CFS

Chronic fatigue syndrome

ALI BAVIYEH 2100476
HESSAN MOLLAZADEH 2018116
SONA CHAHARDAHCHERIK 2101394
MEHRAN MAHINI 2104783
Table of contents
Below topics will cover in this presentation.

Introduction 3-5
History 6-8
Epidemiology 9-12
Etiology 13-16
Clinic 16-20
Diagnosis 20-25
Treatment and Exercise 26-30
conclusion 31-38
References 40
Introduction!

How many people all over the world suffer from Chronic
Fatigue Syndrome?

● 1% to 2.5% of people in

● 0.76% average prevalence

● 80% of patients with CFS are female

 What is CFS ?!
Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis
(ME), is a disorder characterized by extreme fatigue with no underlying
medical condition.
symptom
The hallmark symptom of CFS is persistent and debilitating fatigue that
lasts for at least six months and is not explained by other medical or
psychiatric conditions.
CFS & ME
History
1930s
CFS was first identified as a condition called "myalgic encephalomyelitis" (ME)
1980s
The term "chronic fatigue syndrome" began to be used to describe a
related number of symptoms, and the two terms are now often used
interchangeably
 Epidemiology
CFS affects people of all ages, races, and
socioeconomic backgrounds, but it is more
common in women than in men.
Key points

*120,000,000 m
It is estimated to affect of this the population worldwide

*highest prevalence
found in developed countries and low-income
populations
How CFS affect minority and
low-income populations?

There are several reasons why CFS may disproportionately

affect minority and low-income populations
Three areas

Access to healthcare and diagnostic testing

Environmental factors that can trigger CFS

cultural differences
Etiology
. Some studies have suggested that CFS may be triggered by:
bacterial infections, genetic predisposition, immune
dysfunction, andenvironmental factors such as stress.
For example

_Studies have shown that CFS patients have alterations

in immune function and increased inflammation,
suggesting that immune dysregulation may play a
role in the development of the illness.
_Additionally, CFS patients have been
found to have alterations in brain
function, including abnormalities in the
hypothalamic-pituitary-adrenal (HPA)
axis, which regulates the body's
response to stress.
Clinic
muscle and joint pain
Pain 01

cognitive
memory and concentration
problems difficulties 02

sleep
It can significantly impact a
person's quality of life disturbances 03
muscle and joint pain

alterations in central nervous system function may also contribute to the

development of muscle and joint pain in CFS patients.
memory and concentration problems

CFS is associated with inflammation and immune dysregulation, which can impact the
brain and nervous system
sleep disturbances
alterations in the immune system seen in CFS patients may disrupt the normal sleep-
wake cycle.
Diagnosis
The presence of at least four of the following
symptoms for at least six months:

Impaired memory or Muscle pain and Joint

concentration pain

Sore throat Headaches

Tender lymph nodes Post-exertional malaise

 How to diagnosis

Medical history 01 02 Physical exam

Laboratory tests 03 04 Additional tests

 Note A:

It is important to note that CFS is a

diagnosis of exclusion
 Note B:

Chronic Fatigue Syndrome (CFS) is a complex and

controversial condition characterized by persistent
fatigue that does not improve with rest, and which is
not caused by any underlying medical condition.
Treatment and
Exercise
 Medications
Certain medications may
be prescribed to manage
specific of CFS, such as
pain, sleep disturbances,
or depression.
 Lifestyle changes
Lifestyle changes such as
pacing activities, improving
sleep habits, and managing
stress may be helpful in
managing symptoms of
CFS.
 Cognitive-behavioral therapy (CBT)

CBT is a type of talk

therapy that can be
helpful in managing the
psychological symptoms
of CFS, such as anxiety
or depression.
 Graded exercise therapy (GET)

GET involves gradually

increasing physical activity
levels in a supervised and
structured manner.
conclusion
Treatment and
Epidemiology Clinic Exercise

01 02 03 04 05 06

History Etiology Diagnosis

 History

1930s 1930s
ME CFS
 Epidemiology

^0.76% average prevalence

^120,000,000 m
 Etiology
^bacterial infections
^genetic predisposition
^immune dysfunction
^andenvironmental factors
 Clinic
^muscle and joint pain
^cognitive difficulties
^sleep disturbances
 Diagnosis

^Medical history
^Physical exam
^Laboratory tests
^Additional tests
 Treatment and Exercise

^Medications
^Lifestyle changes
^Cognitive-behavioral therapy (CBT)
^Graded exercise therapy (GET)
 COLLABORATORS

ALI BAVIYEH 2100476

HESSAN MOLLAZADEH 2018116

SONA CHAHARDAHCHERIK 2101394

MEHRAN MAHINI 2104783

 References

-- Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue

Syndrome: Redefining an Illness. Washington, DC: The National Academies
Press; 2015.

Home - Solve ME/CFS Initiative (solvecfs.org)

The ME Association – We Support, Inform, Campaign and Invest in Biomedical

Research

--Friedberg F, Jason LA. Understanding Chronic Fatigue Syndrome: An

Empirical Guide to Assessment and Treatment. Washington, DC: American
Psychological Association; 1998

Home - Solve ME/CFS Initiative (solvecfs.org)