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Cognitive and Behavioral Practice xxx (2021) xxx–xxx

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Digital Mental Health Interventions for Child


and Adolescent Anxiety
Muniya S. Khanna, The OCD & Anxiety Institute
Matthew Carper, Brown University

Anxiety disorders are the most common mental health conditions in children, with approximately 13% of kids struggling
with excessive anxiety. The vast majority do not have access to effective treatments and there continues to be a disjunction
between treatments that are empirically supported and those that are available in the community. Digital mental health
interventions (DMHI) can increase efficiency, reach, and standardization as well as reduce costs of providing of mental
health care. Here we review the extant research on DMHI, including web- or cloud-based programs, mobile applications
(apps), virtual reality (VR), and digital assessment methods such as ecological momentary assessment (EMA) for the deliv-
ery and/or support of evidence-based care in child anxiety. Preliminary research is promising for these tools to improve
access and efficiency of evidence-based practice. However, ethics and practice guidelines are needed and questions remain
regarding what level and quality of therapeutic involvement is needed to maximize treatment completion and outcomes in
youth and whether DMHIs are contraindicated for certain populations or whether they are similarly effective with those
with comorbid conditions is unclear.

A NXIETY disorders affect up to 13% of the child pop-


ulation (Costello et al., 2005; Ghandour et al.,
2018; Merikangas et al., 2010), making it the most com-
Evidence supports the efficacy of cognitive-
behavioral therapy (CBT) for anxiety in youth (for
review see James et al., 2018; Weisz, 2010; for illustra-
mon psychiatric diagnosis across development, surpass- tive studies see Kendall et al., 2008, and Walkup
ing behavior problems and mood and substance use et al., 2008), but the vast majority do not have access
disorders. Lifetime prevalence rates for any anxiety dis- to effective treatments and there continues to be a dis-
order in children and adolescents in the U.S. is junction between treatments that are empirically sup-
reported to be almost 32% (Merikangas et al., 2010). ported and those that are available/provided in the
According to the latest epidemiological reports, this community (Merikangas et al., 2011). A widely
rate is steadily increasing (Bitsko et al., 2018). Over endorsed goal is to broaden the range of treatment
the last decade, anxiety has overtaken depression as delivery models (delivery formats) to bridge the gap
the most common reason college students seek coun- between empirically supported treatments and the ser-
seling services. Anxiety causes substantial impairment vices typically provided (Beidas et al., 2012; Kazdin &
in school, family relationships, and social functioning Blase, 2011). Digital mental health interventions
(Bitsko et al., 2018; Costello et al., 2005; Kendall (DMHI), including internet-based cognitive behavioral
et al., 2010). Left untreated, anxiety problems are asso- therapy (iCBT), may provide opportunities to reach
ciated with future anxiety disorders, depression, and many individuals in need of mental health care in a
substance use problems in adulthood (Beesdo et al., potentially efficient, cost-effective, and nonstigmatizing
2009). However, when anxiety in youth is treated effec- way. DMHI and tools have several practical advantages:
tively, there can be benefits in reducing subsequent
sequelae (Benjamin et al., 2013). 1. Cost: services provided via internet can reduce cost
over conventional face-to-face treatment for patients
and health systems.
Keywords: child and adolescent; anxiety; digital mental health
tools; CBT

1077-7229/20/Ó 2021 Association for Behavioral and Cognitive


Therapies. Published by Elsevier Ltd. All rights reserved.

Please cite this article as: Khanna and Carper, Digital Mental Health Interventions for Child and Adolescent Anxiety, https://doi.org/10.1016/j.
cbpra.2021.05.003
2 Khanna & Carper

2. Availability: computers with internet access and Rooksby et al., 2015). For example, an RCT comparing
mobile devices can be available in multiple settings online versus clinic delivery of CBT for adolescent anx-
(e.g., schools, community agencies, hospitals, iety found that both the online and clinic delivery for-
homes). mats performed better than a waitlist control, with 78%
3. Access: online access offers anonymity and privacy, of adolescents in the online condition no longer meet-
reducing barriers that may otherwise deter a patient ing criteria for their primary anxiety disorder at post-
from pursuing treatment. treatment (Spence et al., 2011). These gains were
4. Treatment integrity: digital interventions can pro- maintained at both 6- and 12-month follow-up assess-
vide standardized therapy components such as psy- ments. Additionally, there were no significant differ-
choeducation, progressive muscle relaxation, and ences in outcomes between the online and clinic
standardized therapy materials (e.g., role-play activi-
delivery formats.
ties), homework assignments, and knowledge
Web-based programs have also been extended to
checks.
primary care settings to improve access to psychologi-
5. Personalized treatment: while maintaining treat-
cal treatment. In one study that took place in New Zeal-
ment components in the preferred sequence,
internet-based programs can be customized for each and, an online therapist-assisted CBT program was
patient (e.g., modify instructions based on client implemented in primary care settings following a natu-
responses). ral disaster. A large number of families enrolled in the
6. Rehearsal: a digital format can facilitate review of study and approximately half of those enrolled com-
material as needed. pleted 4 sessions. Results revealed that youth who com-
7. Data gathering: a digital format also increases effi- pleted more sessions had lower anxiety at their last
ciency and reduces cost of record keeping and data session, with most of the improvement occurring early
collection. Using internet-based programs, user- in treatment (Moor et al., 2019).
input can be automatically recorded, stored in Web-based parent interventions for youth anxiety
secured databases, and monitored regularly. also exist and have been shown to be helpful at increas-
ing parent knowledge of how to parent anxious youth.
A variety of approaches exist for intervening with
One study examining a web-based parent training pro-
anxious youth that incorporate digital technology into
gram (WPT), Child Anxiety Tales, as compared to a
the treatment process. In the following section we
bibliotherapy (BIB) and waitlist control (WLC) condi-
review five of the more common categories of DMHI
tion found that parent knowledge increased for partic-
for youth, including web- or cloud-based programs,
ipants in the WPT and BIB conditions, but not for
mobile technologies, virtual reality, assessment meth-
those in the WLC condition (Khanna et al., 2017). This
ods such as ecological momentary assessment (EMA)
study also showed decreases in parent ratings of their
and passive sensors, and stand-alone versus clinician-
child’s anxiety on one outcome measure, but not the
assisted programs.
other, potentially pointing to parents being better able
to identify anxiety symptoms as their knowledge of par-
Web- and Cloud-Based Programs enting anxious kids increases. However, further
research is needed with clinical populations before
Given the large proportion of youth and parents in
conclusions regarding its efficacy can be drawn.
the U.S. who have access to the internet (Pew Research
Center, 2015a, 2015b), treatment developers have
made a variety of digital resources available online.
These resources include parent training interventions Mobile Technologies
(e.g., Khanna et al., 2017), full intervention packages As smartphone use continues to grow among youth
(e.g., Khanna & Kendall, 2010; Spence et al., 2011; and adolescents, app developers are teaming up with
Tillfors et al., 2011), and preventative interventions researchers to develop a variety of mobile health
(e.g., Attwood et al., 2012). A relatively recent system- (mHealth) interventions for mental health concerns,
atic review concluded that online interventions and including anxiety disorders. These apps vary in their
prevention programs are effective for youth anxiety functionality, with some apps being used as adjuncts
and depressive symptoms (Clarke et al., 2015). The to treatment (e.g., monitoring of homework compli-
authors of this review also concluded that some face- ance), others providing in-the-moment intervention
to-face or web-based support was an important feature when triggered by various prompts, and others func-
with regards to retention and outcomes. tioning as fully stand-alone treatment packages. Many
Randomized clinical trials (RCTs) have also pro- apps for youth mental health have not received empir-
vided support for web-based interventions for youth ical support, but several have been tested in research
anxiety (Pennant et al., 2015; Podina et al., 2016; studies (for review, see Bry et al., 2018).
Digital Mental Health Interventions for Child and Adolescent Anxiety 3

Anxiety Coach (Mayo Clinic, 2018) is one app that has iety disorder (SAD) revealed that VR programs were
received some empirical support in recent years. This acceptable, feasible, and credible treatment components,
app provides assessments of anxious symptoms, psychoe- with both parents and youth indicating it was a high-
ducational material related to anxiety and exposure- quality program and that they would recommend it to
based treatment, and a useful guide for designing and a friend (Sarver et al., 2014). Another small study used
executing exposures in one’s own environment (for VR environments to reduce specific phobias in youth
review, see Carper, 2017). Anxiety coach has been tested with autism spectrum disorder (ASD) and found that
in several research studies as an adjunct to treatment and 89% of participants were able to face their phobic stimuli
has demonstrated preliminary effectiveness (Whiteside, following treatment and approximately half of the sam-
2016; Whiteside et al., 2014). ple completely overcame their phobia at posttreatment
The SmartCAT is another mobile app that has been (Maskey et al., 2014).
developed for youth anxiety and is used as an adjunct
to treatment (Pramana et al., 2014). SmartCAT is an Assessment Methods
ecological momentary intervention that reinforces
The potential impact of technology on mental
skills learned in session in patient’s natural environ-
health spans both intervention and assessment. Ecolog-
ments. The app also has a clinician portal that allows
ical momentary assessment (EMA; Shiffman et al.,
bidirectional communication between patient and
2008) methods have been used for some time to collect
therapist. Preliminary support for the effectiveness of
data in patients’ real-world contexts. EMA methods are
SmartCAT comes from several studies, including an
being extended to smartphones, allowing for the
open trial that showed youth used the app an average
remote uploading of data, prompts triggered by passive
of 5.8 minutes per day and 86% of youth no longer
data collection, etc. (Estrin & Sim, 2010; Kendall et al.,
met diagnostic criteria for an anxiety disorder at 2-
2015; Luxton et al., 2011; Mohr et al., 2017). One par-
month follow-up (Silk et al., 2020).
ticular advantage of EMA methods is that they reduce
retrospective recall bias associated with self-report
Virtual Reality questionnaires (Piasecki et al., 2007; Solhan et al.,
Over the last decade, technology continues to advance 2009), increasing measurement precision. Indeed,
to the point where virtual reality devices are becoming EMA methods have been used to examine the process
more and more ubiquitous. Given that some anxiety tar- of change in CBT for youth anxiety (e.g., Silk et al.,
gets are difficult to target directly with in vivo exposures 2011; Tan et al., 2012), shedding light on important
in many outpatient settings (e.g., public speaking), vir- aspects of the therapeutic process that may have been
tual reality (VR) has been explored as a way to facilitate missed with less frequent measurement intervals.
exposure and increase adherence to exposure-based This technology becomes more advanced at a stag-
treatments. VR environments can be created to simulate gering rate. In the mid-20th century, Gordon Moore
just about any anxiety-provoking situation. For example, published a paper where he argued that the number
clinicians in private practice may not have access to live of transistors in a dense integrated circuit doubles
spiders (for treating spider phobias), crowds willing to lis- every 2 years (Moore, 1965). This was later generalized
ten to a youth practice a speech (for public speaking to the rate of improvement of all technology and ter-
fears), or other exposure-relevant stimuli. Research with med “Moore’s Law,” which states that processing speed
young adults has found that VR environments lead to a (and other markers) advance at a rate of two times
comparable biological stress response (i.e., heart rate every 2 years. As EMA technologies improve, it will
variability and saliva cortisol) as real-world environments become easier to collect psychophysiological measures
in public speaking exposures (Kothgassner et al., 2016), of psychological constructs and map these more objec-
highlighting their potential to aid in exposure-based tive reported measurement strategies onto self-
treatments. Research with adults also has found a high reported data. For example, researchers could exam-
preference (76% of sample) for VR exposures relative ine concordance between psychophysiological markers
to in vivo exposures, and that the refusal rate for of habituation and self-reported SUDS ratings. As these
in vivo exposures (27%) was much higher than it was passive data collection methods become more accu-
for VR exposures (3%), suggesting VR may be used to rate, they can also be incorporated into digital inter-
facilitate exposure in patients who would otherwise not vention packages where specific interventions are
participate in exposure-based treatments (Garcia- triggered by changes in psychophysiological arousal
Palacios et al., 2007). or other data being collected passively.
Several programs exist and are in development using Smartphone and other device sensors have already
VR to facilitate treatment of youth anxiety (Albano et al., allowed for some passive collection of a variety of psy-
2018). One study using VR to treat childhood social anx- chophysiological data from youth. To address these
4 Khanna & Carper

emerging technologies, the Food and Drug Adminis- ous questions about when and how this category of
tration has created a digital health action plan to facil- interventions can be safely, ethically, and effectively
itate innovation in the area of digital health (U.S. Food employed in concert with various other treatment
and Drug Administration, 2018). Use of passive data modalities. Potential challenges include concerns
collection strategies invites inquiry into a variety of sci- about privacy, client safety, reimbursement, treatment
entific topics that were previously much more difficult integrity as well as the development, or dearth, of ther-
to answer. However, as researchers’ use of passive data apeutic alliance in computer/internet-assisted treat-
collection strategies increases, it will become increas- ments. Moreover, when, where, and for whom DMHIs
ingly important for policymakers to develop regula- may be indicated or counterindicated requires clarifi-
tions around the privacy of these data and for cation. The opportunities for offering psychological
researchers to have in-depth conversations about the interventions through computers and/or over the
risks of data breaches with potential participants. As internet are developing more rapidly than the legal,
will be discussed later in the section on future direc- ethical, and regulatory standards required to guide
tions, these passive sensors and other technology- their use (Van Allen & Roberts, 2011).
based assessment measures can be used to trigger inter- The possibility of privacy and security breaches, in
ventions in the moment. particular, could be a concern. Though a dialogue
about how to manage threats to confidentiality and pri-
Stand-Alone Versus Clinician-Assisted vacy through encryption techniques has begun, a con-
A review of the types of digital mental health inter- sensus has yet to be reached regarding how
ventions for youth anxiety would not be complete with- computerized interventions can be best integrated
out a brief discussion of differences between stand- and supported in the current mental health care sys-
alone and clinician-assisted technology packages. The tem (Kramer et al., 2013; Schwartz & Lonborg, 2011;
specific technologies reviewed above can be provided Yuen et al., 2012). As such, the continued development
both with and without therapist support. Given that of regulatory, ethical, financial and legal standards per-
youth are often not intrinsically motivated to engage tinent to the delivery of technologically enhanced psy-
in exposure therapy and therapeutic work early in tra- chological treatments will be critical to the widespread
ditional CBT for youth anxiety is focused on facilitating adoption of these treatments (Comer & Barlow, 2014).
“buy in” from youth, there is a notion that therapist In the meantime, various professional associations
support is a necessary aspect of any DMHI (see have provided guidelines with several common themes,
Kendall et al., 2015). In their meta-analysis of online among them the importance and provision of
youth mental health prevention interventions, Clarke informed client consent, the necessity of data encryp-
et al. (2015) found that while it is difficult to draw tion and secure password use and the education of
strong conclusions about the type or intensity of guid- patients at large about the ranging quality of mental
ance and support necessary due to variation in method- health information and interventions on the internet
ologies and quality of existing studies, there is evidence (Proudfoot et al., 2011). To these ends, the World
that patient support (either face-to-face or web-based) Health Organization has established an international
improves program completion and program outcomes. e-health code of ethics to guide practitioners employ-
Another meta-analysis concluded that youth benefited ing electronically enhanced methods, and the Euro-
more from minimal therapist involvement than from pean Union has established an international
significant therapist involvement (Podina et al., initiative, MedCERTAIN, designed to educate the pub-
2016), suggesting there may be more flexibility in lic, evaluate health care sites as well as guide and
how involved therapists should be than was previously encourage website providers to adhere to the World
thought. Future research is certainly needed to deter- Health Organization’s e-health ethics code.
mine optimal levels of therapist support that maximize Given the newness of DMHIs, researchers suggest
therapeutic benefits while minimizing costs and clini- that informed consent should include an in-depth
cian time. description of the therapy structure and process, its for-
mat, potential risks, benefits and safeguards, and the
Limitations of DMHI limits of confidentiality, including those incurred by
simply conducting treatment via the internet
Like their strengths, the limitations of different
(Proudfoot et al., 2011). Informed consent must also
DMHIs for anxiety vary. Though research supports
include a discussion of legal requirements, information
the potential for these interventions to bring
about the clinician and clarification of how records will
evidence-based treatments to a broader range of anx-
be collected, stored and protected. Further, given that
ious youth and their families without compromising
these computerized treatments aim to deliver treat-
treatment fidelity or efficacy, it has also raised numer-
Digital Mental Health Interventions for Child and Adolescent Anxiety 5

ment to families in unconventional, potentially unsu- (Ellis et al., 2009). This diversity is only likely to
pervised settings, such as the home, guidelines for increase as technology broadens the reach of
appropriate patient monitoring, risk screening (e.g., evidence-based practice to more remote, often
suicidality), handling of clinical emergencies, coordi- neglected patient populations (e.g., American Indians,
nation with local collaborators, and navigation of state Alaska Natives, inhabitants of rural Appalachia). With
and federal regulations and licensure requirements this variety will come a growing need to provide flexi-
will be key. ble, sensitive, and culturally appropriate care within
Whether DMHIs increase or decrease the integrity the context of computerized interventions, a potential
of evidence-based treatments can be debated. Though challenge (see Brooks et al., 2013). Many studies have
greater treatment integrity may be facilitated simply by not included data on participant ethnicities, thus it is
the standardized nature of computerized programs rel- unclear to what extent programs should be tailored
ative to face-to-face interventions, poor client adher- to different cultural or ethnic groups (Richardson
ence in DMHIs may be a significant limitation to et al., 2010).
ensuring that youth receive treatment as intended Finally, it will be important to consider how DMHIs
(Kendall et al., 2011; Richardson et al., 2010). This crit- may best be presented to current mental health practi-
icism appears particularly applicable in the case of tioners, payers, and families to ensure their widespread
computer-based interventions, where dropout rates support and adoption. Notably, there remains a
have been over 60% in some studies (Cunningham marked research-to-practice gap between efficacy trials
et al., 2009; March et al., 2009). No matter how faith- and study and understanding of how to promote treat-
fully information may be delivered via a computer- ments acceptance and implementation in the commu-
program, the integrity of a treatment will likely be com- nity. Considering how, why, and at what rate
promised if treatment is incomplete or cursorily innovations such as computerized interventions may
accomplished. Another challenge to treatment integ- spread through social and extant mental health net-
rity in computer-based programs is the lack of live works will be critical to ensure that the potential public
opportunities for exposure tasks, though exposure is health benefits of these treatments are realized
considered an essential element of CBT approaches (Dingfelder & Mandell, 2011; Hill et al., 2018). Despite
(Kendall et al., 2011). Therapist flexibility, an impor- much progress in the study of DMHIs for adults, one
tant component to personalizing and maintaining cli- study suggests that adult practitioners are more likely
ent engagement in CBT treatments (“flexibility to recommend bibliotherapy than computerized inter-
within fidelity”; Kendall et al., 2008), may also be less ventions, a trend that may, for the time being, also
in the case of computer-assisted versus face-to-face appear when considering the dissemination of these
CBT programs (Khanna & Kendall, 2010). In sum, treatments for children (Proudfoot et al., 2011).
though DMHIs promise an enhanced ability to dissem-
inate standardized treatment materials and protocols
to the community and have been associated with Recommendations for Future Research
increased integrity relative to conventional CBT in and Development
some studies, the novelty of this technological medium
The development and use of DMHIs for youth anx-
may also pose challenges to therapist flexibility, treat-
iety is still in its nascency and much work remains to be
ment adherence and completion, and particularly the
done before DMHIs become a standard part of clini-
modeling, guidance, and, in some cases, accomplish-
cians’ “tool kit.” This is likely due in part to the gap that
ment of exposures. These challenges appear accentu-
exists between research and practice (Westfall et al.,
ated in DMHIs and may make an argument for
2007) but is also likely due to a variety of other factors.
computer/internet-assisted approaches for clients
Empirical reviews of apps for mental health have noted
who are likely to drop out of treatment or participate
that the vast majority do not have much, if any,
in a sporadic, limited fashion.
research support (Bry et al., 2018).
Other challenges that will face the broad dissemina-
Several avenues for future research and develop-
tion, implementation, and effectiveness of computer-
ment of DMHIs exist. These include dissemination
ized interventions include the great variety of
and implementation efforts aimed at getting DMHIs
providers and clients that these programs are designed
used in the community, harnessing emerging tech-
to serve. Children with anxiety disorders are currently
nologies (e.g., passive sensors, context-triggered assess-
served by a diverse mental health network, comprised
ment and intervention, etc.) and improving
of providers with a broad range of educational back-
regulations around the use of DMHIs (see Myers
grounds as well as variable experiences and receptive-
et al., 2008; Myers et al., 2017), and developing part-
ness to DMHIs and other evidence-based practices
nerships with industry to facilitate the ongoing devel-
6 Khanna & Carper

opment and maintenance of DMHIs (see Carper et al., effectiveness of iCBT programs, these different parties
2013, and Hill et al., 2018). may have different interests in the results and a poten-
Despite support for the efficacy of DMHIs in research tial risk of bias arises in reporting on the results. They
settings and the over 2000 apps that exist and are mar- recommend that research groups take measures to
keted for anxiety (Chan et al., 2014), these interventions minimize the risk of bias in reporting including prereg-
are rarely used by practicing clinicians, highlighting the istration of the effectiveness trial, involving an indepen-
need in the field for a better understanding of factors dent statistician to conduct the statistical analyses, and
that facilitate and/or impede successful implementation if feasible, to install an independent data and safety
and longer-term sustainability outcomes. The fact that monitoring board.
national surveys have found that more than half of Amer- RCTs will be needed to determine when and for
icans have downloaded an app related to their health whom these treatments may be indicated. Questions
(Krebs & Duncan, 2015) makes the lack of use in prac- also remain regarding what level and quality of thera-
tice settings particularly problematic. peutic involvement is needed to maximize treatment
Gaining an understanding of how to get apps and completion and outcomes in youth. Further, whether
other DMHIs that we know are efficacious used in prac- DMHIs are counterindicated for any populations or
tice settings remains one of the highest priorities for diagnostic presentations is unclear.
future research. Up to 83% of youth with anxiety disorders may pre-
There is great promise for the utilization of DMHIs sent with a second psychological disorder (Cummings
in treating child anxiety disorders, but much still to et al., 2014; Kendall et al., 2010; Verduin & Kendall,
confirm and clarify regarding the optimal use of these 2003). Anxiety disorders are commonly comorbid with
technologies for the diverse range of youth and provi- depressive disorders (Kaufman & Charney, 2000), aut-
ders they are designed to assist. Computerized treat- ism spectrum disorders (Kerns & Kendall, 2012), atten-
ments merit large-scale, well-controlled trials with tion deficit-hyperactivity disorder (Pliszka, 2000),
active control groups such as conventional CBTs in disruptive or oppositional behavior (Lehmkuhl et al.,
community settings. Such work will be critical to deter- 2009) and, in adolescents and young adults, substance
mining whether or not there is empirical support for abuse (Deas & Brown, 2006). Whether outcomes from
these treatments and therein to establishing their effi- DMHIs for child anxiety are diminished by these
cacy and effectiveness. comorbid presentations, or whether anxiety treatment
The lack of well-controlled data on DMHI for child has a spillover and beneficial effect on these condi-
anxiety as arguably contributed to the difficulty in tions, also requires further study.
developing programs that are scalable and sustainable Finally, it will become increasingly important to
beyond academic evaluation and that can ultimately develop strong ethical and legal regulations around
be adopted by health care providers. In an effort to the practice of mental health in the digital age. Several
move the field forward, a group of international states have already begun to adopt guidelines for allow-
experts in child and adolescent anxiety and DMHI con- ing clinicians from other states to practice across state
vened for a 3-day workshop that was funded following a lines if they are providing tele-mental health services.
peer-reviewed process at the Lorentz Centre at the However, there remains a lack of regulation around
University of Leiden, The Netherlands in October apps for mental health, which is concerning given
2017 (#iCBTLorentz Workshop Group). The group the sheer number of apps for mental health that are
published a consensus statement and recommenda- on the market now. Whether this regulatory work is
tions for the development, evaluation, engagement, done by state licensing boards, national professional
and dissemination of DMHIs for anxiety in children organizations (i.e., APA), or both remains to be seen.
and adolescents (Hill et al., 2018). Regarding evalua- Information and communication technologies are
tion standards, they recommend “that any new psycho- ever rapidly evolving, altering the social landscape
logical treatment program, whether iCBT or face-to- and also the avenues by which mental health interven-
face, should be evaluated via the gold standard (RCT).” tions may reach and improve the lives of youth and
The group made special note of the inherent conflict their families. A challenge for researchers and service
of interest that exist in DMHI research and develop- providers will be to keep up with the alacrity of these
ment efforts and encourage researchers to both clearly innovations and communicate their availability to
acknowledge any conflicts and ensure independent patients and providers (Carper et al., 2013).
data collection and analysis many different parties are
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