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    Perhitungan Kadar Curcuminoid

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    qccendo nonsteril
    The document describes analyzing the curcuminoid content in Lupo Curc capsules using the USP method. Three samples were tested in triplicate. The average curcuminoid content of the samples was 100.313-100.938% of the labeled amount of 250mg per capsule, indicating the product meets specifications. The method involves HPLC to separate and quantify curcumin, demethoxycurcumin, and bisdemethoxycurcumin, which are then summed to give the total curcuminoid content. The results demonstrate the product contains equivalent or slightly more than the labeled amount of curcuminoids.

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    Perhitungan Kadar Curcuminoid

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    qccendo nonsteril
    7 views8 pages
    The document describes analyzing the curcuminoid content in Lupo Curc capsules using the USP method. Three samples were tested in triplicate. The average curcuminoid content of the samples was 100.313-100.938% of the labeled amount of 250mg per capsule, indicating the product meets specifications. The method involves HPLC to separate and quantify curcumin, demethoxycurcumin, and bisdemethoxycurcumin, which are then summed to give the total curcuminoid content. The results demonstrate the product contains equivalent or slightly more than the labeled amount of curcuminoids.

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    Perhitungan Kadar Curcuminoid (1)

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    The document describes analyzing the curcuminoid content in Lupo Curc capsules using the USP method. Three samples were tested in triplicate. The average curcuminoid content of the samples was 100.313-100.938% of the labeled amount of 250mg per capsule, indicating the product meets specifications. The method involves HPLC to separate and quantify curcumin, demethoxycurcumin, and bisdemethoxycurcumin, which are then summed to give the total curcuminoid content. The results demonstrate the product contains equivalent or slightly more than the labeled amount of curcuminoids.

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    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
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    7 views8 pages

    Perhitungan Kadar Curcuminoid

    Uploaded by

    qccendo nonsteril
    The document describes analyzing the curcuminoid content in Lupo Curc capsules using the USP method. Three samples were tested in triplicate. The average curcuminoid content of the samples was 100.313-100.938% of the labeled amount of 250mg per capsule, indicating the product meets specifications. The method involves HPLC to separate and quantify curcumin, demethoxycurcumin, and bisdemethoxycurcumin, which are then summed to give the total curcuminoid content. The results demonstrate the product contains equivalent or slightly more than the labeled amount of curcuminoids.

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    PERHITUGNAN KADAR CUCRUMINOID KAPSUL METODE USP GUID-C036F962-7999-4C07-96B5-D179A3BB3C

    6F962-7999-4C07-96B5-D179A3BB3C7C_2_en-US

    Diketahui:
    Kapsul Lupo Curc (data 5 Oktober
    2022)
    terkandung:
    250 mg Cucuminoid dalam 450 mg
    SPL (per kapsul)
    V
    Jumlah Curcuminoid (mg) Larutan Stok (mL)
    STD 50 mg 31 50
    rata2 %Area 5x injeksi
    Curcumin 96.308% 29.85548
    Desmethoxycurcumin 2.952% 0.91512
    Bisdesmethoxycurcumin 0.738% 0.22878
    Total 100.00% 31.00

    Area STD: Area Sampel:


    Curcumin 4600347.57 Curcumin
    desmethoxycurcumin 141110.85 desmethoxycurcumin
    Bisdesmethoxycurcumin 35232.94 Bisdesmethoxycurcumin

    Cs mg/mL W (bobot sampel)


    Curcumin 0.02388 Wf (rata2 bobot isi kapsul)
    Desmethoxycurcumin 0.00073 Wu (bobot isi kapsul yang diam
    Bisdesmethoxycurcumin 0.00018

    kandungan (mg)
    Q1 (Curcumin) 247.43427334
    Q2 (Desmethoxycurcumin) 7.4141649334
    Q3 (Bisdesmethoxycurcumin) 1.8360906584
    Total Q 256.68452894

    Kadar Total Curcuminoid


    %Total Curcuminoid = (total
    curcuminoid/jumlah curcuminoid
    sesuai label per kapsul) 102.674
    D
    Pengenceran (mL)
    25

    4719290.75
    141512.53
    35000.58

    mg
    450.8
    55.8
    PERHITUGNAN KADAR CUCRUMINOID KAPSUL METODE USP GUID-C036F962-7999-4C07-96B5-D179A3BB3C
    6F962-7999-4C07-96B5-D179A3BB3C7C_2_en-US

    Diketahui:
    Kapsul Lupo Curc (data 5 Oktober
    2022)
    terkandung:
    250 mg Cucuminoid dalam 450 mg
    SPL (per kapsul)
    V
    Jumlah Curcuminoid (mg) Larutan Stok (mL)
    STD 50 mg 31 50
    rata2 %Area 7x injeksi
    Curcumin 96.201% 29.82231
    Desmethoxycurcumin 3.029% 0.93899
    Bisdesmethoxycurcumin 0.770% 0.2387
    Total 100.000% 31.00

    Area STD: Area Sampel Antara Atas


    Curcumin 10946882.76 Curcumin
    desmethoxycurcumin 344675.29 desmethoxycurcumin
    Bisdesmethoxycurcumin 87619.67 Bisdesmethoxycurcumin

    Cs mg/mL W (bobot sampel)


    Curcumin 0.02386 Wf (rata2 bobot isi kapsul)
    Desmethoxycurcumin 0.00075 Wu (bobot isi kapsul yang diam
    Bisdesmethoxycurcumin 0.00019

    Q1 (Curcumin)
    Q2 (Desmethoxycurcumin)
    Q3 (Bisdesmethoxycurcumin)
    Total Q

    Kadar Total Curcuminoid


    %Total Curcuminoid = (total
    curcuminoid/jumlah
    curcuminoid sesuai label per
    kapsul)
    D
    Pengenceran (mL)
    25

    Area Sampel Antara Tengah


    10997880.23 Curcumin 10997283.12
    141512.53 desmethoxycurcumin 141512.53
    35000.58 Bisdesmethoxycurcumin 35000.58

    mg W (bobot sampel) mg
    450 Wf (rata2 bobot isi kapsul) 450
    55.8 Wu (bobot isi kapsul yang diamb 55.8

    kandungan (mg) kandungan (mg)


    241.62291202 Q1 (Curcumin) 1.004604083291
    3.10902363645 Q2 (Desmethoxycurcumin) 0
    0.76896109842 Q3 (Bisdesmethoxycurcumin) 0
    245.500896755 Total Q 1.004604083291

    Kadar Total Curcuminoid


    %Total Curcuminoid = (total
    curcuminoid/jumlah
    curcuminoid sesuai label per
    98.200 kapsul) 0.402
    Area Sampel Antara Bawah
    Curcumin 10897282.22
    desmethoxycurcumin 141512.53
    Bisdesmethoxycurcumin 35000.58

    W (bobot sampel) mg
    Wf (rata2 bobot isi kapsul) 450
    Wu (bobot isi kapsul yang diam 55.8

    kandungan (mg)
    Q1 (Curcumin) 0
    Q2 (Desmethoxycurcumin) 0
    Q3 (Bisdesmethoxycurcumin) 0
    Total Q 0

    Kadar Total Curcuminoid


    %Total Curcuminoid = (total
    curcuminoid/jumlah
    curcuminoid sesuai label per
    kapsul) 0.000
    642 645 643
    100.313 100.781 100.469

    645 644 640


    100.781 100.625 100.000

    642 644 641 640 639 641 642 641


    100.313 100.625 100.156 100.000 99.844 100.156 100.313 100.156

    645 645 646 644 644 646 643 642


    100.781 100.781 100.938 100.625 100.625 100.938 100.469 100.313

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