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investigations to determine the phase of disease (chronic, accelerated, or
blast crisis). Definitive diagnosis is established by genetic testing
demonstrating the bcr-abl fusion gene. 

A 68-year-old male comes to his provider’s office for evaluation of fatigue,

weakness, and 8 kg (17.6 lb) unintentional weight loss over the past 2
months. Moreover, the patient reports feeling bloated after eating small
quantities of food during this same time period. His past medical history is
notable for hypertension, and the patient is currently taking
hydrochlorothiazide. Physical exam reveals oral mucosal pallor. Cardiac and
pulmonary exams are non-contributory. Abdominal exam reveals
hepatosplenomegaly. Laboratory testing results are as follows:  
 
 Laboratory value   Result 
 Hemoglobin   9.5 g/dL 
 Hematocrit   28.5% 
 Leukocytes   2,700/mm3 
 Platelets   100,000/mm3 

Biopsy of the bone marrow biopsy shows increased fibrosis and reduced cell
count. Polymerase chain reaction testing reveals a mutation in a gene
encoding for a non-receptor tyrosine kinase. Which of the following diseases
is also caused by an identical mutation?

Elimination tool

A. Fanconi anemia

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B. Acute myeloid leukemia

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C. Follicular lymphoma

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