6
AMINES
ORGANIC CHEMISTRY
AMINES
by Dr. M.K. JAIN (HOD- CHEMISTRY)
v. By Reductive Amination of carbonyl compounds?
Preparation
1. Ammonolysis of alkyl halides (Hofmann's Method) :
2. Ammonolysis of alkanols :
4. By Hydrolysis :
3. Reduction (i) Hofmann's Bromamide reaction :
(i) By nitroalkanes :
(ii) Gabriel phthalimide reaction :
(ii) By Alkyl cyanides (Mendius Reaction) :
(iii)By Oximes :
(iv)By Acid Amides :
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CHEMISTRY AMINES
Chemical Properties
(i) Basic nature of amines :
(iii) Alkyl isocyanides :
(iv) Alkyl Isocyanates (Wurtz Method) :
(v) Leuckart reaction :
(vi) Ritter reaction :
(vii) Lossen rearrangement :
(viii) Schmit reaction :
(ix) Curtius reaction :
(ii) Reaction with water :
Physical Properties
(i) Solubility :
(ii) Boiling point
(iii) Alkylation :
Explaination :
(iv) Acetylation :
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CHEMISTRY AMINES
(v) Benzoylation : (Schotten-Baumann reaction)
(vi) Acidic behaviour :
(vii) With Grignard's reagent :
(viii) With Tilden's reagent :
(ix) With Hinsberg's reagent :
(b) Secondary amines :
(x) With Phenyl isocyanate :
(c) Tertiary amines :
(xi) Mannich reaction :
0 0 0
(xvi) Distinction between 1 ,2 and 3 amines :
(a) Reaction with HNO2:
(Xii) Hofmann's Mustard oil reaction (HMO reaction)
(xiii) With aldehydes :
(b) Reaction with benzene sulphon yl chloride :
(xiv) Hofmann carbylamine reaction (Isocyanide test) :
(xv) Oxidation
(a) Primary amines :
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CHEMISTRY AMINES
(c) Reaction with diethyloxalate (Hofmann's method) (ii) Halogenation :
ANILINE (iii) Nitration :
Methods of Preparation
(i) Lab method :
(ii) Industrial method :
Reactions
(i) Catalytic hydrogenation :
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CHEMISTRY AMINES
(iv) Sulphonation :
(v) Coupling reaction :
(vi) Reaction with phosgene :
(x) Oxidation :
(vii) Reaction with CS2+ Solid KOH :
(viii) Arylation :
Test for Aniline :
(ix) Diazotization :
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CHEMISTRY AMINES
Uses :
(iv) By the dehydration of aldoximes :
Resonance in Aniline and related points (v) From Primary amines :
Physical Properties
Chemical Properties
(i) Hydrolysis :
(ii) Reduction :
(b) Stephen's reaction :
(c) Mendius reaction
CYANIDES AND ISOCYANIDES
Preparation
(i) From alkyl halides :
(iii) Reaction with Grignard reagent :
(ii) From acid amides :
(iii) From Grignard reagent : (iv) Ethanolysis :
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CHEMISTRY AMINES
ISOCYANIDES
Preparation
(i) From alkyl halides :
(ii) From primary amines (carbylamine reaction) : ETHYL NITRITE (C2H5-O-N=O)
1. Preparation
(i) By adding conc. HCl or sulphuric acid to an
aqueous solution of sodium nitrite and ethyl alcohol.
(iii) From N-alkyformamide :
(ii) By the action of N2O3 on ethanol :
(iii) By the reaction between ethyl iodide and potassium nitrite.
Physical Properties
2. Properties
Chemical Properties
(i) Hydrolysis :
3. Uses
(ii) Reduction :
NITRO ALKANE
(iii) Action of heat :
(iv) Addition reactions :
Preparation
(i) From alkyl halides :
ALKYL NITRITES AND NITROALKANES
(ii)By direct nitration of alkanes :
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CHEMISTRY AMINES
Properties
Uses
(i)
(ii) Reduction :
NITROBENZENE
(iii) Action of nitrous acid :
METHODS OF PREPARATION
(i) By Nitration of Benzene (Laboratory Method)
(ii) By Oxidation of Aniline :
(iv) Halogenation :
Physical properties
Chemical reactions
(1) Reactions due to Nitro group
(v) Hydrolysis :
(a) Reduction in acidic medium :
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CHEMISTRY AMINES
(b) Neutral medium :
(c) Alkaline medium :
(d) Electrolytic reduction :
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CHEMISTRY AMINES
(c) Catalytic reaction : (3) Nucleophilic substitution reactions :
(f) Reduction by Lithium aluminium hydride (LiAlH4) :
(2) Electrophilic substitution reaction due to benzene ring :
Test of Nitrobenzene : (Mulliken and Barker test)
Uses
MISCELLANEOUS SOLVED EXAMPLES
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CHEMISTRY AMINES
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Daily Practice Problems
TARGET : IIT-JEE / NEET
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CHEMISTRY AMINES
3
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CHEMISTRY AMINES
3 M.K. JAIN CLASSES PVT. LTD. (NEET/ IIT-JEE/ KVPY) 9414301104 | [Link]
CHEMISTRY AMINES
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SOLUTION
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CHEMISTRY AMINES
3
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CHEMISTRY AMINES
3 M.K. JAIN CLASSES PVT. LTD. (NEET/ IIT-JEE/ KVPY) 9414301104 | [Link]
CHEMISTRY AMINES
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CHEMISTRY AMINES
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CHEMISTRY AMINES
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