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  • BFK Hitung Kel.3 Edit

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    LINDA YULIANTI
    17 views6 pages
    The document contains calculations to determine the dissolution rate of a drug over 30 minutes. It measures the absorbance at various time points and uses that to calculate the drug concentration released. It then uses this to determine the dissolution rate in mg/min/cm^2, the area under the curve, and ultimately the dissolution efficiency which is 339.958.17%.

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    The document contains calculations to determine the dissolution rate of a drug over 30 minutes. It measures the absorbance at various time points and uses that to calculate the drug concentration released. It then uses this to determine the dissolution rate in mg/min/cm^2, the area under the curve, and ultimately the dissolution efficiency which is 339.958.17%.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    17 views6 pages

    BFK Hitung Kel.3 Edit

    Uploaded by

    LINDA YULIANTI
    The document contains calculations to determine the dissolution rate of a drug over 30 minutes. It measures the absorbance at various time points and uses that to calculate the drug concentration released. It then uses this to determine the dissolution rate in mg/min/cm^2, the area under the curve, and ultimately the dissolution efficiency which is 339.958.17%.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 6

     Perhitungan

    - 1 menit : 0,268
    Abs : 0,268
    Y = 0,073x - 0,042
    0,268 = 0,073x - 0,042
    0,31 = 0,073x
    X = 4,247 µg/ml x FP
    X = 4,247 µg/ml x 100 = 424,7 µg/ml
    X = 424,7 µg/ml : 1000 = 0,425 mg/ml
    X = 0,425 mg/ml x 900 = 382,5 mg

    - 5 menit : 0,722
    Abs : 0,722
    Y = 0,073x - 0,042
    0,722 = 0,073x - 0,042
    0,764 = 0,073x
    X = 10,466 µg/ml x FP
    X = 10,466 µg/ml x 100 = 1.046,6 µg/ml
    X = 1.046,6 µg/ml : 1000 = 1,047 mg/ml
    X = 1,047 mg/ml x 900 = 942,3 mg

    - 10 menit : 0,283
    Abs : 0,283
    Y = 0,073x - 0,042
    0,283 = 0,073x - 0,042
    0,325 = 0,073x
    X = 4,452 µg/ml x FP
    X = 4,452 µg/ml x 105 = 467,46 µg/ml
    X = 467,46 µg/ml : 1000 = 0,468 mg/ml
    X = 0,468 mg/ml x 900 = 421,2 mg
    - 15 menit : 0,267
    Abs : 0,267
    Y = 0,073x - 0,042
    0,267 = 0,073x - 0,042
    0,309 = 0,073x
    X = 4,233 µg/ml x FP
    X = 4,233 µg/ml x 105 = 444,47 µg/ml
    X = 444,47 µg/ml : 1000 = 0,445 mg/ml
    X = 0,445 mg/ml x 900 = 400,5 mg

    - 20 menit : 0,614
    Abs : 0,614
    Y = 0,073x - 0,042
    0,614 = 0,073x - 0,042
    0,656 = 0,073x
    X = 8,986 µg/ml x FP
    X = 8,986 µg/ml x 105 = 943,53 µg/ml
    X = 943,53 µg/ml : 1000 = 0,944 mg/ml
    X = 0,944 mg/ml x 900 = 849,6 mg

    - 25 menit : 0,478
    Abs : 0,478
    Y = 0,073x - 0,042
    0,478 = 0,073x - 0,042
    0,52 = 0,073x
    X = 7,123 µg/ml x FP
    X = 7,123 µg/ml x 105 = 747,92 µg/ml
    X = 747,92 µg/ml : 1000 = 0,748 mg/ml
    X = 0,748 mg/ml x 900 = 673,2 mg
    - 30 menit : 0,614
    Abs : 0,614
    Y = 0,073x - 0,042
    0,614 = 0,073x - 0,042
    0,656 = 0,073x
    X = 8,986 µg/ml x FP
    X = 8,986 µg/ml x 105 = 943,53 µg/ml
    X = 943,53 µg/ml : 1000 = 0,944 mg/ml
    X = 0,944 mg/ml x 900 = 849,6 mg

    Menit 1
     Mg/men.cm2 = kadar terkoreksi
    Menit x luas obat
    = 382,5
    1 menit x 1,33 cm2
    = 382,5
    1,33
    = 287,59
     AUC = (kadar terkoreksi x 0 menit) + (kadar terkoreksi x 1 menit)
    2
    = (0) + (382,5 x 1)
    2
    = 191,25

    Menit 5
     Mg/men.cm2 = kadar terkoreksi
    Menit x luas obat
    = 944,43
    5 menit x 1,33 cm2
    = 944,43
    6,65
    = 140,02
     AUC = (kadar terkoreksi x 1 menit) + (kadar terkoreksi x 5 menit)
    2
    = (382,5 x 1) + (944,43 x 5)
    2
    = 2.552,33
     Menit 10
     Mg/men.cm2 = kadar terkoreksi
    Menit x luas obat
    = 426,45
    10 menit x 1,33 cm2
    = 426,45
    13,3
    = 32,06
     AUC = (kadar terkoreksi x 5 menit) + (kadar terkoreksi x 10 menit)
    2
    = (944,43 x 5) + (426,45 x 10)
    2
    = 4.493,33

    Menit 15
     Mg/men.cm2 = kadar terkoreksi
    Menit x luas obat
    = 402,87
    15 menit x 1,33 cm2
    = 402,87
    19,95
    = 20,19
     AUC = (kadar terkoreksi x 10 menit) + (kadar terkoreksi x 15 menit)
    2
    = (426,45 x 10) + (402,87 x 15)
    2
    = 5.153,78

    Menit 20
     Mg/men.cm2 = kadar terkoreksi
    Menit x luas obat
    = 851,84
    20 menit x 1,33 cm2
    = 851,84
    26,6
    = 32,02
     AUC = (kadar terkoreksi x 15 menit)+(kadar terkoreksi x 20 menit)

    2
    = (402,87 x 15) + (851,84 x 20)
    2
    = 11.539,93
    Menit 25
     Mg/men.cm2 = kadar terkoreksi
    Menit x luas obat
    = 677,93
    25 menit x 1,33 cm2
    = 677,93
    33,25
    = 20,39
     AUC = (kadar terkoreksi x 20 menit) + (kadar terkoreksi x 25 menit)
    2
    = (851,84x20) + (677,93 x 25)
    2

    = 16.992,53

    Menit 30
     Mg/men.cm2 = kadar terkoreksi
    Menit x luas obat
    = 853,37
    30 menit x 1,33 cm2
    = 853,37
    39,9
    = 21,39
     AUC = (kadar terkoreksi x 25 menit) + (kadar terkoreksi x 30 menit)
    2
    = (677,93x25) + (853,37x30)
    2
    = 21.274,68

    Menit Abs FP Kadar obat Kadar obat SD FK Kadar Kecepatan disolusi AUC
    terdisolusi terdisolusi obat
    mg/ml mg terkoreksi mg/menit
    mg/menit
    .cm

    1 0,268 100x 0,425 382,5 382,5 0 382,5 382,500 287,59 191,25


    5 0,722 100x 1,047 942,3 942,3 2,13 944,43 188,886 140,02 2.552,33
    10 0,283 105x 0,468 421,2 421,2 5,25 426,45 42,645 32,06 4.493,33
    15 0,267 105x 0,445 400,5 400,5 2,37 402,87 26,858 20,19 5.153,78
    20 0,614 105x 0,944 849,6 849,6 2,24 851,84 42,592 32,02 11.539,93
    25 0,478 105x 0,748 673,2 673,2 4,73 677,93 27,117 20,39 16.992,53
    30 0,614 105x 0,944 849,6 849,6 3,77 853,37 28,446 21,39 21.274,68

    AUC total = 191,25 + 2.552,33 + 4.493,33+ 5.153,78 + 11.539,93 + 16.992,53 + 21.274,68


    = 57.704,5
    Efisiensi disolusi ( DE )
    DE = AUC total x 100%
    Bobot tablet x waktu sampling
    = 57.704,5 x 100%
    0,5658 x 30
    = 3.399,58 x 100%
    = 339.958,17%

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