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ABSTRACT. The role of gynecology for transgender healthcare has traditionally been limited to
hysterectomy and oophorectomy in female-to-male transsexuals (FtM). But much more health issues
within the broad spectrum of gynecology are relevant for transsexuals of both sexes. From procreation to
cancer prevention, from genital health maintenance to pelvic floor disorders, from dyspareunia to libido
loss, gynecology may play a major role for healthcare maintenance of the transgender population.
In this article several gynecological aspects are highlighted with special attention to the context of
transsexualism. The lack of knowledge of gynecologists about the special needs of this population, and
in many countries a reserved attitude of doctors toward transgender persons, still is a limiting factor of
gynecological care for transgender persons.
238
Michael A. A. van Trotsenburg 239
functional problems and maintaining genital the perineo-scrotal flap used for lining the poste-
health. rior wall. These clots might lead to discharge and
This survey describes gynecological aspects infection, which can be prevented by epilation of
of transgender health care within the course the perineum and lower part of the scrotum in
of gender transition and thereafter. Cross-sex good time. Last but not least, lower urinary tract
hormonal treatment and its special requirements infections are more probable because the shape
are outside the scope of this article. of the opening of the shortened urethra is con-
structed in a gaping fashion in order to prevent
stenosis (Selvaggi et al., 2005).
MALE-TO-FEMALE In addition, MtFs may suffer from functional
disorders of the lower urinary tract caused by
To date the technique of choice for creating damage of the autonomous nerve supply of
a neovagina for transsexuals is the inverted pe- the bladder floor during dissection between the
nile skin flap technique (Monstrey, Selvaggi, & rectum and the bladder and due to a change
Ceulemans, 2007), mostly augmented by a pos- of the position of the bladder itself (Hoebeke
teriorly pedicled perineo-scrotal flap to ensure et al., 2005). Kuhn, Hiltebrand, and Birkhauser
a diameter of the neovagina suitable for inter- (2007) recently considered a dysfunctional blad-
course. Because the process of shrinkage of the der (e.g., overactive bladder and stress urinary
neovagina is inherent to the creation of this or- incontinence) quite normal after SRS.
gan, patients are instructed accurately by their
surgeons about matters of dilation in order to Intercourse After SRS
maintain diameter and length of the neovagina.
Some of those concerned do see the operation as In addition to emotional concerns about sex-
the last hurdle on a long path, and they refuse any uality as a female with newly created organs,
further medical care in order to give themselves and without any experience, anatomic facts also
the appearance of normality regarding their new complicate satisfying and painless intercourse.
gender. Due to the anatomy of the male pelvis, the axis
and the dimensions of the neovagina differ sub-
Hygiene stantially from a biologic vagina. The vaginal
axis from a biologic woman, measured from the
Many transsexuals do not know how to deal introitus to the pelvic diaphragm, is vertical and
with disorders of the newly created genital struc- posterior. The upper vagina changes its axis at
tures. Counseling about genital hygiene, sexu- the level of the pelvic diaphragm and becomes
ality, prevention of (sexually transmitted) gen- more horizontal (Barnhart et al., 2006). The axis
ital diseases, and possible clinical symptoms of the neovagina in MtFs is less vertical. The
of urogenital disorders should be offered rou- anatomic circumstances need to be known for
tinely after being released from postoperative satisfactory intercourse for both the transsexual
care. However, a heavy emotional strain is put female and a male sexual partner. During in-
on the (newly created) genital region, some- tercourse the erected penis might push against
times leading to overcompensation on genital the anterior wall of the vagina and against the
hygiene. gaping meatus of the urethra. Because the com-
Transsexuals are possibly more vulnerable to missura posterior is often pulled up, covering a
infections due to missing biologic barriers. Cre- substantial part of the introitus, penetration be-
ation of labia minora covering the introitus of comes more difficult, potentially causing pain
the neovagina is one of the most difficult parts of to the woman. A transsexual female should be
transgender surgery and this is often not created fully aware of the specific characteristics of the
or only allusive. Doederlein bacilli do not colo- constructed genital region. Information about
nize the epithelium of the neovagina creating a anatomy and functioning of the neovagina is
protective acid milieu, and mucus, dandruff, and a prerequisite for satisfying sexual intercourse.
sebum can be clotted around the hair follicles of (At least at the beginning) a transsexual female
240 INTERNATIONAL JOURNAL OF TRANSGENDERISM
needs to guide a sexual partner in order to make larly making it more difficult to judge prop-
it pleasant to both of them. Information from a erly standard imaging techniques. In that case
gynecologist or gynecological nurse may help mammography and ultrasound might be insuf-
bridge the gap between expectations and physi- ficient to detect small suspicious lesions. Mag-
cal opportunities. netic resonance imaging (MRI) may serve as an
alternative. There is a consistent and growing
Hormone-Sensitive Tissue body of evidence that adding MRI provides a
highly sensitive screening strategy (sensitivity
Supraphysiologic hormone therapy requires
range: 93–100%) compared to mammography
an increased observation of hormone-sensitive
alone (25–59%) or mammography plus ultra-
tissue. Posttransitionally, regular checkups at in-
sound with or without clinical breast examina-
tervals of one to two years constitute the mini-
tion (49–67%; Lalonde, David, & Trop, 2005;
mum requirement and must include genital ex-
Lord et al., 2007). In addition, it is worth men-
amination.
tioning that breast implants do not increase the
Breast risk for developing breast cancer or any other
malignancy (Lipworth et al., 2008).
Depending on the country of origin, 9–12% Summarizing, arguments for breast cancer
of all women will be given a diagnosis of breast screening of transsexuals are by no means ro-
cancer in their lifetimes and 3.5% will die of bust enough to be recommended. However, dis-
the disease. Breast cancer in males is rare but crepancies between the general population and
increasing and constitutes 0.2–1.5% of all ma- transsexuals regarding the incidence of breast
lignant tumors in men and 1% of all breast can- cancer is worrying. Transsexuals should always
cers. Additionally men with breast cancer are be informed that they might be at risk for breast
significantly at risk for a second cancer (Bagchi, cancer. If a suspicious mass is detected by self-
2007). examination or by any imaging technique, exci-
Surprisingly, only casuistic reports on breast sion should be recommended imperatively.
carcinomas in MtFs after long-term hormone
substitution have been published. In view of the Prostate
supraphysiological hormone treatment and bear-
ing in mind that most breast cancers are estrogen- Prostatectomy is not part of the recommended
and/or progesterone-receptor positive, from an surgical procedures of SRS, because prostate-
oncologic point of view a higher percentage of ctomy shows substantial morbidity. Therefore,
breast cancer in transsexuals would be expected digital rectal examination of the prostate in pa-
(Gooren, Giltay, & Bunck, 2008). Is breast can- tients older than 50 years should be manda-
cer underreported for transsexuals? Or will the tory, preferably at the start of cross-sex hor-
incidence start to rise as the occult cancers reveal monal treatment. If the prostate is enlarged or
themselves later and MtFs get older? a lump palpable, patients should be referred to a
Breast cancer screening is very much in de- urologist for further examination; for example,
bate (Jorgensen, Klahn, & Gotzsche, 2007). In prostate-specific antigen (PSA) screening and
populations where there are screening programs, eventually an ultrasound-guided biopsy. Cross-
these provide early detection of malignancies re- sex hormone treatment usually leads to hypotro-
sulting in 25% lower mortality rates. These gains phy of the prostate but not always. It is of note
must be weighed against the losses of expense, that PSA screening in MtFs under anti-androgen
radiation, and false-positive diagnoses with their treatment is not valid.
accompanying anxiety and investigations. For older males, benign prostatic hyperpla-
Transsexuals often have implants mostly sia (BPH) is a common finding and cancer of
placed behind the pectoral muscle because the prostate is not rare. For MtFs, lower urinary
hormone-induced gynecomastia has not resulted tract symptoms are less often reported and only
in subjectively satisfying enlargement. Some- some singular case reports have been published.
times breast prostheses are placed subglandu- As a result of cross-sex hormonal treatment
Michael A. A. van Trotsenburg 241
the prostate is hardly palpable and shrunk from ways be prevented by condom use because HPV
a chestnut-shaped organ to a cherry-sized or- can be transmitted also from infected skin adja-
gan or even smaller. However, there is increas- cent to genital mucosa (Winer et al., 2006).
ing evidence that estrogen and estrogen recep- The association of HPV high risk types and
tors play an important role in the pathogenesis anogenital cancers, as well as cancers of the
of prostate cancer (Bonkhoff & Berges, 2008). mouth, the upper respiratory tract, and skin,
Therefore, after SRS, examination of the female especially of the fingers and periungual re-
genital region should always include palpation gion, is well established. Parallel to the rising
of the prostate, especially in MtFs who started prevalence of HPV infection, increased num-
cross-sex hormone therapy beyond the age bers of high-grade dysplasia and cancer of the
of 50. vulva and the vagina among younger women
have been reported (Joura, 2002; Joura, Losch,
Human Papilloma Virus Infection Haider-Angeler, Breitenecker, & Leodolter,
(for FtM and MtF) 2000).
Ample evidence exists that cancers of the
Infection of the genital tract in both men colon, rectum, and anus are significantly asso-
and women is most frequently caused by her- ciated with high-risk serotypes, especially HPV
pes simplex virus (HSV) types 1 and 2, human 16, and can be considered as a consequence of
papilloma viruses (HPV), with approximately sexually or otherwise acquired infection in the
40 anogenital types, and Chlamydia trachoma- anal mucosa (Damin et al., 2007; Frisch, 2002).
tis and has risen to epidemic levels. Sexual behaviors and several case reports about
HPV infections lead to anogenital cancer in dysplasia and cancer of the genital region of
approximately 1 out of 100 of those infected, in transgender persons make it plausible to suggest
particular cervical cancer. Obviously, prevention an equally high risk compared to the general pop-
of severe cervical dysplasia or cervical cancer is ulation (Harder, Erni, & Banic, 2002; Lawrence,
no issue for the transgender population. How- 2001). Therefore, regular gynecologic examina-
ever, a case report of a transsexual with cervical tion of the neovagina originated either from pe-
cancer has been published (Driák, 2004; Driák & nile epithelium or a sigmoid colon segment and
Samudovský, 2005). Additionally, accidental all adjacent tissue is strongly recommended.
detection of cervical stumps left in situ causes Prevention of HPV-associated dysplasia or
concern: Supracervical hysterectomy is becom- cancer is increasingly recognized. The prospects
ing increasingly popular because it is a simple, for prophylactic HPV vaccines are extremely
time-sparing technique with suggested, but so promising. The potential benefits of vaccination
far not proven, less negative impact on sexu- to reduce the burden of recurrent respiratory pa-
ality and the pelvic floor. Patients are not al- pillomatosis and cancers of the vagina, vulva,
ways aware that a cervical stump is left behind cervix, anus, penis, and head/neck have urged
that warrants cytological screening. Although many countries to approve programs to vacci-
supracervical hysterectomy has significant ad- nate young girls between 9 and 16 years of age
vantages in terms of technical simplification and and young women between 16 and 26 years of
quicker postoperative recovery, this technique is age. Many experts feel that boys and young men
not suitable for FtMs. Due to considerable vagi- should also be vaccinated. To date HPV vacci-
nal atrophy and obvious emotional restraints, the nation of HPV-seronegative transsexuals is not
cervix left behind is not easily accessible for car- promoted. However, if the indication for vacci-
rying out a pap smear. nation is extended to adults, transsexuals will
Epidemiological data confirm the fact that certainly benefit.
women who do not attend to organized cytolog- Many (European) transsexuals still do smoke.
ical screening have a much higher prevalence Unfortunately, HPV and smoking do multiply
of oncogenic HPV types than the general popu- the risks for several cancers. Progression of
lation (Stenvall, Wikstrom, & Wilander, 2007). dysplasia likewise seems to be associated with
Furthermore, genital HPV infection cannot al- smoking (Moore et al., 2001).
242 INTERNATIONAL JOURNAL OF TRANSGENDERISM
considering gynecological examination immedi- cept of the SRS of FtMs and have gained substan-
ately prior to surgery during narcosis, provided tial experience with this procedure. However,
that informed consent has laid down proceedings vaginectomy is still not part of the routine proce-
in case of detection of any unexpected (malig- dure and is fraught with problems, for instance,
nant) disorder. major intraoperative bleeding or rectum or blad-
Hysterectomy and BSO preferably should be der perforation. Undoubtedly, morbidity caused
performed (laparoscopically assisted) vaginally by radical vaginectomy for oncologic purposes
or as a total laparoscopic procedure. Gynecolo- will be judged different from vaginectomy per-
gists familiar with these modern techniques are formed in healthy young patients suffering from
widespread in every country but so far are not gender dysphoria. That is why vaginectomy
available in every hospital. Laparotomy with a should be indicated only if complaints are sub-
stigmatizing (Pfannenstiel) incision should be stantial. In addition, one should bear in mind that
abandoned for routine FtM hysterectomy and parts of the vaginal lining can be used for metoid-
BSO. Laparotomy should only be performed ioplasty (Hage, 1996), and not every FtM suffers
with special indications due to relevant intraab- from substantial vaginal discharge. Last but not
dominal morbidity or to solve surgical compli- least, not every FtM is at loggerheads with the
cations. vagina.
If postoperative histopathological workup re- To our knowledge, no paper has been pub-
veals cervical intraepithelial neoplasia (CIN) III lished about the special conditions of vaginec-
lesions or cervical carcinoma in situ (Cis), there tomy in transsexuals or the results of vaginec-
is clear evidence that follow-up of the vaginal tomies in terms of patient satisfaction. Personal
vault must be maintained, including pap smears experience shows that removal of the vagina is
of the vagina and eventually vaginoscopy with a highly appreciated by FtMs. Complications af-
colposcope. Dysplasia of the cervix potentially terwards did not even lead to a negative attitude
spreads to the fornices of the vagina. If no sus- towards this procedure. For example, vaginec-
picious lesions are detected, there is no rationale tomy leads to distraught innervations of the blad-
for routine follow-up of the vagina (Mouithys der floor, potentially causing temporarily loss of
et al., 2003). detrusor sensation and incomplete emptying of
the bladder. However, these complications are
Vaginectomy restored within days.
Vaginectomy can be performed during the
In general, only early stages of primary vagi- same surgical session of hysterectomy and BSO,
nal cancer, and by way of exception vaginal in- either abdominally or vaginally. However, this
traepithelial neoplasia (VaIN) stage III lesions extension is yet not recommended and is only
occupying the entire vagina, give an indication done by exception (Ergeneli, Duran, Ozcan, &
for total vaginectomy. VaIN often accompanies Erdogan, 1999). Techniques are under debate
CIN or may be extensions into the vagina from to remove the upper parts of the vagina dur-
CIN. Both lesions are triggered by HPV high- ing hysterectomy laparoscopically. This proce-
risk serotypes. However, vaginal carcinoma and dure requires much more expertise than a simple
its premalignant phase, VaIN III, are rare condi- straightforward laparoscopic hysterectomy be-
tions. Beyond gynecologic oncology, sex reas- cause distal ureter preparation is difficult and
signment surgery may be another indication for challenging. More often, vaginectomy is per-
total vaginectomy. formed together with a reconstruction of the
FtMs increasingly ask for vaginectomy, fixed part of the urethra.
either to get rid of an organ with an indisputable Androgen treatment often, but not always,
female connotation or due to complaints derived causes considerable changes of the vulva,
from vaginal discharge, especially associated vagina, and urethra, comparable to the senile at-
with sexual arousal. Some gender teams (e.g., rophic status of postmenopausal women. Symp-
Ghent/Belgium and Amsterdam/The Nether- toms, from pruritus to incontinence, are often
lands) have integrated vaginectomy into the con- present but complaints are regularly suppressed.
244 INTERNATIONAL JOURNAL OF TRANSGENDERISM
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