Name:

Exercise 9: Renal System Physiology: Activity 2: The Effect of Pressure on Glomerular Filtration Lab Report

Pre-lab Quiz Results

You scored 100% by answering 4 out of 4 questions correctly.

1. Which of the following forces promotes filtration?

You correctly answered: c. blood pressure in the glomerular capillaries

2. The glomerular filtration rate can be altered by

You correctly answered: b. changing the afferent arteriole resistance.

3. In 24 hours human glomerular capillaries can filter as much as __________ liters of filtrate.
You correctly answered: c. 180

4. Which of the following statements about the filtrate in the renal corpuscle is false?
You correctly answered: d. Normally, more than 40% of the blood that enters the glomerular capillaries becomes filtrate.

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Experiment Results
Predict Question:
Predict Question 1: What will happen to the glomerular capillary pressure and filtration rate if you increase the blood
pressure in the left source beaker?
Your answer : a. Both pressure and filtration rate will increase.

Predict Question 2: What will happen to the filtrate pressure in Bowman's capsule (not directly measured in this experiment)
and filtration rate if you close the one-way valve between the collecting duct and the urinary bladder?
Your answer : d. Pressure will increase and filtration rate will decrease.

Stop & Think Questions:

What is the important relation that underlies the observed increase in glomerular filtration rate when the blood pressure is
increased?
You correctly answered: c. pressure and flow are directly proportional.

What medical condition is analogous to the closed valve?

You correctly answered: b. a tumor obstructing the renal tubule

Experiment Data:

Afferent Radius Efferent Radius Beaker Press. Glomerular Glom. Filt. Rate Urine Volume Valve Status
(mm) (mm) (mm Hg) Press. (mm Hg) (ml/min) (ml)
0.50 0.45 70 49.72 58.57 161.76 open
0.50 0.45 80 52.40 91.78 186.23 open
0.50 0.45 90 55.08 124.99 200.44 open
0.50 0.45 100 57.76 158.20 209.72 open
0.50 0.45 70 49.72 58.57 161.76 open
0.50 0.45 70 49.72 26.94 0.00 closed
0.50 0.45 100 57.76 120.60 0.00 closed
0.50 0.45 100 57.76 158.20 209.72 open

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Post-lab Quiz Results
You scored 100% by answering 4 out of 4 questions correctly.

1. In humans, the glomerular filtration rate normally ranges from

You correctly answered: b. 80 to 140 ml/min.

2. Which of the following does not have a significant impact on the glomerular filtration rate?
You correctly answered: d. renal tubule length

3. In the absence of any regulatory mechanisms, what do you think would happen to the glomerular filtration rate of a
person who experiences an increase in blood pressure?
You correctly answered: a. The glomerular filtration rate could increase.

4. What would happen to the glomerular filtration rate of a person who experiences a large hemorrhage?
You correctly answered: b. The glomerular filtration rate would decrease.

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Review Sheet Results
1. As blood pressure increased, what happened to the glomerular capillary pressure and the glomerular filtration rate? How
well did the results compare with your prediction?
Your answer:
Saya memperkirakan bahwa dengan meningkatnya tekanan darah, tekanan kapiler glomerulus dan laju filtrasi juga akan
meningkat. Hasil tersebut membuktikan prediksi saya karena semakin banyak darah yang masuk ke kapiler di kapsul
Bowman, semakin tinggi tekanan yang naik, serta laju filtrasi yang meningkat akibat tekanan yang tinggi. Ini selalu untuk
lebih banyak penyaringan darah

2. Compare the urine volume in your baseline data with the urine volume as you increased the blood pressure. How did the
urine volume change?
Your answer:
Dapat dilihat bahwa ketika tekanan darah meningkat maka produksi urin juga meningkat. Dengan demikian menunjukkan
bahwa tekanan glomerulus, laju filtrasi, dan volume urin semuanya akan meningkat karena setiap kali tekanan glomerulus
meningkat, laju filtrasi harus meningkat dari tekanan tinggi dan terakhir laju filtrasi yang tinggi menyebabkan peningkatan
volume urin.

3. How could the change in urine volume with the increase in blood pressure be viewed as being beneficial to the body?
Your answer:
Peningkatan volume urin dapat bermanfaat bagi tubuh karena itu berarti limbah disaring keluar dari tubuh lebih cepat dari
biasanya. Semakin sering buang air kecil menyebabkan kehilangan air, mengakibatkan konsumsi cairan yang lebih tinggi
untuk menggantikan cairan yang hilang saat buang air kecil. Yang juga meningkatkan volume urin, menciptakan siklus yang
bermanfaat dalam menyaring limbah dengan cepat dari mengonsumsi cairan dengan laju yang meningkat untuk
menggantikan apa yang hilang.

4. When the one-way valve between the collecting duct and the urinary bladder was closed, what happened to the filtrate
pressure in Bowman's capsule (this is not directly measured in this experiment) and the glomerular filtration rate? How well
did the results compare with your prediction?
Your answer:
Setiap kali katup ditutup, tekanan filtrasi tetap sama, tetapi laju filtrasi glomerulus menurun. Saya sebelumnya
memperkirakan bahwa tekanan akan meningkat dan laju filtrasi akan menurun. Data menunjukkan bahwa tekanan
glomerulus adalah sama dibandingkan dengan tingkat dengan katup terbuka, menunjukkan bahwa tekanan tidak
terpengaruh. Namun, data membuktikan bahwa laju filtrasi menurun setiap kali katup tertutup, dibandingkan dengan
terbuka. Hal ini karena sudah ada filtrat di dalam kandung kemih karena tidak ada keluaran urin, sehingga sistem tidak
dapat menyaring lebih banyak.

5. How did increasing the blood pressure alter the results when the valve was closed?
Your answer:
Setiap kali tekanan darah meningkat saat katup ditutup, itu terutama mempengaruhi laju filtrasi glomerulus. Laju filtrasi
glomerulus menurun karena tidak ada output urin. Laju filtrasi ini menurun karena tekanan glomerulus tetap sama dan
membebani sistem filtrasi sehingga menyebabkan pergerakan pada laju yang lebih lambat.

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