Clinical Research Centre

Hospital Tuanku Fauziah

Unit Profile
 Vision & mission
Vision
To become the leading clinical research
institution in northern region of peninsular
Malaysia.

Mission
To improve patients’ health outcome
through ethical and quality clinical research.

Establishment
Clinical Research Centre Hospital Tuanku
Fauziah, Kangar, Perlis (CRC HTF) was
established on May 7th, 2007.

Its main function is to establish conducive

environment to enable ethical and quality
clinical research projects to be carried out for
the improvements of patients’ health
outcome.
 Head of Unit
2007
Dr Sia Soon Keat
Department of Internal Medicine

2008-2009
Dr Zalwani Zainuddin
Department of Internal Medicine

2009-2013
Dr Yeap Ewe Juan
Department of Orthopaedics

2014-2016
Dr Noram Azlan Ramli
Department of Ophthalmology

2017-2019
Dr Nizar Bidin
Department of O&G

2020
Dr Khairul Shakir Ab Rahman
Department of Pathology

2021-2023
Dr Ruzita Jamaluddin
Department of Psychiatry and Mental Health
LEVEL 1, “BLOK KLINIK PAKAR” (NEXT TO “DEWAN INSANIAH”)
Source: htf.moh.gov.my
ORGANIZATION CHART
 CRC HTF STAFF

Dr Ruzita Jamaluddin Dr Irma Liyana Mushaddik Mr Ang Wei Chern Dr Noor Suhaiza Morat Dr Amalina Anuar
Head Deputy Admin manager Medical officer UD52 Medical officer UD48
Consultant Psychiatrist UD56 Medical officer UD52 Pharmacist UF48 2023 2018
2021 2021 2016

SN Siti Zulaiha Che Hat Ms Siti Ertina Asli Ms Nor Efarina Abdul
CRM Study Coordinator Mr Rohaizan Isa
Staff nurse U29 Rahman
2009 Operational assistant N11
2018 Administrative assistant N19
2010
2010
 CRC COMMITTEE MEMBERS :
APPOINTMENT DATE 2022 - 2023
HOSPITAL RESEARCH REVIEW COMMITTEE :
APPOINTMENT DATE 2022-2023
 PERFORMANCE INDICATOR FOR
CRC HTF
1. Number of NMRR registered IIR (Investigator Initiated Research)
2. Number of research collaboration with IPTA/IPTS
3. Number of publications :
• Number of publications by CRC staffs
• Types of published articles
• Publication in high indexed journal
4. Number of ISR (Industrial Sponsored Research)
5. Research Consultations
6. CRC research training activities
7. CRC staffs achievements
Updated 1 April 2023

NMRR - REGISTRED IIR 2018 -2023

JKN PKD HTF

55

51
47

45
38

4
15
11
2 4
2 3 2 1
1
2018 2019 2020 2021 2022 2023
 NMRR - REGISTRED IIR HTF, 2023
No. NMRR ID Project Full Title Principal Investigator
Knowledge, Attitude and Practice on Preparation and Administration of SITI ZULAIHA BINTI CHE
1 NMRR ID-23-00175-ULY Intravenous Medications among Nurses in Hospital Tuanku Fauziah, Perlis HAT

COVID-19 and Climate Change: Prospects for a ‘Green’ Recovery in the

2 NMRR ID-23-00211-TFX Indian Ocean Region SEE MING SHE
KNOWLEDGE AND ATTITUDE ABOUT ACUTE DELIRIUM IN THE
ELDERLY AMONG EMERGENCY DEPARTMENT DOCTORS IN
3 NMRR ID-23-00225-FMQ MALAYSIAN GOVERNMENT HOSPITALS Mohd Johar Bin Jaafar
Quality of Work-Life, Burnout and Professional Commitment among Nurses: A
4 NMRR ID-23-00227-QKT Multicentre Analysis Government and Private Hospitals in Malaysia VALERMATHIE A/P VELLU
Patient Profile and Mental Health Issues Among New Cases Referred To The
Hospital Tuanku Fauziah Psychiatric Team Before, During And After The
5 NMRR ID-23-00239-RCQ COVID-19 Pandemic: A 4-Year Retrospective Analysis Ruzita binti Jamaluddin
The Local Needs and Gaps in Pharmacogenomics Knowledge and Education Safa Hassan Mohamed
6 NMRR ID-23-00292-PWX Among Healthcare Professionals in Malaysia: A Delphi Study Hassan Omran
Ketogenic diet in women with polycystic ovarian syndrome (PCOS): a
7 NMRR ID-23-00295-9N5 systematic review and meta-analysis of clinical trials KARNIZA BT KHALID
8 NMRR ID-23-00407-YMC Perception of Pain among Surgical Ward Patients: A Cross-Sectional Study Jason Wong Soon Keong
NIK NUR
The Journey to Embryonal Rhabdomyosarcoma (FNCLCC Grade 2) detection: FARAHIYAH@HIDAYAH
9 NMRR ID-23-00604-FWH A Case Report BINTI NIK ZAINAL ABIDIN
Shoulder dystocia: a review on incidence, maternal and perinatal risk factors
10 NMRR ID-23-00746-2DH and outcome Nur Farihan binti Mukhtar
Faktor-Faktor yang Mempengaruhi Niat Penggunaan ICD-11 Dalam Kalangan
Pegawai Tadbir Rekod Perubatan dan Penolong Pegawai Tadbir Rekod
11 NMRR ID-23-00756-KIH Perubatan di Fasiliti KKM Zaleha binti Md. Isa
AN ONLINE SURVEY OF AUDIOLOGIST’S AWARENESS AND PRACTICE
12 NMRR ID-23-00957-FDQ OF AUDITORY PROCESSING IN MINISTRY OF HEALTH MALAYSIA MERLINDA W BERNARD

13 NMRR ID-23-01061-EM1 AUDIT ON READMISSION RATE OF UNSTABLE ANGINA CHUAH SEAN JYI
Factors contributing to HPV vaccine hesitancy among adolescents and the
14 NMRR ID-23-01062-XDU recommended interventions: A review of quality improvement methodologies KARNIZA BT KHALID
Cardiology Clinic Hospital Tuanku Fauziah Clinical Audit 2022: Adherence to
ACEi/ARB in STEMI Patients Admitted to CCU HTF between January and
15 NMRR ID-23-00538-T23 June 2022 Khairul Azhar Bin Abu Bakar
 NMRR- REGISTRED IIR JKN PERLIS, 2023
No NMRR ID Project Full Title Principal Investigator
.
IDENTIFYING PREVENTABLE FACTORS FOR
NMRR ID-23-00410- EARLY CASE DETECTION AND TREATMENT Rafidah Binti Ali, MOHD
1 75L ADHERENCE IN LEPROSY FIRDAUS BIN RAZALI

NMRR- REGISTRED IIR PKD 2023

No NMRR ID Project Full Title Principal Investigator
.
SITTI FATIMAH BINTI
NMRR ID-23-00587- Depression, Anxiety and Stress Among Pregnant AJUI (KK Kangar, KK
1 ZAA Women in Perlis: A Cross Sectional Survey Beseri)
RESEARCH COLLABORATION WITH IPTA/IPTS 2019-2023
16
14
14 13 13

12
10 10
10
No.

0
2019 2020 2021 2022 2023
Year
Minimum 10 collaboration with IPTA/S in a year

Updated 1 May 2023

 RESEARCH COLLABORATION WITH IPTA/IPTS 2023
No Research Title Main researcher at site Collaboration Institution Current status
1 Health Utility and Health-related Quality of Life of Ang Wei Chern Universiti Sains Malaysia Write-up
HIV Patients in a Malaysian State Hospital (CRC HTF) (NMRR-21-1549-60908)
2 Prevalens dan Faktor-faktor yang Berkaitan Dengan Dr. Amalina Anuar Open University Malaysia Report Writing
Anemia Semasa Kehamilan: Sebuah Kajian (CRC HTF) (OUM) (NMRR-22-02473-3DR)
Kuantitatif Dalam Kalangan Ibu Hamil Di Klinik
Kesihatan Di Negeri Perlis
3 RESOLVE-Randomised Evaluation of Sodium Dr Wan Syamir Zharif bin University of Sydney New site in HTF
Dialysate Levels on Vascular Events Wan Ahmad Kammal (NMRR-19-3823-52045)
(Nephro HTF)
4 Snakebite: Evaluation of Knowledge among Farmers Ang Wei Chern Universiti Kebangsaan Data collection (NMRR-
in the State of Perlis (CRC HTF) Malaysia (UKM) 21-1797-61372)
5 Experience of preceptors on Provisional Registered Ang Wei Chern Universiti Kebangsaan Data collection (NMRR
Pharmacist (PRP) training programme in the state of (CRC HTF) Malaysia (UKM) ID-22-02283-YCO)
Perlis, Malaysia: a qualitative study.
6 Budget Impact Analysis of Ferric Derisomaltose for Ang Wei Chern Monash University Malaysia Pending publication in
the Treatment of Iron-Deficiency in Malaysia (CRC HTF) MJMHS
7 Factors affecting choice of post graduate training Datuk Seri Dr Paras Doshi University of Cambridge Protocol writing and
pathway in internal medicine in Malaysia (Medical HTF) NMRR registration
8 Breast cancer status, grading system, etiology, and Dr Khairul Shakir Ab Rahman Universiti Malaysia Perlis Published in 2023
challenges in Asia: an updated review (Pathology HTF) (UniMaP) https://doi.org/10.1515/
oncologie-2022-1011
9 Morphological features-oriented fusion extraction Dr Khairul Shakir Ab Rahman Universiti Malaysia Perlis Applying FRGS grant
method for quantification of tubules and non-tubules (Pathology HTF) (UniMaP) and NMRR
in breast carcinoma
10 A novel formulation of automated tumor volume Dr Wan Irnawati Wan Ab Universiti Malaysia Perlis Applying FRGS grant
detection and characterization method using fusion Rahman (Radiology HTF) (UniMaP) and NMRR
feature extraction
 PUBLICATION ACHIEVEMENT 2018-2023

MSQH Std 26.5.1.6b

Bilangan penerbitan: Minimum 2 setahun (sebagai denominator)
Updated 1 May 2023
 CRC STAFFS ACHIEVEMENTS IN
PUBLICATIONS 2021-2023
40

35 34

30

25
24 17
20
10 15
15

10
17 10
5
14
5
0

2021 2022 2023

CRC non-CRC
TYPES OF PUBLISHED ARTICLES 2021-2013
30

25 24

20

16
15

10
10

6 6
5 4
3
2 2
0

2021 2022 2023

Original article case report review article
 PUBLICATIONS IN HIGH INDEXED
JOURNALS 2021-2023

18
17 17
16

14 13
12 11
10

8
8 7
6

2021 2022 2023

high indexed journal non high indexed journal

*High indexed journal : Web of

Science (SCI or SCIE) / Scopus
 Publications from HTF 2023
No Author Title Journal High index IF SJR
journal
- - -
1 First author: Paracetamol as analgesia The Malaysian Journal
Dr Nur Farihan following Spontaneous of Nursing
Mukhtar Vaginal Delivery:
(O&G, HTF) Reappraisal of Practice

2 First author: Lithium toxicity in a Current Psychiatry Scopus - 0.14

Ruzita Jamaluddin patient with bipolar (Q4)
(Psychiatry & CRC, disorder: Lesson learned
HTF)

3 Co-author: Pap Smear Images Diagnostics WoS (SCIE) 3.992 0.66

Dr Khairul Shakir Ab Classification Using Scopus
Rahman Machine Learning: (Q2)
(Pathology A Literature Matrix
Department , HTF)

4 Co-author Artificial Intelligence Diagnostics WoS (SCIE) 3.992 0.66

Dr Khairul Shakir Ab (AI) in Breast Imaging: Scopus
Rahman A Scientometric (Q2)
(Pathology Umbrella Review
Department, HTF)
No Author Title Journal High index IF SJR
journal

5 First author: Mental Health Burden from Malaysian Journal of Scopus - 0.14
SN Siti Zulaiha Che Hat COVID-19: Findings from Medicine and Health (Q4)
(CRC, HTF) a Single Hybrid Hospital in Sciences
Northwest Malaysia

6 Co author: Exploration of hybrid deep International Journal of Scopus - 0.39

Ang Wei Chern learning algorithms for Advances in Intelligent (Q3)
(CRC, HTF) covid-19 mRNA vaccine Informatics
degradation prediction
system

7 First author Holistic Approach to Malaysian Journal of - - -

Dr Syuhaida Shuib Ecstasy-induced Atrial Medical Research
(Emergency Fibrillation in a Young
Department, HTF) Patient: A Case Report

8 Co-author Fuzzy Relevant Regions 2022 IEEE International - - -

Dr Khairul Shakir Ab Segmentation in Breast conference on Automatic
Rahman Histopathology Images Control and Intelligent
(Pathology Department , using FCM Systems (12CACIS)
HTF)
No Author Title Journal High index IF SJR
journal
9 Co-author A Non-Mitosis Reduction 2022 IEEE International - - -
Dr Khairul Shakir Ab Method using Semantic conference on Automatic
Rahman Descriptors for Breast Control and Intelligent
(Pathology Department , Cancer Mitosis Detection Systems (12CACIS)
HTF) Application

10 Co-author: Nuclei Segmentation in 2022 IEEE International - - -

Dr Khairul Shakir Ab Breast Histopathology conference on Automatic
Rahman Images using FCM Control and Intelligent
(Pathology Department , Systems (12CACIS)
HTF)

11 Co-author: Smart Management Journal of Advanced - - -

Dr Nur Diana Mastura Waiting System for Research in Applied
Zulkifli Outpatient Clinic Sciences and Engineering
(Pathology Department , Technology
HTF)

12 Co author Breast cancer status, Oncologie Journal Scopus - 0.14

Dr Khairul Shakir Ab grading system, etiology, (Q4)
Rahman and challenges in Asia: an
(Pathology Department , updated review
HTF)
No Author Title Journal High index IF SJR
journal
13 Co-author Perception Regarding MDPI antibiotics WoS (SCIE) 5.22 0.97
Dr Muhammad the NICE Guideline on Scopus
Ridwan Yeop Ismail Antibiotic Prophylaxis (Q1)
(OMF, HTF) against Infective
Endocarditis Following
Dental Procedures: A
Cross-Sectional Study

14 First author: Inequalities in International Journal of WoS (SCIE) 1.851 -

Ang Wei Chern Consumption Social Determinants of
(CRC, HTF) Expenditure on Health and Health
Pharmaceuticals: Services
Evidence from Malaysia

15 First author: The rare case of Medical Journal of - - -

Irma Liyana Mushaddik synchronous multiple Malaysia Case Reports
(CRC, HTF) primary malignancies of
invasive ductal
carcinoma and diffuse
large B-cell lymphoma
in a single patient: A
diagnostic conundrum
Publication Award 2022

Psychiatry
Department
received
Outstanding
Publication
Award 2022
 Industrial Sponsored Research (ISR)
Involvement 2019-2023
6

5
5

3 3
No.

2 2
2

0
2019 2020 2021 2022 2023
Year
Updated 1 May 2023
ISR List of ISR in Perlis
Principal Year Year
investigator Site Department Title of study Sponsor activated completed
Dr Ruzita
binti Confirmatory Study of DSP-5423P in Patients with Sumitomo
Jamaluddin HTF Psychiatry Schizophrenia (Phase 3) Dainippon 2017 2018
A Randomized, Multicenter, Double-Blind, Parallel-Group,
Placebo-Controlled Study to Investigate the Efficacy and
Dr Siti Akma Safety of Canagliflozin in Children and Adolescents (>=10
binti Ishak HTF Paediatrics to <18 years) with Type 2 Diabetes Mellitus Janssen 2018 Ongoing
A Phase III, Randomized, Observer-bind, Multicenter
Study to Evaluate the Efficacy, Immunogenicity and
Safety of Seqirus’ Cell-Based Quadrivalent Subunit
Influenza Virus Vaccine (QIVc) Compared to a Non-
Dr Siti Akma Influenza Vaccine when Administered in Healthy Subjects
binti Ishak HTF Paediatrics aged 6 months through 47 Months Seqirus 2019 2020
A Phase 2, Double-blind, Placebo-controlled Study to
Evaluate the Antiviral Activity, Clinical Outcomes, Safety,
Tolerability, and Pharmacokinetic/Pharmacodynamic
Relationships of Different Doses of JNJ-53718678 in
Children >28 Days and <3 Years of Age With Acute
Dr Siti Akma Respiratory Tract Infection Due to Respiratory Syncytial
binti Ishak HTF Paediatrics Virus Infection Janssen 2019 2022
A Phase 2b, Randomized, Double-Blind, Placebo-
Controlled Study of EDP-938 Administered Orally for the
Dr Suhaila Treatment of Acute Upper Respiratory Tract Infection with Enanta 2022
binti Ab Internal Respiratory Syncytial Virus in Ambulatory Adult Subjects Pharmaceutical (Premature
Wahab HTF Medicine (RSVP) s - closure)
Dr Suhaila A Randomized, Placebo-Controlled, Phase III Study to Kintor
binti Ab Internal Evaluate the Efficacy and Safety of Proxalutamide Pharmaceutical
Wahab HTF Medicine (GT0918) in Hospitalized COVID-19 Subjects s 2022 2022
Randomised, double-blind, placebo-controlled and
parallel dose group trial to investigate efficacy and safety
Dr Noorhafini of multiple doses of oral BI 690517 over 14 weeks, alone
binti Abdul Internal and in combination with empagliflozin, in patients with Boehringer
Sukur HTF Medicine diabetic and non-diabetic chronic kidney disease Ingelheim 2022 Ongoing
 ONGOING ISR IN HTF : CURRENT STATUS

NO TITLE OF STUDY PI TARGET ACHIEVED STATUS

1 A Randomized, Multicenter, Dr Siti Akma 2 2 2 subjects
Double-Blind, Parallel- binti Ishak completed the
Group, Placebo-Controlled study visit.
Study to Investigate the Awaiting for
Efficacy and Safety of Close out visit
Canagliflozin in Children
and Adolescents (>=10 to
<18 years) with Type 2
Diabetes Mellitus

2 Randomised, double-blind, Dr Noorhafini 2 1 ongoing

placebo-controlled and binti Abdul
parallel dose group trial to Sukur
investigate efficacy and
safety of multiple doses of
oral BI 690517 over 14
weeks, alone and in
combination with
empagliflozin, in patients
with diabetic and non-
diabetic chronic kidney
disease
 CRC RESEARCH TRAINING ACTIVITIES
2018-2023
6
5 5
5
4 4 4
4
3
No.

0
2018 2019 2020 2021 2022 2023
Year
MSQH Std 26.5.1.6a
Bilangan latihan dianjurkan: Minimum 2 setahun (sebagai denominator)

Updated 5 May 2023

 CRC RESEARCH TRAINING ACTIVITIES 2023

No. Event / Workshop / Course Date Venue

1. Good Clinical Practice (GCP) Workshop 07/03/2023 (Tuesday) - 09/03/2023 Online & Putra Regency, Perlis /
(Thursday) Hotel Seri Malaysia, Perlis

2. Introduction to Clinical Research (ICR) 13/03/2023 (Monday) - 14/03/2023 Online - zoom

(Tuesday)

3. Protocol Writing & NMRR Registration 16/03/2023 (Thursday) - 17/03/2023 Bilik Gerakan, JKN
Workshop (Friday)

4. Basic Biostatistics Workshop 07/06/2023 (Wednesday) - 08/06/2023 Dewan MRI, HTF/ Bilik Gerakan, JKN
(Thursday)

5. Publication Retreat Workshop 14/06/2022 (Wednesday) - 16/06/2023 Bilik Gerakan, JKN

(Friday)

6. Hari Kualiti & Penyelidikan 2023 26 – 27 October 2023 JKN Perlis

7. Research Consultation Clinic (RCC) Appointment basis CRC Office, HTF

Good Clinical Practice 2023 on
7th – 9th March 2023
Introduction to Clinical Research 2023 on
13th -14th March 2023
Protocol Development & NMRR Registration 2023
on 16th – 17th March 2023
ACHIEVEMENTS
Snippet from CRM bulletin Issue 12

STAR Recruiter Award for BRILLIANT Study

Principal investigator: Dr Ruzita Jamaluddin

Department of Psychiatry and Mental Health
HTF
 Snippet from
CRM bulletin Issue
20
Rising Stars in Paediatrics

Dr Siti Akma Ishak

Department of Paediatrics
HTF
 Awards Recipient
MR ANG WEI CHERN
CRC ADMIN MANAGER / PHARMACIST

2021 1 Best Oral Presentation

3rd World Congress on Integration & Islamicization (IMAM)
2021

2 Outstanding Poster Award

National Pharmacists Convention 2021

3 Young Investigator Award (Clinical)

National Institute of Health (NIH)

2022 1 2nd place oral presentation

23rd Islamic Medical Association of Malaysia (IMAM)

2 2nd runner up poster presentation

15th National Conference for Clinical Research (NCCR)
 2nd place oral presentation 2nd runner up
23rd Islamic Medical poster presentation
Association of Malaysia 15th National Conference
(IMAM) for Clinical Research
Annual Scientific Conference (NCCR)
8-9 Oct 2022 18-20 Oct 2022
 Awards Recipient
DR KARNIZA BINTI KHALID
DEPUTY HEAD / MEDICAL OFFICER UD 52

2021 1 Best Oral Presentation

9th International Conference on Biological & Medical
Sciences, Suzhou, China (ICBMS 2021) [Virtual meeting]

2022 1 3rd place Oral Presentation – RCSI & UCD Medical College
(RUMC) Research Day 2022 [Virtual meeting]

2 2nd place ePoster Presentation

26th Malaysian Society of Paediatric Haematology and
Oncology (MASPHO) Annual Scientific Meeting
[Virtual meeting]
RCSI & UCD (RUMC)
Research Day 2022
 CRC HTF was ranked 1st
for no. of ongoing
research on COVID-19
among all CRC network
in Malaysia (Jan-Jun
2021)

Source: CRC Network Meeting 02-Sep-2021

 CRC HTF was ranked 2nd
for no. of publications
among all CRC network
in Malaysia in Jan-Jun
2021

Source: CRC Network Meeting 02-Sep-2021

 Contributions from CRC staff
Dr Ruzita Jamaluddin Head of Unit 1. Panel Jawatankuasa Etika Penyelidikan Manusia UniMAP
2021-Current
2. Industry panel for AHIBS Action Research Challenge
2021
Dr Karniza Khalid Deputy / 1. Panel Jawatankuasa Etika Penyelidikan Manusia UniMAP
Medical 2021-Current
officer UD52 2. Panel for state level QA projects presentation (JKN
Perlis) 2022
3. Industry panel for AHIBS Action Research Challenge
2021
4. Elected as expert panel for Projek Kajian Awal Dasar
Perpaduan Negeri Selangor by Institut Kajian Etnik UKM
Bangi 2021
Mr Ang Wei Chern Admin 1. Jury for Research and Innovation Exhibition UniMAP
manager / (EREKA) 2021
Pharmacist 2. Scientific Research Secretariat for Perlis Research &
Quality Day 2018
Dr Amalina Anuar Medical 1. Scientific Research Secretariat for Perlis Research &
officer UD48 Quality Day 2018
OVERVIEW : ISR WORK PROCESS
IN HTF
STUDY DOCUMENT / IP / SAMPLE
STORAGE
◦ Each clinical trial documents and
study materials will be stored in a
dedicated steel locked cabinet
◦ Each cabinet will be labelled with
NMRR ID, Protocol number, protocol
title, sponsor, CRO and PI
◦ Investigational products (IP) are stored
in the 2-8° C pharmaceutical fridge
◦ Clinical trial samples are stored in -30°
C freezer before shipment to central
lab
Contingency Plan
for Sample
Storage in
Pharmaceutical
Freezer , HTF

PF : Pharmaceutical
Freezer
TG : Thermoguard System
 Contingency Plan for
Investigational Products (IP)
Storage in Pharmaceutical
Fridge , HTF

PF : Pharmaceutical Fridge
IP : Investigational Products
TG : Thermoguard System