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Lypmhomas
Lypmhomas
HL and NHL
· Hodgkin —> Better prognosis. Bimodal: 25-30s and >60s
· NHL -> Children and adults. Don’t have RS cells, spread non-contiguously. Involve extra
nodal sites. Skin, brain and GI tract.
HL
· Histology:
o RS cells. Binuclear. Neoplastic B-cells. Look like owl eyes.
§ Cytokines: IL-5, IL-10, M-CSF, catatoxin
§ NF-kb mutation may occur. Overexpression, Promotes growth, survival and
division of RS cells.
o Hodgkin cells: Large mononucleated version of RS. Surrounded by non-neoplastic
inflammatory cells (mostly T cells and eosinophils).
o Can activate fibroblasts Secretion of collagen PINK
NHL
· T-cell lymphoma (adult)
o Leukemia (abnormal leukocytes), aggressive, HTLV (Human T lymphotropic virus that
spreds through fluids like IV drugs with needles and breast feeding.
o Increased bone resorpcion.
o Severe hypercalcemia and bone lesions
· Mycosis fungoids
o Lymphoma of the skin
o Path or plaque like lessions
§ Looks like fungal lessions
o Biopsy
§ Pautrier microabscesses in epidermis: Filled with neoplasic lymphocytes.
§ CD4* helper T cells with CEREBRIFORM nucleus
§ Sezary suncrome Itchy rash, erythema.
Symptoms
DX