Calculations Master Class 2020

Calculations
Master Class
2020

CALCULATING DOSAGES
Please use this page for making notes:
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
___________________________________________________________________
© Copyright ProPharmace Ltd 2020 2

1- Master B, weighing 28lb, has been admitted to hospital and has been
diagnosed with nephrotic syndrome. The specialist doctor prescribes
spironolactone 25mg/5ml at a dose of 3mg/kg daily in two divided doses.
How many mL of spironolactone 25mg/5ml should Master B receive for each

dose? Give your answer to one decimal place.
mL

2- Miss S is a 5 year old girl weighing 18kg. She suffers from renal disease and
her doctor wants her to start taking alfacalcidol to prevent vitamin D
deficiency. He prescribes her 25ng/kg once daily for the first two weeks and
then 15ng/kg thereafter. One drop of alfacalcidol 2mcg/ml oral drops
contains approximately 0.1mcg of alfacalcidol.
How many drops of the alfacalcidol oral drops will Miss S use in the first 2 months?
Give your answer to the nearest whole drop.
drop(s)

3- Mr L who weighs 121kg and is 5 foot 9 inches tall has been admitted to
hospital following an acute overdose of paracetamol tablets.

What quantity in grams of acetylcysteine would have been administered 21 hours
after initiating treatment with Acetylcysteine Concentrate for Intravenous Infusion
to Mr L? Give your answer to one decimal place.


ESTIMATIONS OF KIDNEY FUNCTION

_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________


4- Ms. R is a 59 year old woman with hypertension, hypercholesterolaemia, and

osteoarthritis. She is being seen at the outpatient nephrology clinic to
evaluate her declining renal function and, if necessary, modify the doses of
her medications. She is 5 feet 6 inches tall and her biochemistry results are
provided below.
Test Results Units Reference Range

Serum urea 7.6 mmol/L 2.5-7.5
Serum creatinine 105 micromol/L 46-92

The formula for Ideal Body Weight is given below.

Ideal Body Weight, kg, Men = 50 + (2.3 for every inch over 5 feet)
Ideal Body Weight, kg, Women = 45.5 + (2.3 for every inch over 5 feet)

The Cockcroft and Gault Formula is given below.

Estimated Creatinine Clearance = (140-age) x Weight (kg) x Constant
In mL/min Serum Creatinine

Constant = 1.23 Men; 1.04 Women

What is the estimated creatinine clearance for Ms R? Give your answer to the
nearest whole number.
mL/min

5- Mr B who is 52 years old and weighs 65kg suffers with mild renal impairment.
His doctor would like to calculate his creatinine clearance before deciding on
a suitable dose of venlafaxine for the treatment of his depression. Mr B’s last
measured serum creatinine level is 17.5 micromol/dL.
creatinine clearance (mL/min) = constant x (140 - age) x weight (kg)

serum creatinine (micromol/L)

Constant is 1.04 for women and 1.23 for men

Calculate Mr B’s creatinine clearance. Give your answer to two decimal places.

mL/min


6- Mrs F is currently in hospital and requires a dose of drug Y. She weighs 58kg
and is 83 years old. Her serum creatinine level is 295micromoles/L.

The dosage schedule in renal impairment for drug Y is as follows:
CrCl 20-50mL/min 2.5mg/kg every 8 hours
CrCl 10-20mL/min 1.25mg/kg every 12 hours
CrCl < 10mL/min 0.625mg/kg every 12 hours

creatinine clearance (mL/min) = constant x (140 - age) x weight (kg)

serum creatinine (micromol/L)

Constant is 1.04 for women and 1.23 for men

What is the most appropriate daily dose in milligrams for Mrs F?

mg

DISPLACEMENT VOLUMES AND VALUES

_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________

7- You are asked to prepare the following order for zinc oxide 400 mg
suppositories.

Zinc oxide 400 mg
Theobroma oil (as the base) to a sufficient quantity
Supply 50 suppositories

You use a 2g mould for the suppositories and the displacement value of zinc oxide is
4.7.

How many grams of theobroma oil will you require to prepare this order? Give
your answer to one decimal place.

8- A doctor prescribes ceftriaxone 250mg as a single dose for the treatment of

acute uncomplicated gonorrhea to be given by deep intramuscular injection.
Ceftriaxone is available as 1-g vial. Each 1-g vial has a displacement volume
of 0.55mL. The nurse adds 3.5mL of 1% lidocaine injection BP to reconstitute
the contents of the vial.
What quantity in mL of the reconstituted solution must the nurse administer? Give
your answer to one decimal place.
mL

9- You receive a prescription for a batch of 80 1-g suppositories, each containing

65mg of drug A. Drug A has a displacement value of 1.2 and 1.2g of
glycogelatin base is equal to 1g of theobroma oil base. You make a 20%
excess to allow for losses in preparation and use the glycogelatin base.
What is the total amount in grams of glycogelatin base that is required to produce
this order? Give your answer to two decimal places.

CONCENTRATIONS
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________


10- You have been given an order to extemporaneously prepare a 10%w/w

salicylic ointment. You have a 2.5%w/w salicylic acid ointment in stock.

How many grams of salicylic acid should be added to 40g of the stock ointment to
produce a 10% w/w ointment? Give your answer to two decimal places.


11- You are working in a specials manufacturing unit and you are preparing a bulk
order of Zinc and Icthammol cream BP for a number of dermatology clinics.
The order is to prepare 650 boxes each containing 150 packs of 27.5g tubes
of cream.
The Zinc and Icthammol cream BP formulation contains the following:
5% icthammol
3% cetostearyl alcohol
10% wool fat in zinc cream

What is the weight in kg of wool fat required to prepare the bulk order? Give your
answer to two decimal places.
Kg

12- You are a hospital pre-registration pharmacist and you have been asked to
prepare a hydrogen peroxide solution required for skin disinfection. You have
been told to mix together 350ml of hydrogen peroxide solution BP 6% and
250ml of hydrogen peroxide solution BP 10 vols.
What will be the final concentration %v/v of the resulting solution? Give your
answer to one decimal place.
%v/v

DILUTIONS
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________

13- You are requested to manufacture a stock solution of copper sulphate so that
when it is diluted 1 in 1000 it makes a final solution of 0.02%.
How many grams of copper sulphate is required to make 725ml of the stock
solution?

14- You are working in the hospital and the lab technician from the
manufacturing unit explains to you that he has been asked to prepare a
glucose 5% solution needed for infusion from a stock solution of glucose 30%.
What volume of water in litres will the lab technician need to add to the 700ml of
glucose 30% to produce the required strength? Give your answer to one decimal
place.

15- A stock solution containing 25% w/v of drug A is used to prepare an
antiseptic such that when the antiseptic is diluted 1 in 25, a 1 in 500 wash
solution is obtained which is ready for use by the patient.

How many mL of the stock solution is required to prepare 7 litres of the antiseptic
to fulfill a bulk manufacturing order?

mL

MOLECULAR WEIGHT
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________


16- You are working in the hospital aseptic lab and you need to add 30 mmol of
potassium chloride to a 1L intravenous infusion bag of glucose 5%. You have
potassium chloride 35% w/v solution in stock.
The molecular mass of potassium chloride is 75.
What volume in mL of potassium chloride 35% w/v solution do you require?

mL

17- Mr JP, a 31-year-old athlete who weighs 89kg visits his pharmacy to buy three
packs of O.R.S hydration soluble tablets to prevent dehydration, as he is
currently preparing to run the marathon in very hot conditions. Each pack
contains 24 tablets and Mr JP finishes the three packs in one week.
O.R.S hydration tablets contain the following ingredients:
Ingredient mg/tablet
Citric acid 429
Sodium hydrogen carbonate 331
Riboflavin 5 phosphate 0.3
Aspartame 14
Flavour Lemon 40
Glucose 1826
Potassium chloride 150
Sodium chloride 176
PEG 6000 33.7
Weight of one tablet: 3 grams
The molecular mass of sodium chloride is 58.5.
The molecular mass of potassium chloride is 74.5.
How many millimoles of chloride will Mr JP have received from the O.R.S hydration
tablets after one week?

mmol


18- You are required to prepare an intravenous infusion of sodium chloride. The
instructions are to weigh out 6.3g of sodium chloride and make up to a
volume of 500mL with water for injections.

The molecular mass of sodium chloride is 58.

What is the molarity of the resulting solution? Give your answer to two decimal
places.


USING PROVIDED FORMULAE

_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________

19- Mrs M is a 54 year old inpatient on the oncology ward. She weighs 62kg and
her height is 1.63 metres. Mrs M suffers from advanced B-cell chronic
lymphocytic leukaemia (CLL). The specialist doctor wants to start her on
treatment with fludarbine phosphate via intravenous infusion using
50mg/2ml injection vials in 0.9% sodium chloride solution. After
reconstitution, each vial is stable for 8 hours only.
The formula for calculating body surface area is provided below.
Assuming that Mrs M is given the maximum full length of treatment to achieve a
successful response, how many vials will be required?

vial(s)

20- You are working in a Specials Manufacturing Unit and receive an order for
1250 mL of Ferrous Sulphate Mixture.
The formula for Ferrous Sulphate Mixture is provided below.
Ferrous Sulphate 60 mg
Ascorbic Acid 10 mg
Orange Syrup 0.5 mL
Double strength chloroform water to 5 mL
What is the quantity of Ascorbic Acid expressed in grams required for this
formulation? Give your answer to two decimal places.

21- You receive a special order to prepare twenty-eight propranolol powder
sachets each containing 6mg of active ingredient with the total powder
weighing 250mg. You have all the equipment you need, including a balance,
which weighs accurately between 50mg and 1000mg. The diluent you have
available for use is lactose and you decide to calculate for formulating two
powders in excess.

What is the total quantity of lactose expressed in milligrams that you will require?

mg

INFUSION RATES
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________

22- A 2-year-old child weighing 12kg has undergone heart surgery and needs to
be started on a dopamine infusion. The doctor has asked the nurse to
administer 10mcg/kg/min at an infusion rate of 5ml/hr. You have available
dopamine 200mg/5ml ampoules and 250ml bags of Sodium Chloride 0.9%.
What volume in mLs of the dopamine solution is required to be added to the

250ml of Sodium Chloride 0.9% to provide the prescribed dose and infusion rate?

mL


23- Mrs S, a 49 year old mother who weighs 66kg has been admitted to the
intensive care unit in the A&E ward. The consultant doctor prescribes
diprivan 1% for sedation via continuous infusion at a dose of 2.5mg/kg/hour.
Diprivan 1% is available as a 100ml vial that needs to be diluted with dextrose
5% to 2mg/ml prior to administration.

What is a suitable infusion flow rate in mL/minute for the administration
of diprivan 1% to Mrs S? Give your answer to one decimal place.

mL/min

24- Mr C, who weighs 82kg, is being administered a saline drip with a fixed drop
size and adjustable flow at a rate of 1.6 litres of saline 0.9% over 13 hours,
having suffered a major fall while at work.

Assuming that 1ml is equivalent to 20 drops, what should the drop rate be set to in
drops/min? Give your answer to a whole number.

drops/min

PHARMACOKINETICS

_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________

25- Patient B weighing 60kg is to be given Drug X via intramuscular

administration. It has been calculated that the volume of distribution of
Drug X is 15 L/kg and maximum blood levels are reached 30-90 minutes after
an intramuscular dose. Drug X is also estimated to have a half-life of 20
hours. Patient B is administered a dose of 50mg in 2mL by intramuscular
injection. As it undergoes considerable first pass metabolism, it has an
effective bioavailability of 80%.

What would be the expected concentration in mcg/L in Patient B’s blood after 60
minutes of administering Drug X assuming maximum blood concentration has been
achieved? Give your answer to one decimal place.

mcg/L

26- Mr H who weighs 76kg is participating in a clinical trial for a new diuretic
known as drug X. Immediately after administering drug X to Mr H
intravenously, the initial serum concentration was 84mg/L. The clearance
rate of drug X is 6ml/kg/minute.

How many grams of drug X will be cleared from Mr H’S body 2.5 hours after
administration? Give your answer to two decimal places.


27- Mr B is a 70 year old man with a body weight of 69kg who suffers from atrial
fibrillation. He requires an oral loading dose of digoxin. The volume of
distribution (VD) per kg body weight is 6 L, the salt factor (S) = 1 and the
bioavailability (F) = 0.7.
What dose in mcg should be given to Mr B to achieve a target plasma

concentration (Cp) of 1.25 micrograms/L? Give your answer to the nearest whole
number.

mcg

HEALTH ECONOMICS
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________

28- Drug D is a novel oral anticoagulant drug that has recently undergone testing
in a clinical trial and the following data was collected. The clinical trial project
team want to calculate the efficacy of drug D by determining in how many
subjects (n) Pulmonary Embolism (PE) was prevented after taking the drug in
comparison with the placebo group.

Placebo Group Treatment Group
Event
(n=1000) (n=1000)
PE 35 15
No PE 965 985

Absolute risk reduction (ARR) = difference in the rate of a particular event in the
treatment group compared with the control e.g. if ARR is 0.1, this means a 10%
reduction in PE in the treatment group compared with the placebo group

ARR = (event rate in placebo group) – (event rate in treatment group)

Numbers needed to treat (NNT) = Number of people needed to be treated to
achieve the desired goal of a treatment e.g. if NNT is 10, this means 10 people need
to be treated to prevent one PE

NNT = 1/ARR

What is the NNT for drug D? Give your answer to the nearest whole unit.
NNT

29- You are working as a medicines management pharmacist and have been
tasked with identifying potential cost savings that can be made with
prescribing. You identify that Venlalic® XL tablets once daily is cheaper than
Efexor® XL capsules once daily.

Drug/Brand Quantitiy Basic Price

Venlafaxine 75mg
Modified-release capsules 28 2208
Efexor XL

Venlafaxine 75mg
Modified-release tablets 28 1120
VenlalicXL

Calculate the percentage of the potential cost savings per month if 50 patients are
switched from Efexor XL to Venlalic XL Tablets?

30- A wholesaler offers you atenolol 100 mg tablets at a cost of 40% of the drug
tariff (DT) price. The DT price is 79 pence for a pack of 28 tablets. Your usual
wholesaler provides these at 80% of DT price. You use 50 packs a month.

How much would you save over three months by buying from the cheaper
wholesaler? Give your answer to the nearest pound.
pound(s)

QUANTITIES TO SUPPLY
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________

31- Mr A attends his appointment at his GP surgery and his GP would like to
gradually withdraw his prednisolone corticosteroid treatment. The GP has
issued Mr A with a prescription with the instructions to take 15 mg daily for
one week. From week 2 onwards, the daily dose should be reduced by 2.5 mg
every seven days until stop.

What is the exact number of prednisolone 2.5mg tablets that will be required for
the first 28 day supply?

tablet(s)

32- Mrs NS, a regular customer comes to your pharmacy today with a
prescription for mometasone furoate nasal spray.

How many days will the nasal spray provide treatment for?

day(s)

33- A 6-month-old child of average height and weight and a body surface area of
0.47m2 has been admitted to the paediatric ward. He requires Drug X
450mg/m2 QDS for 7 days. Drug X is available to you as a 0.5%w/v solution.

What is the minimum number of 100mL bottles you would supply to the ward to
fulfill the 7-day course of treatment for this child?

bottle(s)

MISCELLANEOUS QUESTIONS

34- Mrs P is due to be administered with drug E at a dose of 9mg/hour. Drug E is
available as a 6mg/mL solution for injection. The nurse will use a syringe
driver that is 60mm in length and is designed to contain 5mL of injection
solution.

At what rate setting in mm/hour should the syringe driver be set at for Mrs P to
receive her dose?

mm/hour

35- A 55-year-old male patient with Crohn’s disease has been receiving 2040 kcal,
30 mL of lipid and 61.5 grams of protein in a total parenteral nutrition (TPN)
solution at 100mL/hour.

During a ward round, the doctor changes the prescription to decrease the total
kcal/day by 500. No change in protein or lipid content has been ordered. The patient
will receive this TPN solution for 24 hours.

kcal content of macronutrients:

Protein: 4 kcal/g
Carbohydrates: 3.4 kcal/g
Lipids 20%: 2 kcal/mL

Amino acids are synonymous for protein. Dextrose is synonymous for carbohydrates.

What is the final concentration expressed in % w/v of dextrose in the new TPN
solution? Give your answer to one decimal place.

%w/v

36- Mr J, a 29-year-old male has been admitted to hospital with hypokalaemia.

He is prescribed 500ml of potassium chloride 0.15% to be given intravenously
in order to correct the imbalance over 5 hours. One litre of 0.15% potassium
chloride contains 20mmol of KCl.
How much potassium will Mr J receive in mmol/hour?
mmol/hour

37- Mr N is receiving Oramorph Oral Solution 10mg/5mL, 20mL every 4 hours for
pain relief. However he has recently developed dysphagia and his doctor
requests that he is switched over to an equivalent dose of morphine to be
administered as a subcutaneous infusion. The doctor has also agreed that if
breakthrough pain occurs, the patient should be given a rescue dose
equivalent to one tenth of his total 24-hour subcutaneous infusion dose.

What is the correct subcutaneous infusion dose in mg that should be given to Mr N
as a rescue dose?

mg


38- You are required to manufacture a batch of granules containing an active
substance to be made into compressed tablets. The following information is
provided on the worksheet you are working with:
Active substance content of compressed tablet: 500 mg
Mean weight of compressed tablet: 850 mg

What quantity in kilograms of active substance is required to manufacture a 250 kg
batch of granules with an overage of 5%? Give your answer to two decimal places.

Kg


39- You are the pharmacist in the paediatric ward. A nurse calls you regarding
one of her patients requiring parenteral nutrition. She explains to you that
she needs 150ml of glucose 30%, however she only has available a 500ml bag
of glucose 40% and a 2 x 100ml vial of glucose 20%.

What volume in mL of glucose 20% will the nurse require to add to glucose 40% to
produce 150ml of glucose 30%?

mL

40- Mr A has been admitted to the cardiology ward in your hospital after
suffering a stroke. He usually takes 450mg of Drug C orally once daily,
however he now cannot swallow tablets. The specialist doctor wants to
change him onto an equivalent dose of Drug C elixir.

The bioavailability of drug C elixir =0.6
The bioavailability of drug C tablets = 0.7

What dose of drug C of elixir expressed in milligrams would you recommend for Mr
A?

mg

Calculations Master Class 2020

Uploaded by

Document Information

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Calculations Master Class 2020

Uploaded by

Copyright:

Available Formats

Calculations

© Copyright ProPharmace Ltd 2020 2

How many mL of spironolactone 25mg/5ml should Master B receive for each

© Copyright ProPharmace Ltd 2020 3

© Copyright ProPharmace Ltd 2020 4

© Copyright ProPharmace Ltd 2020 5

ESTIMATIONS OF KIDNEY FUNCTION

Please use this page for making notes:

© Copyright ProPharmace Ltd 2020 6

4- Ms. R is a 59 year old woman with hypertension, hypercholesterolaemia, and

Test Results Units Reference Range

© Copyright ProPharmace Ltd 2020 7

creatinine clearance (mL/min) = constant x (140 - age) x weight (kg)

© Copyright ProPharmace Ltd 2020 8

© Copyright ProPharmace Ltd 2020 9

DISPLACEMENT VOLUMES AND VALUES

Please use this page for making notes:

© Copyright ProPharmace Ltd 2020 10

© Copyright ProPharmace Ltd 2020 11

8- A doctor prescribes ceftriaxone 250mg as a single dose for the treatment of

© Copyright ProPharmace Ltd 2020 12

9- You receive a prescription for a batch of 80 1-g suppositories, each containing

© Copyright ProPharmace Ltd 2020 13

© Copyright ProPharmace Ltd 2020 14

10- You have been given an order to extemporaneously prepare a 10%w/w

© Copyright ProPharmace Ltd 2020 15

The Zinc and Icthammol cream BP formulation contains the following:

© Copyright ProPharmace Ltd 2020 16

© Copyright ProPharmace Ltd 2020 17

© Copyright ProPharmace Ltd 2020 18

© Copyright ProPharmace Ltd 2020 19

© Copyright ProPharmace Ltd 2020 20

© Copyright ProPharmace Ltd 2020 21

© Copyright ProPharmace Ltd 2020 22

The molecular mass of potassium chloride is 75.

What volume in mL of potassium chloride 35% w/v solution do you require?

© Copyright ProPharmace Ltd 2020 23

O.R.S hydration tablets contain the following ingredients:

Weight of one tablet: 3 grams

The molecular mass of sodium chloride is 58.5.

The molecular mass of potassium chloride is 74.5.

© Copyright ProPharmace Ltd 2020 24

© Copyright ProPharmace Ltd 2020 25

USING PROVIDED FORMULAE

© Copyright ProPharmace Ltd 2020 26

The formula for calculating body surface area is provided below.

© Copyright ProPharmace Ltd 2020 27

The formula for Ferrous Sulphate Mixture is provided below.

© Copyright ProPharmace Ltd 2020 28

© Copyright ProPharmace Ltd 2020 29

© Copyright ProPharmace Ltd 2020 30

What volume in mLs of the dopamine solution is required to be added to the

© Copyright ProPharmace Ltd 2020 31

© Copyright ProPharmace Ltd 2020 32

© Copyright ProPharmace Ltd 2020 33

© Copyright ProPharmace Ltd 2020 34

25- Patient B weighing 60kg is to be given Drug X via intramuscular

© Copyright ProPharmace Ltd 2020 35

© Copyright ProPharmace Ltd 2020 36

What dose in mcg should be given to Mr B to achieve a target plasma

© Copyright ProPharmace Ltd 2020 37

© Copyright ProPharmace Ltd 2020 38

© Copyright ProPharmace Ltd 2020 39