Anticancer- methotrexate, aminopterin, piritrexim, methylbenzoprim, dichlorobenzoprim, raltitrexed,

pemetrexed, pralatrexate, trimetrexate, nolatrexed, talotrexin

Antibacterial- trimethoprim, Pyrimethamine, sulphamethoxazole, iclaprim

Anti-infective and anticancer-trimethoprim, pemetrexed

Antimalarial- cycloguanil, proguanil(prodrug), dapsone

Lometrexol

Metho-Acute lymphoblastic leukemia (ALL)

Piri-advanced bladder cancer

Methotrexate (MTX) is now the most popular treatment drug for rheumatoid arthritis.
Aminopterin was later supplanted by methotrexate for treating cancer because of its better
therapeutic index, which was once used as an antineoplastic agent in treating pediatric
leukemia.

Piritrexim is a lipid-soluble analog of methotrexate that has been used to treat methotrexate-

resistant tumors.

Occasionally, trimethoprim is used to treat other types of infections, such as chest infections and
acne. It is combined with other drugs to treat certain types of pneumonia.

s a medication used with leucovorin to treat the parasitic diseases toxoplasmosis.

Methylbenzoprim is frequently used in cancer chemotherapy.

Dichlorobenzoprim is a lipophilic diaminopyrimidine antifolate undergoing preclinical investigation as

an anticancer agent at the Pharmaceutical.