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() Race Web soe [ 3 When the volume of distribution increases (and clearance remains the same}, steady-state plasma, ron: concentration will have more peak-to-trough variation. aaswer Ome OFalse 4 Halt-ife: Chonse atleast [] 2 lame nme token tar the plasma cencentrston to ral ey heir during the terminal elminston | one answer prase [Ob hesuns "per hourt [es ne tme taken ror the amaunt ar drug ia tne nay tora ty nat © Geereases as elnination rate constant Increases 1 & increases as the elinination rate constantincreases 5 Major role of receptors: Choose one 2_vetermine cy clminationSee eh ee ee Foca anol Pel ininiani) 5 Major role of receptors: sis Choose one © a.determine rate of drug elimination a (© determine srug acon selecinty ime Remaining (© © actos rug storage ates 0:52:54 8 Choose ere a.atpurin ame © 8 gopuin © © appre -acie pycapramn ©. dLipoprotein 7 What is the goal of Good Clinical Practice? Choose atleast =) a. To ensure te drug stability. one ansiier (24. To protect the rigths and safety of clinical subjects 1. Teensure qualty and iteonty of data 5 Major role of re Chonse one Oa vetermine rate of 2 clmination 2 ptr:vstati [") Comeiridere {} HotWall gratuite ("} Fersanalzesziore call. |") Raccolta Web Stee (") Sii suggeréi {"} WindorsMeda 8 Matabollsm usually generates: Chase ane @ a. More polar an insine metabaltes t (© b.Less polar and inactive metabolites © 6.Le8s polar and active metateltes (Time Remaining a (©. dare patar ana actve metanartes 4 9 Drugs are generally tess rapidly distributed to highly perfused tissues (compared with poorly perfused mone, — tssues). Angwer Ome OF alse 10 Theophyline 's administrteu to @ patient at 90 mgfnour vi constant IY infusion. the patient as 3 total body clearance ons, fr neuphyline of 90 mLéminuke, what sould this palar’s steady-state plasma concentraiun be? Chosse one © a. .625 mgt. © brno mgt ©. 04 mpi fo 5 Major role of receptors: Chonse one Oa vetermine rate of 2 clmination 240 ——_Theopnytine i administrated to 2 patent at 30 mgfnour vs constant lvusion the patient has 8 tta| boxy clesrance nite YOrtHeophyline of SO mLimnute, what snouia this patient's steady-state pissma cancentranan f=? Choase one © 2.0626 ng as enews © b100mgt Time Remaining © 6.0.1maft 0:54:41 1" Concerning parenteral drug administration: sons Choose one © a. less previctable compared to oral diinistration route = © b not acceptable for uncensciaus patients ©. c.mare reclctsble compared to orsl adhinistrtion route 12 An-example of an agent that exerts much offs effects through intracellular receptors Choose one Oa. avetylehoine srever © bcoparnine © © comcosterois ° a.insuln 5 Major role of receptors: Choose one 2_vetermine cy clmination8 ‘Wo generic brands of equal strenght of a drug (as a tablet) are given orally. Tablet A results in an AUC of 600 (mg/Ly'hour, while Tablet B results in an AUC of 200 (mg/L/'hour. Therefore, peak plasma concentration must ‘os! Sige be higher for product A. Angwer. Ome ‘ [Time Remaining Fane 0:50:15, a 44 What is the purpose of Phase I clinial trials? 7 sits Choose ane a, To select a lead campoure!trom a lead! series, ome © bi To dentty a target population (© 6 Twestabtsn the setery ar ainsrston to humans © a. Totest emer ne proposed erug setuaty works 16 Factors associated with drug absorption that can result in incomplete absorption (Multiple Answer) change atleast 2 ctug metabolism ny gastraintestinal nara drug tyoprioty ©. drug instabity in gastric aia d.presence of food inthe Glirsct oa 5 Major role of receptors: Choose one 2_vetermine cy clmination16 What Is an antimetaboutte? Shease one y 2 res nenete aes oes me Rem —) t © 4. Chemicterapics trat slow doym tre metabolism of tne patent 28 a side effect © © Drugs that siow down tne metabolism of infective agents 7 The oral bioavailability of a drug: (Choose at least 43.18. measure of tne extent to which it enters the systemic circulation one anewer [Cb maybe intiuenced by changing the exciptent of the oral formulanon C1 .itis party defined iy the rato of the area under the plasma concentratian time curve (AUC) following oral administration divided by trat following intravenous administration, C1 @ mayne reduced ty nepatie CYP450 induction a ee Le ea a 18 One of the following statement is incorrect. Please identity it. 5 Major role of receptors: Choose one 2_vetermine cy clmination€ PB vrenrs pions comer ) OF av ec0 P| (BD Pinvistats (7) Come icine [") HolMed gratuta [ Persondlzzacicne col. [} Racooks Web Sie {7 Stisuggerti |) Wirdonsttedia (Cima 18 _One ofthe folowing statement is incorrect Please identi it Time Remaining wee 0:49:33 Chosse one © a. he locstbrain bse, which invevescrug mevement oreugh gi cel membranes Aner ansver 3 capilaty membranes, she main hnarance 9 ray atrbvtn to the CNS © 8 mostus enter the CNS by simple dtusin at rates tht are propsctonal ote in Eclibity ofthe narionzedferm atthe cus © © receplorsmesitectransrer alews certan nepbaes to gen acess tothe bein © 8: alstongly ented drug enter eel tre CNS (© some crugs eave se chs ay passing om ne cerearspinal mus ie he cus] loos 5 sinuses trough te aracrno 19 One of the drugs below DO NOT target the bactertal cell wal: vs Choose one a Penciin ° © b.Amaxicitin © © Vaneomicn © a Allbeta lactams © © Aminoglycosides Chonse one Oa cetermine rate of 2 clmination 220 Pharmacokinetic advantages associated with transdermal drug delivery (Multiple Answer) |e (Choose atleast"). relstively constant, sustsinec therapeutic plasma crug concentrations one ansyer. 5] 8. commonly nw siae-ertet incience 1D © good patient compliance {Time Remaining Do not good patient comaliance 0:49:09 24 ‘Miced function oxidases system is referred to Choose one @ a. phase Isystem angie. © phase m system © c.phase ll system 22 Hatrste determines: Cheose one Oa. the loating dose (© 6 the te to reach the steady-state (© c.the average crug concentration at steady-state dunng constant dosing : Chonse one Oa cetermine rate of 2 clmination 223 25 Instantaneous distribution to most body tissues and fluids is assumed in which of the following models? Chaase one Factors affecting choase at ieast What does Phase Chaase one © a.one-comparonent model (Ob. tio-compartment model © © mut-comparment model passive diffusion (Multiple Answer) 1 acnersy ‘a Ernerormmental pl ©. Thickness and surface area of ime membrane 1D G.Allthe proposed items cuinical testing test? © a. Anim subjects ©. Healy human yolunizers ©. ¢. Widespread aiferentil population 1. People wn me target alsesse/concin {Time Remaining 0:44:04vistas {_! Gomenetnre |_| Hott grchuta {_” Persenalezanionecol. {_! Raccaka Web Sie | Sti sige 28 4 27 28 The elimination rate of a drug is Influenced by: Choose atleast] 8. exretion af it breakeiown products in the urine [1 b.renal exertion af unchanged aug [© metaboism or the erug ithe Iver ana ctner nsaues Hirdowatesio| Time Remaining 0:43:13, ‘Only one antifungal drug below doesn't have anything to do with fungal CELL MEMBRANE or CELL WALL: Cheoseone 3 Terbinatne anever © 8 SFucjesine © © Amphetercn © 0 Aaoles Clearance: Choose atleast [a depends onthe elmination rate one ane Fy refers tn the emclency of tne elimination of erug by an organ or the whole ody 1 © irefered ta an organ, cannot be greater then blood flow throuch thet ergsn [C] a tagemer ism dosing rte ana sloavalsniy, determines tne stesey-state drug Ceneentrion curing castart a0sIng29 30 4 a a4 Wma Is the Principal Investigator? Choose one 2, An individual that reports tie progress ofan investigation ansier Time Remaining | (© 8 Anindividual thats invaled in the management of clinical bial (© ¢-Am neivicual thet colects and recorc’s data ofthe study 0:42:53, For a drug that has a first-order elimination and follows a one-compartment model, which of the following plots would result in a curved line? Choose ane © plasma concertratonversus be aes © 8. log plasms concentration versus time, Renal exeretion factor most likely to be sensitive to drug lonization state: Cheese one © lemeruar tration anaes © b. passive tubular reabsonpton (© & tubular seeretion32 33, ue 34, ‘The MAIN function of Phase I metabolism is. ‘choose one angie 8. prepare the compound tor phase # 1 to prepare the compound forthe eseretion ® ° © e-to prepare the compound forthe distribution ° 4. to prepare the compound far phase i Clavulante acta and tazobactam are currently used as: Time Remaining 2:28 Choose one 3. Antiviral agents =“ (© 6b Antimicrobial sgents. They ere usedlin monatrerapy © ©. Suiede nhttors of bacterial betslactamases (© 0 Setalattamics having a strang hetalsctam rng, mune tothe ction oF aetalactemases (© © Newly synthetizee cephalosporins Genetic variation may be involved in: (Multiple Answer) Cheese atleast] 8. merapeune ranure b. adverse urug reaction34 ores 36 res 36 Genatie vartation may be involved in: (Mulnple Answer) Choose atleast C] a. therspeutic failure ane anne 1b. eaverse dug resction [1 e.non-ceverse drug resction Blotechnologieal insulin can induce an immune response due to: Choose one 8. modined structure enewer OB. low solu ity © .proauenon resauais © 4 binding to other proteins ‘The aims of GLP is to eliminate: Choase one =a Aaverse entects © b Data collection © ¢. Human error ‘Time Remaining 0:42:097 Which is a broad-spectrum Inductor: (Multiple Answer} Chonse atleast [] 2 cimetiane 1 b Phenavartital Sy eemerene ‘Time Remaining 0:41:44 DG Aceteminaphen 38 ‘True statement(s) concerning compatitive inhibition (taultiple Answer) Chonse atleast [wih competitive hniution, mayimal rug eect cannot be obtained, even at nigh agonist one answer ‘eaneerirations Db wth compentive inninton, the dose-ertects curve shined tn the let 1 c.compettive action is based on reversible drup/antagorist binding at receptor sites 1 ciwith competitive inhitition, the dose-effects curve shited to te right 39 with a drug that follows first-order elimination, the amount of drug eliminated per unt time: Choose one a. remains constant wile the fraction of drug eliminated decreases © b ecresses while the fraction of crug eliminated remains constant39 res 40 a concentrations bb. with competitive inition, the dose-effects curve shifted to tne left ©. compettive actin fs based on reversible drusiartagcrist aning at receptor sites obooce wth comoestve inhition, the dose-etfects curve shifted tothe rignt ime Renaming —] 0:41:17 With a drug that follows first-order elimination, the amount of drug eliminated per unit time: Choose one «©. remsins constant whl the fraction of drug el minated decreases (© decreases while tne traction of crug eliminated remains constant Receptors are usually Choose one © a Lipid “er © b Prin © e.0NA ees