main sation for the losses.
characteristic. Cells lose their specificity and dedifferentiate
to omnipotent cells (inversed embryological specificity) that Clinically, the prognosis is quite good to the left of the RCD.
can easily also lose their restrain control and begin to migrate Pathological conditions react very well using simple thera-
to other locations in the body (metastases). In this phase of py schemes in bioregulatory medicine as auto-regulating sy-
complete degeneration, the body becomes increasingly in- stems (ARS) remain intact and can be influenced. To the right
fluenced by endogenous homotoxins (ie, toxins generated of the RCD, the prognosis is more dubious and there is a
within the body through cellular destruction). All malignant tendency for aggravation. Bioregulatory medicine can also
tumors (cancers) are classified here. be very effective, but the therapy schemes will be more com-
plex because of the need for more pillars of antihomotoxic
2.3 The regulation/compensation division treatment.

Between the third (deposition) and fourth (impregnation) 3. Classification on the table
phases, there is the so-called regulation/compensation divisi-
on (RCD). It is an artificial dividing line between the 2 phases Although disease is dynamic, it is interesting to be able to
that refers to the demarcation point that separates the ability classify a patient on the DET every time the patient is seen in
of a patient to self-regulate or merely to compensate for the consultation. It is only then that an evolution of the patient
damage if there is no external help. can be evaluated correctly homotoxicologically. Therefore,
the patient’s history is essential for a good understanding of
what evolution is really going on and for determining the
DISEASE EVOLUTION TABLE (DET)
correct medications to support an evolution towards a more
HEALTH Status of Regulation / Deregulation DISEASE

Organ System/Tissue
1. EPIDERMAL
Humo ral Pha s e s
Excretion Phase Inflammation Phase Deposition Phase
Matrix Phases
Impregnation Phase
Cellular Phases
Degeneration Phase Dedifferentiation Phase
healthy state (health evolution) or to counter a negative
trend, called disease evolution.
Increased sweating, Cerumen, Sebum, Dermatitis, Impetigo, Abscess, Hyperkeratosis, Seborrhoic eczema, Atopic eczema, Urticaria, Warts, Psoriasis, Decubitus ulceration, Squamous cell carcinoma,
Smegma Furuncle, Otitis externa Naevus, Skin tags (soft warts) Fissura ani, Acne rosacea, Hirsutism Radiation injury, Pemphigus vulgaris Basal cell carcinoma, Melanoma

2. ORODERMAL
Hypersalivation, Hyperlacrimation Otitis media, Pharyngitis, Stomatitis,
Gingivitis, Apthous ulceration, Glossitis,
Rhinitis (acute), Sinusitis (acute),
Laryngitis, Dental abscess
ECTODERMAL
Nasal polyp, Eustachian tube catarrh Atopic rhinitis, Hay fever, Otosclerosis, Deafness (transmission), Leucoplakia (orodermal),
(serous otitis media), Dental granuloma Sinusitis (chronic), Rhinitis (iatrogenic), Ozaena, Atrophic rhinitis, Dental caries, Cancer of the tongue, Laryngeal cancer,
Anosmia, Menière’s syndrome, Parodontosis Nasopharyngeal cancer, Tracheal cancer
Hypoacusis

3. NEURODERMAL Increased secretion of neurotransmitters Neuralgia, Neuritis, Polyneuritis, Neuroma, Amyloid deposition, Epilepsy (petit mal), Paresis, Tics, Parkinson disease, Epilepsy (grand mal), Glioma, Meningioma, Astrocytoma
PNS and CNS Meningitis, Encephalitis, Heavy metal deposition Neuritis (toxic), Attention-deficit/ Alzheimer’s disease, Multiple sclerosis,
Trigeminal neuralgia (acute) hyperactivity syndrome (ADHS), Guillain- Amyotrophic lateral sclerosis,
Barré syndrome, Poliomyelitis (acute), Peripheral neural atrophy,
Trigeminal neuralgia (chronic) Diabetic neuropathy, Neurofibromatosis

4. EYE
Conjunctivitis (acute) Pterygium, Mouches volantes (floaters),
Iris spots (initial)
Uveitis, Allergic conjunctivitis,
Iris spots (chronic), Iritis, Astigmatism,
Myopia, Presbyopia, Keratoconus,
Pannus, Arch (senile)
Glaucoma, Cataract, Hemianopsia,
Macular degeneration, Paralytic mydriasis
Retinal cancer, Retinoblastoma
We previously mentioned that relocations from left towards
right and from top towards bottom on the table are signs of
5. SYMPATHICODERMAL Increased adrenalin and Flushes, Hypervagotony, Ganglion neuroma Dysautonomia (including orthostatic Addison’s disease, Reflex sympathetic Pheochromocytoma, Neuroblastoma
noradrenaline secretion Hypersympathicotonus hypotension) dystrophy (RSD) or Sudeck’s syndrome,
Horner’s syndrome

disease aggravation or disease evolution. The inverse direc-

1. Respiratory Sputum Bronchitis (acute), Tracheitis Nasal polyp Bronchitis (asthmatic), COPD (chronic obstructive pulmonary Tracheal cancer, Bronchial cancer
Chronic tracheitis (viral), Cystic fibrosis disease), Atrophy of bronchial mucosa
6. MUCODERMAL

2. Digestive Increased digestive juices Esophagitis (acute), Gastritis (acute), Gastric polyps, Intestinal polyps, Gastric ulcer, Duodenal ulcer, Crohn´s disease, Colitis ulcerosa, Barret’s esophagus, Esophageal cancer,
Gastroenteritis (acute), Colitis Obstipation, Melanosis of the colon Gluten enteropathy (mild), Atrophy of the small intestinal villi, Gastric cancer, Duodenal cancer,
Leaky gut syndrome, Dysbiosis Gluten enteropathy (severe) Rectal cancer
ENDODERMAL

3. Urogenital Increased mucous production Bartholinitis, Cystitis, Urethritis, Bladder polyps, Uterine polyps Interstitial cystitis Atrophy of the urogenital mucosa Bladder cancer, Cervical carcinoma
Infections of the urogenital mucosa

1. Exocrine Lactorrhea Mastitis Mammary cysts, Breast calcifications Mammary fibroadenoma, Breast atrophy, Gynecomastia Mammary carcinoma

tions are signs of disease ameliorations and are called health

R E GUL ATIO N/ COMP EN SATI ON DIV IS IO N

Sexual Fibrocystic mastopathy

7. ORGANODERMAL

2. Exocrine Increased bile salt secretion, Pancreatitis, Sialitis Cholelithiasis, Steatosis hepatica, Pancreatic Chronic hepatitis, Chronic pancreatitis, Hepatic cirrhosis, Liver cancer, Pancreatic cancer
Digestive Increased gastric acid secretion calcifications, Pancreatic cysts, Liver cysts, Viral pancreatitis (e.g. mumps), Hepatic iatrogenic disease
Wilson’s disease, Salivary gland calcifications Alcoholic hepatitis, Cystic fibrosis

3. Respiratory
4. Endocrine
Increased thyroid hormones, Parathyroid
hormones, Thymic hormones, Insulin, Gluca-
gon, Enteric hormones, Cortico-suprarenal
hormones, Adenohypophyseal hormones
Acute pulmonary abscess, Pneumonia
Thyroiditis , e.g. de Quervain’s thyroiditis
evolution.
Bronchiectasis, Pneumoconiosis Bronchial asthma, Cystic fibrosis Emphysema, Chronic pulmonary abscess, Pulmonary cancer
Interstitial fibrosis of the lung,
Fungal balls
Thyroid cysts, Adrenal cysts, Adrenal ade- Grave’s disease, Hashimoto’s disease (2nd stage), Thyroid cancer, Parathyroid cancer,
noma, Hypophyseal adenoma, Thymoma, Hashimoto’s disease (1st stage), Riedel’s thyroiditis, Parathyroid atrophy Adrenal cancer, Carcinoid syndrome
Insulinoma, Parathyroid gland adenoma, Puerpural thyroiditis, Cushing’s syndrome,
Thyroid goiter, Adrenal adenomas Precocious puberty, Adrenal exhaustion

8. CONNECT. TISSUE Increased secretion of metalloproteinases, Abscess, Reactive inflammatory response Lipoma, Storage of toxins in the matrix, Mixed connective tissue disease (MCTD), Scleroderma, Carbohydrate deficient Sarcoma
Increase in glycoprotein formation of the matrix, Tendinitis Amyloidosis, Mucopolysaccharidosis, Marfan’s syndrome, glycoprotein syndrome, Peyronie’s disease,
Periarthritis humeroscapularis calcinosa Ehlers-Danlos syndrome, Sphingolipidosis Progeria, Dupuytren’s contracture

9. OSTEODERMAL

3.1 Decision tree for classification

Osteomyelitis, Chondroitis Osteophyte formation, Bone cysts Osteomalacia, Early osteoporosis Osteoporosis, Paget’s disease Osteosarcoma

1. Blood Leukocytosis neutrophila, Thrombocytosis, Polycytemia (reactive), Eosinophilia, Leukopenia, Anemia Aplastic anemia, Thrombocytopenia Leukemia
Anemia related to acute infection Hypercoagulation (including anemia of chronic disorders), (including idiopathic thrombocyopaenic
MESENCHYMAL
10. HEMODERMAL

Hypercoagulation purpura), Pancytopenia, Vaquez’s disease

2. Heart Increased cardiac output, Tachycardia Myocarditis, Extrasystoles, Left ventricular hypertrophy, Angina pectoris, Atrial enlargement, Myocardial infarct, Ventricular arrhytmia, Sarcoma
Acute rheumatic fever Coronary atheroma Arrhytmia cordis, Rheumatic fever affecting Stenosis and insufficiency of the cardiac
the heart, Prolapse of the mitral valve valves
(Barlow’s syndrome), Cardiomyopathy
3. Vascular Increased production of Phlebitis, Arteritis, Venous stasis, Arterial plaques (atheroma), Vasculitis, Arteriosclerosis, Varicose veins, Peripheral vascular disease, Aneurysm, Angiosarcoma
endothelial mediators Endothelial inflammation Hemorrhoids Panarteritis nodosa, Angioma, Varicocele Arteritis obliterans

11. LYMPHODERMAL Increased lymph production Tonsillitis, Adenitis, Adenoiditis, Lymph edema, Lymph adenopathy, Indurated edema, Lymphatic tuberculosis, Elephantiasis Lymphoma (Hodgkin’s, Non Hodgkin’s),
Lymphangitis Tonsillar hypertrophy, Venerial lymphogranuloma, Lymphosarcoma

To classify a current patient’s disease on the DET, we look at

Adenoid hypertrophy Cat scratch disease
MESODERMAL

12. CAVODERMAL Increased synovial liquid, Arthritis, Polyarthritis, Synovitis, Hydrops (articular), Gouty tophi, Chronic arthritis, Reiter’s syndrome, Arthrosis, Ankylosing spondylitis Sarcoma, Chondrosarcoma
Cerebrospinal fluid Acute rheumatic disease Hemarthrosis Hydrocephaly, Spinal disc herniation

13. NEPHRODERMAL Frequent urination Nephritis, Glomerulonephritis, Pyelitis Nephrolithiasis, Renal cysts, Renal sand,
Orthostatic albuminuria, Hematuria
Pre-clinical nephrosis, Nephrotic syndrome,
Chronic hematuria,
Goodpasture’s syndrome,
Auto-immune glomerulonephritis
Nephrosis, Chronic glomerulonephritis,
Tuberculosis of the urogenital tract
Hypernephroma, Wilms’ tumor
the affected tissue first. The vertical axis gives a classification
of tissue going from more structured to less structured, such
14. SERODERMAL Increased production of serous fluid Pleuritis, Peritonitis, Pericarditis Pleural effusion Chronic exsudative pleuritis and Pleural, pericardial and peritoneal Mesothelioma,
serositis, Ascites, Chronic pericarditis tuberculosis, Pleural adhesions Primary peritoneal carcinoma,
Primary pleural cancer

as the mesenchyme. This classification from top towards bot-

M Increased seminal fluid Prostatitis, Epididymitis, Orchitis Spermatocoele, Early benign prostatic Benign prostatic hyperplasia (BPH), Sterility Prostate cancer, Testicular cancer,
hyperplasia (BPH) Oligo asthenospermia Seminoma, Teratoma
15. GERMINODERMAL

F Heavy menstruation Ovaritis, Adnexitis, Metritis, Dysmenorrhea Ovarian cysts, Uterine polyps, Chronic adnexitis, Amenorrhea Infertility, Ovarian atrophy Ovarial cancer, Ovarial teratoma
Uterine fibroids

16. MUSCULODERMAL Myalgia Myositis Myogelosis, Myositis ossificans Muscular asthenia,

Mitochondrial myopathy,
Autoimmune dermatomyositis
Muscular atrophy, Muscular dystrophy Myosarcoma tom of the table follows the sequence in embryonic develop-
Self regulation. Self-healing effects. Favourable Prognosis. Compensation. Tendency to aggravation. Doubtful Prognosis.
ment in four poles. Icons on the left of the DET will help reco-
gnize the affected tissue in the embryonic layers (ectodermal,
endodermal, and mesodermal).
Fig. 1: Regulation/compensation division (RCD)
Second, the phase of the disease should be identified. The
main characteristics of every phase should be compared with
This boundary is very important physiologically, pathological- the clinical characteristics of the disease present. The main
ly, and clinically and, thus, therapeutically because it is the phase characteristics are synthesized under 2.2.
3.2 Consequences for therapy When toxins are inhibited from being excreted, they will not
only impregnate locally but will also easily be transferred to
Therapy schemes for a specific disease related to a certain other tissues, even to great distances far from the original
position on the DET will have to conform to certain standards focal point:
in antihomotoxic therapy. These standards are described in
the reference book on bioregulatory medicine and homoto- • In a linear progression, the toxins are transferred to other
xicology.1 tissues of similar embryological origin (eg, tonsillitis [lym-
phodermal] polyarthritis [cavodermal] nephritis
The therapeutic approach differs according to the phase the [nephrodermal]).
patient is in. The types of antihomotoxic medications used • In a disordered progression, phases are skipped and tis-
will vary accordingly. To the left of the RCD, drainage and sues of different embryological origins are entered local-
detoxification merged with immunomodulation are empha- ly and/or at a distance.
sized; to the right of the RCD, cell and organ support are
added within the therapy strategy. Here, the disease tends to evolve negatively in the ontogene-
tic and phylogenetic sense.
The main point regarding the DET is that the farther right
and in depth the patient is, the more complex the patient’s 3.2.2 Health evolution
antihomotoxic therapy protocol.
A regression in the patient’s pathological condition with the
3.2.1 Disease evolution relative signs and symptoms (and actually with the reappea-
rance of old signs and symptoms) from the right to the left of
The patient’s pathological status progresses (evolves) on the the table or from the bottom to the top of the table or even
DET towards more serious conditions, too often for iatroge- a combination of both is an indication of an ameliorating
nic reasons. process. This process is called health evolution.
DISEASE EVOLUTION TABLE (DET)
Progression of the patient’s signs and symptoms from the left HEALTH Status of Regulation / Deregulation DISEASE

to the right of the table or from the top to the bottom of the
Humoral Phases Matrix Phases Cellular Phases
Organ System/Tissue Excretion Phase Inflammation Phase Deposition Phase Impregnation Phase Degeneration Phase Dedifferentiation Phase
1. EPIDERMAL
Increased sweating, Cerumen, Sebum, Dermatitis, Impetigo, Abscess, Hyperkeratosis, Seborrhoic eczema, Atopic eczema, Urticaria, Warts, Psoriasis, Decubitus ulceration, Squamous cell carcinoma,
Smegma Furuncle, Otitis externa Naevus, Skin tags (soft warts) Fissura ani, Acne rosacea, Hirsutism Radiation injury, Pemphigus vulgaris Basal cell carcinoma, Melanoma

table or even a combination of both is a condition of worse- 2. ORODERMAL

Hypersalivation, Hyperlacrimation
Gingivitis, Apthous ulceration, Glossitis,
Otitis media, Pharyngitis, Stomatitis,
Rhinitis (acute), Sinusitis (acute),
Laryngitis, Dental abscess
Nasal polyp, Eustachian tube catarrh
(serous otitis media), Dental granuloma
Atopic rhinitis, Hay fever,
Sinusitis (chronic), Rhinitis (iatrogenic),
Anosmia, Menière’s syndrome,
Hypoacusis
Otosclerosis, Deafness (transmission),
Ozaena, Atrophic rhinitis, Dental caries,
Parodontosis
Leucoplakia (orodermal),
Cancer of the tongue, Laryngeal cancer,
Nasopharyngeal cancer, Tracheal cancer

ning and is called a disease evolution. The inhibition or sup-

ECTODERMAL

3. NEURODERMAL Increased secretion of neurotransmitters Neuralgia, Neuritis, Polyneuritis, Neuroma, Amyloid deposition, Epilepsy (petit mal), Paresis, Tics, Parkinson disease, Epilepsy (grand mal), Glioma, Meningioma, Astrocytoma
PNS and CNS Meningitis, Encephalitis, Heavy metal deposition Neuritis (toxic), Attention-deficit/ Alzheimer’s disease, Multiple sclerosis,
Trigeminal neuralgia (acute) hyperactivity syndrome (ADHS), Guillain- Amyotrophic lateral sclerosis,
Barré syndrome, Poliomyelitis (acute), Peripheral neural atrophy,
Trigeminal neuralgia (chronic) Diabetic neuropathy, Neurofibromatosis

pression of natural biological defense mechanisms (eg, the

4. EYE
Conjunctivitis (acute) Pterygium, Mouches volantes (floaters), Uveitis, Allergic conjunctivitis, Glaucoma, Cataract, Hemianopsia, Retinal cancer, Retinoblastoma
Iris spots (initial) Iris spots (chronic), Iritis, Astigmatism, Macular degeneration, Paralytic mydriasis
Myopia, Presbyopia, Keratoconus,
Pannus, Arch (senile)

5. SYMPATHICODERMAL Increased adrenalin and Flushes, Hypervagotony, Ganglion neuroma Dysautonomia (including orthostatic Addison’s disease, Reflex sympathetic Pheochromocytoma, Neuroblastoma
noradrenaline secretion Hypersympathicotonus hypotension) dystrophy (RSD) or Sudeck’s syndrome,

indiscriminate use of anti-inflammatory drugs) is frequently

Horner’s syndrome

1. Respiratory Sputum Bronchitis (acute), Tracheitis Nasal polyp Bronchitis (asthmatic), COPD (chronic obstructive pulmonary Tracheal cancer, Bronchial cancer
Chronic tracheitis (viral), Cystic fibrosis disease), Atrophy of bronchial mucosa
6. MUCODERMAL

responsible for the progressive involvement of the body in

2. Digestive Increased digestive juices Esophagitis (acute), Gastritis (acute), Gastric polyps, Intestinal polyps, Gastric ulcer, Duodenal ulcer, Crohn´s disease, Colitis ulcerosa, Barret’s esophagus, Esophageal cancer,
Gastroenteritis (acute), Colitis Obstipation, Melanosis of the colon Gluten enteropathy (mild), Atrophy of the small intestinal villi, Gastric cancer, Duodenal cancer,
Leaky gut syndrome, Dysbiosis Gluten enteropathy (severe) Rectal cancer
ENDODERMAL

3. Urogenital Increased mucous production Bartholinitis, Cystitis, Urethritis, Bladder polyps, Uterine polyps Interstitial cystitis Atrophy of the urogenital mucosa Bladder cancer, Cervical carcinoma
Infections of the urogenital mucosa

other pathological conditions.

1. Exocrine Lactorrhea Mastitis Mammary cysts, Breast calcifications Mammary fibroadenoma, Breast atrophy, Gynecomastia Mammary carcinoma
R EG UL ATIO N / CO M P E N S AT I O N D I V I S I O N

Sexual Fibrocystic mastopathy

7. ORGANODERMAL

2. Exocrine Increased bile salt secretion,
Digestive Increased gastric acid secretion
3. Respiratory
4. Endocrine
Increased thyroid hormones, Parathyroid
hormones, Thymic hormones, Insulin, Gluca-
gon, Enteric hormones, Cortico-suprarenal
hormones, Adenohypophyseal hormones
Pancreatitis, Sialitis
Acute pulmonary abscess, Pneumonia
Thyroiditis , e.g. de Quervain’s thyroiditis
Cholelithiasis, Steatosis hepatica, Pancreatic Chronic hepatitis, Chronic pancreatitis, Hepatic cirrhosis, Liver cancer, Pancreatic cancer
calcifications, Pancreatic cysts, Liver cysts, Viral pancreatitis (e.g. mumps), Hepatic iatrogenic disease
Wilson’s disease, Salivary gland calcifications Alcoholic hepatitis, Cystic fibrosis
Bronchiectasis, Pneumoconiosis Bronchial asthma, Cystic fibrosis Emphysema, Chronic pulmonary abscess, Pulmonary cancer
Interstitial fibrosis of the lung,
Fungal balls
Thyroid cysts, Adrenal cysts, Adrenal ade- Grave’s disease, Hashimoto’s disease (2nd stage), Thyroid cancer, Parathyroid cancer,
noma, Hypophyseal adenoma, Thymoma, Hashimoto’s disease (1st stage), Riedel’s thyroiditis, Parathyroid atrophy Adrenal cancer, Carcinoid syndrome
Insulinoma, Parathyroid gland adenoma, Puerpural thyroiditis, Cushing’s syndrome,
Thyroid goiter, Adrenal adenomas Precocious puberty, Adrenal exhaustion

DISEASE EVOLUTION TABLE (DET)

8. CONNECT. TISSUE Increased secretion of metalloproteinases, Abscess, Reactive inflammatory response Lipoma, Storage of toxins in the matrix, Mixed connective tissue disease (MCTD), Scleroderma, Carbohydrate deficient Sarcoma
Increase in glycoprotein formation of the matrix, Tendinitis Amyloidosis, Mucopolysaccharidosis, Marfan’s syndrome, glycoprotein syndrome, Peyronie’s disease,
Periarthritis humeroscapularis calcinosa Ehlers-Danlos syndrome, Sphingolipidosis Progeria, Dupuytren’s contracture

9. OSTEODERMAL
Osteomyelitis, Chondroitis Osteophyte formation, Bone cysts Osteomalacia, Early osteoporosis Osteoporosis, Paget’s disease Osteosarcoma
HEALTH Status of Regulation / Deregulation DISEASE

Humo ral P h a s e s Matrix Phases Cellular Phases 1. Blood Leukocytosis neutrophila, Thrombocytosis, Polycytemia (reactive), Eosinophilia, Leukopenia, Anemia Aplastic anemia, Thrombocytopenia Leukemia
Anemia related to acute infection Hypercoagulation (including anemia of chronic disorders), (including idiopathic thrombocyopaenic
MESENCHYMAL

Organ System/Tissue
10. HEMODERMAL

Excretion Phase Inflammation Phase Deposition Phase Impregnation Phase Degeneration Phase Dedifferentiation Phase Hypercoagulation purpura), Pancytopenia, Vaquez’s disease

2. Heart Increased cardiac output, Tachycardia Myocarditis, Extrasystoles, Left ventricular hypertrophy, Angina pectoris, Atrial enlargement, Myocardial infarct, Ventricular arrhytmia, Sarcoma
1. EPIDERMAL Acute rheumatic fever Coronary atheroma Arrhytmia cordis, Rheumatic fever affecting Stenosis and insufficiency of the cardiac
Increased sweating, Cerumen, Sebum, Dermatitis, Impetigo, Abscess, Hyperkeratosis, Seborrhoic eczema, Atopic eczema, Urticaria, Warts, Psoriasis, Decubitus ulceration, Squamous cell carcinoma,
Smegma the heart, Prolapse of the mitral valve valves
Furuncle, Otitis externa Naevus, Skin tags (soft warts) Fissura ani, Acne rosacea, Hirsutism Radiation injury, Pemphigus vulgaris Basal cell carcinoma, Melanoma (Barlow’s syndrome), Cardiomyopathy
3. Vascular Increased production of Phlebitis, Arteritis, Venous stasis, Arterial plaques (atheroma), Vasculitis, Arteriosclerosis, Varicose veins, Peripheral vascular disease, Aneurysm, Angiosarcoma
endothelial mediators Endothelial inflammation Hemorrhoids Panarteritis nodosa, Angioma, Varicocele Arteritis obliterans

2. ORODERMAL
Hypersalivation, Hyperlacrimation Otitis media, Pharyngitis, Stomatitis,
Gingivitis, Apthous ulceration, Glossitis,
Rhinitis (acute), Sinusitis (acute),
Laryngitis, Dental abscess
ECTODERMAL
Nasal polyp, Eustachian tube catarrh Atopic rhinitis, Hay fever,
(serous otitis media), Dental granuloma Sinusitis (chronic), Rhinitis (iatrogenic),
Anosmia, Menière’s syndrome,
Hypoacusis
11. LYMPHODERMAL Increased lymph production Tonsillitis, Adenitis, Adenoiditis, Lymph edema, Lymph adenopathy, Indurated edema, Lymphatic tuberculosis, Elephantiasis Lymphoma (Hodgkin’s, Non Hodgkin’s),
Otosclerosis, Deafness (transmission), Leucoplakia (orodermal), Lymphangitis Tonsillar hypertrophy, Venerial lymphogranuloma, Lymphosarcoma
Ozaena, Atrophic rhinitis, Dental caries, Cancer of the tongue, Laryngeal cancer, Adenoid hypertrophy Cat scratch disease
Parodontosis Nasopharyngeal cancer, Tracheal cancer

MESODERMAL

3. NEURODERMAL 12. CAVODERMAL Increased synovial liquid, Arthritis, Polyarthritis, Synovitis, Hydrops (articular), Gouty tophi, Chronic arthritis, Reiter’s syndrome, Arthrosis, Ankylosing spondylitis Sarcoma, Chondrosarcoma
Increased secretion of neurotransmitters Neuralgia, Neuritis, Polyneuritis, Neuroma, Amyloid deposition, Epilepsy (petit mal), Paresis, Tics, Parkinson disease, Epilepsy (grand mal), Glioma, Meningioma, Astrocytoma
PNS and CNS Cerebrospinal fluid Acute rheumatic disease Hemarthrosis Hydrocephaly, Spinal disc herniation
Meningitis, Encephalitis, Heavy metal deposition Neuritis (toxic), Attention-deficit/ Alzheimer’s disease, Multiple sclerosis,
Trigeminal neuralgia (acute) hyperactivity syndrome (ADHS), Guillain- Amyotrophic lateral sclerosis,
Barré syndrome, Poliomyelitis (acute), Peripheral neural atrophy,
Trigeminal neuralgia (chronic) Diabetic neuropathy, Neurofibromatosis

13. NEPHRODERMAL Frequent urination Nephritis, Glomerulonephritis, Pyelitis Nephrolithiasis, Renal cysts, Renal sand, Pre-clinical nephrosis, Nephrotic syndrome, Nephrosis, Chronic glomerulonephritis, Hypernephroma, Wilms’ tumor
4. EYE

Conjunctivitis (acute)
Pterygium, Mouches volantes (floaters), Uveitis, Allergic conjunctivitis,
Iris spots (initial) Iris spots (chronic), Iritis, Astigmatism,
Myopia, Presbyopia, Keratoconus,
Pannus, Arch (senile)
63915 04/09 Ach © International Academy for Homotoxicology GmbH, Baden-Baden, Germany
Glaucoma, Cataract, Hemianopsia, Retinal cancer, Retinoblastoma Orthostatic albuminuria, Hematuria Chronic hematuria, Tuberculosis of the urogenital tract
Macular degeneration, Paralytic mydriasis Goodpasture’s syndrome,
Auto-immune glomerulonephritis

14. SERODERMAL Increased production of serous fluid Pleuritis, Peritonitis, Pericarditis Pleural effusion Chronic exsudative pleuritis and Pleural, pericardial and peritoneal Mesothelioma,
5. SYMPATHICODERMAL Increased adrenalin and Flushes, Hypervagotony, Ganglion neuroma Dysautonomia (including orthostatic Addison’s disease, Reflex sympathetic Pheochromocytoma, Neuroblastoma serositis, Ascites, Chronic pericarditis tuberculosis, Pleural adhesions Primary peritoneal carcinoma,
noradrenaline secretion Hypersympathicotonus hypotension) dystrophy (RSD) or Sudeck’s syndrome, Primary pleural cancer
Horner’s syndrome

M Increased seminal fluid Prostatitis, Epididymitis, Orchitis Spermatocoele, Early benign prostatic Benign prostatic hyperplasia (BPH), Sterility Prostate cancer, Testicular cancer,
hyperplasia (BPH) Oligo asthenospermia Seminoma, Teratoma
1. Respiratory Sputum Bronchitis (acute), Tracheitis Nasal polyp Bronchitis (asthmatic), COPD (chronic obstructive pulmonary Tracheal cancer, Bronchial cancer
15. GERMINODERMAL

Chronic tracheitis (viral), Cystic fibrosis disease), Atrophy of bronchial mucosa

6. MUCODERMAL

2. Digestive Increased digestive juices Esophagitis (acute), Gastritis (acute), Gastric polyps, Intestinal polyps, Gastric ulcer, Duodenal ulcer, Crohn´s disease, Colitis ulcerosa, Barret’s esophagus, Esophageal cancer,
Gastroenteritis (acute), Colitis Obstipation, Melanosis of the colon Gluten enteropathy (mild), Atrophy of the small intestinal villi, Gastric cancer, Duodenal cancer,
Leaky gut syndrome, Dysbiosis Gluten enteropathy (severe) Rectal cancer
F Heavy menstruation Ovaritis, Adnexitis, Metritis, Dysmenorrhea Ovarian cysts, Uterine polyps, Chronic adnexitis, Amenorrhea Infertility, Ovarian atrophy Ovarial cancer, Ovarial teratoma
Uterine fibroids
ENDODERMAL

3. Urogenital Increased mucous production Bartholinitis, Cystitis, Urethritis, Bladder polyps, Uterine polyps Interstitial cystitis Atrophy of the urogenital mucosa Bladder cancer, Cervical carcinoma
Infections of the urogenital mucosa

1. Exocrine Lactorrhea Mastitis Mammary cysts, Breast calcifications Mammary fibroadenoma, Breast atrophy, Gynecomastia Mammary carcinoma
R E GUL ATIO N/ COMP EN SATI ON DIV IS ION

Sexual Fibrocystic mastopathy 16. MUSCULODERMAL Myalgia Myositis Myogelosis, Myositis ossificans Muscular asthenia, Muscular atrophy, Muscular dystrophy Myosarcoma
Mitochondrial myopathy,
7. ORGANODERMAL

2. Exocrine Increased bile salt secretion,
Digestive Increased gastric acid secretion
3. Respiratory
4. Endocrine
Increased thyroid hormones, Parathyroid
hormones, Thymic hormones, Insulin, Gluca-
gon, Enteric hormones, Cortico-suprarenal
hormones, Adenohypophyseal hormones
Pancreatitis, Sialitis
Acute pulmonary abscess, Pneumonia
Thyroiditis , e.g. de Quervain’s thyroiditis
Autoimmune dermatomyositis
Cholelithiasis, Steatosis hepatica, Pancreatic Chronic hepatitis, Chronic pancreatitis, Hepatic cirrhosis, Liver cancer, Pancreatic cancer
calcifications, Pancreatic cysts, Liver cysts, Viral pancreatitis (e.g. mumps), Hepatic iatrogenic disease
Wilson’s disease, Salivary gland calcifications Alcoholic hepatitis, Cystic fibrosis
Bronchiectasis, Pneumoconiosis Bronchial asthma, Cystic fibrosis Emphysema, Chronic pulmonary abscess, Pulmonary cancer
Interstitial fibrosis of the lung,
Fungal balls
Thyroid cysts, Adrenal cysts, Adrenal ade- Grave’s disease, Hashimoto’s disease (2nd stage), Thyroid cancer, Parathyroid cancer,
noma, Hypophyseal adenoma, Thymoma, Hashimoto’s disease (1st stage), Riedel’s thyroiditis, Parathyroid atrophy Adrenal cancer, Carcinoid syndrome Self regulation. Self-healing effects. Favourable Prognosis. Compensation. Tendency to aggravation. Doubtful Prognosis.
Insulinoma, Parathyroid gland adenoma, Puerpural thyroiditis, Cushing’s syndrome,
Thyroid goiter, Adrenal adenomas Precocious puberty, Adrenal exhaustion

8. CONNECT. TISSUE Increased secretion of metalloproteinases, Abscess, Reactive inflammatory response Lipoma, Storage of toxins in the matrix, Mixed connective tissue disease (MCTD), Scleroderma, Carbohydrate deficient Sarcoma
Increase in glycoprotein formation of the matrix, Tendinitis Amyloidosis, Mucopolysaccharidosis, Marfan’s syndrome, glycoprotein syndrome, Peyronie’s disease,
Periarthritis humeroscapularis calcinosa Ehlers-Danlos syndrome, Sphingolipidosis Progeria, Dupuytren’s contracture

9. OSTEODERMAL
Osteomyelitis, Chondroitis Osteophyte formation, Bone cysts Osteomalacia, Early osteoporosis Osteoporosis, Paget’s disease Osteosarcoma

1. Blood Leukocytosis neutrophila, Thrombocytosis, Polycytemia (reactive), Eosinophilia, Leukopenia, Anemia Aplastic anemia, Thrombocytopenia Leukemia

Fig. 3: Example for health evolution

Anemia related to acute infection Hypercoagulation (including anemia of chronic disorders), (including idiopathic thrombocyopaenic
MESENCHYMAL
10. HEMODERMAL

Hypercoagulation purpura), Pancytopenia, Vaquez’s disease

2. Heart Increased cardiac output, Tachycardia Myocarditis, Extrasystoles, Left ventricular hypertrophy, Angina pectoris, Atrial enlargement, Myocardial infarct, Ventricular arrhytmia, Sarcoma
Acute rheumatic fever Coronary atheroma Arrhytmia cordis, Rheumatic fever affecting Stenosis and insufficiency of the cardiac
the heart, Prolapse of the mitral valve valves
(Barlow’s syndrome), Cardiomyopathy
3. Vascular Increased production of Phlebitis, Arteritis, Venous stasis, Arterial plaques (atheroma), Vasculitis, Arteriosclerosis, Varicose veins, Peripheral vascular disease, Aneurysm, Angiosarcoma
endothelial mediators Endothelial inflammation Hemorrhoids Panarteritis nodosa, Angioma, Varicocele Arteritis obliterans

11. LYMPHODERMAL Increased lymph production Tonsillitis, Adenitis, Adenoiditis, Lymph edema, Lymph adenopathy, Indurated edema, Lymphatic tuberculosis, Elephantiasis Lymphoma (Hodgkin’s, Non Hodgkin’s),
Lymphangitis Tonsillar hypertrophy, Venerial lymphogranuloma, Lymphosarcoma
Adenoid hypertrophy Cat scratch disease
MESODERMAL

12. CAVODERMAL Increased synovial liquid, Arthritis, Polyarthritis, Synovitis, Hydrops (articular), Gouty tophi, Chronic arthritis, Reiter’s syndrome, Arthrosis, Ankylosing spondylitis Sarcoma, Chondrosarcoma
Cerebrospinal fluid Acute rheumatic disease Hemarthrosis Hydrocephaly, Spinal disc herniation

13. NEPHRODERMAL Frequent urination Nephritis, Glomerulonephritis, Pyelitis Nephrolithiasis, Renal cysts, Renal sand, Pre-clinical nephrosis, Nephrotic syndrome, Nephrosis, Chronic glomerulonephritis, Hypernephroma, Wilms’ tumor
Orthostatic albuminuria, Hematuria Chronic hematuria, Tuberculosis of the urogenital tract
Goodpasture’s syndrome,
Auto-immune glomerulonephritis

14. SERODERMAL

In these cases, the disease tends to evolve positively in the

Increased production of serous fluid Pleuritis, Peritonitis, Pericarditis Pleural effusion Chronic exsudative pleuritis and Pleural, pericardial and peritoneal Mesothelioma,
serositis, Ascites, Chronic pericarditis tuberculosis, Pleural adhesions Primary peritoneal carcinoma,
Primary pleural cancer

M Increased seminal fluid Prostatitis, Epididymitis, Orchitis Spermatocoele, Early benign prostatic Benign prostatic hyperplasia (BPH), Sterility Prostate cancer, Testicular cancer,
hyperplasia (BPH) Oligo asthenospermia Seminoma, Teratoma

ontogenetic and phylogenetic sense.

15. GERMINODERMAL

F Heavy menstruation Ovaritis, Adnexitis, Metritis, Dysmenorrhea Ovarian cysts, Uterine polyps, Chronic adnexitis, Amenorrhea Infertility, Ovarian atrophy Ovarial cancer, Ovarial teratoma
Uterine fibroids

16. MUSCULODERMAL Myalgia Myositis Myogelosis, Myositis ossificans Muscular asthenia, Muscular atrophy, Muscular dystrophy Myosarcoma
Mitochondrial myopathy,
Autoimmune dermatomyositis

Self regulation. Self-healing effects. Favourable Prognosis. Compensation. Tendency to aggravation. Doubtful Prognosis.
On the DET, we see an evolution of the patient’s history from
bottom towards the top and from right towards the left of
the table.
Fig. 2: Example for disease evolution

1 Smit A, O‘Byrne A, Van Brandt B, Bianchi I, Küstermann K.

Introduction to Bioregulatory Medicine. Stuttgart, Germany:
Thieme Publishers; 2009.