Your cells for your health

Lipogems’ people alongside Physicians and Surgeons

aim to improve Patient’s life all over the world
providing innovative Technologies and Medical solutions.
 LIPOGEMS® system is a disposable device for
liposuction, processing and adipose tissue
reinjection.

Procedure takes place in a single surgical time.

It’s a disposable device that progressively reduces

adipose tissue clusters size, washing completely
pro-infiammatory oil and blood debrids through a
minimal manipulation “free enzyme” in a aseptic
closed system completely prefilled by room tempe-
rature physiological solution.

LIPOGEMS® product is a non-expanded and microfractured fat

tissue ready for autologous settings.

The non-expanded LIPOGEMS® product shows a remarkably preser-

ved stromal vascular fraction (SVF) with slit-like capillaries wedged
between adipocytes and stromal stalks with evident vascular lumina,
harboring a significantly higher percentage of mature pericytes and
hMSCs.

LIPOGEMS® product promotes natural regeneration process of

tissues, finding application in many diseases.

Areas of application:
• Coloproctology
• Gynecology
• Orthopedics
• Otolaryngology
• Plastic aesthetic and reconstructive surgery
• Urology
• Vulnology

PRODUCT KIT CODES

Kit for general surgery 60 cc LG SK 60
Kit for general surgery 240 cc LG SK 240
Kit only processing 60 cc LG PK 60
Kit only processing 240 cc LG PK 240

Set of anesthesia/suction 60 cc LG H&I 60

Set of anesthesia/suction 240 cc LG H&I 240

Set of cannulas for anesthesia LGC A 17G P05

Set of cannulas for suction LGC LA 13G P05
Set of needle/cannula for infiltration LGC I 20G P05
INFILTRATION / ANESTHESIA
Saline solution containing adrenaline and lidocaine is injected in the
subcutaneus adipose tissue with a specific disposable cannula (17g).

LIPOSUCTION
Liposuction is performed by a special progressive stop 60 cc vaclok
or 10cc luer lock siringes connected to a 19 cm 13g aspirating
cannula with 5 oval holes at the end of the cannula.

STEP 1
Connect the tube of the blue filter to the bag of the salin solution.
Turn the device positioning the grey filter upward.
Open both tubes.
Fill the device with saline solution holding it vertical and once it is full,
close both tubes.

STEP 2
Turn the device positioning the blue filter upward.
Close the tube of the blue filter and open the tube of the grey filter.
Connect the syringe containing lipoaspirate to the valve of the blue filter.
Push lipoaspirate into the device through the blue filter.

STEP 3
Open both tubes to allow the continuos flow of saline solution.
The lipoaspirate introduced into the device is subjected to a kind of “shaking” while the action
of stainless steel spheres further emulsifies and microfragments the lipoaspirate.
When the saline solution looks completely clear; stop of “shaking” and close both tubes.

STEP 4
Connect two luerlock syringes to the two filters ( blue and grey ) to allow LIPOGEMS®
tissue extraction.
Turn the device with the grey filter upward.
Open the tube of the blue filter.
Withdraw 10cc of saline solution throught the syringe connected to the blue filter.
Close the tube of the blue filter.

.
STEP 5
Hold vertical the device with grey filter upward.
Acting on the syringe connected to the blue filter, push 10cc of saline
solution into the device to allow LIPOGEMS® tissue to flow through
the grey filter into the connected syringe.

LIPOGEMS® TISSUE IS NOW READY TO BE USED IN THE SPECIFIC

AREAS OF APPLICATION.
Our scientific board:

Prof. Arnold I. Caplan (Cleveland)

Prof. Bruno Peault (Edimburgh – Los Angeles)
Prof. Camillo Ricordi (Miami)
Prof. Carlo Tremolada (Milano)
Prof. Carlo Ventura (Bologna)

Lipogems International is an Italian biotech company

based in Milan who works in the medical field

SCIENTIFIC PARTNERSHIPS
• Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale “A. Avogadro”
Novara - Prof. M. Bosetti
• Case Western Reserve University
Cleveland, Ohio - Prof. A. I. Caplan
• Divisione di Ortopedia e Traumatologia , Azienda Ospedaliero-Universitaria di Modena, Università di Modena e Reggio Emilia
Modena - Prof F. Catani
• Divisione di Chirurgia Plastica e Microchirurgia, Azienda Ospedaliero-Universitaria di Modena, Università di Modena e Reggio Emilia
Modena - Prof. G. De Santis
• Dipartimento di Scienze Mediche e Chirurgiche, Università degli Studi di Modena e Reggio Emilia
Modena - Prof. M. Dominici
• Centre for regenerative medicine in Edimburgh and University of California
Edimburgh - Los Angeles - Prof. B. Peault
• Division of Cellular Transplantation, Department of Surgery and Diabetes Research Institute, University of Miami
Miami - Prof. C.Ricordi
• Istituto Image
Milano - Prof. C. Tremolada
• Laboratory of Molecular Biology and Stem Cell Engineering, Università di Bologna
Bologna - Prof. C. Ventura

BIBLIOGRAPHY
Bianchi F.*, Maioli M., Leonardi E., Olivi E., Pasquinelli G., Valente S., Mendez A.J., Ricordi C., Raffaini M., Tremolada C., Ventura C.
«A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild
mechanical forces from human lipoaspirates.»
Cell Transplant. 2013;22(11):2063-77. doi: 10.3727/096368912X657855. Epub 2012 Oct
*Laboratory of Molecular Biology and Stem Cell Engineering-National Institute of Biostructures and Biosystems, Bologna, Italy.
Carelli S., Messaggio F., Canazza A., Hebda D., Caremoli F., Latorre E., Grimoldi M.G., Colli M., Bulfamante G., Tremolada C.
«Characteristics and Properties of Mesenchymal Stem Cells Derived from Micro-fragmented Adipose Tissue.»
Cell Transplant. 2014 April 29
Maioli M.*, Rinaldi S., Santaniello S., Castagna A., Pigliaru G., Delitala A., Bianchi F., Tremolada C., Fontani V., Ventura C.
«Radio electric asymmetric conveyed fields and human adipose-derived cells obtained with a non-enzymatic method and device:
a novel approach to multipotency.»
Cell Transplant. 2013 Aug 30. doi: 10.3727/096368913X672037. [Epub ahead of print]
*Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna, Italy
Tremolada C.*, Palmieri G., Ricordi C.
«Adipocyte transplantation and stem cells: plastic surgery meets regenerative medicine.»
Cell Transplant. 2010;19(10):1217-23. doi: 10.3727/096368910X507187. Epub 2010 May 4.
*Istituto Image and San Paolo Hospital, Milan, Italy

Lipogems International SpA

Viale Bianca Maria 24 - 20129 Milano MI
Tel. +39.02.37072408/9 - Fax +39.02.37072410
www.lipogems.eu
C.F. e P.IVA 07093190960