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  • Anaerobic Infections, Central Nervous System

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    Radia Lacheheb
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    Anaerobic bacteria are a common cause of brain abscess, subdural empyema, or septic central nervous system thrombophlebitis. These organisms typically reach the CNS via direct extension from sinusitis, otitis, or mastoiditis, or through hematogenous spread from chronic lung infections. Patients present with various neurologic deficits. Diagnosis involves MRI or CT scans and culture of infected tissue. Treatment consists of surgical drainage along with a combination of intravenous ceftriaxone and metronidazole antibiotics for 6-8 weeks based on follow-up imaging, though some small multiple brain abscesses can be treated with antibiotics alone.

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    Anaerobic bacteria are a common cause of brain abscess, subdural empyema, or septic central nervous system thrombophlebitis. These organisms typically reach the CNS via direct extension from sinusitis, otitis, or mastoiditis, or through hematogenous spread from chronic lung infections. Patients present with various neurologic deficits. Diagnosis involves MRI or CT scans and culture of infected tissue. Treatment consists of surgical drainage along with a combination of intravenous ceftriaxone and metronidazole antibiotics for 6-8 weeks based on follow-up imaging, though some small multiple brain abscesses can be treated with antibiotics alone.

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    8 views1 page

    Anaerobic Infections, Central Nervous System

    Uploaded by

    Radia Lacheheb
    Anaerobic bacteria are a common cause of brain abscess, subdural empyema, or septic central nervous system thrombophlebitis. These organisms typically reach the CNS via direct extension from sinusitis, otitis, or mastoiditis, or through hematogenous spread from chronic lung infections. Patients present with various neurologic deficits. Diagnosis involves MRI or CT scans and culture of infected tissue. Treatment consists of surgical drainage along with a combination of intravenous ceftriaxone and metronidazole antibiotics for 6-8 weeks based on follow-up imaging, though some small multiple brain abscesses can be treated with antibiotics alone.

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    © All Rights Reserved
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    Quick Medical Diagnosis & Treatment 2021

    Anaerobic Infections, Central Nervous System

    For further information, see CMDT Part 33­31: Anaerobic Infections

    Key Features
    Common cause of brain abscess, subdural empyema, or septic CNS thrombophlebitis

    The organisms reach CNS by direct extension from sinusitis, otitis, or mastoiditis or by hematogenous spread from chronic lung infections

    Clinical Findings
    Various neurologic deficits

    Diagnosis
    MRI scan (most sensitive) or CT scan

    Culture of infected tissue

    Treatment
    Antimicrobial therapy is an important adjunct to surgical drainage

    Ceftriaxone, 2 g every 12 hours intravenously, plus metronidazole, 500 mg every 8 hours intravenously

    Duration of antibiotic therapy is 6–8 weeks but should be based on follow­up imaging

    Some small multiple brain abscesses can be treated with antibiotics alone without surgical drainage

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