ASSOCIATIONS BETWEEN COVID-19 VACCINATION STATUS WITH POSITIVITY AND CYCLE THRESHOLD VALUE

Juslan Kasmar,Sudirman Katu,Risna Halim,Ariyantin Ulfa

Tropical medicine and infectious disease division,
Internal medicine depa emen, Hasanuddin University,Makassar-Sulawesi Selatan
Introduction Table 1. Baseline characteristics of sample (n =147) Mean Ct Value with vaccination status
Vaccination improves immunity and prevents progressivity of Variable Mean ± SD n (%)
clinical symptoms and mo ality caused by SARS-COV-2 Age (years) 47,73±15,06  
infection. Real-time PCR is considered the gold standard CT Value 26,8 ± 5,92
con rmato test for coronavirus disease 2019. Cycle threshold Gender    
values are being utilized to diagnose or predict SARS-CoV-2 Female   47(40,5)
infection and can be correlated with the viral load. Understanding Male   69(59,5)
Age Group    
the interpretation of cycle threshold values could play a crucial < 30 years   18(15,5)
role in interpreting viral load and disease severity. 30-60 years   72(62,1)
  > 60 years     26(22,4)
Objectives Vaccination status     Discussion
unvaccinated   91(78,4) Unvaccinated patients have a higher risk of COVID-19 infection
To determine associations between COVID-19 vaccination status full dose of   25(21,6) and lower CT value compared to them who had full dose of
with positivity and cycle threshold value. vaccination
Table 2. Associations between mean CT-Value with vaccination. So we can concluded that there is an associations
Methodology vaccination status between vaccination status of COVID-19 with positivity and cycle
threshold value.
We obtaining data from COVID-19 patients medical record in Variabel Unvaccinate Full dose of P value* References
Wahidin Sudirohusodo Hospital during August - September 2021. d(n=91) vaccination
Analysis of data using chi square and Mantel-Haenszel with P (n=25) Pritchard, E., Matthews, P. C., Stoesser, N,et al. (2021). Impact of
value of < 0.05 is signi cantly related. Vaccination status divided CT-Value 25,52±5,46 31,5±5,17 0,000
1.
vaccination on new SARS-CoV-2 infections in the United Kingdom. Nature
into unvaccinated and full dose of vaccination,cycle threshold Medicine, 27(8), 1370–1378.
value are from PCR test .        
Results *Independent Test    
In this table the mean CT Value in the group that has been
2. Antonelli, M., Penfold, R. S., Merino, J,et al. (2021). Risk factors and disease
pro le of post-vaccination SARS-CoV-2 infection in UK users of the
COVID Symptom Study app: a prospective, community-based, nested,
During the study period,we obtained 116 patients were con rmed vaccinated with full dose has a much higher CT-Value than case-control study. The Lancet Infectious Diseases
COVID 19. Consist of 91 patients (78.4%) unvaccinated and 25 those who have not been vaccinated, with a signi cance of Cabezas C, Coma E, Mora N,et al. (2021). Associations of BNT162b2
patients (17%) had full dose of vaccination. Associations p= 0.000, where p<0.05
3.
vaccination with SARS-CoV-2 infection and hospital admission and death
between mean CT-Value and unvaccinated status are 25.52±5.46 with covid-19 in nursing homes and healthcare workers in Catalonia:
prospective coho study.BMJ.
and CT-value with full dose of vaccination are 31.5±6.27, with OR : Rabaan, A. A., Tirupathi, R., Sule, A.et al (2021). Viral Dynamics and Real-
10,43 and p= 0.000. 4.
Time RT-PCR Ct Values Correlation with Disease Severity in COVID-19.
Diagnostics, 11(6), 1091.
Ade, C., Pum, J., Abele, I.et al (2021). Analysis of cycle threshold values in
5.
SARS-CoV-2-PCR in a long-term study. Journal of Clinical Virology, 138,