Glimpse of Ayurveda herbs as antitubercular agent/ hepatoprotective role in ATT

S.No Title of the Drug details Outcomes References

. study
KATUKI

1. Picrorhiza In a randomised, Significant reduction (p

Vaidya AB,
kurroa (Kutaki) double-blind < 0.05) in liver lipid
Antarkar DS,
Royle ex Benth placebo controlled content, Bi, GOT andDoshi JC, Bhatt
as a trial in patients GPT was recorded. The
AD, Ramesh V,
hepatoprotective diagnosed to have time in days required
Vora PV, Perissond
agent-- acute viral hepatitis for total serum bilirubin
D, Baxi AJ, Kale
experimental & (HBsAg negative), to drop to average value
PM.
clinical studies. Kutaki root powder was also highly Picrorhizakurroa
375 mg three times significant. (Kutaki) Royle ex
a day was given for Benth as a
2 weeks (n = 15) or hepatoprotective
a matching placebo agent--
(n = 18) was given. experimental &
clinical studies. J
Postgrad Med.
1996;42(4):105-8.
PMID: 9715310.
2. Antihepatotoxic Antihepatotoxic Co-administration of Jeyakumar, Ravethi
effect of effect of the Picrorhiza kurroa & Rajesh, R &
Picrorhiza ethanol extract of (Kutaki) (50 mg/kg/day Meena, Brijvasi &
kurroa on Picrorhiza kurroa for 45 days) Rajaprabhu, D &
mitochondrial rhizomes and roots significantly prevented Ganesan,
defense system (PK) on liver these antitubercular Balaraman &
in antitubercular mitochondrial drugs-induced Buddhan, S & R,
drugs (isoniazid antioxidant defense alterations and Anandan.
and rifampicin)- system in maintained the rats at Antihepatotoxic
induced antitubercular near normal status. effect of Picrorhiza
hepatitis in rats drugs (isoniazid kurroa on
and rifampicin)- mitochondrial
induced hepatitis in defense system in
rats has been antitubercular
investigated. drugs (isoniazid
and rifampicin)-
induced hepatitis in
 rats. Journal of
Medicinal Plants
Research. 2008; 2:
17-19.
BHRINGARAJ

3. Hepatoprotectiv Eclipta Alba Methanolic extract of P.

e of Eclipta Methanolic Extract E.alba significantly Shanmugapandivan
Alba improved the INH-RIF et al /
Methanolic induced Hepatoprotective
Extract in hepatotoxicity by of Eclipta Alba
Isoniazid and regulating the hepatic Methanolic Extract
Rifampicin marker in Isoniazid and
Proved enzymes, inhibition of Rifampicin Proved
Oxidative lipid peroxidation, Oxidative Hepatic
Hepatic Injury. improving the status of Injury.International
antioxidants. Journal of
Pharmacy Research
& Technology.
2020; 10 (2): 74-79
4. In-vitro MABA Ethanolic and The result of the in- RamaiahMaddi,
anti-tuberculosis aqueous extracts vitro anti-tubercular Devilal K, Satish
assay of Eclipta were prepared for activity of the crude Babu, Harika P. In-
Alba (L.) Hassk evaluation of anti-
extracts at vitro MABA anti-
whole plant tubercular activity
concentrations of 1 tuberculosis assay
against mg/mL, 25 mg/mL, of Eclipta Alba (L.)
Mycobacterium 50mg/mL and Hassk whole plant.
tuberculosis. 100mg/mL revealed Pharma Innovation
that both the extracts 2017;6(5):103-105.
(aqueous and ethanolic)
inhibited the growth of
the bacterium at MIC of
1 mg/ml.
DRONPUSHPI

5. Ameliorative Alcoholic extracts Alcoholic extracts of L. Bhini Bais, Payal

effect of Leucas were prepared for cephalotes possesses Saiju,
cephalotes evaluation of anti- significant Ameliorative effect
extract on tubercular activity hepatoprotective of Leucas
isoniazid and against potential against cephalotes extract
 rifampicin Mycobacterium isoniazid and rifampicin on isoniazid and
induced tuberculosis. induced heptoxicity. rifampicin induced
hepatotoxicity hepatotoxicity,
Asian Pacific
Journal of Tropical
Biomedicine,2014;
4 (2):S633-S638
6. Hepatoprotectiv Hydro alcoholic The drug possesses Sofi G, Khan MY,
e activity of (1:1) extract of significant degree of Jafri MA.
Gumma (Leucas Gumma (583mg/kg hepatoprotective effect Hepatoprotective
cephalotes orally) was used to against carbon activity of Gumma
Spreng.) against screen the extent of tetrachloride induced (Leucas cephalotes
Carbon hepatoprotection in hepatotoxicity and if Spreng.) against
tetrachloride the rats subjected Gumma extract used as Carbon
induced to hepatotoxicity. a prophylactic measure tetrachloride
hepatotoxicity will serve as better induced
in wistar rats hepatoprotective agent hepatotoxicity in
and ameliorate various wistar rats. Anc Sci
liver diseases Life.
particularly of acute 2011;31(2):44-48.
nature. The drug
probably produced
effect by inhibition of
oxidative stress,
because
carbontetrachloride
causes hepatic damage
via oxidative
degeneration.

GUDUCHI
7. Tinospora Crude extract of T. Crude extract of T. Mukeshwar Pandey
cordifolia: a cordifolia cordifolia showed Int J Pharm Bio Sci
climbing shrub protective effect 2012 Oct; 3(4): (P)
In health care on drug induced liver 612 - 628
management injury and
immunosuppression by
isoniazid, rifampicin
and pyrazinamide.
Aerial root extract has
 protective action
against liver injury
induced
by the above-mentioned
anti-tubercular drugs
and it prevents
immunosuppression. It
is
suggested that
consumption of
hepatoprotective herbs
like TC with the above
said drugs could
minimize the liver
toxicity
8. Tinospora Ether extract of T. Ether extract of the Mukeshwar Pandey
cordifolia: a cordifolia stem distillate of aerial Int J Pharm Bio Sci
climbing shrub part of T. cordifolia has 2012 Oct; 3(4): (P)
In health care inhibited the in vitro 612 - 628
management growth of
Mycobacterium
tuberculosis at 1:50,000
dilutions. Its ethanolic
extract has exhibited
significant antipyretic
activity in experimental
rats.