Classification Labelling of Chemicals (CLP) - Grant Maloney FIIRSM - 0

qwertyuiopasdfghjklzxcvbnmqwertyuiopasdfghjklzxc
vbnmqwertyuiopasdfghjklzxcvbnmqwertyuiopasdfgh
jklzxcvbnmqwertyuiopasdfghjklzxcvbnmqwertyuiop
Classification & Labelling of
Chemicals (CLP)
asdfghjklzxcvbnmqwertyuiopasdfghjklzxcvbnmqwert
Compatibility & Conversion
yuiopasdfghjklzxcvbnmqwertyuiopasdfghjklzxcvbnm
(V1 R2)
16/03/2012
qwertyuiopasdfghjklzxcvbnmqwertyuiopasdfghjklzxc
Grant Maloney CMIOSH, FIIRSM
vbnmqwertyuiopasdfghjklzxcvbnmqwertyuiopasdfgh
jklzxcvbnmqwertyuiopasdfghjklzxcvbnmqwertyuiop
asdfghjklzxcvbnmqwertyuiopasdfghjklzxcvbnmqwert
yuiopasdfghjklzxcvbnmqwertyuiopasdfghjklzxcvbnm
rtyuiopasdfghjklzxcvbnmqwertyuiopasdfghjklzxcvbn
mqwertyuiopasdfghjklzxcvbnmqwertyuiopasdfghjklz
xcvbnmqwertyuiopasdfghjklzxcvbnmqwertyuiopasdf
ghjklzxcvbnmqwertyuiopasdfghjklzxcvbnmqwertyui
opasdfghjklzxcvbnmqwertyuiopasdfghjklzxcvbnmqw
ertyuiopasdfghjklzxcvbnmqwertyuiopasdfghjklzxcvb
nmqwertyuiopasdfghjklzxcvbnmqwertyuiopasdfghjkl
zxcvbnmrtyuiopasdfghjklzxcvbnmqwertyuiopasdfghj
klzxcvbnmqwertyuiopasdfghjklzxcvbnmqwertyuiopa
sdfghjklzxcvbnmqwertyuiopasdfghjklzxcvbnmqwerty
uiopasdfghjklzxcvbnmqwertyuiopasdfghjklzxcvbnmq
wertyuiopasdfghjklzxcvbnmqwertyuiopasdfghjklzxcv
bnmqwertyuiopasdfghjklzxcvbnmqwertyuiopasdfghj
klzxcvbnmqwertyuiopasdfghjklzxcvbnmqwertyuiopa
2
INDEX
 FORWARD ENVIRONMENTAL HAZARDS

 CHEMICALS HAZARD INFORMATION AND PACKAGING FOR SUPPLY
REGULATIONS: CHIP4  ACUTE AQUATIC TOXICITY
 CHRONIC AQUATIC TOXICITY
 REGISTRATION, EVALUATION AND AUTHORISATION OF  OZONE LAYER
CHEMICALS: (REACH)
 HAZARD STATEMENTS
 CONTROL OF SUBSTANCES HAZARDOUS TO HEALTH (COSHH)
 HAZARD STATEMENTS ADDITIONAL CODES & LABELLING
 ABBREVIATIONS
 RISK PHRASES  PRECAUTIONARY STATEMENTS
 SAFETY PHRASES
 EU DIRECTIVES
 GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND  GLOSSARY

LABELLING OF CHEMICALS (GHS)
 GLOBAL GHS INITIATIVES
 CLASSIFICATION, LABELLING AND PACKAGING REGULATIONS -
 BIBLIOGRAPHY
(CLP)
 DISCLAIMER
 SAFETY DATA SHEETS
PHYSICAL HAZARDS
EXPLOSIVES
FLAMMABLE GASES
FLAMMABLE AEROSOLS
OXIDIZING GASES
GASES UNDER PRESSURE
FLAMMABLE LIQUIDS
FLAMMABLE SOLIDS
SELF-REACTIVE SUBSTANCES
PYROPHORIC LIQUIDS AND SOILIDS
SELF-HEATING SUBSTANCES
SUBSTANCES WHICH IN CONTACT WITH WATER EMIT
OXIDIZING LIQUIDS AND SOLIDS

ORGANIC PEROXIDES
SUBSTANCES CORROSIVE TO METAL
HEALTH HAZARDS
ACUTE TOXICITY
SKIN CORROSION
SKIN IRRITATION
EYE EFFECTS
SENSITIZATION
GERM CELL MUTAGENICITY
CARCINOGENICITY
REPRODUCTIVE TOXICITY
TARGET ORGAN SYSTEMIC TOXICITY: SINGLE EXPOSURE
TARGET ORGAN SYSTEMIC TOXICITY: REPEATED EXP
ASPIRATION TOXICITY
Created and Compiled by Grant Maloney – CMIOSH, FIIRSM, FInstLM, FISQEM, MIET Dated March 2012 http://uk.linkedin.com/pub/grant-maloney/30/a30/b67
3
FORWARD
Initially this document started life as a project for my own Continual

Professional Development (CPD)! Whilst it very much remained a work in
progress I discovered that many of my peers requested copies of the
document; therefore, I have made this document freely available to all
other like minded professionals in the hope that it could form an ideal
base for further learning and understanding of the subject matter.
This document has been created and assembled from other freely
available information on the World Wide Web and therefore much of the
information contained within was not created by me. The only credit I
can honestly accept is for time and patience in compiling and formatting
the information so that it is decipherable.
Please remember that this manuscript is not intended to be a definitive

guide, for this you must refer to the Regulations, Statutes and Directives.
Please feel free to comment at the LinkedIn profiles listed in the footer,
constructive comments only please?
Enjoy!
Many Thanks
Grant Maloney
4
The (Chemicals Hazard Information and REACH - Registration, Evaluation and

Packaging for Supply) Regulations: CHIP4 Authorisation of Chemicals
Definition Definition
CHIP - The Chemical (Hazard Information and Packaging for Supply) Regulations EC 1907/2006, Registration, Evaluation and Authorisation of Chemicals (REACH)
provide information on hazardous chemicals in Great Britain. These regulations are a European Union regulation concerning chemicals and their safe uses. REACH
are designed to comply with various European Union (EU) directives relating to is designed to protect human health and the environment by identifying the
the supply of dangerous chemicals. properties of chemicals before they are used commercially.
CHIP has been amended on a regular basis since it was first adopted as the REACH is a European system. It is a direct-acting Regulation, not a Directive, and is
Chemicals (Hazard Information and Packaging for Supply) Regulations in 1994. managed centrally by the new European Chemicals Agency (ECHA)
Therefore, one may see references to CHIP 96, 98, 99 etc. The latest version of
CHIP revoked all previous versions, so rely only on the latest version of CHIP REACH is a single system that replaced approximately 40 other European
(currently 2009, also known as CHIP4) when planning your regulatory compliance. Directives and Regulations. The legislation took effect June 1, 2007, with phase-in
of various components continuing through June 1, 2009 and beyond.
The CHIP regulations will gradually be replaced by the European Regulation on
Classification, Labelling and Packaging of Substances and Mixtures (known as the REACH repeals some parts of the existing European system for investigating and
CLP Regulation, (EC) No 1272/2008) which is the EU's implementation of the controlling chemical hazards, predominantly the Existing and New Substances
Globally Harmonised System on the Classification and Labelling of Chemicals regimes (known as ESR and NONS), and replaces these initiatives. It also leaves
(GHS). others in place, particularly the Chemical Agents Directive (CAD), under which the
Carcinogens and Mutagens Directive (CMD) was made.
Additional Info
COSHH implements CAD and CMD, neither of which is repealed by REACH or CLP.
CHIP4 (2009) no longer addresses Material Safety Data Sheets (SDS's); those COSHH will subsequently remain substantially in place.
regulations have become part of the European REACH regulation.
Additional Info
CHIP4 regulations require the supplier of a dangerous chemical to:
REACH has several goals:
 Identify the hazards (dangers) of the chemical. This
process is called "classification".  A "high level of protection" for human health and the
 Provide information about the hazards to their environment from risks that can be posed by chemicals.
customers. This information is usually provided on the  Enhance the competitiveness of the EU chemicals industry.
package/label.  Ensure a smoothly functioning market with regulations that do
 Package the material safely. not vary significantly among the EU member states.
 Have substances of high concern eventually replaced by less
dangerous substances or technologies where economically and
technically viable.
Under REACH, all manufacturers and importers of chemicals must identify and
manage risks linked to the substances they manufacture and market. For REACH requires manufacturers and importers of substances to register them with
substances produced or imported in quantities of 1 tonne or more per year per the European Chemicals Agency (ECHA). ECHA manages the registration,
company, manufacturers and importers need to demonstrate that they have evaluation, authorization and restriction processes for chemical substances to
appropriately done so by means of a registration dossier which they must submit ensure their safe use as well as the competitiveness of European industry. ECHA
to ECHA. began accepting registrations June 1, 2008.
Not all substances are covered by REACH. Examples of exempted items include
radioactive substances, non-isolated intermediates, and waste. While REACH is
designed not to overlap or conflict with other chemical legislation, there are
certain classes of materials that are covered by REACH under certain
circumstances or with tailored provisions.
MSDS Relevance
Manufacturers and importers in the European Union must provide their

downstream users with the risk information they need to use the substance
safely. This is accomplished via the classification and labelling system and Safety
Data Sheets (SDS). See REACH and GHS for more information.
5
SAFETY DATA SHEETS
The safety data sheet shall include the following 16 headings in accordance with SECTION 12: Ecological information
Article 31. The 16 section of the MSDS 12.1. Toxicity
12.2. Persistence and degradability
COMMISSION REGULATION (EU) No 453/2010 of 20 May 2010 amending 12.3. Bio accumulative potential
Regulation (EC) No 1907/2006 of the European Parliament and of the Council on 12.4. Mobility in soil
the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) 12.5. Results of PBT and v PvB assessment
12.6. Other adverse effects
PART B
The safety data sheet shall include the following 16 headings in accordance with
SECTION 13: Disposal considerations
Article 31 and in addition the subheadings also listed except Section 3, where only
13.1. Waste treatment methods
subsection 3.1 or 3.2 need to be included as appropriate:
SECTION 14: Transport information
SECTION 1: Identification of the substance/mixture and of the
14.1. UN number
company/undertaking 14.2. UN proper shipping name
1.1. Product identifier 14.3. Transport hazard class(es)
1.2. Relevant identified uses of the substance or mixture and uses advised 14.4. Packing group
against 14.5. Environmental hazards
1.3. Details of the supplier of the safety data sheet 14.6. Special precautions for user
1.4. Emergency telephone number 14.7. Transport in bulk according to Annex II of MARPOL73/78 and the IBC
Code
SECTION 2: Hazards identification
2.1. Classification of the substance or mixture SECTION 15: Regulatory information
2.2. Label elements 15.1. Safety, health and environmental regulations/legislation specific for
2.3. Other hazards the substance or mixture
15.2. Chemical safety assessment
SECTION 3: Composition/information on ingredients
3.1. Substances SECTION 16: Other information
3.2. Mixtures
SECTION 4: First aid measures

4.1. Description of first aid measures
4.2. Most important symptoms and effects, both acute and delayed
4.3. Indication of any immediate medical attention and special treatment
needed
SECTION 5: Fire fighting measures

5.1. Extinguishing media
5.2. Special hazards arising from the substance or mixture
5.3. Advice for fire-fighters
SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency
procedures
6.2. Environmental precautions
6.3. Methods and material for containment and cleaning up
6.4. Reference to other sections
SECTION 7: Handling and storage

7.1. Precautions for safe handling
7.2. Conditions for safe storage, including any incompatibilities
7.3. Specific end use(s)
SECTION 8: Exposure controls/personal protection

8.1. Control parameters
8.2. Exposure controls
SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties
9.2. Other information
SECTION 10: Stability and reactivity

10.1. Reactivity
10.2. Chemical stability
10.3. Possibility of hazardous reactions
10.4. Conditions to avoid
10.5. Incompatible materials
10.6. Hazardous decomposition products
SECTION 11: Toxicological information

11.1. Information on toxicological effects
6
Control of Substances Hazardous To Health Regulations 2002 -

COSHH
Definition The COSHH 2002 regulations are complementary to the Chemicals (Hazard
Information and Packaging for Supply) Regulations 2009 (CHIP4) which require
The Control of Substances Hazardous to Health Regulations 2002 is a United labelling of hazardous substances by suppliers.
Kingdom Statutory Instrument that stipulates general requirements on employers
to protect employees and other persons from the hazards of substances used at CHIP4 implements the SDS Directive (already repealed by REACH), and aspects of
work by risk assessment, control of exposure, health surveillance and incident the Dangerous Substances Directive (DSD) and the Dangerous Preparations
planning. There are also duties on employees' to take care of their own exposure Directive (DPD), both of which will be repealed by CLP. CHIP4 is being amended
to hazardous substances and prohibitions on the import of certain substances into to reflect the REACH changes, and later will be completely repealed as a result of
the European Economic Area. CLP.
Additional Info As COSHH is wider in scope than REACH (E.g. covering substances such as welding
fumes, and wood and flour dust), and because it places valuable importance on
Employer compliance with COSHH requires eight steps: employers’ responsibility to assess and manage risks to workers, it is beneficial to
 Assess the risks from hazardous substances in your the health and safety of employees that COSHH remains in place. REACH will
workplace. complement COSHH by providing more information for duty holders to use in
assessing and controlling risk.
 Determine what precautions are needed.
 Prevent or "adequately" control exposure. SDS
 Ensure that control measures are used and maintained.
 Monitor employee exposure to hazardous substances. Substances to which COSHH applies will require an appropriate warning label and
 Carry out appropriate health surveillance. SDS per REACH regulations. Much of the information that employers require for
 Prepare plans and procedures to deal with accidents, COSHH compliance can be found in the SDS's. (This was previously covered in
incidents and emergencies CHIP regulations).
 Ensure employees are properly informed, trained, and
Hazard Warnings
supervised.
Symbol Hazard
These regulations not only prevent injuries to employees, but can also improve
productivity, reduce accidents, and lessen legal/regulatory liabilities. Like most
workplace safety regulations, they benefit employers and employees alike.
Very Toxic
Under the regulations, a Substance Hazardous to Health is any of the following: Toxic
Carcinogenic category 1
 Any substance classified as dangerous to health under CHIP
regulations. These will have ratings of T+ (very toxic), T Carcinogenic category 2
(toxic), X (harmful), C (corrosive), or XI (irritant) under CHIP. Mutagen category 1
 Substances with workplace exposure limits listed in the HSE Mutagen category 2
publication EH40/2005 Workplace exposure limits.
Reproductive Toxin Cat 1
 Biological agents that are directly connected with or
incidental to the work. Examples include exposures from Reproductive Toxin Cat 2
sewage treatment or air conditioning systems.
 Any kind of dust if it exceeds COSHH concentration limits. Harmful
 Any other substance which creates a risk to health but isn't
Irritant
specifically covered by CHIP. Examples include asphyxiates,
pesticides, cosmetics, and medicines. Carcinogenic category 3
Mutagen category 3
Substances not "hazardous to health" under COSHH include:
Reproductive Toxin Cat 3
 Substances with their own regulations, such as asbestos and
lead. Extremely Flammable
 Substances which are hazardous only because they are Flammable
radioactive, at high pressure, at extreme temperature, have
explosive or flammable properties, or are biological agents
outside the employer's control (infectious diseases, for
Corrosive
example).
Breach of the regulations by an employer or employee is a crime, punishable on

summary conviction with a fine of up to £400. If convicted on indictment in the
Crown Court, an offender can be sentenced to an unlimited fine. Either an Oxidising
individual or a corporation can be punished and sentencing practice is published
by the Sentencing Guidelines Council. Enforcement is the responsibility of the
Health and Safety Executive or in some cases, local authorities.
Explosive
Where a person suffers damage caused by a breach of a duty imposed by
regulations, they have a cause of action in tort against the offender.
Dangerous to the Environment
7
COSHH Abbreviations & Brief Description
Symbol Abbrev Hazard Description of hazard Symbol Abbrev Hazard Description of hazard
Repr category 1 Chemicals that produce or increase the incidence of

(Physicochemical) Cat 1 reproductive non-heritable effects in progeny and/or impairment in
toxins reproductive functions or capacity.
E explosive Chemicals that explode.

Repr category 2
Cat 2 reproductive
toxins
O oxidising Chemicals that react exothermically with other

chemicals. Repr category 3
Cat 3 reproductive
toxins
F+ extremely Chemicals that have an extremely low flash point and

flammable boiling point, and gases that catch fire in contact with
air. Xn harmful Chemicals that may cause damage to health.
F highly Chemicals that may catch fire in contact with air, only
flammable need brief contact with an ignition source, have a very C corrosive Chemicals that may destroy living tissue on contact.
low flash point or evolve highly flammable gases in
contact with water.
Xi irritant Chemicals that may cause inflammation to the skin or

(Health) other mucous membranes.
T+ very toxic Chemicals that at very low levels cause damage to

health. (Environmental)
T toxic Chemicals that at low levels cause damage to health. N dangerous Chemicals that may present an immediate or delayed
for the danger to one or more components of the environment
environment
Carc Cat 1 category 1 Chemicals that may cause cancer or increase its
carcinogens incidence.
Carc Cat 2 category 2

carcinogens
Carc Cat 3 category 3

carcinogens
Muta Cat category 1 Chemicals that induce heritable genetic defects or

1 mutagens increase their incidence.
Chemicals that induce heritable genetic defects or

increase their incidence.
Chemicals that induce heritable genetic defects or

increase their incidence.
Muta Cat category 2

2 mutagens
Muta Cat category 3

3 mutagens
8
Risk Phrases
R39/27 Very Toxic: danger of very serious irreversible effects in contact with skin T+
Risk phrase DESCRIPTION OF HAZARD Abr R39/27/28 Very Toxic: danger of very serious irreversible effects in contact with skin and T+
if swallowed
R1 Explosive when dry N R39/28 Very Toxic: danger of very serious irreversible effects if swallowed T+
R2 Risk of explosion by shock, friction, fire or other sources of ignition N R40 Limited evidence of a carcinogenic effect Xn
R3 Extreme risk of explosion by shock, friction, fire or other sources of ignition N R41 Risk of serious damage to eyes Xn
R4 Forms very sensitive explosive metallic compounds N R42 May cause sensitisation by inhalation Xn
R5 Heating may cause an explosion N R43 May cause sensitisation by skin contact Xn
R42/43 May cause sensitisation by inhalation and skin contact Xn
R6 Explosive with or without contact with air N
R44 Risk of explosion if heated under confinement E
R7 May cause fire F R45 May cause cancer CC3
R8 Contact with combustible material may cause fire F R46 May cause heritable genetic damage MC3
R9 Explosive when mixed with combustible material E R48 Danger of serious damage to health by prolonged exposure Xn
R10 Flammable F R48/20 Harmful: danger of serious damage to health by prolonged exposure through Xn
R11 Highly flammable F+ inhalation
R12 Extremely flammable O R48/20/21 Harmful: danger of serious damage to health by prolonged exposure through Xn/Xi
R14 Reacts violently with water O inhalation and in contact with skin
R14/15 Reacts violently with water, liberating extremely flammable gases O/F R48/20/21/22 Harmful: danger of serious damage to health by prolonged exposure through Xn/Xi
R15 Contact with water liberates extremely flammable gases F inhalation, in contact with skin and if swallowed
R15/29 Contact with water liberates toxic, extremely flammable gases F+ R48/20/22 Harmful: danger of serious damage to health by prolonged exposure through Xn/Xi
R16 Explosive when mixed with oxidising substances N inhalation and if swallowed
R17 Spontaneously flammable in air F+ R48/21 Harmful: danger of serious damage to health by prolonged exposure in contact Xn/Xi
R18 In use, may form flammable/explosive vapour-air mixture F+ with skin
R19 May form explosive peroxides N R48/21/22 Harmful: danger of serious damage to health by prolonged exposure in contact Xn/Xi
R20 Harmful by inhalation Xn with skin and if swallowed
R20/21 Harmful by inhalation and in contact with skin Xn/Xi R48/22 Harmful: danger of serious damage to health by prolonged exposure if Xn
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed Xn/Xi swallowed
R20/22 Harmful by inhalation and if swallowed Xn/Xi R48/23 Toxic: danger of serious damage to health by prolonged exposure through T
R21 Harmful in contact with skin Xi inhalation
R21/22 Harmful in contact with skin and if swallowed Xn/Xi R48/23/24 Toxic: danger of serious damage to health by prolonged exposure through T
R22 Harmful if swallowed Xn inhalation and in contact with skin
R23 Toxic by inhalation T R48/23/24/25 Toxic: danger of serious damage to health by prolonged exposure through T
R23/24 Toxic by inhalation and in contact with skin T inhalation, in contact with skin and if swallowed
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed T R48/23/25 Toxic: danger of serious damage to health by prolonged exposure through T
R23/25 Toxic by inhalation and if swallowed T inhalation and if swallowed
R24 Toxic in contact with skin T R48/24 Toxic: danger of serious damage to health by prolonged exposure in contact T
with skin
R24/25 Toxic in contact with skin and if swallowed T
R25 Toxic if swallowed T R48/24/25 Toxic: danger of serious damage to health by prolonged exposure in contact T
with skin and if swallowed
R26 Very toxic by inhalation T+
R48/25 Toxic: danger of serious damage to health by prolonged exposure if T
R26/27 Very toxic by inhalation and in contact with skin T+
swallowed
R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed T+ R49 May cause cancer by inhalation CC
R26/28 Very toxic by inhalation and if swallowed T+ R50 Very toxic to aquatic organisms N
R27 Very toxic in contact with skin T+ R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the N
R27/28 Very toxic in contact with skin and if swallowed T+ aquatic environment
R28 Very toxic if swallowed T+ R51 Toxic to aquatic organisms N
R51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic N
R29 Contact with water liberates toxic gas T
environment
R30 Can become highly flammable in use F
R52 Harmful to aquatic organisms N
Risk phrase DESCRIPTION OF HAZARD Abr R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in the N
aquatic environment
R31 Contact with acids liberates toxic gas T R53 May cause long-term adverse effects in the aquatic environment N
R54 Toxic to flora N
R32 Contact with acids liberates very toxic gas T+
R33 Danger of cumulative effects Xn R55 Toxic to fauna N
R56 Toxic to soil organisms N
R34 Causes burns Xn
R35 Causes severe burns Xn R57 Toxic to bees N
R58 May cause long-term adverse effects in the environment N
R36 Irritating to eyes Xi
R59 Dangerous for the ozone layer N
R36/37 Irritating to eyes and respiratory system Xi
R60 May impair fertility MC /
R36/37/38 Irritating to eyes, respiratory system and skin Xi
RC
R36/38 Irritating to eyes and skin Xi
R61 May cause harm to the unborn child MC /
R37 Irritating to respiratory system Xi
RC
R37/38 Irritating to respiratory system and skin Xi
R62 Possible risk of impaired fertility MC /
R38 Irritating to skin Xi
RC
R39 Danger of very serious irreversible effects
R63 Possible risk of harm to the unborn child MC /
R39/23 Toxic: danger of very serious irreversible effects through inhalation T
RC
R39/23/24 Toxic: danger of very serious irreversible effects through inhalation and in T
R64 May cause harm to breast-fed babies MC /
contact with skin
RC
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in T
R65 Harmful: may cause lung damage if swallowed Xn
contact with skin and if swallowed
R66 Repeated exposure may cause skin dryness or cracking Xn
R39/23/25 Toxic: danger of very serious irreversible effects through inhalation and if T
R67 Vapours may cause drowsiness and dizziness Xn
swallowed
R68 Possible risk of irreversible effects Xn/Xi
R39/24 Toxic: danger of very serious irreversible effects in contact with skin T
R68/20 Harmful: possible risk of irreversible effects through inhalation Xn/Xi
R39/24/25 Toxic: danger of very serious irreversible effects in contact with skin and if T
R68/20/21 Harmful: possible risk of irreversible effects through inhalation and in contact Xn/Xi
swallowed
with skin
R39/25 Toxic: danger of very serious irreversible effects if swallowed T
R68/20/21/22 Harmful: possible risk of irreversible effects through inhalation, in contact with Xn/Xi
R39/26 Very Toxic: danger of very serious irreversible effects through inhalation T+
skin and if swallowed
R39/26/27 Very Toxic: danger of very serious irreversible effects through inhalation and T+
R68/20/22 Harmful: possible risk of irreversible effects through inhalation and if Xn/Xi
in contact with skin
swallowed
R39/26/27/28 Very Toxic: danger of very serious irreversible effects through inhalation, in T+
R68/21 Harmful: possible risk of irreversible effects in contact with skin Xn/Xi
contact with skin and if swallowed
R68/21/22 Harmful: possible risk of irreversible effects in contact with skin and if Xn/Xi
R39/26/28 Very Toxic: danger of very serious irreversible effects through inhalation and T+
swallowed
if swallowed
R68/22 Harmful: possible risk of irreversible effects if swallowed Xn/Xi
9
Safety Phrases
S1 Keep locked up S47/49 Keep only in the original container at temperature not exceeding..OC (to be specified by
S1/2 Keep locked up and out of the reach of children the manufacturer)
S2 Keep out of the reach of children S48 Keep wet with. appropriate material to be specified by the Manufacturer)
S3 Keep in a cool place S49 Keep only in the original container
S3/7 Keep container tightly closed in a cool place S50 Do not mix with ... (to be specified by the manufacturer)
S3/7/9 Keep container tightly closed in a cool, well-ventilated place S51 Use only in well-ventilated areas
S3/9/14 Keep in a cool, well-ventilated place away from .(incompatible materials to be S52 Not recommended for interior use on large surface areas
indicated by the manufacturer) S53 Avoid exposure - obtain special instructions before use
S3/9/14/49 Keep only in the original container in a cool, well-ventilated place away from S56 Dispose of this material and its container at hazardous or special waste collection point
(incompatible materials to be indicated by the manufacturer. S57 Use appropriate containment to avoid environmental contamination
S3/9/49 Keep only in the original container in a cool, well-ventilated place S59 Refer to manufacturer/supplier for information on recovery/recycling
S3/14 Keep in a cool place away from .(incompatible materials to be indicated by the S60 This material and its container must be disposed of as hazardous waste
manufacturer) S61 Avoid release to the environment. Refer to special instructions/safety data sheet
S4 Keep away from living quarters S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this
S5 Keep contents under ... (appropriate liquid to be specified by the manufacturer) container or label
S6 Keep under ... (inert gas to be specified by the manufacturer) S63 In case of accident by inhalation: remove casualty to fresh air and keep at rest
S7 Keep container tightly closed S64 If swallowed, rinse mouth with water (only if the person is conscious)
S7/8 Keep container tightly closed and dry
S7/9 Keep container tightly closed and in a well-ventilated place
S7/47 Keep container tightly closed and at temperature not exceeding .. OC (to be
specified by the manufacturer)
S8 Keep container dry
S9 Keep container in a well-ventilated place
S12 Do not keep the container sealed
S13 Keep away from food, drink and animal feeding stuffs
S14 Keep away from ... (incompatible materials to be indicated by the manufacturer
S15 Keep away from heat
S16 Keep away from sources of ignition - No smoking
S17 Keep away from combustible material
S18 Handle and open container with care
S21 When using do not smoke
S20/21 When using do not eat, drink or smoke
S22 Do not breathe dust
S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by
the manufacturer)
S24 Avoid contact with skin
S24/25 Avoid contact with skin and eyes
S25 Avoid contact with eyes
S26 In case of contact with eyes, rinse immediately with plenty of water and seek
medical advice
S27 Take off immediately all contaminated clothing
S27/28 After contact with skin, take off immediately all contaminated clothing, and wash
immediately with plenty of ... (to be specified by the manufacturer)
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the
manufacturer)
S29 Do not empty into drains
S29/35 Do not empty into drains; dispose of this material and its container in a safe way
S29/56 Do not empty into drains, dispose of this material and its container at hazardous or
special Waste collection point
S30 Never add water to this product
S33 Take precautionary measures against static discharges
S35 This material and its container must be disposed of in a safe way
S36 Wear suitable protective clothing
S36/37 Wear suitable protective clothing and gloves
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection
S36/39 Wear suitable protective clothing and eye/face protection
S37 Wear suitable gloves
S37/39 Wear suitable gloves and eye/face protection
S38 In case of insufficient ventilation wear suitable respiratory equipment
S39 Wear eye/face protection
S40 To clean the floor and all objects contaminated by this material use (to be specified
by the manufacturer)
S41 In case of fire and/or explosion do not breathe fumes
S42 During fumigation/spraying wear suitable respiratory equipment (appropriate
wording to be specified by the manufacturer)
S43 In case of fire use ... (indicate in the space the precise type of fire-fighting
equipment. If water Increases the risk add - Never use water)
S45 In case of accident or if you feel unwell seek medical advice immediately (show the
label where possible)
S46 If swallowed, seek medical advice immediately and show this container or label
S47 Keep at temperature not exceeding ... OC (to be specified by the manufacturer)
10
Global Harmonisation System

(GHS) &
The Chemical, Labelling &
Packaging Regulations. (CLP)
11
Globally Harmonized System of

Classification and Labelling of Chemicals
Definition
The Globally Harmonized System of Classification and Labelling of Chemicals

(GHS) is an international consensus system for classifying and labelling hazardous
chemicals. The GHS is designed to streamline the hazard assessment, labelling,
and hazard communication requirements within and between the countries that
adopt it by promoting common, consistent criteria for classifying chemicals
according to their health, physical and environmental hazards, and to develop
compatible labelling, safety data sheets (SDS's) and other information based on
those classifications.
GHS will resolve many, but not all, differences between SDS's and labels between,
for example, the US, Canada, and the European Union.
Additional Info
In the European Union, Safety Data Sheets (SDS) and labels are required to use a
uniform coding system of risk phrases and safety phrases to communicate risks
and precautions. The phrases are accompanied by numbers so the phrases can be
easily translated or understood in multiple languages.
The GHS takes a similar approach but risk phrases and safety phrases will be
replaced. Risk phrases will become Hazard Statements ("H-statements") and
safety phrases will become Precautionary Statements ("P-statements"). This
change makes modifications and additions to the existing R- and S-phrases and
introduces a new numbering system. Note: the phrases must always be written
out in words; the numbers are provided as a reference only and should never be
used as a substitute for the full phrases.
Some GHS resources for other countries include:
 European Union (Classification, Labelling and Packaging (CLP)
SDS Relevance
As the GHS goes into force, there will be significant changes to the labelling and
SDS requirements under the current system, GHS will require a standardized 16-
part format which mirrors the REACH format.
GHS adds some additional required content for Safety Data Sheets (SDS) and
changes the way that some information is currently reported on SDS's. For
example,
 The GHS calls for including the recommended use of the

chemical and restrictions on its use.
 GHS classifications of the substance/mixture and any regional
information must be included.
 GHS labelling elements must be reproduced, either
graphically or in text.
 SDS will be required to list the CAS number of the hazardous
components.
 Hazardous impurities must also be disclosed.
 Additional differences include accidental release measures for
containment and cleanup as well as concise but complete
toxicological and ecological information (such as ecotoxicity,
bioaccumulation potential), mobility in soil, persistence, and
degradability).
12
Classification, Labelling and Packaging
Regulations - (CLP)
Definition Connection between REACH & CLP

 Both contain hazard communication tools: labelling rules are set out in
CLP amends the Dangerous Substance Directive 67/548/EEC12 (DSD), the CLP whereas the Safety Data Sheet (SDS) rules are set out in REACH; a CLP
Dangerous Preparations Directive 1999/45/EC13 (DPD) and Regulation (EC) No label must always be used together with SDS.
1907/200614 (REACH), and will replace DSD and DPD from 1 June 2015. CLP is  The classification of a substance is one mandatory part of REACH
based on the Globally Harmonised System of Classification and Labelling of registration dossier whereas the classification criteria are set out in CLP
Chemicals (GHS, UN 2007) and is implementing the provisions of the GHS within regulation;
the EU, without lowering the protection of human health and environment,
Difference been REACH & CLP
compared to the classification, labelling and packaging system in DSD and
 The core of REACH is registration and the core of CLP is notification,
DPD.
classification and labelling;
 CLP applies to all substances irrespective of the annual tonnage;
It aligns existing EU legislation to the United Nations Globally Harmonised System
(GHS). The new act will complement the REACH Regulation on the registration,
HAZARDCLASSES PICTOGRAMS
evaluation, authorisation and restriction of chemicals.
Additional Info Self reactive’s & Organic

peroxides
The regulation incorporates the classification criteria and labelling rules agreed at and or
UN level, the so called Globally Harmonised System of Classification and Labelling (Depending on Category)
of Chemicals (GHS).
It introduces new classification criteria, hazard symbols (pictograms) and labelling Corrosive To Metals
phrases, while taking account of elements which are part of the current EU
legislation.
The regulation requires companies to appropriately classify, label and package Acute Toxicity
their substances and mixtures before placing them on the market. It aims to (Oral. Dermal & Inhalation)
or
protect workers, consumers and the environment by means of labelling which
(Depending on Category)
reflects possible hazardous effects of a particular chemical.
It also takes over provisions of the REACH Regulation regarding the notification of Skin Corrosion / Irritation
classifications, the establishment of a list of harmonised classifications and the Serious Eye Damage / Eye
creation of a classification and labelling inventory. Irritation or
Implementation Respiratory Sensitiser
Germ Cell Mutagenicity
The manufacturers and importers have already registered more than 140,000 Carcinogenicity
substances with the European Chemicals Agency under the REACH Regulation. Reproductive Toxicity
They had until 1 December 2010 to propose "provisional classifications" for these Specific Target Organ RE
substances, which will be used for the labelling of pure substances from that date. Aspiration
The deadline for classifying mixtures is 31 May 2015.
Skin Sensitiser
Specific Target Organ SE

or
GHS05 GHS09 GHS04
Hazardous To Aquatic
Environment
Gas Under pressure
GHS07 GHS01 GH02 Flammable Liquids / Solids /

Gases / Aerosols /
Pyrophoric liquids and solids.
Substances and mixtures which, in
contact with water, emit
flammable gases.
GHS03 GHS08 GHS06

Oxidising Gases
Oxidising Liquids & Solids
REACH & CLP are two independent pieces of chemical legislation in EU.
Hazardous to Ozone Layer None
A full listing of the above hazard Classifications are contained in the following
pages.
13
Graphic representation of relevant

UN, European and UK OSH systems
PAST
CAD
COSHH
CMD
M&U’S
DSD CHIP
DPD
SDS
ENS
NONS NONS
FUTURE
GHS CLP COSHH
REACH (Including SDS)
PRESENT
CAD
COSHH
CMD
GHS M&U’S
DSD CHIP
DPD
REACH (Including SDS)
14
EXPLOSIVES
Hazard communication for explosives Hazard communication for explosives

Classification Unstable Division 1.1 Division 1.2 Division Division
Classification Division 1.3 Division 1.4
2.2.4
2.2.4 1.5 1.6
GHS
Pictograms GHS Pictograms
Signal Word Danger Danger Danger No Single Word

Signal Word Danger Warning Danger
EU Directive EU Directive
67/548/EEC 67/548/EEC
Transport of Transport of
Dangerous Transport not Dangerous
Goods, Allowed Goods,
Model Model
H200: H201: H202: H203: H204: H205: No

Hazard Unstable Explosive Explosive; Mass Explosive; Severe Hazard Explosive; Fire or May mass hazard
Statements: explosion hazard projection hazard Statements: fire, blast or projection Explode in statement
projection hazard fire
hazard
Precautionary Statements Precautionary Statements
P201 P210 P210 P210 P210 P210 P210
P202 P230 P230 P230 P230 P240 P230
P281 P240 P240 P240 P240 P250 P240
Prevention Prevention
P250 P250 P250 P250 P280 P250
P280 P280 P280 P280 P280
P372 P370+P380 P370+P380 P370+P380 P370+P380 P370+ P370+

P373 P372 P372 P372 P372 P380 P380
Response P380 P373 P373 Response P373 P373 P372 P372
P373 P373
P401 P401 P401 P401 P401 P401 P401

Storage Storage
P501 P501 P501 P501 P501 P501 P501
Disposal Disposal
Description Precautionary Description

An explosive substance or mixture is a solid or liquid substance or mixture of Statement
Substances which are in it capable by chemical reaction of producing gas at P201 Obtain special instructions before use.
such a temperature and pressure and at such a speed as to cause damage to Do not handle until all safety precautions have been read and
P202
the surroundings. understood.
Keep away from heat/sparks/open flames/hot surfaces. - No
P210
smoking.
Pyrotechnic substances are included even when they do not evolve gases.
P230 Keep wetted with
A pyrotechnic substance or mixture is a substance or mixture of substances
P240 Ground/bond container and receiving equipment
designed to produce an effect by heat, light, sound, gas or smoke or a P250 Do not subject to grinding/shock/.../friction.
combination of these as the result of non-detonative P280 Wash...thoroughly after handling
In case of fire: Evacuate area. Fight fire remotely due to the risk
P370+P380
self-sustaining exothermic chemical reactions. of explosion.
P372 Explosion risk in case of fire.
An unstable explosive is an explosive which is thermally unstable and/or too P373 DO NOT fight fire when fire reaches explosives
sensitive for normal handling, transport and use. P380 Evacuate area
P401 Store ...
P501 Dispose of contents/container to ...
An explosive article is an article containing one or more explosive
substances or mixtures.
A pyrotechnic article is an article containing one or more pyrotechnic

substances or mixtures.
An intentional explosive is a substance, mixture or article which is

manufactured with a view to produce a practical explosive or pyrotechnic
effect
15
FLAMMABLE GASES
Description
Hazard communication for flammable gases
Flammable gas means a gas or gas mixture having a flammable range with air at
Classification 20°C and a standard pressure of 101.3 kPa
Category 1A /1B / 1C Category 2
2.3.5
Precautionary Description
Statement
GHS Pictograms No Pictogram P210
smoking.
Leaking gas fire: Do not extinguish, unless leak can be stopped
P377
safely.
P381 Eliminate all ignition sources if safe to do so
P403 Store in a dry place
Signal Word Danger Warning
EU Directive
No Translation No Translation
67/548/EEC
Transport of Not required under

Dangerous
the UN Model
Goods,
Model Regulations
H220: H221:
Hazard
Extremely flammable gas Flammable gas
Statements
Precautionary Statements
Prevention P210 P210
P377 P377
Response P381 P381
Storage P403 P403
Disposal
16
FLAMMABLE AEROSOLS
Description
Hazard communication for flammable Aerosols
Aerosols, this means aerosol dispensers, are any non-refillable receptacles made
Classification of metal, glass or plastics and containing a gas compressed, liquefied or dissolved
2.4.4 under pressure, with or without a liquid, paste or powder, and fitted with a
release device allowing the contents to be ejected as solid or liquid particles in
suspension in a gas, as a foam, paste or powder or in a liquid state or in a
gaseous state.
GHS Pictograms Where an aerosol dispenser contains flammable components but is not classified
as flammable, the quantity of flammable material contained in the aerosol
dispenser must be stated clearly on the label, in the form of the following
wording: “X% by mass of the contents are flammable

EU Directive
67/548/EEC
Transport of Precautionary Description

Dangerous Statement
Goods, P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Model P211 Do not spray on an open flame or other ignition source.
P251 Pressurized container: Do not pierce or burn, even after use.
H220: H221: Protect from sunlight. Do not expose to temperatures exceeding
Hazard P410+P412
Extremely flammable aerosol Flammable aerosol 50 °C/122 °F.
Statements
P210 P210
P251 P251
Response
Storage P410 + P412 P410 + P412
Disposal
17
OXIDISING GASES
Description
Hazard communication for oxidising gases
Oxidising gas means any gas or gas mixture which may, generally by providing
oxygen, cause or contribute to the combustion of other material more than air
Classification does
2.5.4 Category 1
GHS Precautionary Description

Pictograms Statement
P220 Keep/Store away from clothing/.../combustible materials.
P244 Keep reduction valves free from grease and oil.
P370+P376 In case of fire: Stop leak if safe to do so
P403 Store in a dry place.
Signal Word Danger
EU Directive
67/548/EEC
Transport of
Dangerous
Goods,
Model
Hazard H270: (R8)

Statement: May cause or intensify fire; oxidiser
P220
Prevention
P244
Response P370 + P376
Storage P403
Disposal
18
GASES UNDER PRESSURE
Hazard communication for explosives DESCRIPTION
Classificatio Dissolved Gases under pressure are gases which are contained in a receptacle at a pressure
Compressed Liquefied Refrigerated
n gas of 200 kPa (gauge) or more, or which are liquefied or liquefied and refrigerated.
Gas Gas Liquefied Gas
2.2.4
They comprise compressed gases, liquefied gases, dissolved gases and
refrigerated liquefied gases.
GHS Compressed gas

Pictograms A gas which when packaged under pressure is entirely gaseous at - 50 oC;
Including all gases with a critical temperature ≤ - 50 oC.
Liquefied gas
Signal Word Warning Warning Warning Warning A gas which, when packaged under pressure, is partially liquid at temperatures
above - 50 oC. A distinction is made between:
EU Directive
67/548/EEC No Translation No Translation No Translation No Translation (i) high pressure liquefied gas: a gas with a critical temperature between
- 50 oC and + 65 oC; and
Transport of (ii) low pressure liquefied gas: a gas with a critical temperature above
Dangerous
+ 65 oC.
Goods,
Model
Refrigerated liquefied gas
H280: H280: H281: H280: A gas which when packaged is made partially liquid because of its low
Contains gas Contains gas Contains Contains gas Temperature.
Hazard
under under pressure; refrigerated gas, under pressure;
Statements:
pressure; may may explode if may cause may explode if Dissolved gas
explode if heated cryogenic burns heated A gas which when packaged under pressure is dissolved in a liquid phase
heated or injury Solvent.
Prevention P282
P336
Response
P315
P410+P403 P410+P403 P403 P410+P403 Precautionary Description
Storage Statement
P282 Wear cold insulating gloves/face shield/eye protection
Disposal
P315 Get immediate medical advice/attention.
Thaw frosted parts with lukewarm water. Do not rub affected
P336
area
P410+P403 Protect from sunlight. Store in a well-ventilated place.
19
FLAMMABLE LIQUIDS
Description
Hazard communication for flammable liquids
Flammable liquid means a liquid having a flash point of not more than 60 oC.
Classification
Category 1 Category 2 Category 3
2.8.4 A flammable liquid shall be classified in one of the three categories for this class in
accordance with the figures below:
1 Flash point < 23 oC and initial boiling point ≤ 35 oC

GHS Pictograms 2 Flash point < 23 oC and initial boiling point > 35 oC
3 Flash point ≥ 23 oC and ≤ 60 oC (1)
(1) For the purpose of this Regulation gas oils, diesel and light heating oil’s having
a flash point between ≥ 55 oC and ≤ 75 oC may be regarded as Category 3.
Signal Word Danger Danger Warning
EU Directive
67/548/EEC
Statement
Keep away from heat/sparks/open flames/hot surfaces. -
Transport of P210
Dangerous No smoking
Goods, P233 Keep container tightly closed
Model P240 Ground/bond container and receiving equipment.
Use explosion-proof electrical / ventilating / lighting /.../
P241
H224: (R12 or R11) H225: (R11) H226: (R10) equipment.
Hazard Extremely flammable Highly flammable Flammable liquid P242 Use only non-sparking tools.
Statement liquid and vapour liquid and vapour and vapour P243 Take precautionary measures against static discharge.
P280 Wash...thoroughly after handling
Precautionary Statements IF ON SKIN (or hair): Remove/Take off immediately all
P303+P361+P353
contaminated clothing. Rinse skin with water/shower.
P210 P210 P210
P370+P378 In case of fire: Use ... for extinction.
P233 P233 P233
P240 P240 P240 P403+P235 Store in a well-ventilated place. Keep cool.
P241 P241 P241 P501 Dispose of contents/container to ...
Prevention
P242 P242 P242
P243 P243 P243
P280 P280 P280
P303 + P361 + P353 P303 + P361 + P353 P303 + P361 + P353

Response
P370 + P378 P370 + P378 P370 + P378
Storage P403 + P235 P403 + P235 P403 + P235
Disposal P501 P501 P501
20
FLAMMABLE SOLIDS
Description
Hazard communication for flammable Solids
A flammable solid means a solid which is readily combustible, or may cause or
contribute to fire through friction.
Classification
2.8.5 Readily combustible solids are powdered, granular, or pasty substances or
mixtures which are dangerous if they can be easily ignited by brief contact with an
ignition source, such as a burning match, and if the flame spreads rapidly.
GHS Pictograms

Statement
EU Directive Keep away from heat/sparks/open flames/hot surfaces. - No
67/548/EEC P210
smoking
P240 Ground/bond container and receiving equipment.
Use explosion-proof electrical / ventilating / lighting /.../
Transport of P241
equipment.
Dangerous P243 Take precautionary measures against static discharge.
Goods,
Model
H228: (R11) H228: : (R11)

Hazard
Flammable Solid Flammable Solid
Statements
P210 P210
P240 P240
Prevention
P241 P241
P280 P280
Response P370 + P378 P370 + P378
Storage
Disposal
21
SELF-REACTIVE SUBSTANCES AND MIXTURES
DESCRIPTION
Label elements for self-reactive substances and mixtures
Self-reactive substances or mixtures are thermally unstable liquid or solid
Type A Type B Type C&D Type E&F
Classification substances or mixtures liable to undergo a strongly exothermic decomposition
2.9.4 even without participation of oxygen (air). This definition excludes substances and
mixtures classified as explosives, organic peroxides or as oxidising.
2.8.1.2. A self-reactive substance or mixture is regarded as possessing explosive

properties when in laboratory testing the formulation is liable to detonate, to
deflagrate rapidly or to show a violent effect when heated under confinement.
GHS
Pictograms
Statement
Signal Word Danger Danger Danger Warning
P210
smoking.
EU Directive P220 Keep/Store away from clothing/.../combustible materials.
No Translation No Translation P234 Keep only in original container
67/548/EEC
P280 Wash...thoroughly after handling
P370+P380+P375 In case of fire: Evacuate area.
P403+P235 Store in a well-ventilated place. Keep cool.
Same as for P411 Store at temperatures not exceeding ...°C/...°F.
Transport of explosives P420 Store away from other materials
Dangerous (follow P501 Dispose of contents/container to ...
Goods, same symbol
Model selection
process)
H240: H241: H242: (R12) H242: (R12)

Hazard Heating may Heating may Heating may Heating
Statement: cause an cause a fire or cause a fire may cause a
explosion explosion fire
Precautionary Statements Oral

P210 P210 P210 P210
Prevention P220 P220 P220 P220
P234 P234 P234 P234
P280 P280 P280 P280
P370 + P378 P370 + P378
P370 + P378 P370 + P378
Response P370 + P380 P370 + P380
+ P375 + P375
P403 + P235 P403 + P235 P403 + P235 P403 + P235

Storage P411 P411 P411 P411
P420 P420 P420 P420
Disposal P501 P501 P501 P501
TYPE G: There are no labels elements allocated to this hazard category
22
PYROPHORIC LIQUIDS AND SOLIDS
Label elements for pyrophoric liquids and solids DESCRIPTION
Liquid
Classification Pyrophoric liquid means a liquid substance or mixture which, even in
Category 1 Liquids Category 1 Solids
2.9.3, 2.10.3
small quantities, is liable to ignite within five minutes after coming into
contact with air.
The liquid ignites within 5 min when added to an inert carrier and
exposed to air, or it ignites or chars a filter paper on contact with air
GHS Pictograms within 5 min.
Solid
Pyrophoric solid means a solid substance or mixture which, even in small
quantities, is liable to ignite within five minutes after coming into contact
Signal Word Danger Warning with air.
EU Directive
67/548/EEC
Transport of
Dangerous
Goods, Statement
Model Keep away from heat/sparks/open flames/hot surfaces.
P210
- No smoking.
H250: (R17) H250: (R17) P222 Do not allow contact with air.
Hazard Catches fire Catches fire P280 Wash...thoroughly after handling
Statements spontaneously if exposed to air spontaneously if exposed to air IF ON SKIN: Immerse in cool water/wrap in wet
P302+P334
bandages.
P210 P210
P222 P222 P422 Store contents under …
Prevention
P280 P280
P302 + P334 P302 + P334

Response P370 + P378 P370 + P378
Storage P422 P422
Disposal
23
SELF HEATING SUBSTANCES & MIXTURES
Hazard communication for self-heating substances and mixtures

DESCRIPTION
A self-heating substance or mixture is a liquid or solid substance or mixture, other

Classification than a pyrophoric liquid or solid, which, by reaction with air and without energy
Category 1 Category 1
2.11.5 supply, is liable to self-heat; this substance or mixture differs from a pyrophoric
liquid or solid in that it will ignite only when in large amounts (kilograms) and
after long periods of time (hours or days).
GHS Pictograms Self-heating of substances or mixtures, leading to spontaneous combustion, is

caused by reaction of the substance or mixture with oxygen (in the air) and the
heat developed not being conducted away rapidly enough to the surroundings.
Spontaneous combustion occurs when the rate of heat production exceeds the
Signal Word Danger Warning rate of heat loss and the auto-ignition temperature is reached.
EU Directive
67/548/EEC
Transport of
Dangerous
Goods,
Model
Statement
H251: H252:
Hazard Self-heating; may catch Self-heating in large P235 + P410 Keep cool. Protect from sunlight.
Statements fire quantities; may catch fire P280 Wash...thoroughly after handling
P407 Maintain air gap between stacks/pallets.
Precautionary Statements Store bulk masses greater than ... kg/... lbs at temperatures not
P413
P235 + P410 P235 + P410 exceeding ...°C/...°F.
Prevention P420 Store away from other materials.
P280 P280
Response
P407 P422P407
P413 P413
Storage
P420 P420
Disposal
24
SUBSTANCES AND MIXTURES WHICH, IN CONTACT WITH WATER, EMIT

FLAMMABLE GASES
Hazard communication for substances and mixtures which, in contact with water, emit DESCRIPTION
flammable gases
Classification Substances or mixtures which, in contact with water, emit flammable gases
2.12.4 means solid or liquid substances or mixtures which, by interaction with water, are
liable to become spontaneously flammable or to give off flammable gases in
dangerous quantities
GHS Pictograms
Signal Word Danger Danger Warning Precautionary Description

Statement
P233 Keep container tightly closed.
EU Directive No Translation No Translation P231+P232 Handle under inert gas. Protect from moisture.
67/548/EEC P280 Wash...thoroughly after handling
Brush off loose particles from skin. Immerse in cool water/wrap
P335+P334
in wet bandages.
Transport of P402+P404 Store in a dry place. Store in a closed container.
Dangerous P501 Dispose of contents/container to
Goods,
Model
H260: (R15) H261: H261:

In contact with water In contact with In contact with
Hazard releases flammable water releases water releases
Statement gases which may ignite flammable gases flammable gases
spontaneously
P223 P223
P231 + P232 P231 + P232 P231 + P232
Prevention
P280 P280 P280
P335 + P334 P335 + P334

Response P370 + P378 P370 + P378 P370 + P378
Storage P402 + P404 P402 + P404 P402 + P404
25
OXIDISING LIQUIDS AND SOLIDS
DESCRIPTION
Hazard communication for oxidising liquids and oxidising solids
Classification Oxidising liquid means a liquid substance or mixture which, while in itself not
2.13.4 necessarily combustible, may, generally by yielding oxygen, cause, or contribute
to, the combustion of other material.
GHS Pictograms
Statement
Signal Word Danger Danger Warning P210
smoking.
P221 Take any precaution to avoid mixing with combustibles/..
EU Directive P280 Wash...thoroughly after handling
67/548/EEC P306 + P360 IF ON CLOTHING: Rinse immediately contaminated clothing and
skin with plenty of water before removing clothes.
P371 + P380 + In case of major fire and large quantities: Evacuate area. Fight
Transport of P375 fire remotely due to the risk of explosion.
Dangerous P370 + P378 In case of fire: Use ... for extinction.
Goods,
Model P501 Dispose of contents/container to ...
H271: (R9, R8)) H272: (R8) H272: (R8)

May cause fire May intensify May intensify
Hazard
or explosion; strong fire; oxidiser fire; oxidiser
Statement
oxidiser
P210
P210 P210
P220
P220 P220
P221
P280
P280 P280
P283
P306 + P360
P371 + P380 + P375
Response P370 + P378 P370 + P378
P370 + P378
Storage
26
ORGANIC PEROXIDES
DESCRIPTION
Hazard communication for organic peroxides
Organic peroxides means liquid or solid organic substances which contain the
Type A Type B Type C&D Type E&F
Classification bivalent -O-O- structure and may be considered derivatives of hydrogen
2.9.4 peroxide, where one or both of the hydrogen atoms have been replaced by
organic radicals.
The term organic peroxide includes organic peroxide mixtures (formulations)

Containing at least one organic peroxide. Organic peroxides are thermally
unstable substances or mixtures, which can undergo exothermic self-
GHS accelerating decomposition. In addition, they can have one or more of the
Pictograms following properties:
(i) be liable to explosive decomposition;
(ii) burn rapidly;
(iii) be sensitive to impact or friction;
(iv) react dangerously with other substances.
An organic peroxide is regarded as possessing explosive properties when in

laboratory testing the mixture (formulation) is liable to detonate, to
Signal Word Danger Danger Danger Warning deflagrate rapidly or to show a violent effect when heated under
confinement.
EU Directive No Translation No Translation
67/548/EEC
Statement
Same as for Keep away from heat/sparks/open flames/hot surfaces. - No
P210
Transport of explosives smoking.
Dangerous (follow same P220 Keep/Store away from clothing/.../combustible materials.
Goods, symbol P234 Keep only in original container.
Model selection P280 Wash...thoroughly after handling
process) P411+P235 Store at temperatures not exceeding ... °C/... °F. Keep cool
P410 Protect from sunlight.
P420 Store away from other materials.
H240: H241: H242: (R12, R7) H242:(R12, R7)
Hazard Heating may Heating may Heating may Heating
Statement: cause an cause a fire or cause a fire may cause a
explosion explosion fire
Precautionary Statements Oral

P210 P210 P210 P210
P220 P220 P220 P220
P280 P280 P280 P280
Response
P411 + P235 P411 + P235 P411 + P235 P411 + P235
P410 P410 P410 P410
Storage
P420 P420 P420 P420
TYPE G: There are no labels elements allocated to this hazard category
27
SUBSTANCES AND MIXTURES CORROSIVE TO METALS
Hazard communication for substances and mixtures corrosive to metals DESCRIPTION
A substance or a mixture that is corrosive to metals means a substance or a

Classification
mixture which by chemical action will materially damage, or even destroy,
2.5.4 Category 1
metals.
GHS
Pictograms
Statement
P234 Keep only in original container.
Signal Word Danger P390 Absorb spillage to prevent material damage
Store in corrosive resistant/... container with a resistant
P406
inner liner.
EU Directive
67/548/EEC
Transport of
Dangerous
Goods,
Model
Hazard H290: (R34, R35)

Statement: May be corrosive to metals
Prevention P234
Response P390
Storage P406
Disposal
28
ACUTE TOXICITY
DESCRIPTION
Hazard communication in form of labelling for acute toxicity
Acute toxicity means those adverse effects occurring following oral or
Classification dermal administration of a single dose of a substance or a mixture, or
3.1.4 Category 1 Category 2 Category 3 Category 4 multiple doses given within 24 hours, or an inhalation exposure of 4 hours.
The hazard class Acute Toxicity is differentiated into:

 Acute oral toxicity;
GHS  Acute dermal toxicity;
Pictograms  Acute inhalation toxicity.
Signal Word Danger Danger Danger Warning
EUH071 can also be applied to inhaled corrosive substances not tested for acute
EU Directive inhalation toxicity according to CLP Annex II, Section 1.2.6. In addition to an appropriate
67/548/EEC acute toxicity pictogram, a corrosivity pictogram (used for skin and eye corrosivity) may be
added together with the statement ‘corrosive to the respiratory tract’.
Transport of In cases where a substance or mixture has shown clear signs of severe systemic toxicity or
Dangerous mortality in an eye irritation study a supplemental labelling phrase EUH070 “Toxic by eye
Goods, Not required contact“ is required. This additional labelling, based on relevant data, is independent of
Model under any classification in an acute toxicity category
the UN Model
For gases replace
the No 6 in the Regulations
bottom corner of
the pictogram by 2.
Hazard
H300: : (R28) H300: (R28) H301: (R25) H302: (R22) Precautionary Description
Fatal if Fatal if Toxic if Harmful Statement
Statement:
swallowed swallowed swallowed if swallowed P260 Do not breathe dust/fume/gas/mist/vapours/spray.
– Oral
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
H310: (R27) H310: (R27) H311: (R24) H312: (R21)
Fatal in contact Fatal in contact Toxic in contact Harmful in P262 Do not get in eyes, on skin, or on clothing.
– Dermal P264 Wash...thoroughly after handling
with skin with skin with skin contact with
skin P270 Do not eat, drink or smoke when using this product.
H330:(R23, R26) H330:(R23, R26) H331: (R23) H332: (R20) P271 Use only outdoors or in a well-ventilated area
– Inhalation
Fatal if inhaled Fatal if inhaled Toxic if inhaled Harmful if P280 Wash...thoroughly after handling
inhaled P281 Use personal protective equipment as required.
Precautionary Statements Oral P284 Wear respiratory protection.
IF SWALLOWED: Immediately call a POISON CENTER or doctor /
Prevention P264 P264 P301+P310
P264 P264 physician.
(oral) P270 P270
P270 P270 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you
P301+P312
P301 + P310 P301 + P310 P301 + P310 feel unwell.
P301 + P312 IF INHALED: Remove victim to fresh air and keep at rest in a
Response (oral) P321 P321 P321 P304+P340
P330 position comfortable for breathing.
P330 P330 P330
P302+P350 IF ON SKIN: Gently wash with plenty of soap and water.
Storage (oral) P405 P405 P405 P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P310 Immediately call a POISON CENTER or doctor/physician
Disposal (oral) P501 P501 P501 P501 P311 Call a POISON CENTER or doctor/physician.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
Precautionary Statements Dermal P320 Specific treatment is urgent (see ... on this label).
P262 P262 P321 Specific treatment (see ... on this label).
Prevention P264 P264 P280 P280 P322 Specific measures (see ... on this label).
P270 P270 P330 Rinse mouth.
P280 P280 P361 Remove/Take off immediately all contaminated clothing.
P302 + P350 P302 + P350 P302 + P352 P363 Wash contaminated clothing before reuse.
P302 + P352
P310 P310 P312 Store in a well-ventilated place. Keep container tightly
Response P312 P403+P233
P322 P322 P322 closed.
P322
P361 P361 P361 P405 Store locked up.
P363
P363 P363 P363 P501 Dispose of contents/container to ...
Storage P405 P405 P405
Precautionary Statements Inhalation

P260 P260
P271 P271
P271 P271
P284 P284
P304 + P340 P304 + P340 P304 + P340
P304 + P340
Response P310 P310 P311
P312
P320 P320 P321
Storage P403 + P233 P403 + P233 P403 + P233

P405 P405 P405
29
SKIN CORROSION / IRRITATION
DESCRIPTION
Hazard communication in form of labelling for skin corrosion /irritation
Skin Corrosion means the production of irreversible damage to the skin;
Classification namely, visible necrosis through the epidermis and into the dermis,
3.2.4 following the application of a test substance for up to 4 hours.
Corrosive reactions are typified by ulcers, bleeding, bloody scabs, and, by

the end of observation at 14 days, by discolouration due to blanching of
the skin, complete areas of alopecia, and scars. Histopathology shall be
GHS Pictograms considered to evaluate questionable lesions.
Skin Irritation means the production of reversible damage to the skin

following the application of a test substance for up to 4 hours.
EU Directive
67/548/EEC
Transport of Statement
Not required under
Dangerous P260 Do not breathe dust/fume/gas/mist/vapours/spray.
the UN Model
Goods, P264 Wash...thoroughly after handling
Regulations
Model P280 Wash...thoroughly after handling
H314: (R34, R35) H315: (R38)
IF SWALLOWED: Rinse mouth. Do NOT induce
P301+P330+331
Hazard Causes severe skin Causes skin irritation vomiting
Statements burns and eye damage P302+352 IF ON SKIN: Wash with plenty of soap and water.
IF ON SKIN (or hair): Remove/Take off immediately all
Precautionary Statements P303+P361+P353
contaminated clothing. Rinse skin with water/shower.
P260 Immediately call a POISON CENTER or doctor /
P264
P280 physician.
P280
P301 + P330 + P331 IF INHALED: Remove victim to fresh air and keep at
P304+P340
P303 + P361 + P353 rest in a position comfortable for breathing.
P302 + P352
P363 P321 Specific treatment (see ... on this label).
P321
P304 + P340 IF IN EYES: Rinse cautiously with water for several
P310 P305+P351+P338 minutes. Remove contact lenses, if present and easy
P362
P321 to do. Continue rinsing.
P305 + P351 + P338
Take off contaminated clothing and wash before
P362
Storage P405 P405 reuse.
P363 Wash contaminated clothing before reuse.
P405 Store locked up.
Disposal P501 P501 P501 Dispose of contents/container to ...
30
SERIOUS EYE DAMAGE / EYE IRRITATION
Hazard communication in form of labelling for serious eye damage/eye DESCRIPTION

Irritation
Classification Serious eye damage means the production of tissue damage in the eye, or
3.3.4 serious physical decay of vision, following application of a test substance to
the anterior surface of the eye, which is not fully reversible within 21 days of
application.
GHS Pictograms Eye irritation means the production of changes in the eye following the
application of test substance to the anterior surface of the eye, which are
fully reversible within 21 days of application.
EU Directive
67/548/EEC
Dangerous P264 Wash...thoroughly after handling
Goods, P280 Wash...thoroughly after handling
Model IF IN EYES: Rinse cautiously with water for several
H318: (R41) H319: (R36)
Hazard
Causes serious eye damage Causes serious eye irritation
P305+P351+P338 minutes. Remove contact lenses, if present and easy to
Statements do. Continue rinsing.
Precautionary Statements P310 Immediately call a POISON CENTER or doctor / physician.
P264
Prevention P280
P280
P305 + P351 + P338 P305 + P351 + P338
Response
P310 P337 + P313
Storage
Disposal
31
RESPIRATORY OR SKIN SENSISATION
DESCRIPTION
Hazard communication for respiratory or skin sensitisation
Classification Respiratory sensitiser means a substance that will lead to hypersensitivity
3.4.4 of the airways following inhalation of the substance.
Skin sensitiser means a substance that will lead to an allergic response

following skin contact.
GHS Pictograms

EU Directive
No Symbol Used No Symbol Used
67/548/EEC
Dangerous Not required under the UN Not required under the UN
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
Goods, Model Regulations Model Regulations
Model Contaminated work clothing should not be allowed out of
P272
H334: (R42) H317: (R43) the workplace
May cause allergy or asthma May cause an allergic P280 Wash...thoroughly after handling
Hazard
symptoms or breathing skin reaction In case of inadequate ventilation wear respiratory
Statements P285
difficulties if inhaled protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
Precautionary Statements IF INHALED: If breathing is difficult, remove victim to
P261
P261 P304+P341 fresh air and keep at rest in a position comfortable for
Prevention P272
P285 breathing.
P280
P302 + P352 P321 Specific treatment (see ... on this label).
P304 + P341 P333 + P313 If skin irritation or rash occurs: Get medical
Response P333+P313
P342 + P311 P321 advice/attention.
P363 If experiencing respiratory symptoms: Call a POISON
P342+P311
Storage CENTER or doctor/physician.
Disposal P501 P501 P501 Dispose of contents/container to ...
32
GERM CELL MUTAGENICITY
Hazard communication in form of labelling for germ cell mutagenicity DESCRIPTION
Respiratory sensitisation Skin sensitisation A mutation means a permanent change in the amount or structure of the
genetic material in a cell. The term ‘mutation’ applies both to heritable
Classification
Category 1 Category 2 genetic changes that may be manifested at the phenotypic level and to the
3.5.4.
underlying DNA modifications when known.
The term ‘mutagenic’ and ‘mutagen’ will be used for agents giving rise to an
increased occurrence of mutations in populations of cells and/or organisms.
GHS Pictograms
EU Directive Precautionary Description

67/548/EEC Statement
P201 Obtain special instructions before use.
Transport of Do not handle until all safety precautions have been read
Dangerous Not required under the Not required under the UN P202
and understood.
Goods, UN Model Regulations Model Regulations
Model P281 Use personal protective equipment as required.
H340: (R46) H341: (R68) P308+P313 IF exposed or concerned: Get medical advice/attention.
May cause genetic defects Suspected of causing P501 Dispose of contents/container to ...
(state route of exposure if it is genetic defects (state route of
Hazard
conclusively proven that no exposure if it is conclusively
Statements
other routes of exposure proven that no other routes of
cause exposure cause the hazard)
the hazard)
P201 P201
P281 P281
Response P308 + P313 P308 + P313
Storage P405 P405
Disposal P501 P501
33
CARCINOGENIC
DESCRIPTION
Hazard communication in form of labelling for carcinogenicity
Classification Carcinogen means a substance or a mixture of substances which induce
Category 1A or 1B Category 2
3.6.4 cancer or increase its incidence. Substances which have induced benign
and malignant tumours in well performed experimental studies on animals
are considered also to be presumed or suspected human carcinogens unless
there is strong evidence
GHS Pictograms that the mechanism of tumour formation is not relevant for humans.

EU Directive Statement
67/548/EEC P201 Obtain special instructions before use.
Do not handle until all safety precautions have been read
P202
Transport of and understood.
Dangerous Not required under the UN Not required under the UN P281 Use personal protective equipment as required.
Goods, Model Regulations Model Regulations P308+P313 IF exposed or concerned: Get medical advice/attention.
Model P405 Store locked up.
H350: (R45) H351: (R40) P501 Dispose of contents/container to ...
H350i: (R49) Suspected of causing
May cause cancer (state cancer (state route of exposure
Hazard route of exposure if it is if it is conclusively proven that
Statements conclusively proven that no no other routes of exposure
other routes of exposure cause cause the hazard)
the hazard)
P201 P201
P281 P281
Response P308 + P313 P308 + P313
Storage P405 P405
Disposal P501 P501
34
REPRODUCTIVE TOXICITY
DESCRIPTION
Hazard communication in form of labelling for reproductive toxicity
Additional Reproductive toxicity includes adverse effects on sexual function and
Classification Category 1A or category for fertility in adult males and females, as well as developmental toxicity in the
Category 2
3.7.4 Category 1B effects on or via offspring.
Lactation
For the purpose of classification the hazard class Reproductive Toxicity is
differentiated into:
 adverse effects
GHS Pictograms No pictogram  on sexual function and fertility, or
 on development;
 Effects on or via lactation.
Signal Word Danger Warning No signal word
EU Directive
67/548/EEC Precautionary Description
Statement
Transport of Not required Not required P201 Obtain special instructions before use.
Not required under
Dangerous under the UN under the UN Do not handle until all safety precautions have been read
Goods,
the UN Model
Model Model P202
Regulations and understood.
Model Regulations Regulations P260 Do not breathe dust/fume/gas/mist/vapours/spray.
H360: (R62) H361: H362: (R64) P263 Avoid contact during pregnancy/while nursing.
May Damage fertility Suspected of May cause harm to P264 Wash...thoroughly after handling
or the unborn child damaging fertility or breast-fed children.
P281 Use personal protective equipment as required.
(state specific effect ifthe unborn child
known) (state route of (state specific effect P308+P313 IF exposed or concerned: Get medical advice/attention.
Hazard exposure if it is if known) (state P405 Store locked up.
Statement conclusively proven route of exposure if
that no other routes of it is conclusively
exposure cause the proven that no
hazard) other routes of
exposure cause the
hazard)
P201
P201 P201 P260
Prevention P202 P202 P263
P281 P281 P264
P270
Response P308 + P313 P308 + P313 P308 + P313
Storage P405 P405 P405
35
SPECIFIC TARGET ORGAN TOXICITY (SINGLE EVENT)
DESCRIPTION
Hazard communication in form of labelling for STOT-SE
Classification Specific target organ toxicity (single exposure) is defined as specific, non
3.8.4 lethal target organ toxicity arising from a single exposure to a substance or
mixture. All significant health effects that can impair function, both
reversible and irreversible, immediate and/or delayed
GHS Pictograms
Specific target organ toxicity can occur by any route that is relevant for
humans, i.e. principally oral, dermal or inhalation
Signal Word Danger Warning Warning
EU Directive Precautionary Description

67/548/EEC Statement
P201 Obtain special instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Transport of Not required Not required P263 Avoid contact during pregnancy/while nursing.
Not required under
Dangerous under the UN under the UN P264 Wash...thoroughly after handling
the UN Model
Goods, Model Model
Regulations
Regulations Regulations P270 Do not eat, drink or smoke when using this product
Model
IF INHALED: Remove victim to fresh air and keep at rest in a
H370: (R39/X) H371: (R68/X) H335: ( R37) P304+P340
position comfortable for breathing.
Causes damage May cause damage May cause
to organs (or state all to organs (or state respiratory irritation; P307+P311 IF exposed: Call a POISON CENTER or doctor/physician.
organs affected, if all organs affected, or IF exposed or if you feel unwell: Call a POISON CENTER or
P309+P311
known) (state route of if known) (state H336: (R67) doctor/physician.
Hazard
exposure if it is route of exposure if May cause P312 Call a POISON CENTER or doctor/physician if you feel unwell.
Statement
conclusively proven it is conclusively drowsiness and P321 Specific treatment (see ... on this label).
that no other routes of proven that no Dizziness. Consider
exposure cause the other routes of EUH071 also
Store in a well-ventilated place. Keep container tightly
P403+P233
hazard) exposure cause the closed.
hazard) P405 Store locked up.
Precautionary Statements P501 Dispose of contents/container to
P260 P260 P201
P264 P264 P260
P270 P270 P263
Prevention
P264
P270
P307 + P311 P304 + P340

P321 P312
P403 + P233
Storage P405 P405
P405
36
SPECIFIC TARGET ORGAN TOXICITY (REPEATED EVENT)
DESCRIPTION
Hazard communication in form of labelling for STOT RE
Target organ toxicity (repeated exposure) means specific, target organ
Respiratory sensitisation Skin sensitisation
toxicity arising from a repeated exposure to a substance or mixture. All
Classification significant health effects that can impair function, both reversible and
3.9.4. irreversible, immediate and/or delayed
GHS Pictograms
Signal Word Danger Warning Precautionary Description

Statement
EU Directive
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
67/548/EEC P264 Wash...thoroughly after handling
P270 Do not eat, drink or smoke when using this product
Transport of P314 Get medical advice/attention if you feel unwell
Dangerous Not required under the Not required under the UN P501 Dispose of contents/container to ...
Goods, UN Model Regulations Model Regulations
Model
H372: (R48/X) H373: (R33)
Causes damage to organs May cause damage to organs
(state all organs affected, if (state all organs affected, if
known) through prolonged or known) through prolonged or
Hazard
repeated exposure state repeated exposure (state route
Statements
route of exposure if it is of exposure if it is conclusively
conclusively proven that no proven that no other routes of
other routes of exposure exposure cause the hazard)
cause the hazard)
P260
P260
Prevention P264
P270
Response P314 P314
Storage
Disposal P501 P501
37
ASPIRATION HAZARDS
Hazard communication in form of labelling for carcinogenicity

DESCRIPTION
Classification
Category 1A or 1B
3.6.4 These criteria provide a means of classifying substances or mixtures that may
pose an aspiration toxicity hazard to humans.
‘Aspiration’ means the entry of a liquid or solid substance or mixture directly

GHS Pictograms through the oral or nasal cavity, or indirectly from vomiting, into the trachea and
lower respiratory system.
Aspiration toxicity includes severe acute effects such as chemical pneumonia,

varying degrees of pulmonary injury or death following aspiration.
Signal Word Danger
Aspiration is initiated at the moment of inspiration, in the time required to take
EU Directive one breath, as the causative material lodges at the crossroad of the upper
67/548/EEC respiratory and digestive tracts.
Transport of Aspiration of a substance or mixture can occur as it is vomited following ingestion.

Dangerous This has consequences for labelling, particularly where, due to acute toxicity, a
Not required under the UN Model Regulations
Goods, recommendation may be considered to induce vomiting after ingestion. However,
Model if the substance/mixture also presents an aspiration toxicity hazard, the
Recommendation to induce vomiting shall be modified.
H304: A review of the medical literature on chemical aspiration revealed that some
Hazard
hydrocarbons (petroleum distillates) and certain chlorinated hydrocarbons have
Statements May be fatal if swallowed and enters airways been shown to pose an aspiration hazard in humans.
Prevention Statement
IF SWALLOWED: Immediately call a POISON CENTER or
P301 + P310 P301+P310
Response doctor / physician.
P331 P331 Do NOT induce vomiting
Storage P405 P405 Store locked up.
P501 Dispose of contents/container to
Disposal P501
38
AQUATIC ENVIRONMENT - ACUTE
DESCRIPTION
Hazard communication in form of Label elements for hazardous to the
aquatic environment Hazardous to the Aquatic Environment is differentiated into:
 Acute aquatic hazard;
 Chronic (long term) aquatic hazard
Classification
4.1.4 ACUTE - Category 1
Acute aquatic toxicity means the intrinsic property of a substance to be injurious
to an organism in a short term exposure to that substance.
GHS Availability of a substance means the extent to which this substance becomes a
Pictograms soluble or disaggregates species.
Bioavailability (or biological availability) means the extent to which a substance is

taken up by an organism, and distributed to an area within the organism.
Signal Word Warning
Bioaccumulation means the net result of uptake, transformation and elimination
of a substance in an organism due to all routes of exposure (i.e. air, water,
sediment/soil and food).
EU Directive
67/548/EEC
Bio concentration means the net result of uptake, transformation and elimination
of a substance in an organism due to waterborne exposure.
Transport of
Dangerous
Goods,
Model
Hazard H400: (R50)
Statement
Statement: Very toxic to aquatic life
P273 Avoid release to the environment.
P391 Collect spillage.
Precautionary Statements P501 Dispose of contents/container to
Prevention P273
Response P391
Storage
Disposal P501
39
AQUATIC ENVIRONMENT - CHRONIC
Hazard communication in form of Label elements for hazardous to the aquatic DESCRIPTION
environment
Chronic aquatic toxicity means the intrinsic property of a substance to
cause adverse effects to aquatic organisms during exposures which are
CHRONIC
determined in relation to the life-cycle of the organism.
Classification Degradation means the decomposition of organic molecules to smaller

4.1.4 Category 1 Category 2 Category 3 Category 4 molecules and eventually to carbon dioxide, water and salts.
The basic elements used for classification for aquatic environmental

hazards are:
GHS  Acute aquatic toxicity;
No Symbol No Symbol
Pictograms
Used Used  Potential for or actual bioaccumulation;
 Degradation (biotic or abiotic) for organic chemicals;
and
No signal word No signal word No signal word  Chronic aquatic toxicity.
Signal Word Warning
is used is used is used
EU Directive No Symbol No Symbol

67/548/EEC Used Used
Transport of Not required Not required Precautionary Description

Dangerous under the UN under the UN Statement
Goods, Model Model
Regulations Regulations
Model
P391 Collect spillage.
H410:(R50, R53) H411(R10, R53): H412 (R52,R53) H413: (R53) P501 Dispose of contents/container to
Very toxic Toxic to Harmful to May cause
Hazard
to aquatic life aquatic life with aquatic life with long lasting
Statement:
with long lasting long lasting long lasting harmful
effects effects effects effects to
aquatic life
Response P391 P391
Storage
40
OZONE LAYER
DESCRIPTION
Hazard communication in form of Label elements for Hazardous to the Ozone
Layer
Substance Hazardous to the Ozone Layer means a substance which, on the
basis of the available evidence concerning its properties and its predicted
Classification or observed environmental fate and behaviour may present a danger to
3.1.4 Category 1 the structure and/or the functioning of the stratospheric ozone layer.
GHS
No Symbol Used
Pictograms
Signal Word Danger

Statement
P501 Dispose of contents/container to
Hazard EUH059: (R59)

Statement: Hazardous to the Ozone Layer
Transport of
Dangerous
Not required under the UN Model Regulations
Goods,
Model
Prevention P273
Response
Storage
Disposal P501
41
HAZARD STATEMENTS
Code Physical hazard statement Code Health hazard statement
H200 Unstable explosive H300 Fatal if swallowed
H201 Explosive; mass explosive hazard H301 Toxic if swallowed
H202 Explosive; severe projection hazard H302 Harmful if swallowed
H203 Explosive; fire, blast or projection hazard H303 May be harmful if swallowed
H204 Fire or projection hazard H304 May be fatal if swallowed and enters airways
H205 May mass explode in fire H305 May be harmful if swallowed and enters airways
H220 Extremely flammable gas H310 Fatal in contact with skin
H221 Flammable gas H311 Toxic in contact with skin
H222 Extremely flammable aerosol H312 Harmful in contact with skin
H223 Flammable aerosol H313 May be harmful in contact with skin
H224 Extremely flammable liquid and vapour H314 Causes severe skin burns and eye damage
H225 Highly flammable liquid and vapour H315 Causes skin irritation
H226 Flammable liquid and vapour H316 Causes mild skin irritation
H227 Combustible liquid H317 May cause an allergic skin reaction
H228 Flammable solid H318 Causes serious eye damage
H240 Heating may cause an explosion H319 Causes serious eye irritation
H241 Heating may cause a fire or explosion H320 Causes eye irritation
H242 Heating may cause a fire H330 Fatal if inhaled
H250 Catches fire spontaneously if exposed to air H331 Toxic if inhaled
H251 Self-heating;; may catch fire H332 Harmful if inhaled
H252 Self-heating; in large quantities; may catch fire H333 May be harmful if inhaled
In contact with water releases flammable gases which may ignite H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
H260
spontaneously
H335 May cause respiratory irritation
H261 In contact with water releases flammable gas
H336 May cause drowsiness or dizziness
H270 May cause or intensify fire; oxidizer
May cause genetic defects (state route of exposure if it is conclusively proven
H271 May cause fire or explosion; strong oxidizer H340
that no other routes of exposure cause the hazard)
H272 May intensify fire; oxidizer Suspected of causing genetic defects (state route of exposure if it is conclusively
H341
H280 Contains gas under pressure; may explode if heated proven that no other routes of exposure cause the hazard)
May cause cancer (state route of exposure if it is conclusively proven that no
H281 Contains refrigerated gas; may cause cryogenic burns or injury H350
other routes of exposure cause the hazard)
Suspected of causing cancer (state route of exposure if it is conclusively proven
H290 May be corrosive to metals H351
that no other routes of exposure cause the hazard)
May damage fertility or the unborn child (state specific effect if known)(state
H360 route of exposure if it is conclusively proven that no other routes of exposure
cause the hazard)
Suspected of damaging fertility or the unborn child (state specific effect if
H361 known)(state route of exposure if it is conclusively proven that no other routes
of exposure cause the hazard)
H362 May cause harm to breast-fed children
Causes damage to organs (or state all organs affected, if known) (state route of
H370 exposure if it is conclusively proven that no other routes of exposure cause the
hazard)
May cause damage to organs (or state all organs affected, if known)(state route
H371 of exposure if it is conclusively proven that no other routes of exposure cause
the hazard)
Causes damage to organs (state all organs affected, if known) through
H372 prolonged or repeated exposure (state route of exposure if it is conclusively
proven that no other routes of exposure cause the hazard)
May cause damage to organs (state all organs affected, if known) through
H373 prolonged or repeated exposure (state route of exposure if it is conclusively
proven that no other routes of exposure cause the hazard)
Code Environmental hazard statement

H400 Very toxic to aquatic life
H401 Toxic to aquatic life
H402 Harmful to aquatic life
H410 Very toxic to aquatic life with long lasting effects
H411 Toxic to aquatic life with long lasting effects
H412 Harmful to aquatic life with long lasting effects
H413 May cause long lasting harmful effects to aquatic life
42
HAZARD STATEMENTS ADDITIONAL CODES & LABELLING
Reproductive toxicity additional labelling (See Table 3.7.4)
H360 May damage fertility or the unborn child
H361 Suspected of damaging fertility or the unborn child
H360F May damage fertility.
H360D May damage the unborn child.
H361f Suspected of damaging fertility
H361d Suspected of damaging the unborn child.
H360FD May damage fertility. May damage the unborn child.
Suspected of damaging fertility. Suspected of damaging the unborn
H361fd
child.
H360Fd May damage fertility. Suspected of damaging the unborn child.
H360Df May damage the unborn child. Suspected of damaging fertility.
ADDITIONAL LABELLING & PRECAUTIONARY STATEMENTS

EUH001 Explosive when dry
EUH006 Explosive with or without contact with air
EUH014 Reacts violently with water
EUH018 In use, may form flammable/explosive vapour-air mixture
EUH019 May form explosive peroxides
EUH029 Contact with water liberates toxic gas
EUH031 Contact with acids liberates toxic gas.
EUH032 Contact with acids liberates very toxic gas.
EUH044 Risk of explosion if heated under confinement
EUH066 Repeated exposure may cause skin dryness or cracking.
EUH070 Toxic by eye contact.
EUH071 Corrosive to the respiratory tract.
EUH059 Hazardous to the ozone layer
Contains lead. Should not be used on surfaces liable to be chewed
EUH201
or sucked by children
EUH201A Warning! Contains lead
Cyanoacrylate. Danger. Bonds skin and eyes in seconds. Keep out
EUH202
of the reach of children
EUH203 Contains chromium (VI). May produce an allergic reaction
EUH204 Contains isocyanates. May produce an allergic reaction
EUH205 Contains epoxy constituents. May produce an allergic reaction
Warning! Do not use together with other products. May release
EUH206
dangerous gases (chlorine)
Warning! Contains cadmium. Dangerous fumes are formed during
EUH207 use. See information supplied by the manufacturer. Comply with
the safety instructions
Contains (name of sensitising substance). May produce an allergic
EUH208
reaction.
EUH209 Can become highly flammable in use
EUH209A Can become flammable in use
EUH210 Safety data sheet available on request
To avoid risks to human health and the environment, comply with
EUH401
the instructions for use.
–.
43
PRECAUTIONARY STATEMENTS
GENERAL PRECAUTIONARY STATEMENTS RESPONSE PRECAUTIONARY STATEMENTS

If medical advice is needed, have product container or label at P337 If eye irritation persists:
P101 P338 Remove contact lenses, if present and easy to do. Continue rinsing.
hand.
P340 Remove victim to fresh air and keep at rest in a position comfortable
P102 Keep out of reach of children.
for breathing.
P103 Read label before use.
P341 If breathing is difficult, remove victim to fresh air and keep at rest in
PREVENTION PRECAUTIONARY STATEMENTS a position comfortable for breathing.
P201 Obtain special instructions before use. P342 If experiencing respiratory symptoms:
Do not handle until all safety precautions have been read and P350 Gently wash with plenty of soap and water.
P202
understood. P351 Rinse cautiously with water for several minutes.
Keep away from heat/sparks/open flames/hot surfaces. - No P352 Wash with plenty of soap and water.
P210
smoking.
P353 Rinse skin with water/shower.
P211 Do not spray on an open flame or other ignition source.
P360 Rinse immediately contaminated clothing and skin with plenty of
water before removing clothes.
P221 Take any precaution to avoid mixing with combustibles/..
361 Remove/Take off immediately all contaminated clothing.
P222 Do not allow contact with air.
P362 Take off contaminated clothing and wash before reuse.
P230 Keep wetted with ...
P231 Handle under inert gas.
P232 Protect from moisture. P370 In case of fire:
P233 Keep container tightly closed. P371 In case of major fire and large quantities:
P234 Keep only in original container. P372 Explosion risk in case of fire.
P235 Keep cool. P373 DO NOT fight fire when fire reaches explosives.
P240 Ground/bond container and receiving equipment. P374 Fight fire with normal precautions from a reasonable distance.
P241 Use explosion-proof electrical/ventilating/lighting/.../equipment. 375 Fight fire remotely due to the risk of explosion
P242 Use only non-sparking tools. P376 Stop leak if safe to do so.
P243 Take precautionary measures against static discharge. P377 Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P244 Keep reduction valves free from grease and oil. P378 Use ... for extinction.
P250 Do not subject to grinding/shock/.../friction. P380 Evacuate area.
P251 Pressurized container: Do not pierce or burn, even after use. P381 Eliminate all ignition sources if safe to do so.
P260 Do not breathe dust/fume/gas/mist/vapours/spray. P390 Absorb spillage to prevent material damage.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P391 Collect spillage.
P262 Do not get in eyes, on skin, or on clothing. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor /
P263 Avoid contact during pregnancy/while nursing. physician.
P264 Wash...thoroughly after handling P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you
P270 Do not eat, drink or smoke when using this product. feel unwell.
P271 Use only outdoors or in a well-ventilated area P301 + P330 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
Contaminated work clothing should not be allowed out of the
P272 + P331
workplace.
P302 + P334 IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P280 Wash...thoroughly after handling P302 + P350 IF ON SKIN: Gently wash with plenty of soap and water.
P281 Use personal protective equipment as required. P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P282 Wear cold insulating gloves/face shield/eye protection. P303 + P361 IF ON SKIN (or hair): Remove/Take off immediately all contaminated
P283 Wear fire/flame resistant/retardant clothing + P353 clothing. Rinse skin with water/shower.
P284 Wear respiratory protection. P304 + P312 IF INHALED: Call a POISON CENTER or doctor/physician if you feel
P285 In case of inadequate ventilation wear respiratory protection. unwell.
P231 + P232 Handle under inert gas. Protect from moisture. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position
P235 + P410 Keep cool. Protect from sunlight. comfortable for breathing.
RESPONSE PRECAUTIONARY STATEMENTS P304 + P341 IF INHALED: If breathing is difficult, remove victim to fresh air and
keep at rest in a position comfortable for breathing.
P301 If swallowed:
P305 + P351 IF IN EYES: Rinse cautiously with water for several minutes. Remove
P303 If on skin: + P338 contact lenses, if present and easy to do. Continue rinsing.
P302 IF ON SKIN (or hair): P306 + P360 IF ON CLOTHING: Rinse immediately contaminated clothing and skin
P304 If inhaled: with plenty of water before removing clothes.
P305 IF IN EYES: P307 + P311 IF exposed: Call a POISON CENTER or doctor/physician.
P306 IF ON CLOTHING: P308 + P313 IF exposed or concerned: Get medical advice/attention.
P307 IF exposed: P309 + P311 IF exposed or if you feel unwell: Call a POISON CENTER or
P308 IF exposed or concerned: doctor/physician.
P309 IF exposed or if you feel unwell: P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P310 Immediately call a POISON CENTER or doctor/physician. P333 + P313 If skin irritation or rash occurs: Get medical advice/attention.
P311 Call a POISON CENTER or doctor/physician. P335 + P334 Brush off loose particles from skin. Immerse in cool water/wrap in
P312 Call a POISON CENTER or doctor/physician if you feel unwell. wet bandages.
P313 Get medical advice/attention. P337 + P313 If eye irritation persists: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell. P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER or
P315 Get immediate medical advice/attention. doctor/physician.
P320 Specific treatment is urgent (see ... on this label). P370 + P376 In case of fire: Stop leak if safe to do so.
P321 Specific treatment (see ... on this label). P370 + P378 In case of fire: Use ... for extinction.
P322 Specific measures (see ... on this label). P370 + P380 In case of fire: Evacuate area. Fight fire remotely due to the risk of
P330 Rinse mouth. explosion.
P331 Do NOT induce vomiting. P370 + P380 In case of fire: Evacuate area.
P332 If skin irritation occurs: + P375
P333 If skin irritation or rash occurs: P371 + P380 In case of major fire and large quantities: Evacuate area. Fight fire
P334 Immerse in cool water/wrap in wet bandages. + P375 remotely due to the risk of explosion.
P335 Brush off loose particles from skin.
P336 Thaw frosted parts with lukewarm water. Do not rub affected area.
44
PRECAUTIONARY STATEMENTS CONTINUED
STORAGE PRECAUTIONARY STATEMENTS

P401 Store ...
P404 Store in a closed container.
P406 Store in corrosive resistant/... container with a resistant inner
liner.
P407 Maintain air gap between stacks/pallets.
P410 Protect from sunlight.
P411 Store at temperatures not exceeding ...°C/...°F.
P412 Do not expose to temperatures exceeding 50 °C/ 122 °F.
P413 Store bulk masses greater than ... kg/... lbs at temperatures
not exceeding ...°C/...°F.
P420 Store away from other materials.
P420 Store contents under ...
P422 Store contents under …
P402 + P404 Store in a dry place. Store in a closed container.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P403 + P235 Store in a well-ventilated place. Keep cool.
P410 + P403 Protect from sunlight. Store in a well-ventilated place.
P410 + P412 Protect from sunlight. Do not expose to temperatures
exceeding 50 °C/122 °F.
P411 + P235 Store at temperatures not exceeding ... °C/... °F. Keep cool.
DISPOSAL PRECAUTIONARY STATEMENTS
45
EU DIRECTIVES
Exposure to chemical agents and chemical safety - OSH directives Directive 95/50/EC - procedures for transport of dangerous goods
Directive 2009/161/EU - indicative occupational exposure limit values Of 6 October 1995 on uniform procedures for checks on the transport of
dangerous goods by road
Of 17 December 2009 establishing a third list of indicative occupational exposure
limit values in implementation of Council Directive 98/24/EC and amending Directive 91/414/EEC - plant protection products
Commission Directive 2000/39/EC (Text with EEA relevance)
Of 15 July 1991 concerning the placing of plant protection products on the
Directive 2009/148/EC - exposure to asbestos at work market.
Of 30 November 2009 on the protection of workers from the risks related to Directive 67/548/EEC - classification, packaging and labelling of dangerous
exposure to asbestos at work (Text with EEA relevance) substances
Directive 2006/15/EC - indicative occupational exposure limit values Of 27 June 1967 on the approximation of laws, regulations and administrative
provisions relating to the classification, packaging and labeling of dangerous
of 7 February 2006 establishing a second list of indicative occupational exposure substances.
limit values in implementation of Council Directive 98/24/EC and amending
Directives 91/322/EEC and 2000/39/EC
Directive 2004/37/EC - carcinogens or mutagens at work
Of 29 April 2004 on the protection of workers from the risks related to exposure
to carcinogens or mutagens at work (Sixth individual Directive within the meaning
of Article 16(1) Directive 89/391/EEC)
Directive 2000/39/EC - indicative occupational exposure limit values
Of 8 June 2000 establishing a first list of indicative occupational exposure limit

values in implementation of Council Directive 98/24/EC on the protection of the
health and safety of workers from the risks related to chemical agents at work.
Directive 98/24/EC - risks related to chemical agents at work
Of 7 April 1998 on the protection of the health and safety of workers from the
risks related to chemical agents at work (fourteenth individual Directive within
the meaning of Article 16(1) of Directive 89/391/EEC)
Directive 91/322/EEC - indicative limit values
Of 29 May 1991 on establishing indicative limit values by implementing Council

Directive 80/1107/EEC on the protection of workers from the risks related to
exposure to chemical, physical and biological agents at work.
Exposure to chemical agents and chemical safety - OSH related aspects
Regulation (EC) No 1272/2008 - classification, labelling and packaging of

substances and mixtures
of the European Parliament and of the Council of 16 December 2008 on

classification, labeling and packaging of substances and mixtures, amending and
repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC)
No 1907/2006 (Text with EEA relevance)
Directive 2008/68/EC - inland transport of dangerous goods
Of the European Parliament and of the Council of 24 September 2008 on the

inland transport of dangerous goods. This Directive replaces Council Directive
94/55/EC, Council Directive 96/49/EC and Council Directive 96/35/EC.
Regulation (EC) No 1907/2006 - REACH
Of 18 December 2006 concerning the Registration, Evaluation, Authorisation and

Restriction of Chemicals (REACH) and establishing a European Chemicals Agency.
Directive 1999/45/EC - classification, packaging and labeling of dangerous

preparations
Of the European Parliament and of the Council of 31 May 1999 concerning the
approximation of the laws, regulations and administrative provisions of the
Member States relating to the classification, packaging and labeling of dangerous
preparations.
Directive 96/82/EC - major-accident hazards
of 9 December 1996 on the control of major-accident hazards involving dangerous

substance
46
GLOSSARY
CAD Chemical Agents Directive – M&U European Marketing & Use Directive.
Council Directive 98/24/EC on the protection of the health and safety of workers Council Directive 76/769/EEC of 27 July 1976 on the approximation of the laws,
from the risks related to chemical agents at work. Implemented in the UK by regulations and administrative provisions of the Member States relating to
COSHH, and not repealed by REACH or CLP. restrictions on the marketing and use of certain dangerous substances and
preparations. Also refers to the individual restriction Directives on certain
CHIP Chemicals (Hazard Information and Packaging for Supply) substances. Was repealed by REACH on 1 June 2009.
Regulations 2002.
NONS short for the Notification of New Substance
Implementing in the UK the SDS Directive (repealed by REACH), DSD and DPD (will
be repealed by CLP). Will be amended by the forthcoming Defra REACH Regulations 1993, a UK SI implementing part of DSD. Partner regulation to ESR. As
Enforcement SI to account for the REACH repeal, and will be further repealed by the relevant part of DSD is repealed by REACH, UK will repeal NONS in December
HSE to account for forthcoming CLP repeals. 2008 as part of the forthcoming DEFRA REACH Enforcement SI.
CLP European Classification, Labelling and Packaging (CLP) of Substances REACH

and Mixtures Regulation
Direct-acting European legislation –Regulation (EC) No 1907/2006 of the
(Direct-acting European legislation), implementing the United Nations GHS. European Parliament and of the Council of 18 December 2006 concerning the
Currently under negotiation. registration, evaluation, authorisation and restriction of chemicals.
CMD Carcinogens and Mutagens Directive. SDS Directive European Safety Data Sheets Directive.
Directive 2004/37/EC of the European Parliament and of the Council of 29 April Commission Directive 91/155/EEC of 5 March 1991 defining and laying down the
2004 on the protection of workers from the risks related to exposure to detailed arrangements for the system of specific information relating to
carcinogens or mutagens at work. Implemented in the UK by COSHH, and not dangerous preparations in implementation of Article 10 of Council Directive of 7
repealed by REACH or CLP. June 1988 on the approximation of the laws, regulations and administrative
provisions of the Member States relating to the classification, packaging and
COSHH Control of Substances Hazardous to Health Regulations, 2002. labelling of dangerous preparations [this latter Directive was replaced by DPD].
SDS Directive is implemented in the UK as Regulation 5 of the CHIP Regulations.
Implementing in the UK the CAD, CMD, and various M&U restrictions.
SDS Directive is repealed by REACH, therefore CHIP Regulation 5 will be repealed
DPD European Dangerous Preparations Directive. by the forthcoming Defra REACH Enforcement SI.
Directive 1999/45/EC of the European Parliament and of the Council of 31 May SI Statutory Instrument
1999 concerning the approximation of the laws, regulations and administrative
provisions of the Member States relating to the classification, packaging and
labelling of dangerous preparations. Implemented in the UK by CHIP. Will be
repealed by CLP.
DSD European Dangerous Substances Directive.
Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws,

regulations and administrative provisions relating to the classification, packaging
and labelling of dangerous substances. Implemented in the UK by CHIP. Will be
repealed by CLP.
ECHA European Chemicals Agency,
Established by REACH and now based in Helsinki. The focal point for the REACH
system, responsible for managing the registration, evaluation and authorisation
procedures, and most aspects of the new regime, including publication of
guidance.
ESR European Existing Substances Regulation
(Direct-acting European legislation). Council Regulation (EEC) No 793/93 of 23

March 1993 on the evaluation and control of the risks of existing substances.
Partner regulation to NONS. Repealed by REACH.
GHS United Nations Globally Harmonised System for the classification

and labelling of chemicals.
Being implemented in the EU by the CLP Regulation.
47
REFERENCES & BIBLIOGRAPHY
References & Bibliography
Official Journal of the European Union L 353/1 REGULATION (EC) No

1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL
of 16 December 2008 on classification, labelling and packaging of
substances and mixtures, amending and repealing Directives 67/548/EEC
and 1999/45/EC, and amending Regulation (EC) No 1907/2006
Relationships between REACH, CHIP, and COSHH

Health and Safety Executive Board Paper No: MISC/08/12
Date: 28th May 2008
Guidance to Regulation (EC) No 1272/2008 on Classification, Labelling and

Packaging of substances and mixtures- 27 July 2009: Collaboratively
established by EU experts and Edited by Ingrid Langezaal, Kerstin
Nordenhäll and Elisabet Berggren
Insitute for Health and Consumer Protection,
DG Joint Research Centre, European Commission
Disclaimer:
This quick reference guide has been created to enable you to gain a
brief overview of the various chemical legislation and the effects of
the CLP.
Although every effort has been afforded to retain currency you are
advised to refer to the relevant Directives and Statutes for accuracy.

Classification Labelling of Chemicals (CLP) - Grant Maloney FIIRSM - 0

Uploaded by

Document Information

Original Description:

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Classification Labelling of Chemicals (CLP) - Grant Maloney FIIRSM - 0

Uploaded by

Copyright:

Available Formats

qwertyuiopasdfghjklzxcvbnmqwertyuiopasdfghjklzxc

 FORWARD ENVIRONMENTAL HAZARDS

 GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND  GLOSSARY

OXIDIZING LIQUIDS AND SOLIDS

Initially this document started life as a project for my own Continual

Please remember that this manuscript is not intended to be a definitive

The (Chemicals Hazard Information and REACH - Registration, Evaluation and

Manufacturers and importers in the European Union must provide their

SAFETY DATA SHEETS

SECTION 4: First aid measures

SECTION 5: Fire fighting measures

SECTION 6: Accidental release measures

SECTION 7: Handling and storage

SECTION 8: Exposure controls/personal protection

SECTION 9: Physical and chemical properties

SECTION 10: Stability and reactivity

SECTION 11: Toxicological information

Control of Substances Hazardous To Health Regulations 2002 -

Breach of the regulations by an employer or employee is a crime, punishable on

Dangerous to the Environment

COSHH Abbreviations & Brief Description

Repr category 1 Chemicals that produce or increase the incidence of

E explosive Chemicals that explode.

O oxidising Chemicals that react exothermically with other

F+ extremely Chemicals that have an extremely low flash point and

Xi irritant Chemicals that may cause inflammation to the skin or

T+ very toxic Chemicals that at very low levels cause damage to

Carc Cat 2 category 2

Carc Cat 3 category 3

Muta Cat category 1 Chemicals that induce heritable genetic defects or

Chemicals that induce heritable genetic defects or

Chemicals that induce heritable genetic defects or

Muta Cat category 2

Muta Cat category 3

Global Harmonisation System

Globally Harmonized System of

The Globally Harmonized System of Classification and Labelling of Chemicals

Some GHS resources for other countries include:

 European Union (Classification, Labelling and Packaging (CLP)

 The GHS calls for including the recommended use of the

Definition Connection between REACH & CLP

Additional Info Self reactive’s & Organic

Specific Target Organ SE

Gas Under pressure

GHS07 GHS01 GH02 Flammable Liquids / Solids /

GHS03 GHS08 GHS06

Graphic representation of relevant

GHS CLP COSHH

REACH (Including SDS)

REACH (Including SDS)

Hazard communication for explosives Hazard communication for explosives

Signal Word Danger Danger Danger No Single Word

H200: H201: H202: H203: H204: H205: No

P372 P370+P380 P370+P380 P370+P380 P370+P380 P370+ P370+

P401 P401 P401 P401 P401 P401 P401

Description Precautionary Description

A pyrotechnic article is an article containing one or more pyrotechnic

An intentional explosive is a substance, mixture or article which is

Transport of Not required under

Prevention P210 P210

Storage P403 P403

Signal Word Danger Warning