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4. Defecation reflex is dependent on the functioning of spinal 13. Which hormone exerts excitatory effects on small intestinal
neurons present in the ________________. motor activities?
a. upper lumbar region a. VIP
b. lower lumbar region b. Somatostatin
c. lower thoracic region c. CCK
d. sacral region d. Secretin
5. Which statement is INCORRECT about the digestive 14. Distention of the stomach sensed by mechanoreceptors
system? activates the nerve fibers that are located in the
a. An essential part of the endocrine system a. serosa
b. Considered as a very important lymphoid area of the b. muscularis externa
body c. muscularis mucosa
c. Mostly associated with excretion of carbon dioxide d. submucosa
d. Capable of functioning as an excretory system
15. Which of the following is TRUE regarding the contraction of
6. When an Auerbach’s plexus is activated, it is expected to the lower esophageal sphincter?
transmit a. Force of contraction is maintained at a reduce calcium
a. excitatory impulses proximal and inhibitory impulses , hence a low level of myosin-light cha
distal (involved region (GIT) phosphorylation and cross-bridge cycling rate occurs
b. excitatory impulses proximal and distal b. Due to a brief period of stimulation followed by
c. inhibitory impulses distal and proximal sustained contraction.
d. excitatory impulses distal and inhibitory impulses c. Due to prolonged stimulation that results to high level
proximal of myosin-light chain phosphorylation"on.
d. Exhibits rhythmic contraction due to the brief period
7. In cases of constipation, during defecation the following of stimulation.
skeletal muscles are activated to contract, EXCEPT
a. Diaphragm 16. After eating you suddenly feel the urge to defecate. This is
b. External anal sphincter called ___________
c. Abdominal muscles a. Gastroileal reflex
d. All of the options are correct b. Gastrocolic reflex
“When things are hard and you’re tired, I’ll shine on you. Smile brightly so we can be strength to each other.” - SEVENTEEN
1
PHYSIO RATIONALE
MIDTERMS - Compiled Shifting Exams
“When things are hard and you’re tired, I’ll shine on you. Smile brightly so we can be strength to each other.” - SEVENTEEN
2
PHYSIO RATIONALE
MIDTERMS - Compiled Shifting Exams
13. Activation of CFTR in the pancreatic ductal cells occurs 20. Breakdown of food residues reaching the colon is mostly
usually in the presence of thru
a. Secretin a. reduction
b. Substance P b. Hydrolysis
c. CCK c. oxidation
d. Motilin d. Fermentation
14. Gastric acid is essential for the normal absorption of 21. CORRECT regarding acid production of the gastric
a. Cyanocobalamin parietal cell.
b. Retinoic acid a. Leads to increase acidity of the plasma
c. Calcium and iron b. Inactivation of the enzyme carbonic anhydrase in
d. Bile salts the parietal cell
c. Involves activation of the electroneutral hydrogen-
15. After eating a bowl of chicken noodle with egg and once potassium exchange pump
chyme is in d. Major source of hydrogen is the breakdown of
the duodenum, which of the following happens? carbonic acid
a. Somatosta"n is secreted by the I cells of the
duodenum to inhibit the release of gastrin by the G 22. Which of the following is inhibited if the pH of the
cells. stomach is <pH 3?
b. Acetylcholine is released to inhibit gallbladder a. Gastrin
contraction b. CCK
c. Cholecystokinin is released to stimulate pancreatic c. Secretin
acinar cells to increase digestive enzyme d. VIP
secretions.
d. Secretin is secreted in response to the fat and 23. Initial chemical digestion of carbohydrates occurs in the
protein breakdown products to increase a. Duodenum
bicarbonate secretion by the pancreas b. Stomach
c. oral cavity
16. Which of the following enzymes cleaves the α -1,6 bond of d. Pancreas
α limit dextrins?
a. Isomaltase 24. There is greater secretion of the hormone CCK when the
b. Sucrase duodenum is irritated by ______________.
c. α -amylase a. products of CHO digestion
d. Glucoamylase b. Carbohydrates
c. the acidic chyme
17. The end product of digestion of starch is absorbed into d. products of lipid digestion
the bloodstream is __________________.
a. glucose 25. This fatty acid once absorbed (intestines) is transported
b. sucrose towards the lymphatic circulation.
c. Maltotriose a. Propionic acid
d. alpha dextrins b. Butyric acid
c. Oleic acid
18. While eating a sour candy, you start to drool. Which of d. Lauric acid
the following is CORRECT regarding the regulation of
salivary secretions? 26. Which of the following is a paracrine secretion?
a. Sour taste is sensed by the afferent fibers of the a. Histamine
glossopharyngeal nerve to stimulate the sublingual b. Gastrin
glands. c. Secretin
b. Acetylcholine binds with the muscarinic recep of d. CCK
the salivary glands to produce a viscous sali
c. Tac"le s"mulus excites afferent fibers of the
hypoglossal nerve that sends signals to the nu of ,-.$/01$23/#434#5$
tractus solitarius 1. Which of the following properties of platelets allow
d. Glossopharyngeal nerves stimulate the parotid it to repulse adherence to normal endothelium and
gland to increase salivary secretions
yet cause adherence to injured areas of the vessel
wall?
19. INCORRECT about the bile acids/salt synthesized by
hepatocytes A. Presence of contractile proteins actin and
a. 95 % is reabsorbed in the proximal ileum myosin
b. Usually stored in the gallbladder B. Glycoprotein on the platelet cell membrane
c. Undergoes deconjugation in the colon surface and the endothelium
d. All bile acids present in the colon are excreted C. The enzyme systems that synthesize
phospholipid
“When things are hard and you’re tired, I’ll shine on you. Smile brightly so we can be strength to each other.” - SEVENTEEN
3
PHYSIO RATIONALE
MIDTERMS - Compiled Shifting Exams
D. Mitochondrial systems that allow formation 9. Which of the following would shift the oxygen-
of ATP and ADP hemoglobin curve to the left?
A. Exercise
2. AA is a strict vegetarian for 10 years. Upon B. Fever
checking her red blood cells, they were found to be C. Increase 2,3-BPG
_____________________. D. Alkalosis
A. macrocytic
B. large and bizarrely shaped 10. The Rh system of human blood group differs from
C. sickle - shaped that of the ABO system because in the Rh system
D. Microcytic ______________.
A. antibodies develop against antigens not
3. A patient has fibrinogen deficiency, hence it is present in the RBC cell membrane.
expected to have abnormal laboratory results on B. transfusion reaction occurs when a
the following EXCEPT recipient’s red cells are mismatched with the
A. aPTT donor’s plasma.
B. Prothrombin time C. the presence or absence of antigens is used
C. Thrombin time to classify the blood group.
D. Bleeding time D. antibodies develop only if there is repeated
exposure to antigen.
4. Iron is transported in the plasma as
______________. 11. The following coagulation factors, when activated,
A. apotransferrin act as proteolytic enzymes EXCEPT?
B. transferrin A. Stable Factor
C. ferritin B. Stuart-Prower Factor
D. Apoferritin C. Tissue Factor
D. Plasma Thromboplastin Antecedent
5. Which of the following conditions is CORRECTLY
paired? 12. Which of the following is the intermediate cell
A. Megaloblastic anemia- G6PD deficiency stage that have already become committed to a
B. Aplastic anemia- Iron deficiency particular line of cells?
C. Microcytic anemia- Intestinal sprue A. Committed stem cells
D. Hemolytic anemia- ABO incompatibility B. Orthochromatic blast cells
C. Pluripotential hematopoietic stem cells
6. Which of the following is a CORRECT statement D. Colony- forming unit cells
regarding tissue thromboplastin?
A. Necessary for fragmentation of 13. The estimated maximum blood volume of a 50kg
megakaryocytes. female is _________.
B. Must interact with other factors of the blood A. 6L
before it becomes prothrombin activator. B. 5L
C. Capable of directly splitting prothrombin to C. 3.5L
thrombin. D. 4L
D. Thromboplastin is not readily available and
released upon damaged of tissues. 14. The following conditions might result to excessive
bleeding EXCEPT
7. A newborn who fails to receive routine vitamin K A. Hemophilia
prophylaxis may develop hemorrhagic disease of B. Disseminated intravascular coagulation
the newborn. This is due to deficiency of which of C. Liver disease
the clotting factors? D. Renal failure
A. Antihemophilic Factor A
B. Hageman Factor 15. Which of the following is the effect of anemia on
C. Antihemophilic Factor B function of the circulatory system system?
D. Fibrinogen A. Decreased pumping workload on the heart
B. Decreased hypoxia resulting from
8. In which stage of RBC differentiation does the diminished transport of oxygen by the blood.
onset of hemoglobin synthesis occur? C. Increased cardiac output to compensate for
A. Proerythroblast the decrease in perfusion to the different
B. Polychromatophil erythroblast tissues.
C. Reticulocyte D. Increased respiratory rate to excrete oxygen
D. Basophil erythroblast
“When things are hard and you’re tired, I’ll shine on you. Smile brightly so we can be strength to each other.” - SEVENTEEN
4
PHYSIO RATIONALE
MIDTERMS - Compiled Shifting Exams
16. Which of the following factors is NOT required in D. The average mean cell diameter is 7.5um
the formation of platelet plug following injury to a
blood vessel? 23. Which of the following statements is TRUE in the
A. von Willebrand factor regulation of RBC production?
B. Thromboxane A2 A. Erythropoietin is secreted in response to tissue
C. Fibrin stabilizing factor hypoxia
B. Rapid RBC production continues as long as there
D. Serotonin
is an inadequate number of RBCs.
C. Iron is required in the maturation and rate of
17. Which of the following is a result of the production of RBCs
mechanical shrinkage of fibrin strands within the D. The most essential regulator of RBC is the
clot and tends to pull the edge of a wound hemoglobin concentration
together?
A. Appearance of fibrin monomers 24. Which of the following types of anemia is brought about
B. None of the choices by lack of functioning bone marrow and severe form can lead
C. Clot retraction to death of a person unless managed with blood transfusion?
D. Formation of platelet plug A. Aplastic anemia
B. Megaloblastic anemia
18. Which of the following condition will have a low C. Hemolytic anemia
p50? D. Blood loss anemia
A. Fever
25. Stroke patients are given aspirin to prevent them from
B. Strenuous exercise developing new blood clots. This is because aspirin
C. Metabolic Alkalosis A. Inhibits the production of vit K dependent factors
D. Chronic lung disease B. Can interfere with the production of prothrombin
activator
19. Which of the following enzymes is abundant in the C. Can remove several activated coagulation factor
red blood cell allowing it to regulate blood pH and D. Inhibits cyclooxygenase which is needed for
maintain internal homeostasis? platelet aggregation
A. Carbonic peroxidases
B. Cytochrome oxidase 26. Which of the following results from the instantaneous
C. Hydrogen caboxylases action of thrombin on fibrinogen?
D. Carbonic anhydrase A. Plasmin
B. Prothrombin
20. Which of the following is a CORRECT statement C. Thromboplastin
regarding erythropoietin? D. Fibrin
A. Normally about 90% of erythropoietin is
27. Which of the following inhibitors of coagulation acts by
formed in the liver while the rest is in the directly inactivating Factors V and VII?
kidneys. A. Protein C
B. Erythropoietin has little effect in the B. Heparin
stimulation of the production of C. Antithrombin III
proerythroblasts from the lymphocytic stem D. Thrombomodulin
cells in the bone marrow.
C. Numerous red blood cells are formed in the 28. A 50 y/o chronic alcoholic drinker was admitted due to
bone marrow everyday even in the absence of upper gastrointestinal bleeding. aPTT was 25 seconds while
erythropoietin. PT was >20 seconds. This is suggestive of deficiency of which
D. Erythropoietin is the principal stimulus for clotting factors?
red blood cell production in low oxygen A. Factor IX
B. Factor VIII
states.
C. Factor VII
21. The rate-limiting factor of coagulation is D. Factor XII
A. Conversion of prothrombin to thrombin
B. Conversion of fibrinogen to fibrin
C. Activation of fibrin-stabilizing factor
D. Formation of prothrombin activator
“When things are hard and you’re tired, I’ll shine on you. Smile brightly so we can be strength to each other.” - SEVENTEEN
5
PHYSIO RATIONALE
MIDTERMS - Compiled Shifting Exams
“When things are hard and you’re tired, I’ll shine on you. Smile brightly so we can be strength to each other.” - SEVENTEEN
6
PHYSIO RATIONALE
MIDTERMS - Compiled Shifting Exams
19. Which of the following is CORRECT about the flow 26. Urin Which of the following products of the
of blood to and from the heart? classical pathway of the complement system
A. Oxygenated blood from the lungs enters strongly activate phagocytosis by making the
the left atrium by way of the pulmonary antigen more foreign?
artery A. C3b
B. Deoxygenated blood from the B. C5b6789
pulmonary circulation enters the right C. C5a
atrium by way of the vena cava D. C3a, C4a, C5a
C. When the left ventricle contracts,
deoxygenated blood is ejected into the 27. People with HIV can easily die from infection
aorta and distributed to the peripheral because the virus attacks the ajor regulator of
circulation virtually all immune functions which is the. __
D. Oxygenated blood from the right A. neutrophils
ventricle enters the lungs by way of the B. Cytotoxic T cells (Tc)
pulmonary vein C. T helper cells (Th)
D. Plasma cells
20. BM, a 34 year old male, was diagnosed of AV 28. An action potential can be elicited during the
Block. The block could be in which particular relative refractory period by using a stimulus of
region of the AV node? higher intensity than the initial stimulus because
A. Atrio-nodal the __.
B. Nodal HIS A. Na+ channels are now closed
C. Between middle & Nodal HIS B. Na+ channels are activated
D. Middle-nodal C. Na+ channels are still inactivated
D. Na+K+ pump is activated
21. The absolute refractory period in the ventricle
A. coincides with the phase of rapid
depolarization and plateau
“When things are hard and you’re tired, I’ll shine on you. Smile brightly so we can be strength to each other.” - SEVENTEEN