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Groowe one Ga. te sonetact relating arent of hug ite hy 0 tre sian ny answer eonoentration ~ 1B equal to the vont cA tuna tmieby waneer ©. the total volume of the body © the Volume of extrocembar fd © © the Vohime of the body minum the Bees woman gee eC ELE E 15% With a continuous IV infusion of drug, the steady-state plsoms \ca- aris: Choose one © a. inversely proportional to volume of disirinsion 14% Volume of distribution is Mane 4 Choose one () a. the constant relating amount of drug in tim body to = ees answer ation b equal to the volume of total body water © ¢. the total volume of the body © @ the volume of extracetiular fuid © € the volume of the body minus the bless: wake Ble dfs vsusle= oncksle seoralb stursnti auto (res cone harman n-18 ur. SPB biarionineuninvitincedi modjcuiefatterst cha G |) @F~ won.aceate.com Pt Bristol) comeiniore ©) Heal raluts (2 Pesoralzzarcnecol. () Rarcoka Wes ice (3 Stsuozeti ) Wrdonsteds 6 ‘The extent to which a drug is absorbed partially determines its: Choose one answer = Qa elimination rate Ob. bloavalani ueRaaiag o iy [Time Remaining Oe hatesite 0:58:29 - © 4 volume of distribution ————— 7 Plasma refers only to the fluid portion of blood, Including soluble proteins but not formed elements. Answer Ome OFase 8 In a two-compartment model, which of the following is the best definition of beta? Choose one answer = Qa intial rate constart ot elmination © b terminal nat-ite © c.average elimination rate constant © terminal elimination rate constant Ble dfs vsusle= oncksle seoralb stursnti auto (res cone harman n-18 ur. SPB biarionineuninvitincedi modjcuiefatterst cha G |) @F~ won.aceate.com Pt Bristol) comeiniore ©) Heal raluts (2 Pesoralzzarcnecol. () Rarcoka Wes ice (3 Stsuozeti ) Wrdonsteds 6 ‘The extent to which a drug is absorbed partially determines its: Choose one answer = Qa elimination rate Ob. bloavalani ueRaaiag o iy [Time Remaining Oe hatesite 0:58:29 - © 4 volume of distribution ————— 7 Plasma refers only to the fluid portion of blood, Including soluble proteins but not formed elements. Answer Ome OFase 8 In a two-compartment model, which of the following is the best definition of beta? Choose one answer = Qa intial rate constart ot elmination © b terminal nat-ite © c.average elimination rate constant © terminal elimination rate constant Ble dfs vsusle= oncksle seoralb stursnti auto (res cone harman n-18 ur. €P eo Brivo & 9 10 jobs unpeitineedejnedicue 1 comeiisare £ Heisalortuts (2 Persralzacine col. ©) Reco Web ee (2 atisupget £ CHBUSE UTE SNE) arian ste onoesre ur erste © b temminal hatte Wisdonsteis © © average elimination rete eanstant © d terminal etinination rate eanstant Characteristics of renal drug exeration: Choose one answer, a. neatly all drugs are fiteres at the olamaruius © bi. drugs which are weak aciels are excreted faster in aciic urinary pH © drugs which are weak hase are excreted faster in alkaline urinary nH G] [1 row aceae.can During a constant rate intravenous infusion of a drug with a half-life of 24 hours, steady-state plasma concentrations will be achieved after approximately: Choose oneanse, a 12h © b%h Oo c.4an oO d4days © & 1Maays [Time Remaining | 0:5: 7 Ture sac ata WedFea veusiezs omrokge serait sturent ute (© We Geral sheraciontt-18 0 Pf jonine unbitincedlenodoue | /O1~ .acoakecom Pt LB Pit yoitati () Comeinicare () HotMal gratuts {i Personszzacione col () Receoka Web dice |) Sti sugzeriti () WielowsMedis GENERAL PHARMACOLOGY TEST - 18 GIUGNO 2013 i. “ess 4 DNA recombination technology: a Marks: 1 Choose one answer, a. allows you to produce any kind ef orug amaming | © bis used to create new drugs 159:37 © © canbe used only ifthe nostitset produces the drug, © requires row tne exact gene sequence 2 With a continuous IV infusion of drug, the steady-state plasma concentration is: Warts 4 Choose one answer. a. rectly proportionalta clearance © b inversely propartional ta volume of distibution ° ° directly proportional ts drug infusion rate and inversely properticnal tn clearance |. none at ie aove Tied stone ae Vows Gorokge sezalb shurent! aute (res cone harman n-18 ur. €)P > @ vision unbvtincedeiadiae |[ OF wowceae cam Zit B Pit roitati (") Comeinicore (1 Ho'Mal gratuts {i Personslzzacione col (_) Receoks Web dice |) Sti sugzeriti () Wielowstedis sts Choose one answer, =a. Adverse effects, © b Dats callection © ¢ Human eror —— a [Time Remaining 0:56:31 14 ‘Why using the sublingual route we obtain a rapid absorption? (Multiple Answer) Because. Choose atlesstone ©] a. This region is highly vascularized , Ob The epAnetum is thinner CO c.thepHis acia [Dd The pHtis basic 16 ‘The MAIN function of Phase Il metabolism is waite 1 Chaaseane answer, © __a ta prepare the compound far phase | ©. fh tn prensre tne compaund tor tne excretion © Ca pregare the compound for the cistioulan © d Allthe proposed tems target for the G proteim: B answer Tied stone ae Vows Gorokge sezalb shurent! aute (res cone harman n-18 ur. €)P > @ tisirire unbitincedeinediaue G | [Frew acedlcam P| DB Pit yoitati (") Comeinicare () HotMal gratuts {) Personslzzacione col () Receoko Web dice |) Sti sugzeriti () WielowsMedis SEE ensore usta an ener or oar 7 26 ‘Which is a broad-spectrum Inductor: (Multiple Answer) Time Remaining] Choose atleast one =F] a Cimetaine 0:53:14 ansie Ob. Phenoverbital Oc. Berzppyrene [4 Acetarinopnen a ‘wo most important sites for drug elimination are: Choose one answer. © a ungand iver © 6 Iver and gastrointestinal tract 7 Oe kedney and fver Od shin andiver © e.lungand Money 28 ‘4 pew generic drugs tested ina bioavellebltystusy against the innovator brand, The AUCoral forthe genetic 1200 (ng/L}thour and that forthe nnovatar brand 15.1000 udu, % ©. Perteitin Os rewodyconiton tuyeF? Rhine L Acie 40% True statement(s) conceming competitive inhibition Met ‘Choose at oe @a compettive actions based on reverse rfertagore ning = 28 Mess 299 aaah Wf the dose and intravenous AUC are known, the clearance jares memos, = cacwtes > Choose one a. dose x AUC answe’ bb. plasma conoentratioWAUC ¢. AUCIdose Od anne vo determine drug clearance, its enseniil to dari Bret wheter 8 au SESS °°" ‘or two-compartment model, Be —_ Characteristics of renal drug excretion: els Choose one Os vei at rage sre tor oe SOI borage which are week ina ig ose acne 6 Clearance is expressed as the ratio between Marks 4 Choose one > a half-life answer. ; concentration c. time: © ddose (8. AGG enaiogus Of © moleciie Sut lochs an erzyms wary: a 8 substrale b Chemioterapios that slaw down the metatclisen of te patient as 2 side effect C. Drugs that slow down the matabolien f intiectnes agerts CD24. A drug that inhibit the syrthesie of « metaucitie le anewer © ® Lead developer © BD Lend identification © © Target selection DD @ Shorter toncotogy ) 1.500 mg of a drug is given orally snd 260 mg is abvecrtes inte te sysnnee: SOSA: ins what is the oral bioavailability of the (Chooseone 9 2. 1.68 ob3 35% When drug clearance docroanes, steady-state pisemns concentrHsions we Mets Choose one @ decrease anmwe A woremne : (@- What is an antimetabolite? Mares + Choose one a. Acrug analogue of a molecile tt Blocks 2 araneme sing such caer as a substrate ees. gor of he gamert as 2 oe Choose one 6 a 1.06 oo 6.06 oO O68 21 Absorption of 90% of drugs occurs by Marks: t soe © b Pore transport oe Day rly wade We Seg cole 1b, Uptake occurs only jn tinny © Ithas more atfinrty tor the furiget eriaysm (OAD erst tipi tox the tua enzyme) No speciiicity Stucplasine is an antieancsiee: xy © TLacts on an ermymes neh extiting in tamer vege Choose one 6 a 1.06 oo 6.06 oO O68 21 Absorption of 90% of drugs occurs by Marks: t soe © b Pore transport Ble dfs vsusle= oncksle seoralb stursnti auto (© We Geral sheraciontt-18 0 €)P > @ tise unbetinccdeiedieutatenac oro |[ OF wowceae cam Zit LB Pit yoitati (") Comeinicore () HotMal gratuts {) Personszzacine col () Receoka Web dice |) Sti sugzeriti () WielowsMedis 16 ‘The oral bioavailability of a drug: Choose at least one a is a measure of the extent to which it enters the systemic circulation Time Remaining ome bay be innuences by changing ine excipient oF the oral frrutation 0:55:46 1 ccitis panty defnes by te rato of tie area under the plasma carcertration time curve (AUC) flowing oral administration davides by that ranowng intravenous agmnitracon Od. may be reduced by hepatic CYP450 Induction 1 &.two preparasons of the same cruy may have similar AUC but arent peak concentrations (Cmax Ww ‘What is the purpose of pre-clinical testing? sts-4 Choose ore answer, a. Ta vey that a crug is sumMcienby save anu ereutve ta be testes n humans © _b To undergo praminary testing in heathy humans to mantor the effects ofthe chug © € Thereate a nasi outine torte larger seate tutu teats an a wreespread popLiation 18 19 g of adrug ars added and distributed throughout a tank and the resulting concentration is 0.15 g/L, calculate the volume of the tank. Choose one answer = Qa 10L Which is not a ta: he G protein Tied stone ae Vows Gorokge sezalb shurent! aute (res cone harman n-18 ur. €)P > @ vision unbvtincedeiadiae |[ OF wowceae cam Zit B Pit roitati (") Comeinicore (1 Ho'Mal gratuts {i Personslzzacione col (_) Receoks Web dice |) Sti sugzeriti () Wielowstedis sts Choose one answer, =a. Adverse effects, © b Dats callection © ¢ Human eror —— a [Time Remaining 0:56:31 14 ‘Why using the sublingual route we obtain a rapid absorption? (Multiple Answer) Because. Choose atlesstone ©] a. This region is highly vascularized , Ob The epAnetum is thinner CO c.thepHis acia [Dd The pHtis basic 16 ‘The MAIN function of Phase Il metabolism is waite 1 Chaaseane answer, © __a ta prepare the compound far phase | ©. fh tn prensre tne compaund tor tne excretion © Ca pregare the compound for the cistioulan © d Allthe proposed tems Ble dfs vsusle= oncksle seoralb stursnti auto (res cone harman n-18 ur. SPB biarionineuninvitincedi modjcuiefatterst cha G |) @F~ won.aceate.com Pt Bristol) comeiniore ©) Heal raluts (2 Pesoralzzarcnecol. () Rarcoka Wes ice (3 Stsuoceti ) Wrdonsteds 3 ‘What is a synonyinidescription for the Phase 4 trials? Choose one answer, =a Pre Marveting Survetlance Ob. PostMarkeung Survetiance fine Remaking —J © € Pre FDA Appraval en © Post FDA Approval lL 4 Decreasing the dosing interval while keeping the daily dose constant will result in lower mean steady-state concentrations. Anawer OTe OFalse 5 ‘The main determinant of the hepatic clearance of a low hepatic extraction ratio drug is: Wants 1 Choose one answer. a. numnstc clearance © b hepatic blood flow © © elimination rate © a.aose Ble dfs vsusle= oncksle seoralb stursnti auto (res cone harman n-18 ur. SPB biarionineuninvitincedi modjcuiefatterst cha G |) @F~ won.aceate.com Pt Bristol) comeiniore ©) Heal raluts (2 Pesoralzzarcnecol. () Rarcoka Wes ice (3 Stsuoceti ) Wrdonsteds 3 ‘What is a synonyinidescription for the Phase 4 trials? Choose one answer, =a Pre Marveting Survetlance Ob. PostMarkeung Survetiance fine Remaking —J © € Pre FDA Appraval en © Post FDA Approval lL 4 Decreasing the dosing interval while keeping the daily dose constant will result in lower mean steady-state concentrations. Anawer OTe OFalse 5 ‘The main determinant of the hepatic clearance of a low hepatic extraction ratio drug is: Wants 1 Choose one answer. a. numnstc clearance © b hepatic blood flow © © elimination rate © a.aose Ble dfs vsusle= oncksle seoralb stursnti auto (res cone harman n-18 ur. jobs unpeitineedejnedicue [OF vo zea Bristol) comeiniore ©) Heal raluts (2 Pesoralzzarcnecol. () Rarcoka Wes ice (3 Stsuozeti ) Wrdonsteds " ‘The MAIN function of Phase | metapellsm Is Waits4 Choose one answer, 0 prepare the compound for the excretion © Alithe above to prepare the compound for hase noose one . Passes wena anewer eS b, Pore tranaport 6, Pinoaitesis © 6 Camers 22 Major role of receptors: Marks 7 elena. Cepoad one, 0, &. Cokarmeina ate of 8 1D Changes in wiraceltnser calcu Corcnneaion © True Fane 30% — Exampie(s) of second Mes + messenger effect(s) jose one © a. increases in CAMP intracelhser answer concenteats ° b. changes in intraceiuder calczum concentra Ble dfs vsusle= oncksle seoralb stursnti auto (res cone harman n-18 ur. €P eo Brivo & 9 10 jobs unpeitineedejnedicue 1 comeiisare £ Heisalortuts (2 Persralzacine col. ©) Reco Web ee (2 atisupget £ CHBUSE UTE SNE) arian ste onoesre ur erste © b temminal hatte Wisdonsteis © © average elimination rete eanstant © d terminal etinination rate eanstant Characteristics of renal drug exeration: Choose one answer, a. neatly all drugs are fiteres at the olamaruius © bi. drugs which are weak aciels are excreted faster in aciic urinary pH © drugs which are weak hase are excreted faster in alkaline urinary nH G] [1 row aceae.can During a constant rate intravenous infusion of a drug with a half-life of 24 hours, steady-state plasma concentrations will be achieved after approximately: Choose oneanse, a 12h © b%h Oo c.4an oO d4days © & 1Maays [Time Remaining | 0:5: 7 Ble dfs vsusle= oncksle seoralb stursnti auto (res cone harman n-18 ur. jobs unpeitineedejnedicue [OF vo zea Bristol) comeiniore ©) Heal raluts (2 Pesoralzzarcnecol. () Rarcoka Wes ice (3 Stsuozeti ) Wrdonsteds " ‘The MAIN function of Phase | metapellsm Is Waits4 Choose one answer, @ tisiire unbitincedeinediqueittenst sty G | [Frew acedlcam P| LB Pit yoitati (") Comeinicore () HotMal gratuts [1] Personszzacione col) Receoka Web dice |) Sti sugzeriti () Wiedowstedis 36 ‘True statement concerning NON competitive inhibition 4 choose one answer, a. mantralcruy erect cannot be obtained, even at high agonist concentravons © the dose-ctest uve shifted to the et © thedosecefac curve shites tothe eght Time Remaining 0:50:33 7 What dees Phase Il clinical testung test? Choose ane answer. a Animal subjects © 6. Healthy human volunteers © © Widespresd siterenta’ population ©. People wih the target cisease/condiion © @ Large-scale testin penple win target ciseasefpoaviation 38 ‘Which is not a target for the G protein: Choose one ansier, 2. attenyly cyclase bb. phosgholipase C ion channels ° ° Oc proteinkinase a ° Pore transport fe tbdfes Yous conobo sara) Shunant te (© We Geral sheraciontt-18 0 €)P > @ tisiire unbitincedeinediqueittenst sty BB Pit roitati (") Comeinicare (_) HotMal grotuks {] Persorszzacione col.) Receoka Webs ice |) Siti sugzeriti ee eae © dionchannels 39 ‘Which drug 18 an antimetaboiite? Choose ane answer Oa Penicin © 6. Sfuorauracit © © Avaminagycoside Od Tetracycine © e. Macralices 40 Microsomal drug metabolizing enzymes are typically associated with: Choose one answer, a raugh endoplasmic reteutum © b. smoath endoplasmic reticulum © € mitochon G] [1 row aceae.can Wisdonsteis [Time Remaining | 0:49:57 Tied stone ae WedFea veusiezs omrokge serait sturent ute (res cone harman n-18 ur. EP) @ tisionireunpstinccde medio G] [1 row aceae.can A\t DB Pit voitati (") Comeinicore () HotMal gratuts (1) Personslzzacione col () Receoka Web dice |) Sti sugzeriti (_) Wielowstedis 30 ‘Arug given intravenousW results nan AUG of 400 (mg/Lnour. rhe same dose of crug Is glven orally and the resulting AUC 1s 200 mg/L nour, ‘what isthe oral bioavailability? Mts 4 chacceoreansver. §—Oa.0.70 mR — Oo b033 0:51:46 on ———— O 4133 31 IFthe dose and intravenous AUC are known, the clearance (area method) is calculated by: Choose one anawer. <9. AUCIMoe Ob doserauc Oc plasms concentratian/AUC © dose xauc 32 Drugs that are very lipid soluble tend te distribute well into body tissue Anawer OTe OF ase Por , @. halve hepatic extraction ratio (J 6. double hepatic clearance {J ‘¢. double hepatic extraction ratio {] @ halve hepatic clearance Vows Gorokge sezalb shurent! aute (res cone harman n-18 ur. €P eo Brivo £ 18 Wants 4 19 20 Wants 4 jobs unpeitineedejnedicue 1 comeinisore £ Hetsatortuts (2 Persralzacine col. ©) Reece Web ee (2 aisupget If g of a drug are added and distributed throughout a tank and the resulting concentration is 0.15 gil, calculate the volume of the tank. Choose one answer. ° ° Fy | [ rosecm Ae Wisonstedis atoL book [Time Remaining 6.0L, i 0:55:13 200, Lr | ‘One of the drugs below DOES NOT inhibit protein synthesis: Choose one ansier. 20000 a Aminogiyecsides b, Tetraeyctines © Chloramphenicol Amon fe. Macralicies ‘The most common interactions between drugs and receptor are: Choose one answer. ° a, Electrostatic interacvons b. Covelent bonds ‘8 @ synonym description for the Phase 4 tries? Choose one @ Pre Marketing Gurveliance © Post Marketing Surveillance c. Post FDA Approval d. Pre FDA Approval answer Choone ane aan Choose at toast one #4 200.900 » nOO-1000 CH nw no 4 800-600 8, Usually increRses as cinarance inereane b increases as elimination rate Constant decreas CO € Usually decreases as clearance tric ee ee ee Orv directly Proportional to drug inkwslon rate snd sreveeRy PHIRI Clearance d_ none of the above “Sisto ene 6 a Rewcton ina syritionin provsine and ONA Do Reactions that produce energy from a carbon sowce, © © Reactions that produce precursors of macromblectses auch aminoacids, sugars, 3P-ricleotids bf © 9. Reaetions occurring in infective agents onty * ©. The most valuable blochernical reaction as a pharmacological target ixed function oxidases system is referred to poseone (a. phase il system wis © B phase | system © © phase Ill system ofa drug: © a. is equal to the oral administration rate divided by the steady state ‘concentration | @ better measure of the efficiency of drug etirenatin trom the & a Merk: ¢ 19 Henk ¢ rks: | ee eee a el Choose one =a PAST enzyme answer rT © c NADPH (© NADPH Paso reductase (© & Allthe proposed tems Examples of PRODRUG (Multiple Answer) Choose atleast] a Phenoberhtel one anor Cb Acetaminopnen CI ¢.Cecene 1 &.LDora Metabolism usually generates: Choose one § =a. More polar and inactive metabolites answer. (© | Less polar and inactive metabclites © ¢.Less polar and active metaboites Street AY ST oe CCI R CLT tery [Time Remaining 0:59:30 GENERAL PHARMACOLOGY TEST - 15 MAGGIO 2013 | What is the Informed Consent FORM? Choose one = ©, Comprehensive inrormattan regarding tne aug alscavery chase ©. Comprehensive intormatian revarding the precinical study © 5. Comprehensive information regarding the phase | © 5. Comprehensive inrormation regarding the cinesl nial Receptors are usually Choose one = Lipid ae Protein © ©.0NA, ome of second —_ 6 7 8 Routes of administration that avoid " irst-pass" hepatic effects: (Multiple Answer) ‘chaose at least ‘one ansmer, a suuingual bioral o a LD ¢.transderma) 1 ainnatation What is a synonym/description for the Phase 4 trials? Chooseone =a. Pre Marketng Surveliance (©. b. Post Marketing Surveilance ©. 6. Pre FDA Approval (© a. Post FDA Approval Mixed function oxidases system is referred to Choose one ==. a. phase | system © b.phase irsystem ©. e. phase i system {Time Remainin 0:57:05 JL Me moet common interactions betamen drags aed yong ae Choone ane aan Choose at toast one #4 200.900 » nOO-1000 CH nw no 4 800-600 8, Usually increRses as cinarance inereane b increases as elimination rate Constant decreas CO € Usually decreases as clearance tric The plasma clearance Choose at least one 39 What is the purpose of pre-clinical testing? arts 1 Choase one 2. To verity that a drug is sufficiently safe and effective to be tested in humans (©. b. To undergo preliminary testing in healthy hunians to monitor the effects of the drug, (© ©. To create a basic outine for the larger scale future tests on a widespread population 40 ‘One of the drugs below DOES NOT inhibit protein synthesis: ‘Choase one 2. Aminogiycosides answer b. Tetracyctines ©. Chloramphenico} ©. Amoxcttin 00000 €. Macrolides ee RELATE eee cee Sennen Choose one ©. a. bss predictane compared to oral acminstraton route newer (© b not acceptable for unconscious patents jlime Remaining © © more predictable compared te ofal administration route 50:49 35 Which are the targets ofthe drug action? tats 1 Choose one Qa. Receptors ae © benaymes © © camers © 4. Transporters (© e.alitne proposed tems 36 _‘Theopnytine fs aominitrated to a patent at 39 mg/mour via constant V intson if te patent nasa total boc clearance 1, fortneapayline of 80 muminute, wnat shous tis patient's steagy-seate plasma concentration be? Chocseone © 0625 mgt. ‘newer © b100mA. © 601mg © more readily excreted more polar 353 When drug clearance decreases, steady-state plasena concentrations: =i es: 1 Choose one © a. decrease answer Q . increase Ble dfs vsusle= oncksle seoralb stursnti auto (res cone harman n-18 ur. Bi rivvitai£ 20 Wants 4 24 22 wants 1 jobs unpeitineedejnedicue 1 comeiisore £ Hetsatortuts (2 Persinazzacine col | [ rosecm Ae Wisdonstetis Rertoka Wes ce (3 St suozet ‘The most common interactions between drugs and receptor are: Choose one answer. ° ° ° ‘The Insulin receptor is: Chuose one answer. °° Concerning subeutaneus route Chaase ane answer ° ° ° ° a. Elecrostate interactions b Covalent tonds ¢-Allte proposes mem ‘Time Remaining 0:54:30 4g, Nether L a lon channel receptor bb. G.protetn receptor © Tyrosine Kinase receatar advantage! 1 Slow and incanstant absarption fb Slow ane constant ansorgtion High and constant absorption High and incenstant alsaretian 23 A drug given intravenously results in an AUC of 400 (mgiL)‘hour. Ifthe same dose of drug is given orally and the resulting AUC Is 300 (mg/L/-hour, what is the oral bloavailabiity? Time Remaining Chanseane = 8.0.75 © 0.033 © 0.05 © 4199 24 For drugs with a very low hepatie extraction ratio which are completely absorbed, doubling tne hepatic extraction ratio: ore 4 Choose one =). doubles the bioavallautity anwecr ©. b.makes litle dltference to the bioavailability © b-nalves te pioavallanuny ©. G.recuces the bioavallanity by 40% © =. increases the bicavallabilty by 40% 25 Haltuite determines: ors 4 28 ‘The MAIN function of Phase | metabolism is a SIE: (© b.to prepare the compound for the excretion © b.tNo-compartment move! (© © mmuti-compertment mode! 12 13 14 wee eae Who is the Sponsor? ‘choase one Clearance Is expressed as the ratio between a volume an Chaase ane answer (© 3. An inoNteual thar reports the progress of an investigation (© An individual that fs involve in bie management of clinical trial © ©. An inoividual that eallects and recards dats of the study. 2 concentration dose hate 4 time e000 Blotechnological drugs: ‘Choose ane anew (© 2 canbe created chemically © 4 conne extracted ay animals (© £.can be produced in prokaryote eels ime Remainini 0:55:56 Ble dfs vsusle= oncksle seoralb stursnti auto (res cone harman n-18 ur. €P eo Bi rivvitai£ 1 comeiisore £ 33 34 36 Waiks4 naadencdlaveeenst. 7a E |) OF ron azcale ccm Zit HoiMal gratuts {i} Personalzzacone col () Rercoks Web Stix |) Siti suggeriti (_) Widowstedis Biotechnological drugs are: Choose ane answer, © a hacteria proteins used a drugs Time Remaining] © hoprotenns arequces by tuners uses to actvate tne mune system 0:51:15 © c human proteins used 2s crugs ©) new peptise molecules usec! to mime bacteria or tumor proteins Mixed function oxidases system Is referred to Choose ane answer d. Heterdimers. 1 ee ueY Whatte the mechaniam conterning spmcitiaty we ®-tanpimera’” mart onl nn MOS GI posenrin cepa ai What does Phase tit clinical tenting test’? Choose one 0 Large. 8618 ent in patho Ath ta get emmnm ones tation mere b Widespread differentia! pegasation © Healthy human vounteoes Choose at (a. Thicknaes snd surface sree of the mentrane least one arent CG) b. pH environments ©. All the above d. Energy © «& production residuais 1b low sokanity = binding to other secneies 6 modified stiructire least one aon (OD? incroanon as eiirination ite consort decreas ©. UBUAlly decreases a6 clearence increstes d. usually decreases ae volume of dation meena A Or usually ino Choose at (a. Thicknaes snd surface sree of the mentrane least one arent CG) b. pH environments ©. All the above d. Energy newer © 8 Noithey SY Pepe? hide CInu 4. D> Homo \ than

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