Pharmacology (PHT-272) 1444H

Each student should prepare research that includes (Whatever applicable):

1. Introduction (3 POINTS)
2. PK (ADME) (4 POINTS)
3. Pharmacodynamics & References (3 POINTS)
Total (max points) (10 POINTS)

Assignment instructions:
- No more than 2 pages (Fill the provided form – Last page).
- Use Only up-to-date and authentic medical resources (Ex. Textbooks, PubMed,
UptoDate, NICE.org.uk, NHS.org.uk, FDA.gov, CDC.gov, Guideline.gov, ,
Mayo.edu, Medscape.com, Emedicine.com, Drugs.com, Rxlist.com, NIH.gov,
Webmed.com,, PDR.com, PDR).
- Write in your own words and avoid plagiarism

Evaluation Criteria:
1. Contents and Organization
2. Originality (plagiarism)
3. Scientific content
4. Complying with deadlines ( By W 11)i

1 out of 4
 Drug Information

A- Introduction: ( / 3 POINTS)

Generic/Brand Names:

salmeterol/fluticasone & Advair, Airduo, Airduo Respiclick, Serevent, Serevent Diskus, Wixela

Pharmacologic Category:

beta-2 adrenergic agonist class medication

Main Uses:

Salmeterol is a medication used in the management and treatment of asthma and COPD.

B-Pharmacokinetics: ( / 4 POINTS)

Absorption:

through Following chronic administration of an inhaled dose of 42 mcg twice daily,

salmeterol was detected in plasma within 5 to 10 minutes.

Distribution:

Binding of salmeterol to human plasma proteins averages 96% in vitro over the
concentration range of 8 to 7722 ng of salmeterol base per milliliter.

Metabolism:

Salmeterol base is extensively metabolized by hydroxylation.

Elemination:

salmeterol was eliminated in urine and feces, respectively, over a period of 7 days.

C-Pharmcodynamics: ( / 3 POINTS)

Main drug effect:

provide prolonged bronchodilatation to control nocturnal symptoms and improve

maintenance therapy in asthmatic patients.

2 out of 4
Meacnism of action:

By binding to a specific exo-site domain of the beta 2-receptor protein to produce

continuous stimulation of the active site of the receptor.

Main Adverse effects:

(1) Cough producing mucus (2) headache (3) irritation of the throat

D) References:

PubMed

Rxlist.com

Mayar Omar almusawa

4355293

3 out of 4
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