Algorithm 3.

Treatment of acute uncomplicated pyelonephritis in non-pregnant

women

Healthy Non-Pregnant Woman

with acute uncomplicated
pyelonephritis

Assess severity of illness &

likelihood adherence to
treatment

Yes
Septic, too ill or 1. Admit patient
likely to be non- 2. Do urinals urine GS, C/S
adherent 3. Do blood C/S 2x if Septic
4. Start empiric IV Antibiotics (Table 4)

No

1. Do urinals, urine GS,

Reassess patient
C/S.
within 72hours
2. Treat as outpatient
3. Start empiric oral
antibiotics (Table 4)
based on gram stain
1. Shift IV antibiotics to
results.
Yes oral once patient is
Symptoms improved afebrile & can tolerate
on Day 3? oral medications
2. Continue antibiotics for
10-14 days
3. Antibiotics choice
No should be guided by
urine C/S results once
available.
1. Repeat urine C/S
2. Consider doing
radiologic
evaluation
3. Consider urologic
consultation