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  • ERA Patient Brochure JP

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    Noe Jati
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    The document discusses the window of implantation and the ERA test. It notes that the endometrium has an optimal time period for embryo implantation called the window of implantation. When embryo transfer occurs outside this window, even with healthy embryos, implantation failure can result. The ERA test identifies each individual patient's unique window of implantation length and timing through an endometrial biopsy to analyze gene expression patterns. Adjusting the embryo transfer according to the patient's window as identified by the ERA test can improve pregnancy rates by around 25%.

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    The document discusses the window of implantation and the ERA test. It notes that the endometrium has an optimal time period for embryo implantation called the window of implantation. When embryo transfer occurs outside this window, even with healthy embryos, implantation failure can result. The ERA test identifies each individual patient's unique window of implantation length and timing through an endometrial biopsy to analyze gene expression patterns. Adjusting the embryo transfer according to the patient's window as identified by the ERA test can improve pregnancy rates by around 25%.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    11 views2 pages

    ERA Patient Brochure JP

    Uploaded by

    Noe Jati
    The document discusses the window of implantation and the ERA test. It notes that the endometrium has an optimal time period for embryo implantation called the window of implantation. When embryo transfer occurs outside this window, even with healthy embryos, implantation failure can result. The ERA test identifies each individual patient's unique window of implantation length and timing through an endometrial biopsy to analyze gene expression patterns. Adjusting the embryo transfer according to the patient's window as identified by the ERA test can improve pregnancy rates by around 25%.

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    © All Rights Reserved
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    of 2

    For patients who suffer from repeated implantation failure

    and recurrent miscarriage The relationship between infertility


    and the window of implantation

    The endometrium has an optimal time for the implantation of the embryo: the
    window of implantation. When the embryo transfer is done outside of this
    window, implantation failure can occur, even in the case of healthy embryos.

    What kind of test is the ERA test?


    The window of implantation can vary in length and timing from individual to
    individual; for example, some patients may present a window that is shorter Window of
    than usual, while others can have their windows starting earlier during the Implantation
    menstrual cycle.
    By undergoing the ERA test, you can find out the length and timing of your
    own window of implantation. Approximately 50% of women who do the ERA
    test adjust their embryo transfers according to their individual windows.

    Benefits of the ERA test How to perform the ERA test?


    • Identification of the individual window of A small amount of endometrial tissue is collected at
    implantation of each patient in order to the time when the doctor intends to do the embryo
    establish an optimal embryo transfer time transfer. Based on the gene expression pattern of
    • Improvement of the pregnancy rate by the collected tissue sample, ERA identifies when the
    approximately 25%*, per embryo transfer
    endometrium of the patient will be in a receptive
    • Analysis of the endometrial gene expression
    state for the embryo.
    pattern with cutting-edge technology
    ＊ 2016 ASRM Distinguished Researcher Award

    Timing of the embryo transfer Time when the doctor would


    normally transfer the embryo

    Estrogen administration Progesterone


    administration
    Period starts

    HRT
    Natural cycle
    hCG administration

    The window of implantation can vary from patient to patient. Endometrial biopsy collection
    Your window can be:

    Early

    Standard

    Late

    Short
    ERA test results
    You can find out if the genetic expression of your endometrium indicates a standard or a displaced window of implantation at
    the time of the biopsy. Even if your window of implantation falls under the standard timing and length, the ERA test will further
    identify the exact time for embryo transfer, meaning it will inform you of the exact hour when your doctor should perform the
    transfer, so it has increased chances of success. Through ERA, the embryo transfer can be performed at the optimal time after
    adjusting the transfer time or the start date of progesterone intake according to the time recommended in the test results.

    The six possible ERA results and their embryo transfer timelines
    *transfer timelines that are different from the ones listed below may also be possible, please consult your doctor for more details.

    Pre-Receptive Receptive Post-Receptive

    ① 2 days ② 1 day ④ ⑥ 1 day, 2 days

    ③ Early Receptive ⑤ Late Receptive

    ① Pre-Receptive 2 days ・・・Retesting is recommended


    Your biopsy

    ② Pre-Receptive 1 day ・・・Embryo transfer done 24 hours after the biopsy time is recommended
    Your biopsy 24 hours after

    ③ Early-Receptive ・・・ Embryo transfer done 12 hours after the biopsy time is recommended
    Your biopsy 12 hours after

    ④ Receptive
    Your biopsy

    ⑤ Late Receptive ・・・ Embryo transfer done 12 hours before the biopsy time is recommended
    12 hours before Your biopsy

    ⑥ Post-Receptive ・・・ Retesting is recommended


    Your biopsy

    Igenomix Japan K.K. L-Ningyocho 4F, Ningyocho 2-7-10, Nihonbashi, Chuo-ku, Tokyo 103-0013 TEL : 03-6667-0456 E-mail : servicejapan@igenomix.com
    JPFE0048-21 www.igenomix.jp

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