LRH ARH Odds Ratio Study or Subgroup Events Total Events Total Weight M-H, Random, 95% Cl Odds Ratio M-H, Random, 95% Cl LL: Disease Free Survival of Tumor Size <2cm at 3 Years Anchora, 2020 10 78 2 -7825K 5.59 (1.18, 26.41] kim, 2019 13122121614. 7K 1.48 (0.65, 3.37] Nam, 2012 34162 -S «173 41% 8.93 (3.40, 23.46], Subtotal (95% Ch 362 412 113% 4.00 [1.13, 14.15] Total events 87 19 Heterogeneity: Tau? = 0.93; Chi? = 8.34, df = 2 (P = 0.02); " = 76% Test for overall effect: Z = 2.15 (P = 0.03) 1.1.2 Disease Free Survival of Tumor Size < 2em at § Years ‘Anchora, 2020 9 78 15 78 44% 0.55 0.22, 1.34] Chen, 2020 12 63 7 «116 4.1% 3.66 [1.36, 9.86] Chen x, 2020 15 129° 4 196 3.6% 6.32 (2.05, 19.49] Ditto, 2014 2 60 5 602.2% 0.38 {0.07, 2.04) Hans, 2020 7 166 19-218 44% © 0.46 (0.19, 1.12), He, 2020 28 739-25 739°«5.8% 1.12 (0.65, 1.95] kim, 2019 1 12210122, 44K L.A L0.45, 2.72] , 2020 2 113 1 86 13K 153 (0.14, 17:17) Nam, 2012 60 162 25 173 5.9% 3.48 (2.05, 5.92] Uppal, 2020 16 182 2 -822.6K 3.86 (0.87, 17.18] Subtotal (95% ch 1814 1870 386% © 1.52 [083,277] oral events 162 43 Heterogeneity: Tau? = 0.63; Chi? = 36.04, df = 9 (P < 0.0001); = 75% Test for overall effect: Z = 1.35 (P = 0.18) 1.1.3 Disease Free Survival of Tumor Size > 2em at 3 Years ‘Anchora, 2020 19 65 10 65 45% 2.27 (0.96, 5.37] Nam, 2012 41 101 12 90 SK 4.44 (2.15, 9.18], Subtotal (95% CD 166 155 96% 3.31 (1.72, 6.36), Total events 60 2 Heterogeneity: Tau? = 0.06; Chi? = 1.36, df = 1 = 0.24); "= 27% Test for overall effect: Z = 3.60 (P = 0.0003) 1.1.4 Disease Free Survival of Tumor Size > 2em at § Years ‘Anchora, 2020 26 65 15 6S 4.9% 2.22 [1.04, 4.76] Chen, 2020 86 450 193 1353 6.8% 1.42 [1.07, 1.88], Hans, 2020 26 129° «62 «414. «6.0% 1.43 (0.86, 2.38], He, 2020 87 898 61-898 «6.6% 1.47 [1.05, 2.07] , 2020 27 13 22 865.4% 0.91 0.48, 1.75] Nam, 2012 7 101 25 905.5% 6.46 (3.43, 12.14], Uppal, 2020 33 199-17 118 54% 1.18 [0.63, 223], Subtotal (95% CD 1955 3024 40.5% 1,691.16, 2.46] Total events 357 395 Heterogeneity: Tau? = 0.18; Chi? = 24.28, df Test for overall effect: Z = 2.73 (P = 0.006) 75% 6 = 0.0005); Total (95% cl) 4297 5461 100.0% 1,90 [1.40, 2.57] Total events 636 549 Heterogeneity: Tau? = 0.33; Chi? = 82.31, df = 21 (P < 0.00001); " = 74% Test for overall effect: Z = 4.16 (P < 0.0001) Test for subgroup differences: Chi? = 5.01, df = 3 (P = 0.17), P= 40.1% aos 2 Favours LRH Favours ARH