All disease begins

in the gut
-Hippocrates
 Disclaimer: Please Read

The statements made in this guide have not been evaluated by the Food and
Drug Administration and represent the professional opinion(s) of the
authors. The purpose of this guide is not to act as a personal physician to any
reader and is not meant to directly or indirectly diagnose disease, dispense
medical advice, or prescribe the use of any products or services as treatment
for sickness or disease. This information is for educational purposes only. You
should always cooperate with a licensed health professional of your choice
with the goal of creating optimal health. Please consult your physician prior
to implementing any of the strategies mentioned in this guide or starting
any diet or exercise program-especially if you are pregnant or nursing. Any
application or use of the information, resources, or recommendations
contained in this guide is at your own risk.

COPYRIGHT © 2020, 2022 Modern Holistic Health

Modern Holistic Health Roadmap to Understanding and Healing Your Gut

 Why worry about the gut?
Ɣ Responsible for breaking down and absorbing
key nutrients
Ɣ The gut makes the majority of brain's neurotransmitters
Ɣ 70-80% of the immune system is in the gut
Ɣ The gut has more cells than the rest of the human
body combined

Healing the gut is a key component of healing

the rest of the body

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 3

 Functional Medicine Model
- How We Look at the Gut: DIGIN

D Digestion

I Intestinal Permeability

G Gut Microbiome

I Immune Regulation

N Nervous System

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 4

 Digestion
Body breaks down food and absorbs key nutrients
Do you get bloated after eating?
Is there undigested food in your stool?
Does eating fats or carbohydrates cause bloating or gas?

pharynx

oral cavity
parotid tongue
salivary
glands sublingual
submandibular

esophagus

diaphragm
liver
galbladder stomach
pancreas
duodenum pancreatic duct
common bile duct
transverse colon
small intestine
ascending colon descending colon
cecum rectum
appendix anal canal

anus

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 5

 Intestinal Permeability:
“Leaky Gut”
Intestinal
Mucosal Cells
normal tight leaky and
junction inflamed

Blood Circulation Immune Complex

Stream

Blood Brain Inflammation Autoimmunity Malabsorption

Barrier Breach & nutrient deficiency

What causes “leaky gut”?

Ɣ Stress Ɣ Inflammation
Ɣ Poor diet Ɣ Impaired digestion
Ɣ Infection Ɣ Toxins
Ɣ Medications Ɣ Altered microbiome in gut

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 6

 What can leaky gut cause?

Ɣ Chronic Inflammation Ɣ Anxiety

Ɣ Autoimmune Disorders Ɣ Food Intolerances
Ɣ Thyroid disorders Ɣ Adrenal disorders
Ɣ Hormone imbalance

“The cause of a number of diseases is directly associated with

a dysfunctional intestinal barrier”

Symptoms of Leaky Gut

Ɣ Digestive problems- gas, bloating, constipation,

diarrhea
Ɣ Food Intolerances
Ɣ Skin problems- acne, rosacea, eczema
Ɣ Difficulting concentrating/ Brain fog
Ɣ Depression/ Anxiety
Ɣ Autoimmune disease
Ɣ Hormone imbalance- PMS, irregular period

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 7

 Gut Microbiome
Ɣ 100 trillion organisms live in your gut
Ɣ Made up of both “good” and “bad” organisms
Ɣ Roles of gut microbiome
żNutrient Metabolism
żProduction of vitamins and nutrients
żMaintenance of structure of mucosal barrier
żImmune regulation
żProtection against foreign invaders

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 8

 Newest Research on Microbiome
Ɣ West et al found “Changes in microbial composition are
implicated in the increasing propensity for a broad range
of inflammatory diseases, such as allergic disease,
asthma, inflammatory bowel disease (IBD), obesity,
and associated noncommunicable diseases (NCDs).”

Ɣ As published in the Journal of Physiology “ Recent data

have shown that neurogenesis is also regulated by
the microbiome.

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 9

 Good vs Bad
Ɣ A healthy gut has far more good organisms than bad
Ɣ Good organisms keep the bad from growing out of control
and wreaking havoc on your gut and body
Ɣ If the bad organisms take over
  żSkin problems
żCause inflammation
żAllergies
żLeaky gut
Ɣ Bacteria, fungi, parasites

15%
bad bacteria
85%
good bacteria

A healthy bacteria balance means

that the good bacteria overpower the bad bacteria

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 10

 Biofilm
Ɣ Biofilms are protective shields that microbes use to guard
themselves from our immune system
Ɣ A biofilm acts like a glue and create a physical barrier
around colonizing bacteria, fungus, parasites, etc.
Ɣ Biofilms shield the pathogen from our own immune system,
Ɣ They also accelerate the growth of the pathogen throughout
the GI tract while providing an environment for new
pathogens to attach and grow

Irreversible Growth and Attachment of

Absorption BioFilm
Attachment of Division of Other Organisms
of Bacteria Formation
Bacteria Bacteria to BioFilm
(sec) (days-weeks)
(sec-mins) (hrs-days) (week-months)

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 11

 Best Biofilm “Busters”

ƔProteolytic “ace” enzymes Ɣechinacea

Ɣberberine Ɣgoldenseal
Ɣartemisinin Ɣgentian
Ɣcitrus seed extract Ɣgalbanum oil
Ɣblack walnut hulls Ɣoregano oil

SIBO- Small Intestinal

Bacterial Overgrowth

Ɣ Too much bacteria lining the

small intestine
Ɣ Prevents the small intestine from
being able to getting rid of organisms
and properly absorb nutrients
Ɣ Bacteria live off the sugar and starchy
foods you eat
Ɣ Bacteria fermentate in your
small intestine

SIBO:
What happens
when bacteria ends
up in the worng place?

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 12

 SIBO Symptoms
ƔGas and bloating (especially after eating carbs or sugar)
ƔAbdominal pain/ discomfort
ƔDiarrhea
ƔConstipation
ƔVitamin Deficiencies
ƔFood intolerances
ƔFat malabsorption

GOOD BACTERIA BAD BACTERIA

HELPS CONTROL THESE CAUSES THESE

Bloating
Fatigue

Diarrhea
Gas

Abdominal
Pain Skin Issues

Food Nausea/
Intolerances vomiting

Weight Gain

Joint Pain Malnutrition

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 13

 Foods to Avoid with SIBO

ƔProcessed Carbohydrates: Bread, pasta, pastries etc.

ƔStarchy vegetables: Potatoes, squash, yams
ƔProcessed sugar: candy, soda, ice cream,
artificial sweeteners
ƔNatural sugar: Fruits, high glycemic vegetables
ƔFermented foods: pickles, sauerkraut, kimchi
ƔKombucha
ƔKefir

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 14

 Immune Regulation
Ɣ80% of your body’s immune cells are located in the gut
ƔFind any foreign invaders, kills them and creates antibodies
ƔWhen the gut stops working properly autoimmunity and food
sensitivities can occur

Toxins Microorganisms Yeast

Tight Junctions Leaky

and Inflamed

Blood
Stream

,PPXQH5HVSRQVHƔ5HDFWLRQƔ%DQG7&HOOV5HOHDVH

Nutrient Food Gut-Brain Axis Systematic

Autoimmunity
Malabsorption Intolerances Compromised Inflammation

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 15

 Gut-Brain Connection
ƔHave you ever felt butterflies in your stomach when
you’re nervous?
ƔYour brain talks to the gut and your gut talks to the brain
ƔThe good bacteria in your gut produce chemicals that
control mood, appetite, memory
ƔA troubled gut sends signals to the brain AND and a troubled
brain sends signals to the gut
ƔLeaky gut causes a leaky brain

Gut-brain axis

GBA

The ability of the brain to The ability of the

influence the intestinal microbiota to influence
microbiota brain and behavior

Microbiota-
gut interplay

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 16

 What can YOU do to
fix your gut?

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 17

 Foods to Avoid

ƔProcessed Foods
ƔSugar
ƔSoy products
ƔTrigger foods- gluten, dairy, nightshades, alcohol, eggs
ƔGMO fruits and vegetables
ƔConventionally raised meats
ƔChlorinated water or water with fluoride

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 18

 Foods to Help Heal Gut

ƔLeafy greens (3 cups per day)

ƔLow glycemic vegetables - broccoli, cauliflower, squash,
zucchini, brussel sprouts
ƔBone Broth
ƔFermented Foods (Kimchi, Sauerkraut)
ƔRaw Kombucha
ƔHealthy fats (fish, nuts, avocado)
ƔRaw garlic
ƔHigh fiber foods (apples, raspberries, Jerusalem artichokes)

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 19

 4 R’s of Gut Repair

Remove - (3-4 months) Replenish

ƔTrigger foods ƔProbiotics
Ɣ“Critters” ƔDiverse Diet
ƔBiofilm

Replace Repair
ƔSupplementation ƔBarrier Systems
Support

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 20

 Gut Repair & Replenish Protocol

OR

● Complete GI Activation OR GI Activation - S: 1 scoop in water

the AM in water/empty stomach
● Enzyme Complete: 1-2 before/with each meal
● Spore based probiotic of your choice: 1-2 each day at night

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 21

 Complete GI Activation
Complete GI Activation offers comprehensive support for
optimum gastrointestinal health and function. The lining of the
gut must have proper permeability and integrity not only so it can
absorb nutrients, but also to prevent toxins, allergens, and
microbes from gaining access to the bloodstream. Maintaining
gut health is the key to maintaining overall wellness.

The powder version of Complete GI Activation which is

sweetened with stevia leaf extract powder, can be mixed into
any beverage or functional food powder, and it can be used to
help support optimal gastrointestinal health and regularity.
*https://bioonesciences.com/products/complete-gi-activation

Complete GI Activation - S (Glutamine Free)

Complete GI Activation-S is a targeted immune support formula.
This bovine colostrum formula is fortified with a specially
extracted colostrum polypeptide (PRP) concentrate to yield
maximum results.

Numerous scientific studies have shown that colostrum supports

the human immune and cytokine systems. Bovine colostrum is
richer in immune factors than human colostrum and is
biologically transferable to humans.

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 22

 This formula features Immunoglobulins, PRPs, protein, immune
factors, growth factors, vitamins, and minerals to support health
and vitality.

It is laboratory tested to assure it is antibiotic-free. This formula

is carefully processed to provide the highest quality and efficacy.
*https://bioonesciences.com/products/complete-gi-activation-s

Enzyme Complete
Enzyme Complete provides a superior blend of natural plant
enzymes active in a broad pH range to aid in food digestion.

Protease breaks down protein, amylase breaks down starch,

lipase breaks down fat, cellulase breaks down fiber and lactase
breaks down lactose (milk sugar).

Papain and bromelain are primarily protein digesting enzymes.

Taken with meals, this formula helps replace naturally occurring
enzymes that are destroyed in highly processed and cooked
foods.
*https://bioonesciences.com/products/enzyme-complete

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 23

 Additional Resources

Featured podcasts from TribeTalk

by Modern Holistic Health

How Probiotics Can Heal Your Gut with Tina Anderson

Probiotics are one of the best ways to improve your gut health -- but how
do you know your probiotic is actually working? In this episode of TribeTalk,
Dr. V and Ann talking with Tina Anderson, a former in-house counsel for a
major pharmaceutical company turned health and wellness advocate. Tina
created her own line of probiotics after her frustration with the abuses in
the pharmaceutical industry.

*** Use code “Modern” for a 15% discount on any Just Thrive product
(one-time use) ***

https://podcast.modernholistichealth.com/e/80-with-tina-anderson/

What is Leaky Gut & How Does If Affect Me?

You may have heard of "Leaky Gut", but do you really know what it is, and
how it can affect you? Learn that "Leaky Gut" is more than just having a
general "gut issue", but how it can impact your entire biological ecosystem.

https://podcast.modernholistichealth.com/e/what-is-leaky-gut-how-does-it-affect-me/

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 24

 Featured blog articles by Modern Holistic Health

For some time, a standard practice and way of thinking has been to live a
germ-free, antibacterial life. This mindset is based on the premise that “all
germs are bad.” It could be said that American culture is afraid of germs. In
fact, many individuals reach for antibiotics at a doctor’s slightest suggestion
they might be the best remedy. From Lysol to Listerine, attacking the “bad”
has been the modus operandi rather than thinking about a lifestyle that
aims to support the “good stuff.”

Read the full article - https://www.modernholistichealth.com/healthy-microbiome-tips/

Mounting evidence shows a direct link between gut and brain function. The
New York Times shared, “it has long been known that much of our supply
of neurochemicals — an estimated 50 percent of the dopamine, for
example, and a vast majority of the serotonin — originate in the intestine,
where these chemical signals regulate appetite, feelings of fullness and
digestion. But only in recent years has mainstream psychiatric research
given serious consideration to the role microbes might play in creating
those chemicals.”

Read the full article -

https://www.modernholistichealth.com/gut-bacteria-and-mental-health/

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 25

 Stomach ulcers or gastric ulcers are the most common type of ulcers that
develop in the linings of the stomach. They affect about 2.4-6.1% of the
population. They are a form of peptic ulcer disease that can make life
painfully uncomfortable.

People of all ages, irrespective of gender, can suffer from peptic ulcers. In
fact, It is estimated that over 25 million Americans have suffered from a
form of peptic ulcer at some point in their life.

Our goal with this article is to make you aware of the various causes of
stomach ulcers, and how you can adopt natural solutions to relieve
yourself of its undesirable symptoms.

Read the full article -

https://www.modernholistichealth.com/best-natural-solutions-for-stomach-ulcers/

Modern Holistic Health | Roadmap to Understanding and Healing Your Gut 26

 References

Ɣhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983973/
Ɣhttps://drhyman.com/blog/2010/09/27/5-steps-to-kill-hidden
bad-bugs-in-your-gut-that-make-you-sick/
Ɣhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303825/
Ɣhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316216/
Ɣhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528021/
ƔM. E. V. Johansson, M. Phillipson, J. Petersson, A. Velcich, L. Holm, and
G. C. Hansson, “The inner of the two Muc2 mucin-dependent mucus layers
in colon is devoid of bacteria,” Proc. Natl. Acad. Sci., vol. 105, no. 39,
pp. 15064–15069, Sep. 2008.
ƔH. Spits and J. P. Di Santo, “The expanding family of innate lymphoid
cells: regulators and effectors of immunity and tissue remodeling,”
Nat. Immunol., vol. 12, no. 1, pp. 21–27, Jan. 2011.
Ɣhttps://www.hopkinsmedicine.org/research/advancements-in-research/
funda mentals/in-depth/the-gut-where-bacteria-and-immune-system-meet
Ɣhttps://medium.com/@drbradysalcido/how-your-gut-influences-your-
brain-84 1173517673
Ɣhttps://www.mindbodygreen.com/articles/the-best-and-worst-foods-for-
gut-h ealth

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